Guillermo Montoya
Professor, head of research, Professor
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The TRiC/CCT Chaperonin and Its Role in Uncontrolled Proliferation
Wang, D. Y., Kamuda, K., Montoya, Guillermo & Mesa, Pablo, 2020, HSF1 and Molecular Chaperones in Biology and Cancer. Mendillo, M. L., Pincus, D. & ScherzShouval, R. (eds.). Springer, p. 21-40 20 p. (Advances in Experimental Medicine and Biology, Vol. 1243).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Chemogenetic profiling reveals PP2A-independent cytotoxicity of proposed PP2A activators iHAP1 and DT-061
Vit, G., Duro, Joana Maria, Rajendraprasad, G., Hertz, Emil Peter Thrane, Holland, L. K. K., Weisser, Melanie, McEwan, B. C., Lopez-Mendez, B., Sotelo-Parrilla, P., Jeyaprakash, A. A., Montoya, Guillermo, Mailand, Niels, Maeda, K., Kettenbach, A., Barisic, Marin & Nilsson, Jakob, 2022, In: EMBO Journal. 41, 14, e110611.Research output: Contribution to journal › Journal article › Research › peer-review
5'-Cytosine-phosphoguanine (CpG) methylation impacts the activity of natural and engineered meganucleases
Valton, J., Daboussi, F., Leduc, S., Molina, R., Redondo, P., Macmaster, R., Montoya, Guillermo & Duchateau, P., 31 Aug 2012, In: The Journal of Biological Chemistry. 287, 36, p. 30139-50 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A Consensus Binding Motif for the PP4 Protein Phosphatase
Ueki, Y., Kruse, Thomas, Weisser, Melanie, Sundell, G. N., Larsen, Marie Sofie Yoo, Mendez, B. L., Jenkins, N. P., Garvanska, Dimitriya Hristoforova, Cressey, L., Zhang, G., Davey, N., Montoya, Guillermo, Ivarsson, Y., Kettenbach, A. N. & Nilsson, Jakob, 2019, In: Molecular Cell. 76, 6, p. 953-964.e6Research output: Contribution to journal › Journal article › Research › peer-review
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A highly conserved pocket on PP2A-B56 is required for hSgo1 binding and cohesion protection during mitosis
Ueki, Y., Hadders, M. A., Weisser, Melanie, Nasa, I., Sotelo-Parrilla, P., Cressey, L. E., Gupta, T., Hertz, Emil Peter Thrane, Kruse, Thomas, Montoya, Guillermo, Jeyaprakash, A. A., Kettenbach, A., Lens, S. M. A. & Nilsson, Jakob, 2021, In: EMBO Reports. 22, 7, 13 p., e52295.Research output: Contribution to journal › Journal article › Research › peer-review
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DeepFRET, a software for rapid and automated single-molecule FRET data classification using deep learning
Thomsen, J., Sletfjerding, M. B., Jensen, S. B., Stella, S., Paul, B., Malle, M. G., Montoya, Guillermo, Petersen, Troels Christian & Hatzakis, Nikos, Nov 2020, In: eLife. 9, 21 p., e60404.Research output: Contribution to journal › Journal article › Research › peer-review
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Transposons and CRISPR: Rewiring Gene Editing
Tenjo Castano, Francisco Javier, Montoya, Guillermo & Carabias del Rey, Arturo, 2023, In: Biochemistry. 62, 24, p. 3521-3532 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure of the TnsB transposase-DNA complex of type V-K CRISPR-associated transposon
Tenjo Castano, Francisco Javier, Sofos, N., López-Méndez, B., Stutzke, L. S., Fuglsang, Anders, Stella, S. & Montoya, Guillermo, 2022, In: Nature Communications. 13, 14 p., 5792.Research output: Contribution to journal › Journal article › Research › peer-review
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Evolutionary origin of vertebrate OCT4/POU5 functions in supporting pluripotency
Sukparangsi, W., Morganti, E., Lowndes, Molly, Mayeur, H., Weisser, Melanie, Hammachi, F., Peradziryi, H., Roske, F., Hölzenspies, J., Livigni, A., Godard, B. G., Sugahara, F., Kuratani, S., Montoya, Guillermo, Frankenberg, S. R., Mazan, S. & Brickman, Joshua Mark, 2022, In: Nature Communications. 13, 1, 21 p., 5537.Research output: Contribution to journal › Journal article › Research › peer-review
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Direct Observation of CRISPR-Cas12 Conformational Sampling by SM FRET and Cryo EM Reveals how Conformational Activation Promotes Catalysis and Resetting of the Endonuclease Activity
Stella, S., Mesa, Pablo, Thomsen, J., Paul, B., Alcon, P., Jensen, S. B., Moses, M. E., Montoya, Guillermo & Hatzakis, Nikos, 7 Feb 2020, In: Biophysical Journal. 118, 3, p. 223A-224A 2 p.Research output: Contribution to journal › Conference abstract in journal › Research
Expression, purification, crystallization and preliminary X-ray diffraction analysis of the novel modular DNA-binding protein BurrH in its apo form and in complex with its target DNA
Stella, S., Molina, R., Bertonatti, C., Juillerrat, A. & Montoya, Guillermo, 1 Jan 2014, In: Acta Crystallographica Section F:Structural Biology Communications. 70, 1, p. 87-91 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure of the Cpf1 endonuclease R-loop complex after target DNA cleavage
Stella, S., Alcón, P. & Montoya, Guillermo, 22 Jun 2017, In: Nature. 546, 7659, p. 559-563 5 p.Research output: Contribution to journal › Letter › Research › peer-review
Structure of the AvrBs3-DNA complex provides new insights into the initial thymine-recognition mechanism
