Nicolai Jacob Wewer Albrechtsen
Associate Professor
Mann Group
Blegdamsvej 3B
2200 København N
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Molecular and in vivo phenotyping of missense variants of the human glucagon receptor
van der Velden, W. J. C., Lindquist, Peter, Madsen, Jakob Sture, Stassen, R. H. M. J., Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul, Hauser, Alexander Sebastian & Rosenkilde, M. M., 2022, In: Journal of Biological Chemistry. 298, 2, 101413.Research output: Contribution to journal › Journal article › Research › peer-review
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Secretion of glucagon, GLP-1 and GIP may be affected by circadian rhythm in healthy males
Zilstorff, D. B., Richter, Michael Martin, Hannibal, Jens, Jørgensen, Henrik Løvendahl, Sennels, H. P. & Albrechtsen, Nicolai Jacob Wewer, 2024, In: BMC Endocrine Disorders. 24, 1, 9 p., 38.Research output: Contribution to journal › Journal article › Research › peer-review
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Measurement of plasma glucagon in humans: A shift in the performance of a current commercially available radioimmunoassay kit
Wu, T., Rayner, C. K., Jones, K. L., Horowitz, M., Feinle-Bisset, C., Standfield, S. D., Xie, C., Deacon, Carolyn F., Holst, Jens Juul & Albrechtsen, Nicolai Jacob Wewer, 2022, In: Diabetes, Obesity and Metabolism. 24, 6, p. 1182-1184Research output: Contribution to journal › Letter › Research › peer-review
- E-pub ahead of print
Determinants of plasma levels of proglucagon and the metabolic impact of glucagon receptor signalling: a UK Biobank study
Winther-Sørensen, Marie, Garcia, S. L., Bartholdy, Andreas, Ottenheijm, Maud Eline, Banasik, Karina, Brunak, Søren, Sorensen, Charlotte Mehlin, Gluud, Lise Lotte, Knop, Filip Krag, Holst, Jens Juul, Rosenkilde, Mette, Jensen, Majken Karoline & Albrechtsen, Nicolai Jacob Wewer, 6 May 2024, (E-pub ahead of print) In: Diabetologia.Research output: Contribution to journal › Journal article › Research › peer-review
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Glucagon acutely regulates hepatic amino acid catabolism and the effect may be disturbed by steatosis
Winther-Sørensen, M., Galsgaard, K. D., Santos, A., Trammell, S. A. J., Sulek, K., Kuhre, R. E., Pedersen, J., Andersen, D. B., Hassing, A. S., Dall, M., Treebak, J. T., Gillum, M. P., Torekov, S. S., Windeløv, J. A., Hunt, J. E., Kjeldsen, S. A. S., Jepsen, S. L., Vasilopoulou, C. G., Knop, F. K., Ørskov, C. & 7 others, , 2020, In: Molecular Metabolism. 42, 18 p., 101080.Research output: Contribution to journal › Journal article › Research › peer-review
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Hepatic Glucose Production, Ureagenesis, and Lipolysis Quantified using the Perfused Mouse Liver Model
Winther-Sørensen, Marie, Kemp, I. M., Bisgaard, Hanne Cathrine, Holst, Jens Juul & Albrechtsen, Nicolai Jacob Wewer, 2023, In: Journal of Visualized Experiments. 2023, 200, e65596.Research output: Contribution to journal › Journal article › Research › peer-review
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The feedback cycles between glucose, amino acids and lipids and alpha cell secretion and their role in metabolic fatty liver disease
Winther-Sørensen, Marie, Holst, Jens Juul & Albrechtsen, Nicolai Jacob Wewer, 2023, In: Current Opinion in Lipidology. 34, 1, p. 27-31Research output: Contribution to journal › Review › Research › peer-review
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Hepatic steatosis and glucagon resistance develope in parallel resulting in hyperglucagonaemia and hyperaminoacidaemia
Winther-Sørensen, Marie, Galsgaard, Katrine Douglas, Santos, A., Pedersen, J., Hassing, Anna Skab, Dall, M., Treebak, Jonas Thue, Kjeldsen, Sasha Alexandra Sampson, Knop, Filip Krag, Werge, M. P., Eriksen, P. L., Vilstrup, H., Gluud, Lise Lotte, Holst, Jens Juul & Albrechtsen, Nicolai Jacob Wewer, 2020, In: Diabetologia. 63, SUPPL 1, p. S71-S72 142.Research output: Contribution to journal › Conference abstract in journal › Research
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Why is it so difficult to measure glucagon-like peptide-1 in a mouse?
Windeløv, Johanne Agerlin, Albrechtsen, Nicolai Jacob Wewer, Kuhre, Rune Ehrenreich, Jepsen, Sara Lind, Hornburg, D., Pedersen, Jens, Jensen, E. P., Galsgaard, Katrine Douglas, Winther-Sørensen, Marie, Ørgaard, A., Deacon, Carolyn F., Mann, Matthias, Kissow, Hannelouise, Hartmann, Bolette & Holst, Jens Juul, Oct 2017, In: Diabetologia. 60, 10, p. 2066-2075 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Do glucagonomas always produce glucagon?
