Niels Skotte

Niels Skotte

Assistant Professor, Visiting professor

ORCID: 0000-0001-7027-7193

Publication year:
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1 - 25 out of 33Page size: 25
  1. 2010
  2. Published

    Full-length huntingtin levels modulate body weight by influencing insulin-like growth factor 1 expression

    Pouladi, M. A., Xie, Y., Skotte, Niels Henning, Ehrnhoefer, D. E., Graham, R. K., Kim, J. E., Bissada, N., Yang, X. W., Paganetti, P., Friedlander, R. M., Leavitt, B. R. & Hayden, M. R., 15 Apr 2010, In: Human Molecular Genetics. 19, 8, p. 1528-38 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Reduced gluconeogenesis and lactate clearance in Huntington's disease

    Josefsen, K., Nielsen, S. M. B., Campos, A., Seifert, T., Hasholt, Lis Frydenreich, Nielsen, Jørgen Erik, Nørremølle, Anne, Skotte, Niels Henning, Secher, Niels H. & Quistorff, B., 1 Dec 2010, In: Neurobiology of Disease. 40, 3, p. 656-62 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. 2011
  5. Published

    A quantitative method for the specific assessment of caspase-6 activity in cell culture

    Ehrnhoefer, D. E., Skotte, Niels Henning, Savill, J., Nguyen, Y. T. N., Ladha, S., Cao, L., Dullaghan, E. & Hayden, M. R., 2011, In: PLOS ONE. 6, 11, p. e27680

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Modulation of mutant huntingtin expression and processing: Pathogenic pathways and novel therapeutic approaches in Huntington's disease

    Skotte, Niels Henning, Nov 2011

    Research output: Book/Report › Ph.D. thesis › Research

  7. Polycystin-1: a key player in hereditary cystic kidney and liver disorders

    Skotte, Niels Henning, Dec 2011, In: Clinical Genetics. 80, 6, p. 507-9 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Potent and selective antisense oligonucleotides targeting single-nucleotide polymorphisms in the Huntington disease gene / allele-specific silencing of mutant huntingtin

    Carroll, J. B., Warby, S. C., Southwell, A. L., Doty, C. N., Greenlee, S., Skotte, Niels Henning, Hung, G., Bennett, C. F., Freier, S. M. & Hayden, M. R., Dec 2011, In: Molecular therapy : the journal of the American Society of Gene Therapy. 19, 12, p. 2178-85 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. 2012

  10. Rescue from excitotoxicity and axonal degeneration accompanied by age-dependent behavioral and neuroanatomical alterations in caspase-6-deficient mice

    Uribe, V., Wong, B. K. Y., Graham, R. K., Cusack, C. L., Skotte, N. H., Pouladi, M. A., Xie, Y., Feinberg, K., Ou, Y., Ouyang, Y., Deng, Y., Franciosi, S., Bissada, N., Spreeuw, A., Zhang, W., Ehrnhoefer, D. E., Vaid, K., Miller, F. D., Deshmukh, M., Howland, D. & 1 others, Hayden, M. R., 1 May 2012, In: Human Molecular Genetics. 21, 9, p. 1954-67 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Antisense oligonucleotide therapeutics for inherited neurodegenerative diseases

    Southwell, A. L., Skotte, Niels Henning, Bennett, C. F. & Hayden, M. R., Nov 2012, In: Trends in Molecular Medicine. 18, 11, p. 634-43 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. 2013

  13. A fully humanized transgenic mouse model of Huntington disease

    Southwell, A. L., Warby, S. C., Carroll, J. B., Doty, C. N., Skotte, Niels Henning, Zhang, W., Villanueva, Erika Bianca, Kovalik, V., Xie, Y., Pouladi, M. A., Collins, J. A., Yang, X. W., Franciosi, S. & Hayden, M. R., 1 Jan 2013, In: Human Molecular Genetics. 22, 1, p. 18-34 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Rational design of antisense oligonucleotides targeting single nucleotide polymorphisms for potent and allele selective suppression of mutant Huntingtin in the CNS