Stella, S., Molina, R., Yefimenko, I., Prieto, J., Silva, G., Bertonati, C., Juillerat, A., Duchateau, P. & Montoya, Guillermo, 2013, In: Acta Crystallographica Section D: Biological Crystallography. 69, 9, p. 1707-1716 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The genome editing revolution: A CRISPR-Cas TALE off-target story
Stella, S. & Montoya, Guillermo, Jul 2016, In: BioEssays. 38, S1, p. S4-S13Research output: Contribution to journal › Journal article › Research › peer-review
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Conformational Activation Promotes CRISPR-Cas12a Catalysis and Resetting of the Endonuclease Activity
Stella, S., Mesa, Pablo, Thomsen, J., Paul, B., Alcón, P., Jensen, S. B., Saligram, B., Moses, M. E., Hatzakis, Nikos & Montoya, Guillermo, 13 Dec 2018, In: Cell. 175, 7, p. 1856-1871.e21 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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BuD, a helix-loop-helix DNA-binding domain for genome modification
Stella, S., Molina, R., López-Méndez, B., Juillerat, A., Bertonati, C., Daboussi, F., Campos-Olivas, R., Duchateau, P. & Montoya, Guillermo, 2014, In: Acta Crystallographica Section D: Structural Biology. 70, 7, p. 2042-2052 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Class 2 CRISPR-Cas RNA-guided endonucleases: Swiss Army knives of genome editing
Stella, S., Alcón, P. & Montoya, Guillermo, Nov 2017, In: Nature Structural and Molecular Biology. 24, 11, p. 882-892 11 p.Research output: Contribution to journal › Review › Research › peer-review
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A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex
Starnes, L. M., Su, D., Pikkupeura, L. M., Weinert, B. T., Santos, M. A., Mund, A., Soria, R., Cho, Y-W., Pozdnyakova, I., Kubec Højfeldt, M., Lages Lino Vala, A., Yang, W., López-Méndez, B., Lee, J-E., Peng, W., Yuan, J., Ge, K., Montoya, G., Nussenzweig, A., Choudhary, C. R. & 1 others, , 15 Jan 2016, In: Genes & Development. 30, 2, p. 149-163 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structures of the Cmr-β Complex Reveal the Regulation of the Immunity Mechanism of Type III-B CRISPR-Cas
Sofos, N., Feng, M., Stella, S., Pape, T., Fuglsang, Anders, Lin, Jinzhong, Huang, Q., Li, Y., She, Q. & Montoya, Guillermo, 2020, In: Molecular Cell. 79, 5, p. 741-757Research output: Contribution to journal › Journal article › Research › peer-review
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High-Resolution Structure of Cas13b and Biochemical Characterization of RNA Targeting and Cleavage
Slaymaker, I. M., Mesa, Pablo, Kellner, M. J., Kannan, S., Brignole, E., Koob, J., Feliciano, P. R., Stella, S., Abudayyeh, O. O., Gootenberg, J. S., Strecker, J., Montoya, Guillermo & Zhang, F., 2019, In: Cell Reports. 26, 13, p. 3741-3751.e5 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
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TnpB structure reveals minimal functional core of Cas12 nuclease family
Sasnauskas, G., Tamulaitiene, G., Druteika, G., Carabias del Rey, Arturo, Silanskas, A., Kazlauskas, D., Venclovas, Č., Montoya, Guillermo, Karvelis, T. & Siksnys, V., 2023, In: Nature. 616, 7956, p. 384-389 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
Crystallization and preliminary X-ray diffraction analysis of the homing endonuclease I-CvuI from Chlorella vulgaris in complex with its target DNA
Redondo, P., Merino, N., Villate, M., Blanco, F. J., Montoya, Guillermo & Molina, R., Feb 2014, In: Acta crystallographica. Section F, Structural biology communications. 70, Pt 2, p. 256-9 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
Molecular basis of xeroderma pigmentosum group C DNA recognition by engineered meganucleases
Redondo, P., Prieto, J., Muñoz, I. G., Alibés, A., Stricher, F., Serrano, L., Cabaniols, J., Daboussi, F., Arnould, S., Perez, C., Duchateau, P., Pâques, F., Blanco, F. J. & Montoya, Guillermo, 6 Nov 2008, In: Nature. 456, 7218, p. 107-11 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure of the I-SceI nuclease complexed with its dsDNA target and three catalytic metal ions
Prieto, J., Redondo, P., Merino, N., Villate, M., Montoya, Guillermo, Blanco, F. J. & Molina, R., Jun 2016, In: Acta crystallographica. Section F, Structural biology communications. 72, Pt 6, p. 473-9 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
Molecular scissors for in situ cellular repair
Prieto, J., Molina, R. & Montoya, Guillermo, 31 Jan 2012, In: Critical Reviews in Biochemistry and Molecular Biology. 47, 3, p. 207-21 15 p.Research output: Contribution to journal › Review › Research › peer-review
ID: 93716435
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Molecular basis of Tousled-Like Kinase 2 activation
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TRAIP is a PCNA-binding ubiquitin ligase that protects genome stability after replication stress
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Oncogenic Mutations Rewire Signaling Pathways by Switching Protein Recruitment to Phosphotyrosine Sites
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