Albrechtsen, Nicolai Jacob Wewer, Challis, B., Damjanov, I. & Holst, Jens Juul, 1 Feb 2016, In: Bosnian Journal of Basic Medical Sciences. 16, 1, p. 1-7 7 p.Research output: Contribution to journal › Review › Research › peer-review
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On measurements of glucagon secretion in healthy, obese, and Roux-en-Y gastric bypass operated individuals using sandwich ELISA
Albrechtsen, Nicolai Jacob Wewer, Kjeldsen, Sasha Alexandra Sampson, Jensen, N. J., Rungby, Jørgen, Veedfald, Simon, Bojsen-Møller, K. N., Dirksen, C., Jensen, Christian Zinck, Martinussen, C., Madsbad, Sten & Holst, Jens Juul, 2022, In: Scandinavian Journal of Clinical & Laboratory Investigation. 82, 1, p. 75-83Research output: Contribution to journal › Journal article › Research › peer-review
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Letter to the Editor regarding to ‘Activation of GLP-1 receptor signalling by sacubitril/valsartan: Implications for patients with poor glycaemic control’
Albrechtsen, Nicolai Jacob Wewer & Bojsen-Møller, K. N., 2022, In: International Journal of Cardiology. 368, p. 55Research output: Contribution to journal › Letter › Research
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Acute effects on glucose tolerance by neprilysin inhibition in patients with type 2 diabetes
Albrechtsen, Nicolai Jacob Wewer, Møller, A., Martinussen, C., Gluud, Lise Lotte, Rashu, E. B., Richter, Michael Martin, Plomgaard, Peter Stendahl, Goetze, Jens P. , Kjeldsen, Sasha Alexandra Sampson, Hansen, L. H., Gustafsson, Finn, Deacon, Carolyn F., Holst, Jens Juul, Madsbad, Sten & Bojsen-Møller, K. N., 2022, In: Diabetes, Obesity and Metabolism. 24, 10, p. 2017-2026 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Oxyntomodulin Identified as a Marker of Type 2 Diabetes and Gastric Bypass Surgery by Mass-spectrometry Based Profiling of Human Plasma
Albrechtsen, Nicolai Jacob Wewer, Hornburg, D., Albrechtsen, Reidar, Svendsen, B., Toräng, S., Jepsen, Sara Lind, Kuhre, Rune Ehrenreich, Hansen, M., Janus, C., Floyd, A., Lund, Asger Bach, Vilsbøll, Tina, Knop, Filip Krag, drb459, drb459, Deacon, Carolyn F., Meissner, F., Mann, Matthias, Holst, Jens Juul & Hartmann, Bolette, May 2016, In: EBioMedicine. 7, p. 112-120 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Inability of Some Commercial Assays to Measure Suppression of Glucagon Secretion
Albrechtsen, Nicolai Jacob Wewer, Veedfald, Simon, Plamboeck, A., Deacon, Carolyn F., Hartmann, Bolette, Knop, Filip Krag, Vilsbøll, Tina & Holst, Jens Juul, 2016, In: Journal of Diabetes Research. 2016, 5 p., 8352957.Research output: Contribution to journal › Journal article › Research › peer-review
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Sacubitril/Valsartan Augments Postprandial Plasma Concentrations of Active GLP-1 When Combined With Sitagliptin in Men
Albrechtsen, Nicolai Jacob Wewer, Mark, P. D., Terzic, D., Hansen, L. H., Andersen, U. Ø., Hartmann, Bolette, Carr, R. D., Gustafsson, Finn, Deacon, Carolyn F., Holst, Jens Juul, Goetze, Jens P. & Plomgaard, Peter Stendahl, 2019, In: Journal of Clinical Endocrinology and Metabolism. 104, 9, p. 3868-3876Research output: Contribution to journal › Journal article › Research › peer-review
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The biology of glucagon and the consequences of hyperglucagonemia
Albrechtsen, Nicolai Jacob Wewer, Kuhre, Rune Ehrenreich, Pedersen, Jens, Knop, Filip Krag & Holst, Jens Juul, 9 Sep 2016, In: Biomarkers in Medicine. 10, 11, p. 1141-1151 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Evidence of a liver-alpha cell axis in humans: hepatic insulin resistance attenuates relationship between fasting plasma glucagon and glucagonotropic amino acids
Albrechtsen, Nicolai Jacob Wewer, Færch, K., Jensen, T. M., Witte, D. R., Pedersen, Jens, Mahendran, Y., Jonsson, Anna Elisabet, Galsgaard, Katrine Douglas, Winther-Sørensen, Marie, Torekov, Signe Sørensen, Lauritzen, T., Pedersen, Oluf Borbye, Knop, Filip Krag, Hansen, Torben, Jørgensen, M. E., Vistisen, D. & Holst, Jens Juul, 2018, In: Diabetologia. 61, 3, p. 671-680Research output: Contribution to journal › Journal article › Research › peer-review
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Health care professionals from developing countries report educational benefits after an online diabetes course
Albrechtsen, Nicolai Jacob Wewer, Poulsen, K. W., Svensson, L. Ø., Jensen, Lasse X, Holst, Jens Juul & Torekov, Signe Sørensen, 31 May 2017, In: B M C Medical Education. 17, 8 p., 97.Research output: Contribution to journal › Journal article › Research › peer-review
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100 years of glucagon and 100 more
Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul, Cherrington, A. D., Finan, B., Gluud, Lise Lotte, Dean, E. D., Campbell, J. E., Bloom, S. R., Tan, T. M., Knop, Filip Krag & Müller, T. D., 2023, In: Diabetologia. 66, p. 1378–1394Research output: Contribution to journal › Review › Research › peer-review
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Hyperglucagonemia correlates with plasma levels of non-branched-chain amino acids in patients with liver disease independent of type 2 diabetes
Albrechtsen, Nicolai Jacob Wewer, Junker, A. E., Christensen, M., Hædersdal, S., Wibrand, F., Lund, A. M., Galsgaard, Katrine Douglas, Holst, Jens Juul, Knop, Filip Krag & Vilsbøll, Tina, 2018, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 314, 1, p. G91-G96Research output: Contribution to journal › Journal article › Research › peer-review
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A sandwich ELISA for measurement of the primary glucagon-like peptide-1 metabolite
Albrechtsen, Nicolai Jacob Wewer, Asmar, A., Jensen, F., Törang, S., Simonsen, L., Kuhre, Rune Ehrenreich, Asmar, M., Veedfald, Simon, Plamboeck, A., Knop, Filip Krag, Vilsbøll, Tina, Madsbad, Sten, Nauck, M. A., Deacon, Carolyn F., Bülow, J., Holst, Jens Juul & Hartmann, Bolette, 1 Sep 2017, In: American Journal of Physiology: Endocrinology and Metabolism. 313, 3, p. E284-E291Research output: Contribution to journal › Journal article › Research › peer-review
