Nicolai Jacob Wewer Albrechtsen
Associate Professor
Mann Group
Blegdamsvej 3B
2200 København N
- E-pub ahead of print
Determinants of plasma levels of proglucagon and the metabolic impact of glucagon receptor signalling: a UK Biobank study
Winther-Sørensen, Marie, Garcia, S. L., Bartholdy, Andreas, Ottenheijm, Maud Eline, Banasik, Karina, Brunak, Søren, Sorensen, Charlotte Mehlin, Gluud, Lise Lotte, Knop, Filip Krag, Holst, Jens Juul, Rosenkilde, Mette, Jensen, Majken Karoline & Albrechtsen, Nicolai Jacob Wewer, 6 May 2024, (E-pub ahead of print) In: Diabetologia.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Development and evaluation of a glucagon sensitivity test
Kjeldsen, Sasha Alexandra Sampson, Jensen, N. J., Nilsson, M. S. D., Nybing, J. D., Linden, F. H., Hogh-Schmidt, E., Boesen, Mikael Ploug, Madsbad, Sten, Vilstrup, H. V. A., Rashu, E. B., Gluud, Lise Lotte, Haugaard, Steen Bendix, Holst, Jens Juul, Rungby, Jørgen & Albrechtsen, Nicolai Jacob Wewer, 2021, In: Diabetologia. 64, SUPPL 1, p. 189-189 365.Research output: Contribution to journal › Conference abstract in journal › Research
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Development of a glucagon sensitivity test in humans: Pilot data and the GLUSENTIC study protocol
Kjeldsen, S. A. S., Richter, M. M., Jensen, N. J., Nilsson, M. S. D., Heinz, N., Nybing, J. D., Linden, F. H., Høgh-Schmidt, E., Boesen, M. P., Madsbad, S., Vilstrup, H., Schiødt, F. V., Møller, A., Nørgaard, K., Schmidt, S., Rashu, E. B., Gluud, L. L., Haugaard, S. B., Holst, J. J., Rungby, J. & 1 others, , 2023, In: Peptides. 161, 10 p., 170938.Research output: Contribution to journal › Journal article › Research › peer-review
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Different Malabsorptive Obesity Surgery Interventions Result in Distinct Postprandial Amino Acid Metabolomic Signatures
Pereira, S. S., Jarak, I., Carvalho, R. A., Oliveira, P. F., Alves, M. G., Guimaraes, M., Almeida, R., Pereira, A. M., Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul, Nora, M. & Monteiro, M. P., 2020, In: Obesity Surgery. 30, p. 4019-4028Research output: Contribution to journal › Journal article › Research › peer-review
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Differential effects of bile acids on the postprandial secretion of gut hormones: A randomized crossover study
McGlone, E. R., Malallah, K., Cuenco, J., Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul, Vincent, R. P., Ling, C., Khan, O. A., Verma, S., Ahmed, A. R., Walters, J. R. F., Khoo, B., Bloom, S. R. & Tan, T. M. M., 2021, In: American Journal of Physiology - Endocrinology and Metabolism. 320, 4, p. E671-E679Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Discovery of plasma proteins associated with ventricular fibrillation during first ST-elevation myocardial infarction via proteomics
Stampe, N. K., Ottenheijm, Maud Eline, Drici, L., Albrechtsen, Nicolai Jacob Wewer, Nielsen, A. B., Christoffersen, Christina, Warming, P. E., Engstrøm, Thomas, Winkel, B. G., Jabbari, R., Tfelt-Hansen, Jacob & Glinge, C., 2024, In: European Heart Journal: Acute Cardiovascular Care. 13, 3, p. 264–272Research output: Contribution to journal › Journal article › Research › peer-review
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Disruption of glucagon receptor signaling causes hyperaminoacidemia exposing a possible liver-alpha-cell axis
Galsgaard, Katrine Douglas, Winther-Sørensen, Marie, Ørskov, Cathrine, Kissow, Hannelouise, Poulsen, Steen Seier, Vilstrup, H., Prehn, C., Adamski, J., Jepsen, Sara Lind, Hartmann, Bolette, Dal, Jenna Elizabeth Hunt, Charron, M. J., Pedersen, Jens, Albrechtsen, Nicolai Jacob Wewer & Holst, Jens Juul, 2018, In: American Journal of Physiology: Endocrinology and Metabolism. 314, 1, p. E93-E103Research output: Contribution to journal › Journal article › Research › peer-review
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Distinct signaling by insulin and IGF-1 receptors and their extra- and intracellular domains
Nagao, H., Cai, W., Albrechtsen, Nicolai Jacob Wewer, Steger, M., Batista, T. M., Pan, H., Dreyfuss, J. M., Mann, Matthias & Kahn, C. R., 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 17, e2019474118.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Do glucagonomas always produce glucagon?
Albrechtsen, Nicolai Jacob Wewer, Challis, B., Damjanov, I. & Holst, Jens Juul, 1 Feb 2016, In: Bosnian Journal of Basic Medical Sciences. 16, 1, p. 1-7 7 p.Research output: Contribution to journal › Review › Research › peer-review
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Do sodium-glucose transporter-2 inhibitors increase plasma glucagon by direct actions on the alpha-cell? - and does the increase matter for the associated increase in endogenous glucose production?
