Matthias Mann

Matthias Mann

Professor, head of research, Professor


  1. Functional characterization of Rad18 domains for Rad6, ubiquitin, DNA binding and PCNA modification

    Notenboom, V., Hibbert, R. G., van Rossum-Fikkert, S. E., Olsen, Jesper Velgaard, Mann, Matthias & Sixma, T. K., 2007, In: Nucleic Acids Research. 35, 17, p. 5819-30 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    Full Mass Range ΦSDM Orbitrap Mass Spectrometry for DIA Proteome Analysis

    Steigerwald, S., Sinha, A., Fort, K. L., Zeng, W., Niu, Lili, Wichmann, C., Kreutzmann, A., Mourad, D., Aizikov, K., Grinfeld, D., Makarov, A., Mann, Matthias & Meier, F., 2024, In: Molecular and Cellular Proteomics. 12 p., 100713.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Foresight in clinical proteomics: current status, ethical considerations, and future perspectives

    Mundt Madsen, Filip Oskar, Albrechtsen, Nicolai Jacob Wewer, Porsdam Mann, Sebastian, Treit, P., Ghodgaonkar-Steger, M., O’Flaherty, M., Raijmakers, R., Vizcaíno, J. A., Heck, A. J. R. & Mann, Matthias, 2023, In: Open Research Europe. 3, 19 p., 59.

    Research output: Contribution to journalLetterResearchpeer-review

  4. Fibro-adipogenic progenitors of dystrophic mice are insensitive to NOTCH regulation of adipogenesis

    Marinkovic, M., Fuoco, C., Sacco, F., Cerquone Perpetuini, A., Giuliani, G., Micarelli, E., Pavlidou, T., Petrilli, L. L., Reggio, A., Riccio, F., Spada, F., Vumbaca, S., Zuccotti, A., Castagnoli, L., Mann, Matthias, Gargioli, C. & Cesareni, G., Jun 2019, In: Life Science Alliance. 2, 3

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Femtomole sequencing of proteins from polyacrylamide gels by nano-electrospray mass spectrometry

    Wilm, M., Shevchenko, A., Houthaeve, T., Breit, S., Schweigerer, L., Fotsis, T. & Mann, Matthias, 1 Feb 1996, In: Nature. 379, 6564, p. 466-9 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Fam20C regulates protein secretion by Cab45 phosphorylation

    Hecht, T. K., Blank, B., Steger, M., Lopez, V., Beck, G., Ramazanov, B., Mann, Matthias, Tagliabracci, V. & von Blume, J., 1 Jun 2020, In: The Journal of Cell Biology. 219, 6

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    FAM111 protease activity undermines cellular fitness and is amplified by gain-of-function mutations in human disease

    Hoffmann, Saskia, Pentakota, S., Mund, Andreas, Haahr, Peter Thorlund, Coscia, F., Gallo, M., Mann, Matthias, Taylor, Nicholas M I & Mailand, Niels, 2020, In: EMBO Reports. 21, 10, 14 p., e50662.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Extensive quantitative remodeling of the proteome between normal colon tissue and adenocarcinoma

    Wiśniewski, J. R., Ostasiewicz, P., Duś, K., Zielińska, D. F., Gnad, F. & Mann, Matthias, 1 Jan 2012, In: Molecular Systems Biology. 8, 611.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Evidence of Extrapancreatic Glucagon Secretion in Man

    Lund, Asger Bach, Bagger, J. I., Albrechtsen, Nicolai Jacob Wewer, Christensen, M., Grøndahl, M., Hartmann, Bolette, Mathiesen, Elisabeth, Hansen, C. P., Storkholm, J. H., van Hall, Gerrit, Rehfeld, Jens Frederik, Hornburg, D., Meissner, F., Mann, Matthias, Larsen, S., Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, Mar 2016, In: Diabetes. 65, 3, p. 585-597 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Ethical Principles, Constraints and Opportunities in Clinical Proteomics

    Porsdam Mann, Sebastian, Treit, P. V., Geyer, P. E., Omenn, G. S. & Mann, Matthias, 2021, In: Molecular and Cellular Proteomics. 20, 14 p., 100046.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Error-tolerant identification of peptides in sequence databases by peptide sequence tags

    Mann, Matthias & Wilm, M., 15 Dec 1994, In: Analytical Chemistry. 66, 24, p. 4390-9 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Erratum: Evidence of extrapancreatic glucagon secretion in man. Diabetes 2016;65:585-597

    Lund, Asger Bach, Bagger, J. I., Albrechtsen, Nicolai Jacob Wewer, Christensen, M., Grøndahl, M., Hartmann, Bolette, Mathiesen, Elisabeth, Hansen, C. P., Storkholm, J. H., van Hall, Gerrit, Rehfeld, Jens Frederik, Hornburg, D., Meissner, F., Mann, Matthias, Larsen, S., Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, 1 Jun 2016, In: Diabetes. 65, 6, p. 1752 1 p.