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The liver-alpha cell axis and type 2 diabetes
Albrechtsen, Nicolai Jacob Wewer, Pedersen, Jens, Galsgaard, Katrine Douglas, Winther-Sørensen, Marie, Suppli, M. P., Janah, L., Gromada, J., Vilstrup, H., Knop, Filip Krag & Holst, Jens Juul, 2019, In: Endocrine Reviews. 40, 5, p. 1353-1366Research output: Contribution to journal › Review › Research › peer-review
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Plasma Proteome Profiling Reveals Dynamics of Inflammatory and Lipid Homeostasis Markers after Roux-En-Y Gastric Bypass Surgery
Albrechtsen, Nicolai Jacob Wewer, Geyer, P. E., Doll, S., Treit, P. V., Bojsen-Møller, K. N., Martinussen, C., Jørgensen, N. B., Torekov, Signe Sørensen, Meier, F., Niu, Lili, Santos, A., Keilhauer, E. C., Holst, Jens Juul, Madsbad, Sten & Mann, Matthias, 2018, In: Cell Systems. 7, 6, p. 601-612Research output: Contribution to journal › Journal article › Research › peer-review
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The Role of the Transsulfuration Pathway in Non-Alcoholic Fatty Liver Disease
Werge, M. P., McCann, A., Galsgaard, E. D., Holst, D., Bugge, A., Albrechtsen, Nicolai Jacob Wewer & Gluud, Lise Lotte, 2021, In: Journal of Clinical Medicine. 10, 5, 20 p., 1081.Research output: Contribution to journal › Review › Research › peer-review
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Glucose homeostasis and the gastrointestinal tract
Veedfald, Simon, Albrechtsen, Nicolai Jacob Wewer & Holst, Jens Juul, 2019, Molecular Nutrition Carbohydrates. Elsevier, p. 3-19 17 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Circulating Concentrations of C-Type Natriuretic Peptides Increase with Sacubitril/Valsartan Treatment in Healthy Young Men
Thonsgaard, S., Prickett, T. C. R., Hansen, L. H., Albrechtsen, Nicolai Jacob Wewer, Andersen, U. Ø., Terzic, D., Plomgaard, Peter Stendahl, Gustafsson, Finn, Goetze, Jens P. & Mark, P. D., 2022, In: Clinical Chemistry. 68, 5, p. 713–720 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Roles of increased glycemic variability, GLP-1 and glucagon in hypoglycaemia after Roux-en-Y gastric bypass
Tharakan, G., Behary, P., Albrechtsen, Nicolai Jacob Wewer, Chahal, H., Kenkre, J., Miras, A. D., Ahmed, A. R., Holst, Jens Juul, Bloom, S. R. & Tan, T. M. M., 1 Dec 2017, In: European Journal of Endocrinology. 177, p. 455-464 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The effect of a subcutaneous infusion of GLP-1, OXM and PYY on Energy intake and Expenditure in Obese volunteers
Tan, T., Behary, P., Tharakan, G., Minnion, J., Al-Najim, W., Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul & Bloom, S. R., 1 Jul 2017, In: The Journal of clinical endocrinology and metabolism. 102, 7, p. 2364-2372 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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An Analysis of Cosecretion and Coexpression of Gut Hormones From Male Rat Proximal and Distal Small Intestine
Svendsen, B., Pedersen, Jens, Albrechtsen, Nicolai Jacob Wewer, Hartmann, Bolette, Toräng, S., Rehfeld, Jens Frederik, Poulsen, Steen Seier & Holst, Jens Juul, Mar 2015, In: Endocrinology. 156, 3, p. 847-857 11 p., en20141710.Research output: Contribution to journal › Journal article › Research › peer-review
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No effects of a 6-week intervention with a glucagon-like peptide-1 receptor agonist on pancreatic volume and oedema in obese men without diabetes
Svane, M. S., Johannesen, Helle Hjorth, Martinussen, C., Bojsen-Moller, K. N., Hansen, M. L., Hansen, Adam Espe, Deacon, Carolyn F., Hartmann, Bolette, Keller, S. H., Klausen, T. L., Loft, A., Kjær, Andreas, Madsbad, Sten, Lofgren, J., Holst, Jens Juul & Albrechtsen, Nicolai Jacob Wewer, 2020, In: Diabetes, Obesity and Metabolism. 22, 10, p. 1837-1846Research output: Contribution to journal › Journal article › Research › peer-review
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Four weeks treatment with the GLP-1 receptor analogue liraglutide lowers liver fat and concomitantly circulating glucagon in individuals with overweight
Svane, M. S., Johannesen, H. H., Hansen, Adam Espe, Martinussen, C., Bojsen-Møller, K. N., Hansen, M. L., Deacon, Carolyn F., Keller, S. H., Klausen, Thomas Levin, Loft, A., Kjær, Andreas, Löfgren, J., Madsbad, Sten, Holst, Jens Juul & Albrechtsen, Nicolai Jacob Wewer, 2022, In: International Journal of Obesity. 46, 11, p. 2058–2062 8 p.Research output: Contribution to journal › Letter › Research › peer-review
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Effects of a six-week intervention with glucagon-like peptide-1 receptor analogue on pancreatic volume, oedema and DNA synthesis in obese men
Svane, M. S., Johannesen, Helle Hjorth, Martinussen, C., Bojsen-Moller, K. N., Hansen, M. L., Hansen, A. E., Deacon, Carolyn F., Hartmann, Bolette, Keller, S. H., Loft, A., Kjær, Andreas, Madsbad, Sten, Lofgren, J., Holst, Jens Juul & Albrechtsen, Nicolai Jacob Wewer, 2020, In: Diabetologia. 63, SUPPL 1, p. S216-S217 442.Research output: Contribution to journal › Conference abstract in journal › Research
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Peptide YY and glucagon-like peptide-1 contribute to decreased food intake after Roux-en-Y gastric bypass surgery
Svane, M. S., Jørgensen, N. B., Bojsen-Møller, K. N., Dirksen, C., Nielsen, S., Kristiansen, V. B., Toräng, S., Albrechtsen, Nicolai Jacob Wewer, Rehfeld, Jens Frederik, Hartmann, Bolette, Madsbad, Sten & Holst, Jens Juul, 30 Aug 2016, In: International Journal of Obesity. 40, p. 1699–1706Research output: Contribution to journal › Journal article › Research › peer-review
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Signs of Glucagon Resistance After a Two-Week Hypercaloric Diet Intervention
Suppli, M. P., Høgedal, A., Bagger, J. I., Chabanova, E., van Hall, Gerrit, Forman, Julie Lyng, Christensen, Mikkel Bring, Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul & Knop, Filip Krag, 2024, In: Journal of Clinical Endocrinology and Metabolism. 109, 4, p. 955–967 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Glucagon Resistance at the Level of Amino Acid Turnover in Obese Subjects With Hepatic Steatosis
