Fam20C regulates protein secretion by Cab45 phosphorylation

Research output: Contribution to journal › Journal article › Research › peer-review

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Fam20C regulates protein secretion by Cab45 phosphorylation. / Hecht, Tobias Karl-Heinz; Blank, Birgit; Steger, Martin; Lopez, Victor; Beck, Gisela; Ramazanov, Bulat; Mann, Matthias; Tagliabracci, Vincent; von Blume, Julia.

In: The Journal of Cell Biology, Vol. 219, No. 6, 01.06.2020.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Hecht, TK-H, Blank, B, Steger, M, Lopez, V, Beck, G, Ramazanov, B, Mann, M, Tagliabracci, V & von Blume, J 2020, 'Fam20C regulates protein secretion by Cab45 phosphorylation', The Journal of Cell Biology, vol. 219, no. 6. https://doi.org/10.1083/jcb.201910089

APA

Hecht, T. K-H., Blank, B., Steger, M., Lopez, V., Beck, G., Ramazanov, B., Mann, M., Tagliabracci, V., & von Blume, J. (2020). Fam20C regulates protein secretion by Cab45 phosphorylation. The Journal of Cell Biology, 219(6). https://doi.org/10.1083/jcb.201910089

Vancouver

Hecht TK-H, Blank B, Steger M, Lopez V, Beck G, Ramazanov B et al. Fam20C regulates protein secretion by Cab45 phosphorylation. The Journal of Cell Biology. 2020 Jun 1;219(6). https://doi.org/10.1083/jcb.201910089

Author

Hecht, Tobias Karl-Heinz ; Blank, Birgit ; Steger, Martin ; Lopez, Victor ; Beck, Gisela ; Ramazanov, Bulat ; Mann, Matthias ; Tagliabracci, Vincent ; von Blume, Julia. / Fam20C regulates protein secretion by Cab45 phosphorylation. In: The Journal of Cell Biology. 2020 ; Vol. 219, No. 6.

Bibtex

@article{a101e40a34124d41a397b2e550256fe4,
title = "Fam20C regulates protein secretion by Cab45 phosphorylation",
abstract = "The TGN is a key compartment for the sorting and secretion of newly synthesized proteins. At the TGN, soluble proteins are sorted based on the instructions carried in their oligosaccharide backbones or by a Ca2+-mediated process that involves the cargo-sorting protein Cab45. Here, we show that Cab45 is phosphorylated by the Golgi-specific protein kinase Fam20C. Mimicking of phosphorylation translocates Cab45 into TGN-derived vesicles, which goes along with an increased export of LyzC, a Cab45 client. Our findings demonstrate that Fam20C plays a key role in the export of Cab45 clients by fine-tuning Cab45 oligomerization and thus impacts Cab45 retention in the TGN.",
author = "Hecht, {Tobias Karl-Heinz} and Birgit Blank and Martin Steger and Victor Lopez and Gisela Beck and Bulat Ramazanov and Matthias Mann and Vincent Tagliabracci and {von Blume}, Julia",
note = "{\textcopyright} 2020 Hecht et al.",
year = "2020",
month = jun,
day = "1",
doi = "10.1083/jcb.201910089",
language = "English",
volume = "219",
journal = "Journal of Cell Biology",
issn = "0021-9525",
publisher = "Rockefeller University Press",
number = "6",

}

RIS

TY - JOUR

T1 - Fam20C regulates protein secretion by Cab45 phosphorylation

AU - Hecht, Tobias Karl-Heinz

AU - Blank, Birgit

AU - Steger, Martin

AU - Lopez, Victor

AU - Beck, Gisela

AU - Ramazanov, Bulat

AU - Mann, Matthias

AU - Tagliabracci, Vincent

AU - von Blume, Julia

N1 - © 2020 Hecht et al.

PY - 2020/6/1

Y1 - 2020/6/1

N2 - The TGN is a key compartment for the sorting and secretion of newly synthesized proteins. At the TGN, soluble proteins are sorted based on the instructions carried in their oligosaccharide backbones or by a Ca2+-mediated process that involves the cargo-sorting protein Cab45. Here, we show that Cab45 is phosphorylated by the Golgi-specific protein kinase Fam20C. Mimicking of phosphorylation translocates Cab45 into TGN-derived vesicles, which goes along with an increased export of LyzC, a Cab45 client. Our findings demonstrate that Fam20C plays a key role in the export of Cab45 clients by fine-tuning Cab45 oligomerization and thus impacts Cab45 retention in the TGN.

AB - The TGN is a key compartment for the sorting and secretion of newly synthesized proteins. At the TGN, soluble proteins are sorted based on the instructions carried in their oligosaccharide backbones or by a Ca2+-mediated process that involves the cargo-sorting protein Cab45. Here, we show that Cab45 is phosphorylated by the Golgi-specific protein kinase Fam20C. Mimicking of phosphorylation translocates Cab45 into TGN-derived vesicles, which goes along with an increased export of LyzC, a Cab45 client. Our findings demonstrate that Fam20C plays a key role in the export of Cab45 clients by fine-tuning Cab45 oligomerization and thus impacts Cab45 retention in the TGN.

U2 - 10.1083/jcb.201910089

DO - 10.1083/jcb.201910089

M3 - Journal article

C2 - 32422653

VL - 219

JO - Journal of Cell Biology

JF - Journal of Cell Biology

SN - 0021-9525

IS - 6

ER -

ID: 243474795