Matthias Mann
Professor, head of research, Professor
Functional characterization of Rad18 domains for Rad6, ubiquitin, DNA binding and PCNA modification
Notenboom, V., Hibbert, R. G., van Rossum-Fikkert, S. E., Olsen, Jesper Velgaard, Mann, Matthias & Sixma, T. K., 2007, In: Nucleic Acids Research. 35, 17, p. 5819-30 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Full Mass Range ΦSDM Orbitrap Mass Spectrometry for DIA Proteome Analysis
Steigerwald, S., Sinha, A., Fort, K. L., Zeng, W., Niu, Lili, Wichmann, C., Kreutzmann, A., Mourad, D., Aizikov, K., Grinfeld, D., Makarov, A., Mann, Matthias & Meier, F., 2024, In: Molecular and Cellular Proteomics. 12 p., 100713.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Foresight in clinical proteomics: current status, ethical considerations, and future perspectives
Mundt Madsen, Filip Oskar, Albrechtsen, Nicolai Jacob Wewer, Porsdam Mann, Sebastian, Treit, P., Ghodgaonkar-Steger, M., O’Flaherty, M., Raijmakers, R., Vizcaíno, J. A., Heck, A. J. R. & Mann, Matthias, 2023, In: Open Research Europe. 3, 19 p., 59.Research output: Contribution to journal › Letter › Research › peer-review
Fibro-adipogenic progenitors of dystrophic mice are insensitive to NOTCH regulation of adipogenesis
Marinkovic, M., Fuoco, C., Sacco, F., Cerquone Perpetuini, A., Giuliani, G., Micarelli, E., Pavlidou, T., Petrilli, L. L., Reggio, A., Riccio, F., Spada, F., Vumbaca, S., Zuccotti, A., Castagnoli, L., Mann, Matthias, Gargioli, C. & Cesareni, G., Jun 2019, In: Life Science Alliance. 2, 3Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Femtomole sequencing of proteins from polyacrylamide gels by nano-electrospray mass spectrometry
Wilm, M., Shevchenko, A., Houthaeve, T., Breit, S., Schweigerer, L., Fotsis, T. & Mann, Matthias, 1 Feb 1996, In: Nature. 379, 6564, p. 466-9 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
Fam20C regulates protein secretion by Cab45 phosphorylation
Hecht, T. K., Blank, B., Steger, M., Lopez, V., Beck, G., Ramazanov, B., Mann, Matthias, Tagliabracci, V. & von Blume, J., 1 Jun 2020, In: The Journal of Cell Biology. 219, 6Research output: Contribution to journal › Journal article › Research › peer-review
- Published
FAM111 protease activity undermines cellular fitness and is amplified by gain-of-function mutations in human disease
Hoffmann, Saskia, Pentakota, S., Mund, Andreas, Haahr, Peter Thorlund, Coscia, F., Gallo, M., Mann, Matthias, Taylor, Nicholas M I & Mailand, Niels, 2020, In: EMBO Reports. 21, 10, 14 p., e50662.Research output: Contribution to journal › Journal article › Research › peer-review
Extensive quantitative remodeling of the proteome between normal colon tissue and adenocarcinoma
Wiśniewski, J. R., Ostasiewicz, P., Duś, K., Zielińska, D. F., Gnad, F. & Mann, Matthias, 1 Jan 2012, In: Molecular Systems Biology. 8, 611.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Evidence of Extrapancreatic Glucagon Secretion in Man
Lund, Asger Bach, Bagger, J. I., Albrechtsen, Nicolai Jacob Wewer, Christensen, M., Grøndahl, M., Hartmann, Bolette, Mathiesen, Elisabeth, Hansen, C. P., Storkholm, J. H., van Hall, Gerrit, Rehfeld, Jens Frederik, Hornburg, D., Meissner, F., Mann, Matthias, Larsen, S., Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, Mar 2016, In: Diabetes. 65, 3, p. 585-597 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ethical Principles, Constraints and Opportunities in Clinical Proteomics
Porsdam Mann, Sebastian, Treit, P. V., Geyer, P. E., Omenn, G. S. & Mann, Matthias, 2021, In: Molecular and Cellular Proteomics. 20, 14 p., 100046.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Error-tolerant identification of peptides in sequence databases by peptide sequence tags
Mann, Matthias & Wilm, M., 15 Dec 1994, In: Analytical Chemistry. 66, 24, p. 4390-9 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Erratum: Evidence of extrapancreatic glucagon secretion in man. Diabetes 2016;65:585-597