Suppli, M. P., Bagger, J. I., Lund, A., Demant, M., van Hall, Gerrit, Strandberg, C., Kønig, M. J., Rigbolt, K., Langhoff, J. L., Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, 2020, In: Diabetes. 69, 6, p. 1090-1099 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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WITHDRAWN: Glucagon processing
Steiner, D. F., Albrechtsen, Nicolai Jacob Wewer, Rehfeld, Jens Frederik & Holst, Jens Juul, 2016, The Curated Reference Collection in Neuroscience and Biobehavioral Psychology. ElsevierResearch output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Glucagon does not directly stimulate pituitary secretion of ACTH, GH or copeptin
Stangerup, I., Kjeldsen, Sasha Alexandra Sampson, Richter, Michael Martin, Jensen, N. J., Rungby, Jørgen, Haugaard, Steen Bendix, Georg, B., Hannibal, Jens, Møllgård, Kjeld, Albrechtsen, Nicolai Jacob Wewer & Holst, Camilla Bjørnbak, 2024, In: Peptides. 176, 7 p., 171213.Research output: Contribution to journal › Journal article › Research › peer-review
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Discovery of plasma proteins associated with ventricular fibrillation during first ST-elevation myocardial infarction via proteomics
Stampe, N. K., Ottenheijm, Maud Eline, Drici, L., Albrechtsen, Nicolai Jacob Wewer, Nielsen, A. B., Christoffersen, Christina, Warming, P. E., Engstrøm, Thomas, Winkel, B. G., Jabbari, R., Tfelt-Hansen, Jacob & Glinge, C., 2024, In: European Heart Journal: Acute Cardiovascular Care. 13, 3, p. 264–272Research output: Contribution to journal › Journal article › Research › peer-review
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In Vivo Inhibition of Dipeptidyl Peptidase 4 Allows Measurement of GLP-1 Secretion in Mice
Smits, Mark, Galsgaard, Katrine Douglas, Jepsen, Sara Lind, Albrechtsen, Nicolai Jacob Wewer, Hartmann, Bolette & Holst, Jens Juul, 2024, In: Diabetes. 73, 5, p. 671-681Research output: Contribution to journal › Journal article › Research › peer-review
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Secretion of parathyroid hormone may be coupled to insulin secretion in humans
Sass, M. R., Albrechtsen, Nicolai Jacob Wewer, Pedersen, Jens, Hare, Kristine Juul, Borbye-Lorenzen, N., Kiss, K., Vilsbøll, Tina, Knop, Filip Krag, Poulsen, Steen Seier, Jørgensen, Niklas Rye, Holst, Jens Juul, Ørskov, Cathrine & Hartmann, Bolette, 2020, In: Endocrine Connections. 9, 7, p. 747-754Research output: Contribution to journal › Journal article › Research › peer-review
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A knowledge graph to interpret clinical proteomics data
Santos, A., Colaço, A. R., Nielsen, A. B., Niu, Lili, Strauss, Maximilian, Geyer, P. E., Coscia, F., Albrechtsen, Nicolai Jacob Wewer, Mundt, F., Jensen, Lars Juhl & Mann, Matthias, 2022, In: Nature Biotechnology. 40, p. 692–702Research output: Contribution to journal › Journal article › Research › peer-review
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FoxK1 and FoxK2 in insulin regulation of cellular and mitochondrial metabolism
Sakaguchi, M., Cai, W., Wang, C., Cederquist, C. T., Damasio, M., Homan, E. P., Batista, T., Ramirez, A. K., Gupta, M. K., Steger, M., Albrechtsen, Nicolai Jacob Wewer, Singh, S. K., Araki, E., Mann, M., Enerbäck, S. & Kahn, C. R., 5 Apr 2019, In: Nature Communications. 10, 1, 17 p., 1582.Research output: Contribution to journal › Journal article › Research › peer-review
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Plasma proteome profiles treatment efficacy of incretin dual agonism in diet-induced obese female and male mice
Sachs, S., Niu, Lili, Geyer, P., Jall, S., Kleinert, Maximilian, Feuchtinger, A., Stemmer, K., Brielmeier, M., Finan, B., DiMarchi, R. D., Tschop, M. H., Albrechtsen, Nicolai Jacob Wewer, Mann, Matthias, Mueller, T. D. & Hofmann, S. M., 2020, In: Diabetes, Obesity and Metabolism. 23, 1, p. 195-207 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Glucagon-like peptide-1 acutely affects renal blood flow and urinary flow rate in spontaneously hypertensive rats despite significantly reduced renal expression of GLP-1 receptors
Ronn, J., Jensen, E. P., Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul & Sorensen, Charlotte Mehlin, Dec 2017, In: Physiological Reports. 5, 23, 14 p., e13503.Research output: Contribution to journal › Journal article › Research › peer-review
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Hyperglucagonaemia and amino acid alterations in individuals with type 2 diabetes and non-alcoholic fatty liver disease
Rix, I., Johansen, M. L., Lund, A., Suppli, M. P., Chabanova, E., van Hall, Gerrit, Holst, Jens Juul, Albrechtsen, Nicolai Jacob Wewer, Kistorp, Caroline Michaela Nervil & Knop, Filip Krag, 2023, In: Endocrine Connections. 13, 1, 11 p., e230161.Research output: Contribution to journal › Journal article › Research › peer-review
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The Liver-Alpha Cell Axis in Health and in Disease
Richter, Michael Martin, Galsgaard, Katrine Douglas, Elmelund, E., Knop, Filip Krag, Suppli, M. P., Holst, Jens Juul, Winther-Sørensen, Marie, Kjeldsen, Sasha Alexandra Sampson & Albrechtsen, Nicolai Jacob Wewer, 2022, In: Diabetes. 71, +, p. 1852–1861Research output: Contribution to journal › Review › Research › peer-review
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Effect of a 6-Week Carbohydrate-Reduced High-Protein Diet on Levels of FGF21 and GDF15 in People With Type 2 Diabetes
Richter, Michael Martin, Thomsen, M. N., Skytte, M. J., Kjeldsen, Sasha Alexandra Sampson, Samkani, A., Frystyk, J., Magkos, Faidon, Holst, Jens Juul, Madsbad, Sten, Krarup, T., Haugaard, Steen Bendix & Albrechtsen, Nicolai Jacob Wewer, 2024, In: Journal of the Endocrine Society. 8, 4, 11 p., bvae008.Research output: Contribution to journal › Journal article › Research › peer-review
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Preanalytical impact on the accuracy of measurements of glucagon, GLP-1 and GIP in clinical trials