    Research output: Contribution to journalComment/debateResearchpeer-review

  13. Published

    Efficient mitotic checkpoint signaling depends on integrated activities of Bub1 and the RZZ complex

    Zhang, G., Kruse, Thomas, Guasch Boldú, C., Garvanska, Dimitriya Hristoforova, Coscia, F., Mann, Matthias, Barisic, Marin & Nilsson, Jakob, 2019, In: E M B O Journal. 38, 7, e100977.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Effective representation and storage of mass spectrometry-based proteomic data sets for the scientific community

    Olsen, Jesper Velgaard & Mann, Matthias, 1 Jan 2011, In: Science Signaling. 4, 160, p. pe7

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    EASI-tag enables accurate multiplexed and interference-free MS2-based proteome quantification

    Virreira Winter, S., Meier, F., Wichmann, C., Cox, J., Mann, Matthias & Meissner, F., 2018, In: Nature Methods. 15, 7, p. 527-530 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Dynamics in protein translation sustaining T cell preparedness

    Wolf, T., Jin, W., Zoppi, G., Vogel, I. A., Akhmedov, M., Bleck, C. K. E., Beltraminelli, T., Rieckmann, J. C., Ramirez, N. J., Benevento, M., Notarbartolo, S., Bumann, D., Meissner, F., Grimbacher, B., Mann, Matthias, Lanzavecchia, A., Sallusto, F., Kwee, I. & Geiger, R., 6 Jul 2020, (E-pub ahead of print) In: Nature Immunology.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Dynamic human liver proteome atlas reveals functional insights into disease pathways

    Niu, Lili, Geyer, P. E., Gupta, R., Santos, A., Meier, F., Doll, S., Albrechtsen, Nicolai Jacob Wewer, Klein, S., Ortiz, C., Uschner, F. E., Schierwagen, R., Trebicka, J. & Mann, Matthias, 2022, In: Molecular Systems Biology. 18, 5, 24 p., e10947.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Distinct signaling by insulin and IGF-1 receptors and their extra- and intracellular domains

    Nagao, H., Cai, W., Albrechtsen, Nicolai Jacob Wewer, Steger, M., Batista, T. M., Pan, H., Dreyfuss, J. M., Mann, Matthias & Kahn, C. R., 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 17, e2019474118.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Direct proteomic quantification of the secretome of activated immune cells

    Meissner, F., Scheltema, R. A., Mollenkopf, H. & Mann, Matthias, 26 Apr 2013, In: Science (New York, N.Y.). 340, 6131, p. 475-8 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Direct identification of clinically relevant neoepitopes presented on native human melanoma tissue by mass spectrometry

    Bassani-Sternberg, M., Bräunlein, E., Klar, R., Engleitner, T., Sinitcyn, P., Audehm, S., Straub, M., Weber, J., Slotta-Huspenina, J., Specht, K., Martignoni, M. E., Werner, A., Hein, R., H Busch, D., Peschel, C., Rad, R., Cox, J., Mann, Matthias & Krackhardt, A. M., 21 Nov 2016, In: Nature Communications. 7, p. 13404

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Development, use, application of novel TIMS-Tof system

    Mann, Matthias, 2019, In: Molecular & Cellular Proteomics. 18, 8, p. S20 1 p.

