Guillermo Montoya

Guillermo Montoya

Professor, head of research, Professor


  1. Published

    The TRiC/CCT Chaperonin and Its Role in Uncontrolled Proliferation

    Wang, D. Y., Kamuda, K., Montoya, Guillermo & Mesa, Pablo, 2020, HSF1 and Molecular Chaperones in Biology and Cancer. Mendillo, M. L., Pincus, D. & ScherzShouval, R. (eds.). Springer, p. 21-40 20 p. (Advances in Experimental Medicine and Biology, Vol. 1243).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  2. Published

    Chemogenetic profiling reveals PP2A-independent cytotoxicity of proposed PP2A activators iHAP1 and DT-061

    Vit, G., Duro, Joana Maria, Rajendraprasad, G., Hertz, Emil Peter Thrane, Holland, L. K. K., Weisser, Melanie, McEwan, B. C., Lopez-Mendez, B., Sotelo-Parrilla, P., Jeyaprakash, A. A., Montoya, Guillermo, Mailand, Niels, Maeda, K., Kettenbach, A., Barisic, Marin & Nilsson, Jakob, 2022, In: EMBO Journal. 41, 14, e110611.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. 5'-Cytosine-phosphoguanine (CpG) methylation impacts the activity of natural and engineered meganucleases

    Valton, J., Daboussi, F., Leduc, S., Molina, R., Redondo, P., Macmaster, R., Montoya, Guillermo & Duchateau, P., 31 Aug 2012, In: The Journal of Biological Chemistry. 287, 36, p. 30139-50 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    A Consensus Binding Motif for the PP4 Protein Phosphatase

    Ueki, Y., Kruse, Thomas, Weisser, Melanie, Sundell, G. N., Larsen, Marie Sofie Yoo, Mendez, B. L., Jenkins, N. P., Garvanska, Dimitriya Hristoforova, Cressey, L., Zhang, G., Davey, N., Montoya, Guillermo, Ivarsson, Y., Kettenbach, A. N. & Nilsson, Jakob, 2019, In: Molecular Cell. 76, 6, p. 953-964.e6

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    A highly conserved pocket on PP2A-B56 is required for hSgo1 binding and cohesion protection during mitosis

    Ueki, Y., Hadders, M. A., Weisser, Melanie, Nasa, I., Sotelo-Parrilla, P., Cressey, L. E., Gupta, T., Hertz, Emil Peter Thrane, Kruse, Thomas, Montoya, Guillermo, Jeyaprakash, A. A., Kettenbach, A., Lens, S. M. A. & Nilsson, Jakob, 2021, In: EMBO Reports. 22, 7, 13 p., e52295.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    DeepFRET, a software for rapid and automated single-molecule FRET data classification using deep learning

    Thomsen, J., Sletfjerding, M. B., Jensen, S. B., Stella, S., Paul, B., Malle, M. G., Montoya, Guillermo, Petersen, Troels Christian & Hatzakis, Nikos, Nov 2020, In: eLife. 9, 21 p., e60404.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Transposons and CRISPR: Rewiring Gene Editing

    Tenjo Castano, Francisco Javier, Montoya, Guillermo & Carabias del Rey, Arturo, 2023, In: Biochemistry. 62, 24, p. 3521-3532 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Structure of the TnsB transposase-DNA complex of type V-K CRISPR-associated transposon

    Tenjo Castano, Francisco Javier, Sofos, N., López-Méndez, B., Stutzke, L. S., Fuglsang, Anders, Stella, S. & Montoya, Guillermo, 2022, In: Nature Communications. 13, 14 p., 5792.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Evolutionary origin of vertebrate OCT4/POU5 functions in supporting pluripotency

    Sukparangsi, W., Morganti, E., Lowndes, Molly, Mayeur, H., Weisser, Melanie, Hammachi, F., Peradziryi, H., Roske, F., Hölzenspies, J., Livigni, A., Godard, B. G., Sugahara, F., Kuratani, S., Montoya, Guillermo, Frankenberg, S. R., Mazan, S. & Brickman, Joshua Mark, 2022, In: Nature Communications. 13, 1, 21 p., 5537.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Direct Observation of CRISPR-Cas12 Conformational Sampling by SM FRET and Cryo EM Reveals how Conformational Activation Promotes Catalysis and Resetting of the Endonuclease Activity

    Stella, S., Mesa, Pablo, Thomsen, J., Paul, B., Alcon, P., Jensen, S. B., Moses, M. E., Montoya, Guillermo & Hatzakis, Nikos, 7 Feb 2020, In: Biophysical Journal. 118, 3, p. 223A-224A 2 p.

    Research output: Contribution to journalConference abstract in journalResearch

  11. Expression, purification, crystallization and preliminary X-ray diffraction analysis of the novel modular DNA-binding protein BurrH in its apo form and in complex with its target DNA

    Stella, S., Molina, R., Bertonatti, C., Juillerrat, A. & Montoya, Guillermo, 1 Jan 2014, In: Acta Crystallographica Section F:Structural Biology Communications. 70, 1, p. 87-91 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Structure of the Cpf1 endonuclease R-loop complex after target DNA cleavage

    Stella, S., Alcón, P. & Montoya, Guillermo, 22 Jun 2017, In: Nature. 546, 7659, p. 559-563 5 p.

