Matthias Mann
Professor, head of research, Professor
β1- and αv-class integrins cooperate to regulate myosin II during rigidity sensing of fibronectin-based microenvironments
Schiller, H. B., Hermann, M., Polleux, J., Vignaud, T., Zanivan, S., Friedel, C. C., Sun, Z., Raducanu, A., Gottschalk, K., Théry, M., Mann, Matthias & Fässler, R., Jun 2013, In: Nature Cell Biology. 15, 6, p. 625-36 12 p.Research output: Contribution to journal › Journal article › Research
p53 down-regulates SARS coronavirus replication and is targeted by the SARS-unique domain and PLpro via E3 ubiquitin ligase RCHY1
Ma-Lauer, Y., Carbajo-Lozoya, J., Hein, M. Y., Müller, M. A., Deng, W., Lei, J., Meyer, B., Kusov, Y., von Brunn, B., Bairad, D. R., Hünten, S., Drosten, C., Hermeking, H., Leonhardt, H., Mann, Matthias, Hilgenfeld, R. & von Brunn, A., 30 Aug 2016, In: Proceedings of the National Academy of Sciences of the United States of America. 113, 35, p. E5192-201Research output: Contribution to journal › Journal article › Research › peer-review
- Published
diaPASEF: parallel accumulation-serial fragmentation combined with data-independent acquisition
Meier, F., Brunner, A., Frank, M., Ha, A., Bludau, I., Voytik, E., Kaspar-Schoenefeld, S., Lubeck, M., Raether, O., Bache, N., Aebersold, R., Collins, B. C., Roest, H. L. & Mann, Matthias, 2020, In: Nature Methods. 17, 12, p. 1229-1236Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Yeast expression proteomics by high-resolution mass spectrometry
Walther, T. C., Olsen, Jesper Velgaard & Mann, Matthias, 1 Jan 2010, In: Methods in Enzymology. 470, p. 259-80 22 p.Research output: Contribution to journal › Journal article › Research › peer-review
YBX1 mediates translation of oncogenic transcripts to control cell competition in AML
Perner, F., Schnoeder, T. M., Xiong, Y., Jayavelu, A. K., Mashamba, N., Santamaria, N. T., Huber, N., Todorova, K., Hatton, C., Perner, B., Eifert, T., Murphy, C., Hartmann, M., Hoell, J. I., Schröder, N., Brandt, S., Hochhaus, A., Mertens, P. R., Mann, M., Armstrong, S. A. & 2 others, , Feb 2022, In: Leukemia. 36, 2, p. 426-437 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Widespread Proteome Remodeling and Aggregation in Aging C. elegans
Walther, D. M., Kasturi, P., Zheng, M., Pinkert, S., Vecchi, G., Ciryam, P., Morimoto, R. I., Dobson, C. M., Vendruscolo, M., Mann, Matthias & Hartl, F. U., 23 Feb 2017, In: Cell. 168, 5, p. 944Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Why is it so difficult to measure glucagon-like peptide-1 in a mouse?
Windeløv, Johanne Agerlin, Albrechtsen, Nicolai Jacob Wewer, Kuhre, Rune Ehrenreich, Jepsen, Sara Lind, Hornburg, D., Pedersen, Jens, Jensen, E. P., Galsgaard, Katrine Douglas, Winther-Sørensen, Marie, Ørgaard, A., Deacon, Carolyn F., Mann, Matthias, Kissow, Hannelouise, Hartmann, Bolette & Holst, Jens Juul, Oct 2017, In: Diabetologia. 60, 10, p. 2066-2075 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Urinary proteome profiling for stratifying patients with familial Parkinson’s disease
Virreira Winter, S., Karayel, O., Strauss, M. T., Padmanabhan, S., Surface, M., Merchant, K., Alcalay, R. N. & Mann, Matthias, 2021, In: EMBO Molecular Medicine. 13, 3, 19 p., e13257.Research output: Contribution to journal › Journal article › Research › peer-review
Unique ligand and kinase-independent roles of the insulin receptor in regulation of cell cycle, senescence and apoptosis
Nagao, H., Jayavelu, A. K., Cai, W., Pan, H., Dreyfuss, J. M., Batista, T. M., Brandão, B. B., Mann, Matthias & Kahn, C. R., 4 Jan 2023, In: Nature Communications. 14, 1, p. 57Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Unbiased spatial proteomics with single-cell resolution in tissues
Mund, Andreas, Brunner, A. & Mann, Matthias, 2022, In: Molecular Cell. 82, 12, p. 2335-2349 15 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Ultra-high sensitivity mass spectrometry quantifies single-cell proteome changes upon perturbation
Brunner, A., Thielert, Marvin Christoffer, Vasilopoulou, C., Ammar, C., Coscia, F., Mund, Andreas, Hoerning, O. B., Bache, N., Apalategui, A., Lubeck, M., Richter, S., Fischer, D. S., Raether, O., Park, M. A., Meier, F., Theis, F. J. & Mann, Matthias, 2022, In: Molecular Systems Biology. 18, 3, 15 p., e10798.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ultra-deep and quantitative saliva proteome reveals dynamics of the oral microbiome