Rasmussen, C., Richter, Michael Martin, Jensen, N. J., Heinz, N., Hartmann, Bolette, Holst, Jens Juul, Kjeldsen, Sasha Alexandra Sampson & Albrechtsen, Nicolai Jacob Wewer, 2023, In: Scandinavian Journal of Clinical and Laboratory Investigation. 83, 8, p. 591-598Research output: Contribution to journal › Journal article › Research › peer-review
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Cholesteryl ester storage disease of clinical and genetic characterisation: A case report and review of literature
Rashu, E. B., Junker, A. E., Danielsen, K. V., Dahl, E., Hamberg, O., Borgwardt, L., Christensen, Vibeke Brix, Albrechtsen, Nicolai Jacob Wewer & Gluud, Lise Lotte, 2020, In: World Journal of Clinical Cases. 8, 9, p. 1642-1650Research output: Contribution to journal › Journal article › Research › peer-review
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Effects of 3 months of 10-h per-day time-restricted eating and 3 months of follow-up on bodyweight and cardiometabolic health in Danish individuals at high risk of type 2 diabetes: the RESET single-centre, parallel, superiority, open-label, randomised controlled trial
Quist, Jonas Salling, Pedersen, H. E., Jensen, M. M., Clemmensen, K. K. B., Bjerre, N., Ekblond, T. S., Uldal, S., Størling, Joachim, Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul, Torekov, Signe Sørensen, Nyeland, M. E., Vistisen, D., Jørgensen, M. E., Panda, S., Brock, C., Finlayson, G., Blond, Martin Bæk & Færch, K., 2024, In: The Lancet Healthy Longevity. 5, 5, p. e314-e325 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Protocol for a single-centre, parallel-group, randomised, controlled, superiority trial on the effects of time-restricted eating on body weight, behaviour and metabolism in individuals at high risk of type 2 diabetes: the REStricted Eating Time (RESET) study
Quist, Jonas Salling, Jensen, M. M., Clemmensen, K. K. B., Pedersen, H., Bjerre, N., Størling, Joachim, Blond, M. B., Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul, Torekov, Signe Sørensen, Vistisen, D., Jørgensen, M. E., Panda, S., Brock, C., Finlayson, G. & Faerch, K., 2020, In: BMJ Open. 10, 8, 11 p., 037166.Research output: Contribution to journal › Journal article › Research › peer-review
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Inhibiting RHOA Signaling in Mice Increases Glucose Tolerance and Numbers of Enteroendocrine and Other Secretory Cells in the Intestine
Petersen, N., Frimurer, Thomas Michael, Pedersen, M. T., Egerod, Kristoffer Lihme, Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul, Grapin-Botton, A., Jensen, Kim Bak & Schwartz, Thue W., 2018, In: Gastroenterology. 155, 4, p. 1164-1176 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Different Malabsorptive Obesity Surgery Interventions Result in Distinct Postprandial Amino Acid Metabolomic Signatures
Pereira, S. S., Jarak, I., Carvalho, R. A., Oliveira, P. F., Alves, M. G., Guimaraes, M., Almeida, R., Pereira, A. M., Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul, Nora, M. & Monteiro, M. P., 2020, In: Obesity Surgery. 30, p. 4019-4028Research output: Contribution to journal › Journal article › Research › peer-review
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Effects of roux-en-y gastric bypass and sleeve gastrectomy on non-alcoholic fatty liver disease: A 12-month follow-up study with paired liver biopsies
Pedersen, J. S., Rygg, M. O., Serizawa, R. R., Kristiansen, V. B., Albrechtsen, Nicolai Jacob Wewer, Gluud, Lise Lotte, Madsbad, Sten & Bendtsen, Flemming, 2021, In: Journal of Clinical Medicine. 10, 17, 12 p., 3783.Research output: Contribution to journal › Journal article › Research › peer-review
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Nonalcoholic Fatty Liver Disease Impairs the Liver-Alpha Cell Axis Independent of Hepatic Inflammation and Fibrosis
Pedersen, J. S., Rygg, M. O., Kristiansen, V. B., Olsen, B. H., Serizawa, R. R., Holst, Jens Juul, Madsbad, Sten, Gluud, Lise Lotte, Bendtsen, Flemming & Albrechtsen, Nicolai Jacob Wewer, 2020, In: Hepatology Communications. 4, 11, p. 1610-1623 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Long-term changes of pancreatic function in patients with complicated walled-off necrosis
Nøjgaard, C., Werge, M., Naver, Astrid Vinsand, Wilkens Knudsen, A., Albrechtsen, Nicolai Jacob Wewer, Møller, Søren, Gluud, Lise Lotte & Novovic, Srdan, 2022, In: Scandinavian Journal of Gastroenterology. 57, 10, p. 1257-1263Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Defining NASH from a multi-omics systems biology perspective
Niu, Lili, Sulek, K., Vasilopoulou, C. G., Santos, A., Albrechtsen, Nicolai Jacob Wewer, Rasmussen, Simon, Meier, F. & Mann, Matthias, 2021, In: Journal of Clinical Medicine. 10, 20, 22 p., 4673.Research output: Contribution to journal › Review › Research › peer-review
- Published
Plasma proteome profiling discovers potential biomarkers of non-alcoholic fatty liver disease
Niu, Lili, Gupta, R., Geyer, P. E., Albrechtsen, Nicolai Jacob Wewer, Gluud, Lise Lotte, Santos, A., Doll, S., Holst, Jens Juul, Knop, Filip Krag, Vilsbøll, Tina, Junker, A., Sachs, S., Stemmer, K., Mueller, T. D., Tschoep, M. H., Hofmann, S. M. & Mann, Matthias, Aug 2019, In: Molecular & Cellular Proteomics. 18, 8, p. S71 1 p.Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Dynamic human liver proteome atlas reveals functional insights into disease pathways
Niu, Lili, Geyer, P. E., Gupta, R., Santos, A., Meier, F., Doll, S., Albrechtsen, Nicolai Jacob Wewer, Klein, S., Ortiz, C., Uschner, F. E., Schierwagen, R., Trebicka, J. & Mann, Matthias, 2022, In: Molecular Systems Biology. 18, 5, 24 p., e10947.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Plasma proteome profiling discovers novel proteins associated with non-alcoholic fatty liver disease
Niu, Lili, Geyer, P. E., Albrechtsen, Nicolai Jacob Wewer, Gluud, Lise Lotte, Santos, A., Doll, S., Treit, P. V., Holst, Jens Juul, Knop, Filip Krag, Vilsbøll, Tina, Junker, A., Sachs, S., Stemmer, K., Müller, T. D., Tschöp, M. H., Hofmann, S. M. & Mann, Matthias, 2019, In: Molecular Systems Biology. 15, 16 p., e8793.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Predictors of weight loss after bariatric surgery - a cross-disciplinary approach combining physiological, social, and psychological measures
