Phylointeractomics reconstructs functional evolution of protein binding

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Phylointeractomics reconstructs functional evolution of protein binding. / Kappei, Dennis; Scheibe, Marion; Paszkowski-Rogacz, Maciej; Bluhm, Alina; Gossmann, Toni Ingolf; Dietz, Sabrina; Dejung, Mario; Herlyn, Holger; Buchholz, Frank; Mann, Matthias; Butter, Falk.

In: Nature Communications, Vol. 8, 08.02.2017, p. 14334.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Kappei, D, Scheibe, M, Paszkowski-Rogacz, M, Bluhm, A, Gossmann, TI, Dietz, S, Dejung, M, Herlyn, H, Buchholz, F, Mann, M & Butter, F 2017, 'Phylointeractomics reconstructs functional evolution of protein binding', Nature Communications, vol. 8, pp. 14334. https://doi.org/10.1038/ncomms14334

APA

Kappei, D., Scheibe, M., Paszkowski-Rogacz, M., Bluhm, A., Gossmann, T. I., Dietz, S., Dejung, M., Herlyn, H., Buchholz, F., Mann, M., & Butter, F. (2017). Phylointeractomics reconstructs functional evolution of protein binding. Nature Communications, 8, 14334. https://doi.org/10.1038/ncomms14334

Vancouver

Kappei D, Scheibe M, Paszkowski-Rogacz M, Bluhm A, Gossmann TI, Dietz S et al. Phylointeractomics reconstructs functional evolution of protein binding. Nature Communications. 2017 Feb 8;8:14334. https://doi.org/10.1038/ncomms14334

Author

Kappei, Dennis ; Scheibe, Marion ; Paszkowski-Rogacz, Maciej ; Bluhm, Alina ; Gossmann, Toni Ingolf ; Dietz, Sabrina ; Dejung, Mario ; Herlyn, Holger ; Buchholz, Frank ; Mann, Matthias ; Butter, Falk. / Phylointeractomics reconstructs functional evolution of protein binding. In: Nature Communications. 2017 ; Vol. 8. pp. 14334.

Bibtex

@article{21ad61cc58cd4dd1b43a527b48989a1a,
title = "Phylointeractomics reconstructs functional evolution of protein binding",
abstract = "Molecular phylogenomics investigates evolutionary relationships based on genomic data. However, despite genomic sequence conservation, changes in protein interactions can occur relatively rapidly and may cause strong functional diversification. To investigate such functional evolution, we here combine phylogenomics with interaction proteomics. We develop this concept by investigating the molecular evolution of the shelterin complex, which protects telomeres, across 16 vertebrate species from zebrafish to humans covering 450 million years of evolution. Our phylointeractomics screen discovers previously unknown telomere-associated proteins and reveals how homologous proteins undergo functional evolution. For instance, we show that TERF1 evolved as a telomere-binding protein in the common stem lineage of marsupial and placental mammals. Phylointeractomics is a versatile and scalable approach to investigate evolutionary changes in protein function and thus can provide experimental evidence for phylogenomic relationships.",
keywords = "Journal Article",
author = "Dennis Kappei and Marion Scheibe and Maciej Paszkowski-Rogacz and Alina Bluhm and Gossmann, {Toni Ingolf} and Sabrina Dietz and Mario Dejung and Holger Herlyn and Frank Buchholz and Matthias Mann and Falk Butter",
year = "2017",
month = feb,
day = "8",
doi = "10.1038/ncomms14334",
language = "English",
volume = "8",
pages = "14334",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Phylointeractomics reconstructs functional evolution of protein binding

AU - Kappei, Dennis

AU - Scheibe, Marion

AU - Paszkowski-Rogacz, Maciej

AU - Bluhm, Alina

AU - Gossmann, Toni Ingolf

AU - Dietz, Sabrina

AU - Dejung, Mario

AU - Herlyn, Holger

AU - Buchholz, Frank

AU - Mann, Matthias

AU - Butter, Falk

PY - 2017/2/8

Y1 - 2017/2/8

N2 - Molecular phylogenomics investigates evolutionary relationships based on genomic data. However, despite genomic sequence conservation, changes in protein interactions can occur relatively rapidly and may cause strong functional diversification. To investigate such functional evolution, we here combine phylogenomics with interaction proteomics. We develop this concept by investigating the molecular evolution of the shelterin complex, which protects telomeres, across 16 vertebrate species from zebrafish to humans covering 450 million years of evolution. Our phylointeractomics screen discovers previously unknown telomere-associated proteins and reveals how homologous proteins undergo functional evolution. For instance, we show that TERF1 evolved as a telomere-binding protein in the common stem lineage of marsupial and placental mammals. Phylointeractomics is a versatile and scalable approach to investigate evolutionary changes in protein function and thus can provide experimental evidence for phylogenomic relationships.

AB - Molecular phylogenomics investigates evolutionary relationships based on genomic data. However, despite genomic sequence conservation, changes in protein interactions can occur relatively rapidly and may cause strong functional diversification. To investigate such functional evolution, we here combine phylogenomics with interaction proteomics. We develop this concept by investigating the molecular evolution of the shelterin complex, which protects telomeres, across 16 vertebrate species from zebrafish to humans covering 450 million years of evolution. Our phylointeractomics screen discovers previously unknown telomere-associated proteins and reveals how homologous proteins undergo functional evolution. For instance, we show that TERF1 evolved as a telomere-binding protein in the common stem lineage of marsupial and placental mammals. Phylointeractomics is a versatile and scalable approach to investigate evolutionary changes in protein function and thus can provide experimental evidence for phylogenomic relationships.

KW - Journal Article

U2 - 10.1038/ncomms14334

DO - 10.1038/ncomms14334

M3 - Journal article

C2 - 28176777

VL - 8

SP - 14334

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

ER -

ID: 184292418