Niels Skotte

Niels Skotte

Assistant Professor, Visiting professor

ORCID: 0000-0001-7027-7193

Publication year:
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11 - 20 out of 33Page size: 10
  1. 2014

  2. Allele-specific suppression of mutant huntingtin using antisense oligonucleotides: providing a therapeutic option for all Huntington disease patients

    Skotte, Niels Henning, Southwell, A. L., Østergaard, M. E., Carroll, J. B., Warby, S. C., Doty, C. N., Petoukhov, E., Vaid, K., Kordasiewicz, H., Watt, A. T., Freier, S. M., Hung, G., Seth, P. P., Bennett, C. F., Swayze, E. E. & Hayden, M. R., 2014, In: PLOS ONE. 9, 9, p. e107434

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    p53 increases caspase-6 expression and activation in muscle tissue expressing mutant huntingtin

    Ehrnhoefer, D. E., Skotte, Niels Henning, Ladha, S., Nguyen, Y. T. N., Qiu, X., Deng, Y., Huynh, K. T., Engemann, S., Nielsen, S. M., Becanovic, K., Leavitt, B. R., Hasholt, Lis Frydenreich & Hayden, M. R., 1 Feb 2014, In: Human Molecular Genetics. 23, 3, p. 717-29 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response

    Rotblat, B., Southwell, A. L., Ehrnhoefer, D. E., Skotte, N. H., Metzler, M., Franciosi, S., Leprivier, G., Somasekharan, S. P., Barokas, A., Deng, Y., Tang, T., Mathers, J., Cetinbas, N., Daugaard, M., Kwok, B., Li, L., Carnie, C. J., Fink, D., Nitsch, R., Galpin, J. D. & 5 others, Ahern, C. A., Melino, G., Penninger, J. M., Hayden, M. R. & Sorensen, P. H., 25 Feb 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 8, p. 3032-7 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Personalized gene silencing therapeutics for Huntington disease

    Kay, C., Skotte, Niels Henning, Southwell, A. L. & Hayden, M. R., Jul 2014, In: Clinical Genetics. 86, 1, p. 29-36 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. In vivo evaluation of candidate allele-specific mutant huntingtin gene silencing antisense oligonucleotides

    Southwell, A. L., Skotte, Niels Henning, Kordasiewicz, H. B., Østergaard, M. E., Watt, A. T., Carroll, J. B., Doty, C. N., Villanueva, Erika Bianca, Petoukhov, E., Vaid, K., Xie, Y., Freier, S. M., Swayze, E. E., Seth, P. P., Bennett, C. F. & Hayden, M. R., Dec 2014, In: Molecular Therapy. 22, 12, p. 2093-106 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. 2015

  8. Huntingtin Haplotypes Provide Prioritized Target Panels for Allele-specific Silencing in Huntington Disease Patients of European Ancestry

    Kay, C., Collins, J. A., Skotte, Niels Henning, Southwell, A. L., Warby, S. C., Caron, N. S., Doty, C. N., Nguyen, B., Griguoli, A., Ross, C. J., Squitieri, F. & Hayden, M. R., Nov 2015, In: Molecular Therapy. 23, 11, p. 1759-71 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. 2016

  10. Interactome network analysis identifies multiple caspase-6 interactors involved in the pathogenesis of HD

    Riechers, S., Butland, S., Deng, Y., Skotte, Niels Henning, Ehrnhoefer, D. E., Russ, J., Laine, J., Laroche, M., Pouladi, M. A., Wanker, E. E., Hayden, M. R. & Graham, R. K., 15 Apr 2016, In: Human Molecular Genetics. 25, 8, p. 1600-18 19 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. 2017

  12. Palmitoylation of caspase-6 by HIP14 regulates its activation

    Skotte, Niels Henning, Sanders, S. S., Singaraja, R. R., Ehrnhoefer, D. E., Vaid, K., Qiu, X., Kannan, S., Verma, C. & Hayden, M. R., 2017, In: Cell Death and Differentiation. 24, p. 433-444 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    A novel humanized mouse model of Huntington disease for preclinical development of therapeutics targeting mutant huntingtin alleles

    Southwell, A. L., Skotte, N. H., Villanueva, E. B., Østergaard, M. E., Gu, X., Kordasiewicz, H. B., Kay, C., Cheung, D., Xie, Y., Waltl, S., Dal Cengio, L., Findlay-Black, H., Doty, C. N., Petoukhov, E., Iworima, D., Slama, R., Ooi, J., Pouladi, M. A., Yang, X. W., Swayze, E. E. & 2 others, Seth, P. P. & Hayden, M. R., 15 Mar 2017, In: Human Molecular Genetics. 26, 6, p. 1115-1132 18 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. 2018

  15. Huntingtin suppression restores cognitive function in a mouse model of Huntington's disease

    Southwell, A. L., Kordasiewicz, H. B., Langbehn, D., Skotte, Niels Henning, Parsons, M. P., Villanueva, Erika Bianca, Caron, N. S., Østergaard, M. E., Anderson, L. M., Xie, Y., Cengio, L. D., Findlay-Black, H., Doty, C. N., Fitsimmons, B., Swayze, E. E., Seth, P. P., Raymond, L. A., Frank Bennett, C. & Hayden, M. R., 2018, In: Science Translational Medicine. 10, 461, p. 1-12 eaar3959.

    Research output: Contribution to journal › Journal article › Research › peer-review

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