    Østergaard, M. E., Southwell, A. L., Kordasiewicz, H., Watt, A. T., Skotte, Niels Henning, Doty, C. N., Vaid, K., Villanueva, Erika Bianca, Swayze, E. E., Bennett, C. F., Hayden, M. R. & Seth, P. P., Nov 2013, In: Nucleic Acids Research. 41, 21, p. 9634-50 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. 2014

  16. Allele-specific suppression of mutant huntingtin using antisense oligonucleotides: providing a therapeutic option for all Huntington disease patients

    Skotte, Niels Henning, Southwell, A. L., Østergaard, M. E., Carroll, J. B., Warby, S. C., Doty, C. N., Petoukhov, E., Vaid, K., Kordasiewicz, H., Watt, A. T., Freier, S. M., Hung, G., Seth, P. P., Bennett, C. F., Swayze, E. E. & Hayden, M. R., 2014, In: PLOS ONE. 9, 9, p. e107434

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    p53 increases caspase-6 expression and activation in muscle tissue expressing mutant huntingtin

    Ehrnhoefer, D. E., Skotte, Niels Henning, Ladha, S., Nguyen, Y. T. N., Qiu, X., Deng, Y., Huynh, K. T., Engemann, S., Nielsen, S. M., Becanovic, K., Leavitt, B. R., Hasholt, Lis Frydenreich & Hayden, M. R., 1 Feb 2014, In: Human Molecular Genetics. 23, 3, p. 717-29 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response

    Rotblat, B., Southwell, A. L., Ehrnhoefer, D. E., Skotte, N. H., Metzler, M., Franciosi, S., Leprivier, G., Somasekharan, S. P., Barokas, A., Deng, Y., Tang, T., Mathers, J., Cetinbas, N., Daugaard, M., Kwok, B., Li, L., Carnie, C. J., Fink, D., Nitsch, R., Galpin, J. D. & 5 others, Ahern, C. A., Melino, G., Penninger, J. M., Hayden, M. R. & Sorensen, P. H., 25 Feb 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 8, p. 3032-7 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Personalized gene silencing therapeutics for Huntington disease

    Kay, C., Skotte, Niels Henning, Southwell, A. L. & Hayden, M. R., Jul 2014, In: Clinical Genetics. 86, 1, p. 29-36 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. In vivo evaluation of candidate allele-specific mutant huntingtin gene silencing antisense oligonucleotides

    Southwell, A. L., Skotte, Niels Henning, Kordasiewicz, H. B., Østergaard, M. E., Watt, A. T., Carroll, J. B., Doty, C. N., Villanueva, Erika Bianca, Petoukhov, E., Vaid, K., Xie, Y., Freier, S. M., Swayze, E. E., Seth, P. P., Bennett, C. F. & Hayden, M. R., Dec 2014, In: Molecular Therapy. 22, 12, p. 2093-106 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. 2015

  22. Huntingtin Haplotypes Provide Prioritized Target Panels for Allele-specific Silencing in Huntington Disease Patients of European Ancestry

    Kay, C., Collins, J. A., Skotte, Niels Henning, Southwell, A. L., Warby, S. C., Caron, N. S., Doty, C. N., Nguyen, B., Griguoli, A., Ross, C. J., Squitieri, F. & Hayden, M. R., Nov 2015, In: Molecular Therapy. 23, 11, p. 1759-71 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. 2016

  24. Interactome network analysis identifies multiple caspase-6 interactors involved in the pathogenesis of HD

    Riechers, S., Butland, S., Deng, Y., Skotte, Niels Henning, Ehrnhoefer, D. E., Russ, J., Laine, J., Laroche, M., Pouladi, M. A., Wanker, E. E., Hayden, M. R. & Graham, R. K., 15 Apr 2016, In: Human Molecular Genetics. 25, 8, p. 1600-18 19 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. 2017