Lund, Asger Bach, Bagger, J. I., Albrechtsen, Nicolai Jacob Wewer, Christensen, M., Grøndahl, M., Hartmann, Bolette, Mathiesen, Elisabeth, Hansen, C. P., Storkholm, J. H., van Hall, Gerrit, Rehfeld, Jens Frederik, Hornburg, D., Meissner, F., Mann, Matthias, Larsen, S., Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, 1 Jun 2016, In: Diabetes. 65, 6, p. 1752 1 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
- Published
Efficient mitotic checkpoint signaling depends on integrated activities of Bub1 and the RZZ complex
Zhang, G., Kruse, Thomas, Guasch Boldú, C., Garvanska, Dimitriya Hristoforova, Coscia, F., Mann, Matthias, Barisic, Marin & Nilsson, Jakob, 2019, In: E M B O Journal. 38, 7, e100977.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effective representation and storage of mass spectrometry-based proteomic data sets for the scientific community
Olsen, Jesper Velgaard & Mann, Matthias, 1 Jan 2011, In: Science Signaling. 4, 160, p. pe7Research output: Contribution to journal › Journal article › Research › peer-review
- Published
EASI-tag enables accurate multiplexed and interference-free MS2-based proteome quantification
Virreira Winter, S., Meier, F., Wichmann, C., Cox, J., Mann, Matthias & Meissner, F., 2018, In: Nature Methods. 15, 7, p. 527-530 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
Dynamics in protein translation sustaining T cell preparedness
Wolf, T., Jin, W., Zoppi, G., Vogel, I. A., Akhmedov, M., Bleck, C. K. E., Beltraminelli, T., Rieckmann, J. C., Ramirez, N. J., Benevento, M., Notarbartolo, S., Bumann, D., Meissner, F., Grimbacher, B., Mann, Matthias, Lanzavecchia, A., Sallusto, F., Kwee, I. & Geiger, R., 6 Jul 2020, (E-pub ahead of print) In: Nature Immunology.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Dynamic human liver proteome atlas reveals functional insights into disease pathways
Niu, Lili, Geyer, P. E., Gupta, R., Santos, A., Meier, F., Doll, S., Albrechtsen, Nicolai Jacob Wewer, Klein, S., Ortiz, C., Uschner, F. E., Schierwagen, R., Trebicka, J. & Mann, Matthias, 2022, In: Molecular Systems Biology. 18, 5, 24 p., e10947.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Distinct signaling by insulin and IGF-1 receptors and their extra- and intracellular domains
Nagao, H., Cai, W., Albrechtsen, Nicolai Jacob Wewer, Steger, M., Batista, T. M., Pan, H., Dreyfuss, J. M., Mann, Matthias & Kahn, C. R., 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 17, e2019474118.Research output: Contribution to journal › Journal article › Research › peer-review
Direct proteomic quantification of the secretome of activated immune cells
Meissner, F., Scheltema, R. A., Mollenkopf, H. & Mann, Matthias, 26 Apr 2013, In: Science (New York, N.Y.). 340, 6131, p. 475-8 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
Direct identification of clinically relevant neoepitopes presented on native human melanoma tissue by mass spectrometry
Bassani-Sternberg, M., Bräunlein, E., Klar, R., Engleitner, T., Sinitcyn, P., Audehm, S., Straub, M., Weber, J., Slotta-Huspenina, J., Specht, K., Martignoni, M. E., Werner, A., Hein, R., H Busch, D., Peschel, C., Rad, R., Cox, J., Mann, Matthias & Krackhardt, A. M., 21 Nov 2016, In: Nature Communications. 7, p. 13404Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Development, use, application of novel TIMS-Tof system
Mann, Matthias, 2019, In: Molecular & Cellular Proteomics. 18, 8, p. S20 1 p.Research output: Contribution to journal › Conference abstract in journal › Research
Development of phospho-specific Rab protein antibodies to monitor in vivo activity of the LRRK2 Parkinson's disease kinase
Lis, P., Burel, S., Steger, M., Mann, Matthias, Brown, F., Diez, F., Tonelli, F., Holton, J. L., Ho, P. W., Ho, S., Chou, M., Polinski, N. K., Martinez, T. N., Davies, P. & Alessi, D. R., Jan 2018, In: Biochemical Journal. 475, 1, 22 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Democratizing knowledge representation with BioCypher