Nielsen, M. S., Christensen, Bodil Just, Schmidt, J. B., Tækker, L., Holm, Lotte, Lunn, Susanne, Ritz, C., Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul, Schnurr, T. M., Hansen, Torben, le Roux, C. W., Lund, Thomas Bøker, Floyd, A. K. & Sjödin, Anders Mikael, 2020, In: International Journal of Obesity. 44, 11, p. 2291-2302 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Oxyntomodulin and glicentin may predict the effect of bariatric surgery on food preferences and weight loss
Nielsen, M. S., Ritz, C., Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul, le Roux, C. W. & Sjödin, Anders Mikael, 2020, In: Journal of Clinical Endocrinology and Metabolism. 105, 4, p. e1064-e1074Research output: Contribution to journal › Journal article › Research › peer-review
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Factors associated with favorable changes in food preferences after bariatric surgery
Nielsen, M. S., Christensen, Bodil Just, Ritz, C., Holm, Lotte, Lunn, Susanne, Tækker, L., Schmidt, J. B., Bredie, Wender, Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul, Hilbert, A., le Roux, C. W. & Sjödin, Anders Mikael, 2021, In: Obesity Surgery. 31, 8, p. 3514-3524 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Leucine-973 is a crucial residue differentiating insulin and IGF-1 receptor signaling
Nagao, H., Cai, W., Brandão, B. B., Albrechtsen, Nicolai Jacob Wewer, Steger, M., Gattu, A. K., Pan, H., Dreyfuss, J. M., Thomas Wunderlich, F., Mann, Matthias & Ronald Kahn, C., 2023, In: Journal of Clinical Investigation. 133, 4, 18 p., e161472.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Distinct signaling by insulin and IGF-1 receptors and their extra- and intracellular domains
Nagao, H., Cai, W., Albrechtsen, Nicolai Jacob Wewer, Steger, M., Batista, T. M., Pan, H., Dreyfuss, J. M., Mann, Matthias & Kahn, C. R., 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 17, e2019474118.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Foresight in clinical proteomics: current status, ethical considerations, and future perspectives
Mundt Madsen, Filip Oskar, Albrechtsen, Nicolai Jacob Wewer, Porsdam Mann, Sebastian, Treit, P., Ghodgaonkar-Steger, M., O’Flaherty, M., Raijmakers, R., Vizcaíno, J. A., Heck, A. J. R. & Mann, Matthias, 2023, In: Open Research Europe. 3, 19 p., 59.Research output: Contribution to journal › Letter › Research › peer-review
- Published
Plasma FGF-19 Levels are Increased in Patients with Post-Bariatric Hypoglycemia
Mulla, C. M., Goldfine, A. B., Dreyfuss, J. M., Houten, S., Pan, H., Pober, D. M., Albrechtsen, Nicolai Jacob Wewer, Svane, M. S., Schmidt, J. B., Holst, Jens Juul, Craig, C. M., McLaughlin, T. L. & Patti, M., 2019, In: Obesity Surgery. 29, 7, p. 2092-2099Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Secretin release after Roux-en-Y gastric bypass reveals a population of glucose-sensitive S cells in distal small intestine
Modvig, Ida Marie, Andersen, Daniel Bjørklund, Grunddal, Kaare Villum, Kuhre, Rune Ehrenreich, Martinussen, C., Christiansen, Charlotte Bayer, Ørskov, Cathrine, Larraufie, P., Kay, R. G., Reimann, F., Gribble, F. M., Hartmann, Bolette, Bojsen-Moller, K. N., Madsbad, Sten, Albrechtsen, Nicolai Jacob Wewer & Holst, Jens Juul, 2020, In: International Journal of Obesity. 44, 9, p. 1859-1871Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Plasma levels of glucagon but not GLP-1 are elevated in response to inflammation in humans
Modrzynska, J., Klein, C. F., Iversen, Kasper, Bundgård, Henning, Hartmann, Bolette, Mose, M., Rittig, N., Møller, N., Holst, Jens Juul & Albrechtsen, Nicolai Jacob Wewer, 2021, In: Endocrine Connections. 10, 2, p. 205-213 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Differential effects of bile acids on the postprandial secretion of gut hormones: A randomized crossover study
McGlone, E. R., Malallah, K., Cuenco, J., Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul, Vincent, R. P., Ling, C., Khan, O. A., Verma, S., Ahmed, A. R., Walters, J. R. F., Khoo, B., Bloom, S. R. & Tan, T. M. M., 2021, In: American Journal of Physiology - Endocrinology and Metabolism. 320, 4, p. E671-E679Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Arginine-induced glucagon secretion and glucagon-induced enhancement of amino acid catabolism are not influenced by ambient glucose levels in mice
Maruszczak, K., Rasmussen, C., Ceutz, F. R., Ørgaard, A., Elmelund, E., Richter, Michael Martin, Holst, Jens Juul, Winther-Sørensen, Marie & Albrechtsen, Nicolai Jacob Wewer, 2022, In: American Journal of Physiology - Endocrinology and Metabolism. 323, p. E207–E214Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The effect of acute dual SGLT1/SGLT2 inhibition on incretin release and glucose metabolism after gastric bypass surgery
Martinussen, C., Veedfald, Simon, Dirksen, Carsten Moro, Bojsen-Møller, K. N., Svane, M. S., Albrechtsen, Nicolai Jacob Wewer, van Hall, Gerrit, Kristiansen, V. B., Fenger, M., Holst, Jens Juul & Madsbad, Sten, 2020, In: American Journal of Physiology: Endocrinology and Metabolism. 318, 6, p. E956-E964 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Plasma GDF15 levels are similar between subjects after bariatric surgery and matched controls and are unaffected by meals
Martinussen, C., Svane, M. S., Bojsen-Møller, K. N., Jensen, Christian Zinck, Kristiansen, V. B., Bookout, A. L., Jorgensen, S. B., Holst, Jens Juul, Albrechtsen, Nicolai Jacob Wewer, Madsbad, Sten & Kuhre, Rune Ehrenreich, 2021, In: American Journal of Physiology: Endocrinology and Metabolism. p. E443-E452 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Erratum: Evidence of extrapancreatic glucagon secretion in man. Diabetes 2016;65:585-597
Lund, Asger Bach, Bagger, J. I., Albrechtsen, Nicolai Jacob Wewer, Christensen, M., Grøndahl, M., Hartmann, Bolette, Mathiesen, Elisabeth, Hansen, C. P., Storkholm, J. H., van Hall, Gerrit, Rehfeld, Jens Frederik, Hornburg, D., Meissner, F., Mann, Matthias, Larsen, S., Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, 1 Jun 2016, In: Diabetes. 65, 6, p. 1752 1 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
