Lysine acetylation in mitochondria: From inventory to function
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Lysine acetylation in mitochondria : From inventory to function. / Hosp, Fabian; Lassowskat, Ines; Santoro, Valeria; De Vleesschauwer, David; Fliegner, Daniela; Redestig, Henning; Mann, Matthias; Christian, Sven; Hannah, Matthew A; Finkemeier, Iris.
In: Mitochondrion, Vol. 33, 03.2017, p. 58-71.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Lysine acetylation in mitochondria
T2 - From inventory to function
AU - Hosp, Fabian
AU - Lassowskat, Ines
AU - Santoro, Valeria
AU - De Vleesschauwer, David
AU - Fliegner, Daniela
AU - Redestig, Henning
AU - Mann, Matthias
AU - Christian, Sven
AU - Hannah, Matthew A
AU - Finkemeier, Iris
N1 - Copyright © 2016 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
PY - 2017/3
Y1 - 2017/3
N2 - Cellular signaling pathways are regulated in a highly dynamic fashion in order to quickly adapt to distinct environmental conditions. Acetylation of lysine residues represents a central process that orchestrates cellular metabolism and signaling. In mitochondria, acetylation seems to be the most prevalent post-translational modification, presumably linked to the compartmentation and high turnover of acetyl-CoA in this organelle. Similarly, the elevated pH and the higher concentration of metabolites in mitochondria seem to favor non-enzymatic lysine modifications, as well as other acylations. Hence, elucidating the mechanisms for metabolic control of protein acetylation is crucial for our understanding of cellular processes. Recent advances in mass spectrometry-based proteomics have considerably increased our knowledge of the regulatory scope of acetylation. Here, we review the current knowledge and functional impact of mitochondrial protein acetylation across species. We first cover the experimental approaches to identify and analyze lysine acetylation on a global scale, we then explore both commonalities and specific differences of plant and animal acetylomes and the evolutionary conservation of protein acetylation, as well as its particular impact on metabolism and diseases. Important future directions and technical challenges are discussed, and it is pointed out that the transfer of knowledge between species and diseases, both in technology and biology, is of particular importance for further advancements in this field.
AB - Cellular signaling pathways are regulated in a highly dynamic fashion in order to quickly adapt to distinct environmental conditions. Acetylation of lysine residues represents a central process that orchestrates cellular metabolism and signaling. In mitochondria, acetylation seems to be the most prevalent post-translational modification, presumably linked to the compartmentation and high turnover of acetyl-CoA in this organelle. Similarly, the elevated pH and the higher concentration of metabolites in mitochondria seem to favor non-enzymatic lysine modifications, as well as other acylations. Hence, elucidating the mechanisms for metabolic control of protein acetylation is crucial for our understanding of cellular processes. Recent advances in mass spectrometry-based proteomics have considerably increased our knowledge of the regulatory scope of acetylation. Here, we review the current knowledge and functional impact of mitochondrial protein acetylation across species. We first cover the experimental approaches to identify and analyze lysine acetylation on a global scale, we then explore both commonalities and specific differences of plant and animal acetylomes and the evolutionary conservation of protein acetylation, as well as its particular impact on metabolism and diseases. Important future directions and technical challenges are discussed, and it is pointed out that the transfer of knowledge between species and diseases, both in technology and biology, is of particular importance for further advancements in this field.
KW - Acetyl Coenzyme A
KW - Acetylation
KW - Animals
KW - Computational Biology
KW - Lysine
KW - Mass Spectrometry
KW - Mitochondria
KW - Mitochondrial Proteins
KW - Plants
KW - Protein Processing, Post-Translational
KW - Proteomics
KW - Journal Article
KW - Review
U2 - 10.1016/j.mito.2016.07.012
DO - 10.1016/j.mito.2016.07.012
M3 - Review
C2 - 27476757
VL - 33
SP - 58
EP - 71
JO - Mitochondrion
JF - Mitochondrion
SN - 1567-7249
ER -
ID: 186875426