Lobentanzer, S., Aloy, P., Baumbach, J., Bohar, B., Carey, V. J., Charoentong, P., Danhauser, K., Doğan, T., Dreo, J., Dunham, I., Farr, E., Fernandez-Torras, A., Gyori, B. M., Hartung, M., Hoyt, C. T., Klein, C., Korcsmaros, T., Maier, A., Mann, M., Ochoa, D. & 12 others, , 2023, In: Nature Biotechnology. 41, p. 1056-1059Research output: Contribution to journal › Letter › Research › peer-review
Defining the RBPome of primary T helper cells to elucidate higher-order Roquin-mediated mRNA regulation
Hoefig, K. P., Reim, A., Gallus, C., Wong, E. H., Behrens, G., Conrad, C., Xu, M., Kifinger, L., Ito-Kureha, T., Defourny, K. A. Y., Geerlof, A., Mautner, J., Hauck, S. M., Baumjohann, D., Feederle, R., Mann, Matthias, Wierer, M., Glasmacher, E. & Heissmeyer, V., 1 Sep 2021, In: Nature Communications. 12, 1, p. 5208Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Defining NASH from a multi-omics systems biology perspective
Niu, Lili, Sulek, K., Vasilopoulou, C. G., Santos, A., Albrechtsen, Nicolai Jacob Wewer, Rasmussen, Simon, Meier, F. & Mann, Matthias, 2021, In: Journal of Clinical Medicine. 10, 20, 22 p., 4673.Research output: Contribution to journal › Review › Research › peer-review
Defective glycosylation and multisystem abnormalities characterize the primary immunodeficiency XMEN disease
Ravell, J. C., Matsuda-Lennikov, M., Chauvin, S. D., Zou, J., Biancalana, M., Deeb, S. J., Price, S., Su, H. C., Notarangelo, G., Jiang, P., Morawski, A., Kanellopoulou, C., Binder, K. W., Mukherjee, R., Anibal, J. T., Sellers, B., Zheng, L., He, T., George, A. B., Pittaluga, S. & 34 others, , 5 Nov 2019, (E-pub ahead of print) In: The Journal of Clinical Investigation.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Deep proteomics of mouse skeletal muscle enables quantitation of protein isoforms, metabolic pathways and transcription factors
Deshmukh, Atul Shahaji, Murgia, M., Nagaraja, N., Treebak, Jonas Thue, Cox, J. & Mann, Matthias, Apr 2015, In: Molecular and Cellular Proteomics. 14, 4, p. 841-853Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Deep muscle-proteomic analysis of freeze-dried human muscle biopsies reveals fiber type-specific adaptations to exercise training
Deshmukh, Atul Shahaji, Steenberg, D. E., Hostrup, Morten, Birk, Jesper Bratz, Larsen, Jeppe Kjærgaard, Santos, A., Kjøbsted, Rasmus, Hingst, J. R., Schéele, Camilla Charlotte Nielsen, Murgia, M., Kiens, Bente, Richter, Erik A., Mann, Matthias & Wojtaszewski, Jørgen F P, 2021, In: Nature Communications. 12, 15 p., 304.Research output: Contribution to journal › Journal article › Research › peer-review
Deep learning the collisional cross sections of the peptide universe from a million experimental values
Meier, F., Köhler, N. D., Brunner, A. D., Wanka, J. M. H., Voytik, E., Strauss, M. T., Theis, F. J. & Mann, Matthias, 2021, In: Nature Communications. 12, 12 p., 1185.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Deep Visual Proteomics defines single-cell identity and heterogeneity
Mund, A., Coscia, F., Kriston, A., Hollandi, R., Kovács, F., Brunner, A-D., Migh, E., Schweizer, L., Santos, A., Bzorek, M., Naimy, S., Rahbek-Gjerdrum, L. M., Dyring-Andersen, B., Bulkescher, J., Lukas, C., Eckert, M. A., Lengyel, E., Gnann, C., Lundberg, E., Horvath, P. & 1 others, , 2022, In: Nature Biotechnology. 40, p. 1231-1240Research output: Contribution to journal › Journal article › Research › peer-review
Deep Proteomics of Breast Cancer Cells Reveals that Metformin Rewires Signaling Networks Away from a Pro-growth State
Sacco, F., Silvestri, A., Posca, D., Pirrò, S., Gherardini, P. F., Castagnoli, L., Mann, Matthias & Cesareni, G., 23 Mar 2016, In: Cell Systems. 2, 3, p. 159-71 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
Deep Proteome Profiling Reveals Common Prevalence of MZB1-positive Plasma B Cells in Human Lung and Skin Fibrosis