    Research output: Contribution to journalConference abstract in journalResearch

  22. Development of phospho-specific Rab protein antibodies to monitor in vivo activity of the LRRK2 Parkinson's disease kinase

    Lis, P., Burel, S., Steger, M., Mann, Matthias, Brown, F., Diez, F., Tonelli, F., Holton, J. L., Ho, P. W., Ho, S., Chou, M., Polinski, N. K., Martinez, T. N., Davies, P. & Alessi, D. R., Jan 2018, In: Biochemical Journal. 475, 1, 22 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Democratizing knowledge representation with BioCypher

    Lobentanzer, S., Aloy, P., Baumbach, J., Bohar, B., Carey, V. J., Charoentong, P., Danhauser, K., Doğan, T., Dreo, J., Dunham, I., Farr, E., Fernandez-Torras, A., Gyori, B. M., Hartung, M., Hoyt, C. T., Klein, C., Korcsmaros, T., Maier, A., Mann, M., Ochoa, D. & 12 others, Pareja-Lorente, E., Popp, F., Preusse, M., Probul, N., Schwikowski, B., Sen, B., Strauss, Maximilian, Turei, D., Ulusoy, E., Waltemath, D., Wodke, J. A. H. & Saez-Rodriguez, J., 2023, In: Nature Biotechnology. 41, p. 1056-1059

    Research output: Contribution to journalLetterResearchpeer-review

  24. Defining the RBPome of primary T helper cells to elucidate higher-order Roquin-mediated mRNA regulation

    Hoefig, K. P., Reim, A., Gallus, C., Wong, E. H., Behrens, G., Conrad, C., Xu, M., Kifinger, L., Ito-Kureha, T., Defourny, K. A. Y., Geerlof, A., Mautner, J., Hauck, S. M., Baumjohann, D., Feederle, R., Mann, Matthias, Wierer, M., Glasmacher, E. & Heissmeyer, V., 1 Sep 2021, In: Nature Communications. 12, 1, p. 5208

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Defining NASH from a multi-omics systems biology perspective

    Niu, Lili, Sulek, K., Vasilopoulou, C. G., Santos, A., Albrechtsen, Nicolai Jacob Wewer, Rasmussen, Simon, Meier, F. & Mann, Matthias, 2021, In: Journal of Clinical Medicine. 10, 20, 22 p., 4673.

    Research output: Contribution to journalReviewResearchpeer-review

  26. Defective glycosylation and multisystem abnormalities characterize the primary immunodeficiency XMEN disease

    Ravell, J. C., Matsuda-Lennikov, M., Chauvin, S. D., Zou, J., Biancalana, M., Deeb, S. J., Price, S., Su, H. C., Notarangelo, G., Jiang, P., Morawski, A., Kanellopoulou, C., Binder, K. W., Mukherjee, R., Anibal, J. T., Sellers, B., Zheng, L., He, T., George, A. B., Pittaluga, S. & 34 others, Powers, A., Kleiner, D. E., Kapuria, D., Ghany, M., Hunsberger, S., Cohen, J. I., Uzel, G., Bergerson, J., Wolfe, L., Toro, C., Gahl, W., Folio, L. R., Matthews, H., Angelus, P., Chinn, I. K., Orange, J. S., Trujillo-Vargas, C. M., Franco, J. L., Orrego-Arango, J., Gutiérrez-Hincapié, S., Patel, N. C., Raymond, K., Patiroglu, T., Unal, E., Karakukcu, M., Day, A. G., Mehta, P., Masutani, E., De Ravin, S. S., Malech, H. L., Altan-Bonnet, G., Rao, V. K., Mann, Matthias & Lenardo, M. J., 5 Nov 2019, (E-pub ahead of print) In: The Journal of Clinical Investigation.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Deep proteomics of mouse skeletal muscle enables quantitation of protein isoforms, metabolic pathways and transcription factors

    Deshmukh, Atul Shahaji, Murgia, M., Nagaraja, N., Treebak, Jonas Thue, Cox, J. & Mann, Matthias, Apr 2015, In: Molecular and Cellular Proteomics. 14, 4, p. 841-853

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published
  29. Deep learning the collisional cross sections of the peptide universe from a million experimental values

    Meier, F., Köhler, N. D., Brunner, A. D., Wanka, J. M. H., Voytik, E., Strauss, M. T., Theis, F. J. & Mann, Matthias, 2021, In: Nature Communications. 12, 12 p., 1185.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Deep Visual Proteomics defines single-cell identity and heterogeneity

    Mund, A., Coscia, F., Kriston, A., Hollandi, R., Kovács, F., Brunner, A-D., Migh, E., Schweizer, L., Santos, A., Bzorek, M., Naimy, S., Rahbek-Gjerdrum, L. M., Dyring-Andersen, B., Bulkescher, J., Lukas, C., Eckert, M. A., Lengyel, E., Gnann, C., Lundberg, E., Horvath, P. & 1 others, Mann, Matthias, 2022, In: Nature Biotechnology. 40, p. 1231-1240