Grassl, N., Kulak, N. A., Pichler, G., Geyer, P. E., Jung, J., Schubert, S., Sinitcyn, P., Cox, J. & Mann, Matthias, 21 Apr 2016, In: Genome Medicine. 8, 13 p., 44.Research output: Contribution to journal › Journal article › Research › peer-review
UBL3 modification influences protein sorting to small extracellular vesicles
Ageta, H., Ageta-Ishihara, N., Hitachi, K., Karayel, O., Onouchi, T., Yamaguchi, H., Kahyo, T., Hatanaka, K., Ikegami, K., Yoshioka, Y., Nakamura, K., Kosaka, N., Nakatani, M., Uezumi, A., Ide, T., Tsutsumi, Y., Sugimura, H., Kinoshita, M., Ochiya, T., Mann, M. & 2 others, , 26 Sep 2018, In: Nature Communications. 9, 1, p. 3936Research output: Contribution to journal › Journal article › Research › peer-review
Tyrosine phosphoproteomics of fibroblast growth factor signaling: a role for insulin receptor substrate-4
Hinsby, A. M., Olsen, Jesper Velgaard & Mann, Matthias, 2004, In: Journal of Biological Chemistry. 279, 45, p. 46438-47 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Trypsin cleaves exclusively C-terminal to arginine and lysine residues
Olsen, Jesper Velgaard, Ong, S. & Mann, Matthias, 2004, In: Molecular and Cellular Proteomics. 3, 6, p. 608-14 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Trapped ion mobility spectrometry and PASEF enable in-depth lipidomics from minimal sample amounts
Vasilopoulou, C. G., Sulek, K., Brunner, A., Meitei, N. S., Schweiger-Hufnagel, U., Meyer, S. W., Barsch, A., Mann, Matthias & Meier, F., 2020, In: Nature Communications. 11, 1, 11 p., 331.Research output: Contribution to journal › Journal article › Research › peer-review
Trapped Ion Mobility Spectrometry (TIMS) and Parallel Accumulation - Serial Fragmentation (PASEF) in Proteomics
Meier, F., Park, M. A. & Mann, Matthias, 17 Aug 2021, (E-pub ahead of print) In: Molecular and Cellular Proteomics. p. 100138Research output: Contribution to journal › Journal article › Research › peer-review
Transcription Factor MAFF (MAF Basic Leucine Zipper Transcription Factor F) Regulates an Atherosclerosis Relevant Network Connecting Inflammation and Cholesterol Metabolism
von Scheidt, M., Zhao, Y., de Aguiar Vallim, T. Q., Che, N., Wierer, M., Seldin, M. M., Franzén, O., Kurt, Z., Pang, S., Bongiovanni, D., Yamamoto, M., Edwards, P. A., Ruusalepp, A., Kovacic, J. C., Mann, Matthias, Björkegren, J. L. M., Lusis, A. J., Yang, X. & Schunkert, H., 2021, In: Circulation. 143, 18, p. 1809-1823Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Towards Precision Dermatology: Emerging Role of Proteomic Analysis of the Skin
Fredman, G., Skov, Lone, Mann, Matthias & Dyring-Andersen, Beatrice, 2022, In: Dermatology. 238, p. 185–194Research output: Contribution to journal › Review › Research › peer-review
Top-down protein sequencing and MS3 on a hybrid linear quadrupole ion trap-orbitrap mass spectrometer
Macek, B., Waanders, L. F., Olsen, Jesper Velgaard & Mann, Matthias, 2006, In: Molecular and Cellular Proteomics. 5, 5, p. 949-58 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Tissue-specific modulation of gene expression in response to lowered insulin signalling in Drosophila
Tain, L. S., Sehlke, R., Meilenbrock, R. L., Leech, T., Paulitz, J., Chokkalingam, M., Nagaraj, N., Grönke, S., Fröhlich, J., Atanassov, I., Mann, Matthias, Beyer, A. & Partridge, L., 21 Apr 2021, In: eLife. 10Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Time-resolved dissection of early phosphoproteome and ensuing proteome changes in response to TGF-β
J D'Souza, R. C., Knittle, A. M., Nagaraj, N., van Dinther, M., Choudhary, Chunaram, Ten Dijke, P., Mann, Matthias & Sharma, K., Jul 2014, In: Science Signaling. 7, 335, p. rs5 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
The tumor suppressor kinase DAPK3 drives tumor-intrinsic immunity through the STING-IFN-β pathway
Takahashi, M., Lio, C. J., Campeau, A., Steger, M., Ay, F., Mann, Matthias, Gonzalez, D. J., Jain, M. & Sharma, S., Apr 2021, In: Nature Immunology. 22, 4, p. 485-496 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The structural context of posttranslational modifications at a proteome-wide scale
Bludau, I., Willems, S., Zeng, W. F., Strauss, Maximilian, Hansen, F. M., