A Stat6/Pten Axis Links Regulatory T Cells with Adipose Tissue Function

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A Stat6/Pten Axis Links Regulatory T Cells with Adipose Tissue Function. / Kälin, Stefanie; Becker, Maike; Ott, Verena B; Serr, Isabelle; Hosp, Fabian; Mollah, Mohammad M H; Keipert, Susanne; Lamp, Daniel; Rohner-Jeanrenaud, Francoise; Flynn, Victoria K; Scherm, Martin G; Nascimento, Lucas F R; Gerlach, Katharina; Popp, Vanessa; Dietzen, Sarah; Bopp, Tobias; Krishnamurthy, Purna; Kaplan, Mark H; Serrano, Manuel; Woods, Stephen C; Tripal, Philipp; Palmisano, Ralf; Jastroch, Martin; Blüher, Matthias; Wolfrum, Christian; Weigmann, Benno; Ziegler, Anette-Gabriele; Mann, Matthias; Tschöp, Matthias H; Daniel, Carolin.

In: Cell Metabolism, Vol. 26, No. 3, 05.09.2017, p. 475-492.e7.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Kälin, S, Becker, M, Ott, VB, Serr, I, Hosp, F, Mollah, MMH, Keipert, S, Lamp, D, Rohner-Jeanrenaud, F, Flynn, VK, Scherm, MG, Nascimento, LFR, Gerlach, K, Popp, V, Dietzen, S, Bopp, T, Krishnamurthy, P, Kaplan, MH, Serrano, M, Woods, SC, Tripal, P, Palmisano, R, Jastroch, M, Blüher, M, Wolfrum, C, Weigmann, B, Ziegler, A-G, Mann, M, Tschöp, MH & Daniel, C 2017, 'A Stat6/Pten Axis Links Regulatory T Cells with Adipose Tissue Function', Cell Metabolism, vol. 26, no. 3, pp. 475-492.e7. https://doi.org/10.1016/j.cmet.2017.08.008

APA

Kälin, S., Becker, M., Ott, V. B., Serr, I., Hosp, F., Mollah, M. M. H., Keipert, S., Lamp, D., Rohner-Jeanrenaud, F., Flynn, V. K., Scherm, M. G., Nascimento, L. F. R., Gerlach, K., Popp, V., Dietzen, S., Bopp, T., Krishnamurthy, P., Kaplan, M. H., Serrano, M., ... Daniel, C. (2017). A Stat6/Pten Axis Links Regulatory T Cells with Adipose Tissue Function. Cell Metabolism, 26(3), 475-492.e7. https://doi.org/10.1016/j.cmet.2017.08.008

Vancouver

Kälin S, Becker M, Ott VB, Serr I, Hosp F, Mollah MMH et al. A Stat6/Pten Axis Links Regulatory T Cells with Adipose Tissue Function. Cell Metabolism. 2017 Sep 5;26(3):475-492.e7. https://doi.org/10.1016/j.cmet.2017.08.008

Author

Kälin, Stefanie ; Becker, Maike ; Ott, Verena B ; Serr, Isabelle ; Hosp, Fabian ; Mollah, Mohammad M H ; Keipert, Susanne ; Lamp, Daniel ; Rohner-Jeanrenaud, Francoise ; Flynn, Victoria K ; Scherm, Martin G ; Nascimento, Lucas F R ; Gerlach, Katharina ; Popp, Vanessa ; Dietzen, Sarah ; Bopp, Tobias ; Krishnamurthy, Purna ; Kaplan, Mark H ; Serrano, Manuel ; Woods, Stephen C ; Tripal, Philipp ; Palmisano, Ralf ; Jastroch, Martin ; Blüher, Matthias ; Wolfrum, Christian ; Weigmann, Benno ; Ziegler, Anette-Gabriele ; Mann, Matthias ; Tschöp, Matthias H ; Daniel, Carolin. / A Stat6/Pten Axis Links Regulatory T Cells with Adipose Tissue Function. In: Cell Metabolism. 2017 ; Vol. 26, No. 3. pp. 475-492.e7.