    Research output: Contribution to journalLetterResearchpeer-review

  13. Structure of the AvrBs3-DNA complex provides new insights into the initial thymine-recognition mechanism

    Stella, S., Molina, R., Yefimenko, I., Prieto, J., Silva, G., Bertonati, C., Juillerat, A., Duchateau, P. & Montoya, Guillermo, 2013, In: Acta Crystallographica Section D: Biological Crystallography. 69, 9, p. 1707-1716 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    The genome editing revolution: A CRISPR-Cas TALE off-target story

    Stella, S. & Montoya, Guillermo, Jul 2016, In: BioEssays. 38, S1, p. S4-S13

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Conformational Activation Promotes CRISPR-Cas12a Catalysis and Resetting of the Endonuclease Activity

    Stella, S., Mesa, Pablo, Thomsen, J., Paul, B., Alcón, P., Jensen, S. B., Saligram, B., Moses, M. E., Hatzakis, Nikos & Montoya, Guillermo, 13 Dec 2018, In: Cell. 175, 7, p. 1856-1871.e21 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    BuD, a helix-loop-helix DNA-binding domain for genome modification

    Stella, S., Molina, R., López-Méndez, B., Juillerat, A., Bertonati, C., Daboussi, F., Campos-Olivas, R., Duchateau, P. & Montoya, Guillermo, 2014, In: Acta Crystallographica Section D: Structural Biology. 70, 7, p. 2042-2052 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Class 2 CRISPR-Cas RNA-guided endonucleases: Swiss Army knives of genome editing

    Stella, S., Alcón, P. & Montoya, Guillermo, Nov 2017, In: Nature Structural and Molecular Biology. 24, 11, p. 882-892 11 p.

    Research output: Contribution to journalReviewResearchpeer-review

  18. Published

    A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex

    Starnes, L. M., Su, D., Pikkupeura, L. M., Weinert, B. T., Santos, M. A., Mund, A., Soria, R., Cho, Y-W., Pozdnyakova, I., Kubec Højfeldt, M., Lages Lino Vala, A., Yang, W., López-Méndez, B., Lee, J-E., Peng, W., Yuan, J., Ge, K., Montoya, G., Nussenzweig, A., Choudhary, C. R. & 1 others, Daniel, J. A., 15 Jan 2016, In: Genes & Development. 30, 2, p. 149-163 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Structures of the Cmr-β Complex Reveal the Regulation of the Immunity Mechanism of Type III-B CRISPR-Cas

    Sofos, N., Feng, M., Stella, S., Pape, T., Fuglsang, Anders, Lin, Jinzhong, Huang, Q., Li, Y., She, Q. & Montoya, Guillermo, 2020, In: Molecular Cell. 79, 5, p. 741-757

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    High-Resolution Structure of Cas13b and Biochemical Characterization of RNA Targeting and Cleavage

    Slaymaker, I. M., Mesa, Pablo, Kellner, M. J., Kannan, S., Brignole, E., Koob, J., Feliciano, P. R., Stella, S., Abudayyeh, O. O., Gootenberg, J. S., Strecker, J., Montoya, Guillermo & Zhang, F., 2019, In: Cell Reports. 26, 13, p. 3741-3751.e5 17 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    TnpB structure reveals minimal functional core of Cas12 nuclease family

    Sasnauskas, G., Tamulaitiene, G., Druteika, G., Carabias del Rey, Arturo, Silanskas, A., Kazlauskas, D., Venclovas, Č., Montoya, Guillermo, Karvelis, T. & Siksnys, V., 2023, In: Nature. 616, 7956, p. 384-389 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Crystallization and preliminary X-ray diffraction analysis of the homing endonuclease I-CvuI from Chlorella vulgaris in complex with its target DNA

    Redondo, P., Merino, N., Villate, M., Blanco, F. J., Montoya, Guillermo & Molina, R., Feb 2014, In: Acta crystallographica. Section F, Structural biology communications. 70, Pt 2, p. 256-9 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Molecular basis of xeroderma pigmentosum group C DNA recognition by engineered meganucleases

    Redondo, P., Prieto, J., Muñoz, I. G., Alibés, A., Stricher, F., Serrano, L., Cabaniols, J., Daboussi, F., Arnould, S., Perez, C., Duchateau, P., Pâques, F., Blanco, F. J. & Montoya, Guillermo, 6 Nov 2008, In: Nature. 456, 7218, p. 107-11 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Structure of the I-SceI nuclease complexed with its dsDNA target and three catalytic metal ions

    Prieto, J., Redondo, P., Merino, N., Villate, M., Montoya, Guillermo, Blanco, F. J. & Molina, R., Jun 2016, In: Acta crystallographica. Section F, Structural biology communications. 72, Pt 6, p. 473-9 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Molecular scissors for in situ cellular repair

    Prieto, J., Molina, R. & Montoya, Guillermo, 31 Jan 2012, In: Critical Reviews in Biochemistry and Molecular Biology. 47, 3, p. 207-21 15 p.

    Research output: Contribution to journalReviewResearchpeer-review

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ID: 93716435