  26. Palmitoylation of caspase-6 by HIP14 regulates its activation

    Skotte, Niels Henning, Sanders, S. S., Singaraja, R. R., Ehrnhoefer, D. E., Vaid, K., Qiu, X., Kannan, S., Verma, C. & Hayden, M. R., 2017, In: Cell Death and Differentiation. 24, p. 433-444 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    A novel humanized mouse model of Huntington disease for preclinical development of therapeutics targeting mutant huntingtin alleles

    Southwell, A. L., Skotte, N. H., Villanueva, E. B., Østergaard, M. E., Gu, X., Kordasiewicz, H. B., Kay, C., Cheung, D., Xie, Y., Waltl, S., Dal Cengio, L., Findlay-Black, H., Doty, C. N., Petoukhov, E., Iworima, D., Slama, R., Ooi, J., Pouladi, M. A., Yang, X. W., Swayze, E. E. & 2 others, Seth, P. P. & Hayden, M. R., 15 Mar 2017, In: Human Molecular Genetics. 26, 6, p. 1115-1132 18 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. 2018

  29. Huntingtin suppression restores cognitive function in a mouse model of Huntington's disease

    Southwell, A. L., Kordasiewicz, H. B., Langbehn, D., Skotte, Niels Henning, Parsons, M. P., Villanueva, Erika Bianca, Caron, N. S., Østergaard, M. E., Anderson, L. M., Xie, Y., Cengio, L. D., Findlay-Black, H., Doty, C. N., Fitsimmons, B., Swayze, E. E., Seth, P. P., Raymond, L. A., Frank Bennett, C. & Hayden, M. R., 2018, In: Science Translational Medicine. 10, 461, p. 1-12 eaar3959.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Integrative Characterization of the R6/2 Mouse Model of Huntington's Disease Reveals Dysfunctional Astrocyte Metabolism

    Skotte, Niels Henning, Andersen, Jens Velde, Santos, A., Aldana, Blanca, Willert, C. W., Nørremølle, Anne, Waagepetersen, Helle S. & Nielsen, Michael Lund, 2018, In: Cell Reports. 23, 7, p. 2211-2224 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Site-specific characterization of endogenous SUMOylation across species and organs

    Hendriks, Ivo Alexander, Lyon, D., Su, D., Skotte, Niels Henning, Daniel, J. A., Jensen, Lars Juhl & Nielsen, Michael Lund, 2018, In: Nature Communications. 9, p. 1-17 2456.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. 2019

  33. Activation of Caspase-6 Is Promoted by a Mutant Huntingtin Fragment and Blocked by an Allosteric Inhibitor Compound

    Ehrnhoefer, D. E., Skotte, N. H., Reinshagen, J., Qiu, X., Windshuegel, B., Jaishankar, P., Ladha, S., Petina, O., Khankischpur, M., Nguyen, Y. T. N., Caron, N. S., Razeto, A., Zu Rheda, M. M., Deng, Y., Huynh, K. T., Wittig, I., Gribbon, P., Renslo, A. R., Geffken, D., Gul, S. & 1 others, Hayden, M. R., 2019, In: Cell Chemical Biology. 26, 9, p. 1295-1305.e6

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Enhanced cerebral branched-chain amino acid metabolism in R6/2 mouse model of Huntington's disease

    Andersen, Jens Velde, Skotte, Niels Henning, Aldana, Blanca, Nørremølle, Anne & Waagepetersen, Helle S., 2019, In: Cellular and Molecular Life Sciences. 76, 12, p. 2449-2461

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Functional Differences between Synaptic Mitochondria from the Striatum and the Cerebral Cortex

    Petersen, M. H., Willert, C. W., Andersen, Jens Velde, Waagepetersen, Helle S., Skotte, Niels Henning & Nørremølle, Anne, May 2019, In: Neuroscience. 406, p. 432-443 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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