Bibtex

@article{a5ba7d7fee67431b9ee8ec5f1489c482,
title = "A Stat6/Pten Axis Links Regulatory T Cells with Adipose Tissue Function",
abstract = "Obesity and type 2 diabetes are associated with metabolic defects and adipose tissue inflammation. Foxp3(+) regulatory T cells (Tregs) control tissue homeostasis by counteracting local inflammation. However, if and how T cells interlink environmental influences with adipocyte function remains unknown. Here, we report that enhancing sympathetic tone by cold exposure, beta3-adrenergic receptor (ADRB3) stimulation or a short-term high-calorie diet enhances Treg induction in vitro and in vivo. CD4(+) T cell proteomes revealed higher expression of Foxp3 regulatory networks in response to cold or ADRB3 stimulation in vivo reflecting Treg induction. Specifically, Ragulator-interacting protein C17orf59, which limits mTORC1 activity, was upregulated in CD4(+) T cells by either ADRB3 stimulation or cold exposure, suggesting contribution to Treg induction. By loss- and gain-of-function studies, including Treg depletion and transfers in vivo, we demonstrated that a T cell-specific Stat6/Pten axis links cold exposure or ADRB3 stimulation with Foxp3(+) Treg induction and adipose tissue function. Our findings offer a new mechanistic model in which tissue-specific Tregs maintain adipose tissue function.",
keywords = "Journal Article",
author = "Stefanie K{\"a}lin and Maike Becker and Ott, {Verena B} and Isabelle Serr and Fabian Hosp and Mollah, {Mohammad M H} and Susanne Keipert and Daniel Lamp and Francoise Rohner-Jeanrenaud and Flynn, {Victoria K} and Scherm, {Martin G} and Nascimento, {Lucas F R} and Katharina Gerlach and Vanessa Popp and Sarah Dietzen and Tobias Bopp and Purna Krishnamurthy and Kaplan, {Mark H} and Manuel Serrano and Woods, {Stephen C} and Philipp Tripal and Ralf Palmisano and Martin Jastroch and Matthias Bl{\"u}her and Christian Wolfrum and Benno Weigmann and Anette-Gabriele Ziegler and Matthias Mann and Tsch{\"o}p, {Matthias H} and Carolin Daniel",
note = "Copyright {\textcopyright} 2017 Elsevier Inc. All rights reserved.",
year = "2017",
month = sep,
day = "5",
doi = "10.1016/j.cmet.2017.08.008",
language = "English",
volume = "26",
pages = "475--492.e7",
journal = "Cell Metabolism",
issn = "1550-4131",
publisher = "Cell Press",
number = "3",

}

RIS

TY - JOUR

T1 - A Stat6/Pten Axis Links Regulatory T Cells with Adipose Tissue Function

AU - Kälin, Stefanie

AU - Becker, Maike

AU - Ott, Verena B

AU - Serr, Isabelle

AU - Hosp, Fabian

AU - Mollah, Mohammad M H

AU - Keipert, Susanne

AU - Lamp, Daniel

AU - Rohner-Jeanrenaud, Francoise

AU - Flynn, Victoria K

AU - Scherm, Martin G

AU - Nascimento, Lucas F R

AU - Gerlach, Katharina

AU - Popp, Vanessa

AU - Dietzen, Sarah

AU - Bopp, Tobias

AU - Krishnamurthy, Purna

AU - Kaplan, Mark H

AU - Serrano, Manuel

AU - Woods, Stephen C

AU - Tripal, Philipp

AU - Palmisano, Ralf

AU - Jastroch, Martin

AU - Blüher, Matthias

AU - Wolfrum, Christian

AU - Weigmann, Benno

AU - Ziegler, Anette-Gabriele

AU - Mann, Matthias

AU - Tschöp, Matthias H

AU - Daniel, Carolin

N1 - Copyright © 2017 Elsevier Inc. All rights reserved.

PY - 2017/9/5

Y1 - 2017/9/5

N2 - Obesity and type 2 diabetes are associated with metabolic defects and adipose tissue inflammation. Foxp3(+) regulatory T cells (Tregs) control tissue homeostasis by counteracting local inflammation. However, if and how T cells interlink environmental influences with adipocyte function remains unknown. Here, we report that enhancing sympathetic tone by cold exposure, beta3-adrenergic receptor (ADRB3) stimulation or a short-term high-calorie diet enhances Treg induction in vitro and in vivo. CD4(+) T cell proteomes revealed higher expression of Foxp3 regulatory networks in response to cold or ADRB3 stimulation in vivo reflecting Treg induction. Specifically, Ragulator-interacting protein C17orf59, which limits mTORC1 activity, was upregulated in CD4(+) T cells by either ADRB3 stimulation or cold exposure, suggesting contribution to Treg induction. By loss- and gain-of-function studies, including Treg depletion and transfers in vivo, we demonstrated that a T cell-specific Stat6/Pten axis links cold exposure or ADRB3 stimulation with Foxp3(+) Treg induction and adipose tissue function. Our findings offer a new mechanistic model in which tissue-specific Tregs maintain adipose tissue function.

AB - Obesity and type 2 diabetes are associated with metabolic defects and adipose tissue inflammation. Foxp3(+) regulatory T cells (Tregs) control tissue homeostasis by counteracting local inflammation. However, if and how T cells interlink environmental influences with adipocyte function remains unknown. Here, we report that enhancing sympathetic tone by cold exposure, beta3-adrenergic receptor (ADRB3) stimulation or a short-term high-calorie diet enhances Treg induction in vitro and in vivo. CD4(+) T cell proteomes revealed higher expression of Foxp3 regulatory networks in response to cold or ADRB3 stimulation in vivo reflecting Treg induction. Specifically, Ragulator-interacting protein C17orf59, which limits mTORC1 activity, was upregulated in CD4(+) T cells by either ADRB3 stimulation or cold exposure, suggesting contribution to Treg induction. By loss- and gain-of-function studies, including Treg depletion and transfers in vivo, we demonstrated that a T cell-specific Stat6/Pten axis links cold exposure or ADRB3 stimulation with Foxp3(+) Treg induction and adipose tissue function. Our findings offer a new mechanistic model in which tissue-specific Tregs maintain adipose tissue function.

KW - Journal Article

U2 - 10.1016/j.cmet.2017.08.008

DO - 10.1016/j.cmet.2017.08.008

M3 - Journal article

C2 - 28877454

VL - 26

SP - 475-492.e7

JO - Cell Metabolism

JF - Cell Metabolism

SN - 1550-4131

IS - 3

ER -

ID: 184323941