C3G self-regulatory mechanism revealed: implications for hematopoietic malignancies
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Abnormally increased signaling by the GTPase RAP1 favors progression of diverse tumors. We have characterized the auto-regulation and activation of C3G (RAPGEF1), an activator of RAP1. This led us to discover mutations in non-Hodgkin’s lymphomas that activate C3G-RAP1 constitutively, suggesting that deregulation of C3G may favor the dissemination of tumor cells.
| Original language | English |
|---|---|
| Article number | 1837581 |
| Journal | Molecular and Cellular Oncology |
| Volume | 8 |
| Issue number | 1 |
| Number of pages | 4 |
| ISSN | 2372-3556 |
| DOIs |
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| Publication status | Published - 2021 |
- guanine nucleotide exchange factor, non-Hodgkin’s lymphoma, RAP1, RAPGEF1, signaling
Research areas
ID: 254668212