Kuhre, Rune Ehrenreich, Deacon, Carolyn F., Albrechtsen, Nicolai Jacob Wewer & Holst, Jens Juul, 2021, In: Diabetes, Obesity and Metabolism. 23, 9, p. 2009-2019Research output: Contribution to journal › Review › Research › peer-review
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Dynamic human liver proteome atlas reveals functional insights into disease pathways
Niu, Lili, Geyer, P. E., Gupta, R., Santos, A., Meier, F., Doll, S., Albrechtsen, Nicolai Jacob Wewer, Klein, S., Ortiz, C., Uschner, F. E., Schierwagen, R., Trebicka, J. & Mann, Matthias, 2022, In: Molecular Systems Biology. 18, 5, 24 p., e10947.Research output: Contribution to journal › Journal article › Research › peer-review
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Dynamics of glucagon secretion in mice and rats revealed using a validated sandwich ELISA for small sample volumes.
Albrechtsen, Nicolai Jacob Wewer, Kuhre, Rune Ehrenreich, Windeløv, Johanne Agerlin, Ørgaard, A., Deacon, Carolyn F., Kissow, Hannelouise, Hartmann, Bolette & Holst, Jens Juul, 2016, In: American Journal of Physiology: Endocrinology and Metabolism. 311, 2, p. E302-E309 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Effect of a 6-Week Carbohydrate-Reduced High-Protein Diet on Levels of FGF21 and GDF15 in People With Type 2 Diabetes
Richter, Michael Martin, Thomsen, M. N., Skytte, M. J., Kjeldsen, Sasha Alexandra Sampson, Samkani, A., Frystyk, J., Magkos, Faidon, Holst, Jens Juul, Madsbad, Sten, Krarup, T., Haugaard, Steen Bendix & Albrechtsen, Nicolai Jacob Wewer, 2024, In: Journal of the Endocrine Society. 8, 4, 11 p., bvae008.Research output: Contribution to journal › Journal article › Research › peer-review
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Effects of 3 months of 10-h per-day time-restricted eating and 3 months of follow-up on bodyweight and cardiometabolic health in Danish individuals at high risk of type 2 diabetes: the RESET single-centre, parallel, superiority, open-label, randomised controlled trial
Quist, Jonas Salling, Pedersen, H. E., Jensen, M. M., Clemmensen, K. K. B., Bjerre, N., Ekblond, T. S., Uldal, S., Størling, Joachim, Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul, Torekov, Signe Sørensen, Nyeland, M. E., Vistisen, D., Jørgensen, M. E., Panda, S., Brock, C., Finlayson, G., Blond, Martin Bæk & Færch, K., 2024, In: The Lancet Healthy Longevity. 5, 5, p. e314-e325 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Effects of Acute GLP-1 Infusion on Pulmonary and Systemic Hemodynamics in Patients With Heart Failure: A Pilot Study
Clarke, S. J., Pettit, S., Giblett, J. P., Zhao, T., Kydd, A. C., Albrechtsen, Nicolai Jacob Wewer, Deacon, Carolyn F., Parameshwar, J. & Hoole, S. P., 2019, In: Clinical Therapeutics. 41, 1, p. 118-127 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Effects of Exercise Training and IL-6 Receptor Blockade on Gastric Emptying and GLP-1 Secretion in Obese Humans: Secondary Analyses From a Double Blind Randomized Clinical Trial
Lehrskov, L. L., Christensen, R. H., Wedell-Neergaard, A-S., Legaard, G. E., Dorph, E., Larsen, M. K., Henneberg, M., Launbo, N., Fagerlind, S. R., Seide, S. K., Nymand, S., Ball, M., Vinum, N., Dahl, C., Albrechtsen, N. J. W., Holst, J. J., Ried-Larsen, M., Rosenmeier, J. B., Krogh-Madsen, R., Karstoft, K. & 2 others, , 2019, In: Frontiers in Physiology. 10, 11 p., 1249 .Research output: Contribution to journal › Journal article › Research › peer-review
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Effects of Manipulating Circulating Bile Acid Concentrations on Postprandial GLP-1 Secretion and Glucose Metabolism After Roux-en-Y Gastric Bypass
Jonsson, I., Bojsen-Moller, K. N., Kristiansen, V. B., Veedfald, Simon, Albrechtsen, Nicolai Jacob Wewer, Clausen, T. R., Kuhre, Rune Ehrenreich, Rehfeld, Jens Frederik, Holst, Jens Juul, Madsbad, Sten & Svane, M. S., 2021, In: Frontiers in Endocrinology. 12, 11 p., 681116.Research output: Contribution to journal › Journal article › Research › peer-review
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Effects of a six-week intervention with glucagon-like peptide-1 receptor analogue on pancreatic volume, oedema and DNA synthesis in obese men