- Published
Evidence of Extrapancreatic Glucagon Secretion in Man
Lund, Asger Bach, Bagger, J. I., Albrechtsen, Nicolai Jacob Wewer, Christensen, M., Grøndahl, M., Hartmann, Bolette, Mathiesen, Elisabeth, Hansen, C. P., Storkholm, J. H., van Hall, Gerrit, Rehfeld, Jens Frederik, Hornburg, D., Meissner, F., Mann, Matthias, Larsen, S., Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, Mar 2016, In: Diabetes. 65, 3, p. 585-597 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A Potential Role for Endogenous Glucagon in Preventing Post-Bariatric Hypoglycemia
Lobato, C. B., Pereira, S. S., Guimaraes, M., Hartmann, Bolette, Albrechtsen, Nicolai Jacob Wewer, Hilsted, Linda, Holst, Jens Juul, Nora, M. & Monteiro, M. P., 2020, In: Frontiers in Endocrinology. 11, 11 p., 608248.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Systems signatures reveal unique remission-path of Type 2 diabetes following Roux-en-Y gastric bypass surgery
Li, Q-R., Wang, Z-M., Albrechtsen, N. J. W., Wang, D-D., Su, Z-D., Gao, X-F., Wu, Q-Q., Zhang, H-P., Zhu, L., Li, R-X., Jacobsen, S., Jørgensen, N. B., Dirksen, C., Bojsen-Møller, K. N., Petersen, J. S., Madsbad, S., Clausen, T. R., Diderichsen, B., Chen, L-N., Holst, J. J. & 2 others, , 2018, In: EBioMedicine. 28, p. 234-240 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Interleukin-6 Delays Gastric Emptying in Humans with Direct Effects on Glycemic Control
Lehrskov, L. L., Lyngbaek, M. P., Soederlund, L., Legaard, G. E., Ehses, J. A., Heywood, S. E., Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul, Karstoft, K., Pedersen, Bente Klarlund & Ellingsgaard, H., 2018, In: Cell Metabolism. 27, 6, p. 1201-1211Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effects of Exercise Training and IL-6 Receptor Blockade on Gastric Emptying and GLP-1 Secretion in Obese Humans: Secondary Analyses From a Double Blind Randomized Clinical Trial
Lehrskov, L. L., Christensen, R. H., Wedell-Neergaard, A-S., Legaard, G. E., Dorph, E., Larsen, M. K., Henneberg, M., Launbo, N., Fagerlind, S. R., Seide, S. K., Nymand, S., Ball, M., Vinum, N., Dahl, C., Albrechtsen, N. J. W., Holst, J. J., Ried-Larsen, M., Rosenmeier, J. B., Krogh-Madsen, R., Karstoft, K. & 2 others, , 2019, In: Frontiers in Physiology. 10, 11 p., 1249 .Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Interleukin-6 May Not Affect Bone Resorption Marker CTX or Bone Formation Marker P1NP in Humans
Lehrskov, L. L., Kjeldsen, Sasha Alexandra Sampson, Lyngbæk, M. P., Chirstensen, R. H., Wedell-Neergaard, A., Søderlund, L., Jørgensen, Niklas Rye, Krogh-Madsen, Rikke, Albrechtsen, Nicolai Jacob Wewer & Ellingsgaard, H., 2020, In: Endocrine Research. 4, 9, 12 p., bvaa093.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pancreatic α-cell hyperplasia and hyperglucagonemia due to a mutation of the glucagon
Larger, E., Albrechtsen, Nicolai Jacob Wewer, Hansen, L. H., Gelling, R. W., Capeau, J., Deacon, Carolyn F., Madsen, O. D., Yakushiji, F., Meyts, P. D., Holst, Jens Juul & Nishimura, E., 2016, In: Endocrinology, Diabetes & Metabolism Case Reports. 2016, 6 p., EDM160081.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Measurement of the incretin hormones: glucagon-like peptide-1 and glucose-dependent insulinotropic peptide
Kuhre, Rune Ehrenreich, Albrechtsen, Nicolai Jacob Wewer, Hartmann, Bolette, Deacon, Carolyn F. & Holst, Jens Juul, Apr 2015, In: Journal of Diabetes and its Complications. 29, 3, p. 445-450 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GLP-1 Amidation Efficiency Along the Length of the Intestine in Mice, Rats and Pigs and in GLP-1 Secreting Cell Lines
Kuhre, Rune Ehrenreich, Albrechtsen, Nicolai Jacob Wewer, Windeløv, Johanne Agerlin, Svendsen, B., Hartmann, Bolette & Holst, Jens Juul, 31 Jan 2014, In: Peptides. 55, p. 52-57 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pancreatic effects of GLP-1
Kuhre, Rune Ehrenreich, Albrechtsen, Nicolai Jacob Wewer & Holst, Jens Juul, 22 Dec 2014, Diapedia: The Living Textbook of Diabetes. European Association for the Study of Diabetes (EASD)Research output: Chapter in Book/Report/Conference proceeding › Encyclopedia chapter › Communication
- Published
Neuromedin U Does Not Act as a Decretin in Rats
Kuhre, Rune Ehrenreich, Christiansen, Charlotte Bayer, Ghiasi, S. M., Gabe, M. B. N., Skat-Rørdam, P. A., Modvig, Ida Marie, Mandrup-Poulsen, Thomas, Albrechtsen, Reidar, Rosenkilde, Mette, Hartmann, Bolette, Albrechtsen, Nicolai Jacob Wewer & Holst, Jens Juul, 2019, In: Cell Metabolism. 29, 3, p. 719-726.e1-e5 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Bile acids are important direct and indirect regulators of the secretion of appetite- and metabolism-regulating hormones from the gut and pancreas.
Kuhre, Rune Ehrenreich, Albrechtsen, Nicolai Jacob Wewer, Larsen, Olav, Jepsen, Sara Lind, Balk-Møller, E., Andersen, Daniel Bjørklund, Deacon, Carolyn F., Schoonjans, K., Reimann, F., Gribble, F. M., Albrechtsen, Reidar, Hartmann, Bolette, Rosenkilde, Mette & Holst, Jens Juul, 2018, In: Molecular Metabolism. 11, p. 84-95 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
On the relationship between glucose absorption and glucose‐stimulated secretion of GLP‐1, neurotensin, and PYY from different intestinal segments in the rat
Kuhre, Rune Ehrenreich, Christiansen, Charlotte Bayer, Saltiel, M. Y., Albrechtsen, Nicolai Jacob Wewer & Holst, Jens Juul, 3 Dec 2017, In: Physiological Reports. 5, 23, 13 p., e13507.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glucose stimulates neurotensin secretion from the rat small intestine by mechanisms involving SGLT1 and GLUT2 leading to cell depolarization and calcium influx
Kuhre, Rune Ehrenreich, Bechmann, L. E., Hartmann, Bolette, Albrechtsen, Nicolai Jacob Wewer & Holst, Jens Juul, 21 Apr 2015, In: American Journal of Physiology: Endocrinology and Metabolism. 308, 12, p. E1123–E1130 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Peptide production and secretion in GLUTag, NCI-H716 and STC-1 cells: a comparison to native L-cells.