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Deep Proteomics of Breast Cancer Cells Reveals that Metformin Rewires Signaling Networks Away from a Pro-growth State

    Sacco, F., Silvestri, A., Posca, D., Pirrò, S., Gherardini, P. F., Castagnoli, L., Mann, Matthias & Cesareni, G., 23 Mar 2016, In: Cell Systems. 2, 3, p. 159-71 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Deep Proteome Profiling Reveals Common Prevalence of MZB1-positive Plasma B Cells in Human Lung and Skin Fibrosis

    Schiller, H. B., Mayr, C. H., Leuschner, G., Strunz, M., Staab-Weijnitz, C., Preisendörfer, S., Eckes, B., Moinzadeh, P., Krieg, T., Schwartz, D. A., Hatz, R. A., Behr, J., Mann, Matthias & Eickelberg, O., 2017, In: American Journal of Respiratory and Critical Care Medicine. 196, 10, p. 1298–1310

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Decoding signalling networks by mass spectrometry-based proteomics

    Choudhary, Chunaram & Mann, Matthias, 1 Jun 2010, In: Nature Reviews. Molecular Cell Biology. 11, 6, p. 427-39 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Data-independent acquisition method for ubiquitinome analysis reveals regulation of circadian biology

    Hansen, F. M., Tanzer, M. C., Brüning, F., Bludau, I., Stafford, C., Schulman, B. A., Robles, M. S., Karayel, O. & Mann, Matthias, 11 Jan 2021, In: Nature Communications. 12, 1, p. 254

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. DIA-based systems biology approach unveils E3 ubiquitin ligase-dependent responses to a metabolic shift

    Karayel, O., Michaelis, A. C., Mann, Matthias, Schulman, B. A. & Langlois, C. R., 22 Dec 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 51, p. 32806-32815 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. DEAD box protein DDX1 regulates cytoplasmic localization of KSRP

    Chou, C., Lin, W., Lin, C., Luber, C. A., Godbout, R., Mann, Matthias & Chen, C., 4 Sep 2013, In: P L o S One. 8, 9, e73752.

    Research output: Contribution to journalJournal articleResearch

  37. Published

    D13 Saliva biomarker discovery in Huntington’s disease

    Qvist, Filippa Liliendahl, Hellem, M. N., Nielsen, Jørgen Erik, Mann, Matthias & Skotte, Niels Henning, 2022, In: Journal of Neurology, Neurosurgery and Psychiatry. 93, Suppl. 1, p. A24-A25

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  38. Published

    Cytosolic Ptbp2 modulates axon growth in motoneurons through axonal localization and translation of Hnrnpr

    Salehi, S., Zare, A., Prezza, G., Bader, J., Schneider, C., Fischer, U., Meissner, F., Mann, Matthias, Briese, M. & Sendtner, M., 2023, In: Nature Communications. 14, 19 p., 4158.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Cytoplasmic protein aggregates interfere with nucleocytoplasmic transport of protein and RNA

    Woerner, A. C., Frottin, F., Hornburg, D., Feng, L. R., Meissner, F., Patra, M., Tatzelt, J., Mann, Matthias, Winklhofer, K. F., Hartl, F. U. & Hipp, M. S., 8 Jan 2016, In: Science (New York, N.Y.). 351, 6269, p. 173-6 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Cryo-EM structures of Gid12-bound GID E3 reveal steric blockade as a mechanism inhibiting substrate ubiquitylation

    Qiao, S., Lee, C., Sherpa, D., Chrustowicz, J., Cheng, J., Duennebacke, M., Steigenberger, B., Karayel, O., Vu, D. T., von Gronau, S., Mann, Matthias, Wilfling, F. & Schulman, B. A., 2022, In: Nature Communications. 13, 3041.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Cotranslational N-degron masking by acetylation promotes proteome stability in plants

    Linster, E., Forero Ruiz, F. L., Miklankova, P., Ruppert, T., Mueller, J., Armbruster, L., Gong, X., Serino, G., Mann, Matthias, Hell, R. & Wirtz, M., 2022, In: Nature Communications. 13, 1, p. 810

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Cortical circuit alterations precede motor impairments in Huntington's disease mice