Svane, M. S., Johannesen, Helle Hjorth, Martinussen, C., Bojsen-Moller, K. N., Hansen, M. L., Hansen, A. E., Deacon, Carolyn F., Hartmann, Bolette, Keller, S. H., Loft, A., Kjær, Andreas, Madsbad, Sten, Lofgren, J., Holst, Jens Juul & Albrechtsen, Nicolai Jacob Wewer, 2020, In: Diabetologia. 63, SUPPL 1, p. S216-S217 442.Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Effects of an intensive lifestyle intervention on the underlying mechanisms of improved glycaemic control in individuals with type 2 diabetes: a secondary analysis of a randomised clinical trial
Johansen, M. Y., Karstoft, K., MacDonald, C. S., Hansen, K. B., Ellingsgaard, H., Hartmann, Bolette, Albrechtsen, Nicolai Jacob Wewer, Vaag, A. A., Holst, Jens Juul, Pedersen, Bente Klarlund & Ried-Larsen, M., 2020, In: Diabetologia. 63, p. 2410-2422 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Effects of roux-en-y gastric bypass and sleeve gastrectomy on non-alcoholic fatty liver disease: A 12-month follow-up study with paired liver biopsies
Pedersen, J. S., Rygg, M. O., Serizawa, R. R., Kristiansen, V. B., Albrechtsen, Nicolai Jacob Wewer, Gluud, Lise Lotte, Madsbad, Sten & Bendtsen, Flemming, 2021, In: Journal of Clinical Medicine. 10, 17, 12 p., 3783.Research output: Contribution to journal › Journal article › Research › peer-review
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Efficacy and safety of meal-time administration of short-acting exenatide for glycaemic control in type 1 diabetes (MAG1C): a randomised, double-blind, placebo-controlled trial
Johansen, N. J., Dejgaard, T. F., Lund, A., Schluntz, C., Frandsen, C. S., Forman, Julie Lyng, Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul, Pedersen-Bjergaard, Ulrik, Madsbad, Sten, Vilsbøll, Tina, Andersen, H. U. & Knop, Filip Krag, 2020, In: The Lancet Diabetes & Endocrinology. 8, 4, p. 313-324 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Erratum: Evidence of extrapancreatic glucagon secretion in man. Diabetes 2016;65:585-597
Lund, Asger Bach, Bagger, J. I., Albrechtsen, Nicolai Jacob Wewer, Christensen, M., Grøndahl, M., Hartmann, Bolette, Mathiesen, Elisabeth, Hansen, C. P., Storkholm, J. H., van Hall, Gerrit, Rehfeld, Jens Frederik, Hornburg, D., Meissner, F., Mann, Matthias, Larsen, S., Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, 1 Jun 2016, In: Diabetes. 65, 6, p. 1752 1 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
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Evaluation of commercially available glucagon receptor antibodies and glucagon receptor expression
Billeschou, Anna, Johansen, C. D., Christensen, J. B., Kjeldsen, Sasha Alexandra Sampson, Galsgaard, Katrine Douglas, Winther-Sørensen, Marie, Serizawa, R., Hornum, Mads, Porrini, E., Pedersen, Jens, Ørskov, Cathrine, Gluud, Lise Lotte, Sorensen, Charlotte Mehlin, Holst, Jens Juul, Albrechtsen, Reidar & Albrechtsen, Nicolai Jacob Wewer, 2022, In: Communications Biology . 5, 1, 13 p., 1278.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Evidence of Extrapancreatic Glucagon Secretion in Man
Lund, Asger Bach, Bagger, J. I., Albrechtsen, Nicolai Jacob Wewer, Christensen, M., Grøndahl, M., Hartmann, Bolette, Mathiesen, Elisabeth, Hansen, C. P., Storkholm, J. H., van Hall, Gerrit, Rehfeld, Jens Frederik, Hornburg, D., Meissner, F., Mann, Matthias, Larsen, S., Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, Mar 2016, In: Diabetes. 65, 3, p. 585-597 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Evidence of a liver-alpha cell axis in humans: hepatic insulin resistance attenuates relationship between fasting plasma glucagon and glucagonotropic amino acids
Albrechtsen, Nicolai Jacob Wewer, Færch, K., Jensen, T. M., Witte, D. R., Pedersen, Jens, Mahendran, Y., Jonsson, Anna Elisabet, Galsgaard, Katrine Douglas, Winther-Sørensen, Marie, Torekov, Signe Sørensen, Lauritzen, T., Pedersen, Oluf Borbye, Knop, Filip Krag, Hansen, Torben, Jørgensen, M. E., Vistisen, D. & Holst, Jens Juul, 2018, In: Diabetologia. 61, 3, p. 671-680Research output: Contribution to journal › Journal article › Research › peer-review
ID: 95638859
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Treatment with liraglutide may improve markers of CVD reflected by reduced levels of apoB
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Glucagon-like peptide-1 receptor signaling in acinar cells causes growth dependent release of pancreatic enzymes
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Plasma proteome profiling discovers novel proteins associated with non-alcoholic fatty liver disease
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Published