Schiller, H. B., Mayr, C. H., Leuschner, G., Strunz, M., Staab-Weijnitz, C., Preisendörfer, S., Eckes, B., Moinzadeh, P., Krieg, T., Schwartz, D. A., Hatz, R. A., Behr, J., Mann, Matthias & Eickelberg, O., 2017, In: American Journal of Respiratory and Critical Care Medicine. 196, 10, p. 1298–1310Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Decoding signalling networks by mass spectrometry-based proteomics
Choudhary, Chunaram & Mann, Matthias, 1 Jun 2010, In: Nature Reviews. Molecular Cell Biology. 11, 6, p. 427-39 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
Data-independent acquisition method for ubiquitinome analysis reveals regulation of circadian biology
Hansen, F. M., Tanzer, M. C., Brüning, F., Bludau, I., Stafford, C., Schulman, B. A., Robles, M. S., Karayel, O. & Mann, Matthias, 11 Jan 2021, In: Nature Communications. 12, 1, p. 254Research output: Contribution to journal › Journal article › Research › peer-review
DIA-based systems biology approach unveils E3 ubiquitin ligase-dependent responses to a metabolic shift
Karayel, O., Michaelis, A. C., Mann, Matthias, Schulman, B. A. & Langlois, C. R., 22 Dec 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 51, p. 32806-32815 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
DEAD box protein DDX1 regulates cytoplasmic localization of KSRP
Chou, C., Lin, W., Lin, C., Luber, C. A., Godbout, R., Mann, Matthias & Chen, C., 4 Sep 2013, In: P L o S One. 8, 9, e73752.Research output: Contribution to journal › Journal article › Research
- Published
D13 Saliva biomarker discovery in Huntington’s disease
Qvist, Filippa Liliendahl, Hellem, M. N., Nielsen, Jørgen Erik, Mann, Matthias & Skotte, Niels Henning, 2022, In: Journal of Neurology, Neurosurgery and Psychiatry. 93, Suppl. 1, p. A24-A25Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Cytosolic Ptbp2 modulates axon growth in motoneurons through axonal localization and translation of Hnrnpr
Salehi, S., Zare, A., Prezza, G., Bader, J., Schneider, C., Fischer, U., Meissner, F., Mann, Matthias, Briese, M. & Sendtner, M., 2023, In: Nature Communications. 14, 19 p., 4158.Research output: Contribution to journal › Journal article › Research › peer-review
Cytoplasmic protein aggregates interfere with nucleocytoplasmic transport of protein and RNA
Woerner, A. C., Frottin, F., Hornburg, D., Feng, L. R., Meissner, F., Patra, M., Tatzelt, J., Mann, Matthias, Winklhofer, K. F., Hartl, F. U. & Hipp, M. S., 8 Jan 2016, In: Science (New York, N.Y.). 351, 6269, p. 173-6 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
Cryo-EM structures of Gid12-bound GID E3 reveal steric blockade as a mechanism inhibiting substrate ubiquitylation
Qiao, S., Lee, C., Sherpa, D., Chrustowicz, J., Cheng, J., Duennebacke, M., Steigenberger, B., Karayel, O., Vu, D. T., von Gronau, S., Mann, Matthias, Wilfling, F. & Schulman, B. A., 2022, In: Nature Communications. 13, 3041.Research output: Contribution to journal › Journal article › Research › peer-review
Cotranslational N-degron masking by acetylation promotes proteome stability in plants
Linster, E., Forero Ruiz, F. L., Miklankova, P., Ruppert, T., Mueller, J., Armbruster, L., Gong, X., Serino, G., Mann, Matthias, Hell, R. & Wirtz, M., 2022, In: Nature Communications. 13, 1, p. 810Research output: Contribution to journal › Journal article › Research › peer-review
Cortical circuit alterations precede motor impairments in Huntington's disease mice
Burgold, J., Schulz-Trieglaff, E. K., Voelkl, K., Gutiérrez-Ángel, S., Bader, J. M., Hosp, F., Mann, Matthias, Arzberger, T., Klein, R., Liebscher, S. & Dudanova, I., 29 Apr 2019, In: Scientific Reports. 9, 1, p. 6634Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Correction to Feasibility of Large-Scale Phosphoproteomics with Higher Energy Collisional Dissociation Fragmentation