Kuhre, Rune Ehrenreich, Albrechtsen, Nicolai Jacob Wewer, Deacon, Carolyn F., Balk-Møller, E., Rehfeld, Jens Frederik, Relman, F., Gribble, F. M. & Holst, Jens Juul, 2016, In: Journal of Molecular Endocrinology. 56, p. 201-211Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Do sodium-glucose transporter-2 inhibitors increase plasma glucagon by direct actions on the alpha-cell? - and does the increase matter for the associated increase in endogenous glucose production?
Kuhre, Rune Ehrenreich, Deacon, Carolyn F., Albrechtsen, Nicolai Jacob Wewer & Holst, Jens Juul, 2021, In: Diabetes, Obesity and Metabolism. 23, 9, p. 2009-2019Research output: Contribution to journal › Review › Research › peer-review
- Published
No direct effect of SGLT2 activity on glucagon secretion
Kuhre, Rune Ehrenreich, Ghiasi, S. M., Adriaenssens, A. E., Albrechtsen, Nicolai Jacob Wewer, Andersen, Daniel Bjørklund, Aivazidis, A., Chen, L., Mandrup-Poulsen, Thomas, Ørskov, Cathrine, Gribble, F. M., Reimann, F., Wierup, N., Tyrberg, B. & Holst, Jens Juul, 2019, In: Diabetologia. 62, 6, p. 1011-1023Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Universiteterne har brug for en reformpause
Kropp, K., Vallgårda, Karen Asta Arnfred, Hougaard Laustsen-Kiel, A., Albrechtsen, Nicolai Jacob Wewer, Sylow, Lykke, Damgaard, R. B., Kristensen, Line Burholt, Hansen, N. C., Uusimäki, E., Jønsson, A. B., Høyland-Kroghsbo, Nina Molin, Eriksen, J. J., Rasmussen, Laura Vang, Andersen, P. E., Jensen, Louise Kruse, Lomborg, Stine, Morueta-Holme, Naia, Simonsen, K. B., Zetterberg-Nielsen, S. & Autzen, A., 29 Jan 2023, In: Berlingske Tidende.Research output: Contribution to journal › Contribution to newspaper - Comment/debate › Communication
- Published
Development of a glucagon sensitivity test in humans: Pilot data and the GLUSENTIC study protocol
Kjeldsen, S. A. S., Richter, M. M., Jensen, N. J., Nilsson, M. S. D., Heinz, N., Nybing, J. D., Linden, F. H., Høgh-Schmidt, E., Boesen, M. P., Madsbad, S., Vilstrup, H., Schiødt, F. V., Møller, A., Nørgaard, K., Schmidt, S., Rashu, E. B., Gluud, L. L., Haugaard, S. B., Holst, J. J., Rungby, J. & 1 others, , 2023, In: Peptides. 161, 10 p., 170938.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Neprilysin Inhibition Increases Glucagon Levels in Humans and Mice With Potential Effects on Amino Acid Metabolism
Kjeldsen, Sasha Alexandra Sampson, Hansen, L. H., Esser, N., Mongovin, S., Winther-Sørensen, Marie, Galsgaard, Katrine Douglas, Dal, Jenna Elizabeth Hunt, Kissow, Hannelouise, Ceutz, F. R., Terzic, D., Mark, P. D., Plomgaard, Peter Stendahl, Goetze, Jens P. , Goossens, G. H., Blaak, E. E., Deacon, Carolyn F., Rosenkilde, Mette, Zraika, S., Holst, Jens Juul & Albrechtsen, Nicolai Jacob Wewer, 2021, In: Endocrine Research. 5, 9, 15 p., bvab084.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Neprilysin activity is increased in metabolic dysfunction-associated steatotic liver disease and normalizes after bariatric surgery or GLP-1 therapy
Kjeldsen, S. A. S., Gluud, L. L., Werge, M. P., Pedersen, J. S., Bendtsen, F., Alexiadou, K., Tan, T., Torekov, S. S., Iepsen, E. W., Jensen, N. J., Richter, M. M., Goetze, J. P., Rungby, J., Hartmann, B., Holst, J. J., Holst, B., Holt, J., Gustafsson, F., Madsbad, S., Svane, M. S. & 2 others, , 2023, In: iScience. 26, 11, 13 p., 108190.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Markers of Glucagon Resistance Improve With Reductions in Hepatic Steatosis and Body Weight in Type 2 Diabetes
Kjeldsen, Sasha Alexandra Sampson, Thomsen, M. N., Skytte, M. J., Samkani, A., Richter, Michael Martin, Frystyk, J., Magkos, Faidon, Hansen, E., Thomsen, Henrik S., Holst, Jens Juul, Madsbad, Sten, Haugaard, Steen Bendix, Krarup, T. & Albrechtsen, Nicolai Jacob Wewer, 2023, In: Journal of the Endocrine Society. 7, 11, 11 p., bvad122.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Neprilysin inhibition increases plasma glucagon concentrations in humans with possible implications for hepatic amino acid metabolism
Liver-Alpha-Cell Axis Grp, L. A. G., 2020, In: Diabetologia. 63, SUPPL 1, p. S72-S72 1 p., 144.Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Development and evaluation of a glucagon sensitivity test
Kjeldsen, Sasha Alexandra Sampson, Jensen, N. J., Nilsson, M. S. D., Nybing, J. D., Linden, F. H., Hogh-Schmidt, E., Boesen, Mikael Ploug, Madsbad, Sten, Vilstrup, H. V. A., Rashu, E. B., Gluud, Lise Lotte, Haugaard, Steen Bendix, Holst, Jens Juul, Rungby, Jørgen & Albrechtsen, Nicolai Jacob Wewer, 2021, In: Diabetologia. 64, SUPPL 1, p. 189-189 365.Research output: Contribution to journal › Conference abstract in journal › Research
- Published
The GLP-1 receptor agonist lixisenatide reduces postprandial glucose in patients with diabetes secondary to total pancreatectomy: a randomised, placebo-controlled, double-blinded crossover trial
Juel, C. T. B., Lund, A., Andersen, M. M., Hansen, C. P., Storkholm, J. H., Rehfeld, Jens Frederik, van Hall, G., Hartmann, Bolette, Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, Jul 2020, In: Diabetologia. 63, p. 1285-1298Research output: Contribution to journal › Journal article › Research › peer-review
ID: 95638859
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Treatment with liraglutide may improve markers of CVD reflected by reduced levels of apoB
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Glucagon-like peptide-1 receptor signaling in acinar cells causes growth dependent release of pancreatic enzymes
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Plasma proteome profiling discovers novel proteins associated with non-alcoholic fatty liver disease
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