    Burgold, J., Schulz-Trieglaff, E. K., Voelkl, K., Gutiérrez-Ángel, S., Bader, J. M., Hosp, F., Mann, Matthias, Arzberger, T., Klein, R., Liebscher, S. & Dudanova, I., 29 Apr 2019, In: Scientific Reports. 9, 1, p. 6634

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Correction to Feasibility of Large-Scale Phosphoproteomics with Higher Energy Collisional Dissociation Fragmentation

    Nagaraj, N., D'Souza, R. C. J., Cox, J., Olsen, Jesper Velgaard & Mann, Matthias, 2012, In: Journal of Proteome Research.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Constructing a cell-type resolved human liver proteome atlas: THU-034

    Niu, Lili, Geyer, P. & Mann, Matthias, 2018, In: Journal of Hepatology. 68, p. S138-S139

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  45. Published

    Consistency across multi-omics layers in a drug-perturbed gut microbial community

    Wuyts, S., Alves, R., Zimmermann-Kogadeeva, M., Nishijima, S., Blasche, S., Driessen, M., Geyer, P. E., Hercog, R., Kartal, E., Maier, L., Müller, J. B., Garcia Santamarina, S., Schmidt, T. S. B., Sevin, D. C., Telzerow, A., Treit, P. V., Wenzel, T., Typas, A., Patil, K. R., Mann, M. & 2 others, Kuhn, M. & Bork, P., 2023, In: Molecular Systems Biology. 19, 9, 17 p., e11525.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Comprehensive chromatin proteomics resolves functional phases of pluripotency and identifies changes in regulatory components

    Ugur, E., de la Porte, A., Qin, W., Bultmann, S., Ivanova, A., Drukker, M., Mann, Matthias, Wierer, M. & Leonhardt, H., 2023, In: Nucleic Acids Research. 51, 6, p. 2671-2690 20 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Compartment-resolved Proteomic Analysis of Mouse Aorta during Atherosclerotic Plaque Formation Reveals Osteoclast-specific Protein Expression

    Wierer, M., Prestel, M., Schiller, H., Yan, G., Schaab, C., Azghandi, S., Werner, J., Kessler, T., Malik, R., Murgia, M., Aherrahrou, Z., Schunkert, H., Dichgans, M. & Mann, Matthias, Feb 2018, In: Molecular and Cellular Proteomics.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. E-pub ahead of print

    Comparative quantitative proteomic analysis of melanoma subtypes, nevus-associated melanoma, and corresponding nevi

    Naimy, S., Sølberg, J. B. K., Kuczek, D. E., Løvendorf, Marianne Bengtson, Bzorek, M., Litman, Thomas, Mund, Andreas, Gjerdrum, Lise Mette Rahbek, Clark, R. A., Mann, Matthias & Dyring-Andersen, Beatrice, 5 Jan 2024, (E-pub ahead of print) In: The Journal of Investigative Dermatology.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Cohort profile: the MUNICH Preterm and Term Clinical study (MUNICH-PreTCl), a neonatal birth cohort with focus on prenatal and postnatal determinants of infant and childhood morbidity

    Pangratz-Fuehrer, S., Genzel-Boroviczény, O., Bodensohn, W. E., Eisenburger, R., Scharpenack, J., Geyer, P. E., Müller-Reif, J. B., van Hagen, N., Müller, A. M., Jensen, Majken Karoline, Klein, C., Mann, Matthias & Nussbaum, C., 2021, In: BMJ Open. 11, 6, 13 p., e050652.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Circulating Glucagon 1-61 Regulates Blood Glucose by Increasing Insulin Secretion and Hepatic Glucose Production

    Albrechtsen, N. J. W., Kuhre, R. E., Hornburg, D., Jensen, C. Z., Hornum, M., Dirksen, C., Svane, M., Gasbjerg, L. S., Jorgensen, N. B., Gabe, M. N., Balk-Moller, E., Albrechtsen, R., Winther-Sorensen, M., Galsgaard, K. D., Meissner, F., Jorsal, T., Lund, A., Vilsboll, T., Eliasen, R., Bojsen-Moller, K. N. & 9 others, Idorn, T., Deacon, Carolyn F., Knop, Filip Krag, Rosenkilde, Mette, Hartmann, Bolette, Feldt-Rasmussen, Bo, Mann, Matthias, Madsbad, Sten & Holst, Jens Juul, Nov 2017, In: Cell Reports. 21, 6, p. 1452-1460

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 5650809