Nagaraj, N., D'Souza, R. C. J., Cox, J., Olsen, Jesper Velgaard & Mann, Matthias, 2012, In: Journal of Proteome Research.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Constructing a cell-type resolved human liver proteome atlas: THU-034
Niu, Lili, Geyer, P. & Mann, Matthias, 2018, In: Journal of Hepatology. 68, p. S138-S139Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Consistency across multi-omics layers in a drug-perturbed gut microbial community
Wuyts, S., Alves, R., Zimmermann-Kogadeeva, M., Nishijima, S., Blasche, S., Driessen, M., Geyer, P. E., Hercog, R., Kartal, E., Maier, L., Müller, J. B., Garcia Santamarina, S., Schmidt, T. S. B., Sevin, D. C., Telzerow, A., Treit, P. V., Wenzel, T., Typas, A., Patil, K. R., Mann, M. & 2 others, , 2023, In: Molecular Systems Biology. 19, 9, 17 p., e11525.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Comprehensive chromatin proteomics resolves functional phases of pluripotency and identifies changes in regulatory components
Ugur, E., de la Porte, A., Qin, W., Bultmann, S., Ivanova, A., Drukker, M., Mann, Matthias, Wierer, M. & Leonhardt, H., 2023, In: Nucleic Acids Research. 51, 6, p. 2671-2690 20 p.Research output: Contribution to journal › Journal article › Research › peer-review
Compartment-resolved Proteomic Analysis of Mouse Aorta during Atherosclerotic Plaque Formation Reveals Osteoclast-specific Protein Expression
Wierer, M., Prestel, M., Schiller, H., Yan, G., Schaab, C., Azghandi, S., Werner, J., Kessler, T., Malik, R., Murgia, M., Aherrahrou, Z., Schunkert, H., Dichgans, M. & Mann, Matthias, Feb 2018, In: Molecular and Cellular Proteomics.Research output: Contribution to journal › Journal article › Research › peer-review
- E-pub ahead of print
Comparative quantitative proteomic analysis of melanoma subtypes, nevus-associated melanoma, and corresponding nevi
Naimy, S., Sølberg, J. B. K., Kuczek, D. E., Løvendorf, Marianne Bengtson, Bzorek, M., Litman, Thomas, Mund, Andreas, Gjerdrum, Lise Mette Rahbek, Clark, R. A., Mann, Matthias & Dyring-Andersen, Beatrice, 5 Jan 2024, (E-pub ahead of print) In: The Journal of Investigative Dermatology.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cohort profile: the MUNICH Preterm and Term Clinical study (MUNICH-PreTCl), a neonatal birth cohort with focus on prenatal and postnatal determinants of infant and childhood morbidity
Pangratz-Fuehrer, S., Genzel-Boroviczény, O., Bodensohn, W. E., Eisenburger, R., Scharpenack, J., Geyer, P. E., Müller-Reif, J. B., van Hagen, N., Müller, A. M., Jensen, Majken Karoline, Klein, C., Mann, Matthias & Nussbaum, C., 2021, In: BMJ Open. 11, 6, 13 p., e050652.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Circulating Glucagon 1-61 Regulates Blood Glucose by Increasing Insulin Secretion and Hepatic Glucose Production
Albrechtsen, N. J. W., Kuhre, R. E., Hornburg, D., Jensen, C. Z., Hornum, M., Dirksen, C., Svane, M., Gasbjerg, L. S., Jorgensen, N. B., Gabe, M. N., Balk-Moller, E., Albrechtsen, R., Winther-Sorensen, M., Galsgaard, K. D., Meissner, F., Jorsal, T., Lund, A., Vilsboll, T., Eliasen, R., Bojsen-Moller, K. N. & 9 others, , Nov 2017, In: Cell Reports. 21, 6, p. 1452-1460Research output: Contribution to journal › Journal article › Research › peer-review
ID: 5650809
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2010
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Activation of the ATR kinase by the RPA-binding protein ETAA1
Research output: Contribution to journal › Journal article › Research › peer-review
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516
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Region and cell-type resolved quantitative proteomic map of the human heart
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498
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Revisiting biomarker discovery by plasma proteomics
Research output: Contribution to journal › Review › Research › peer-review
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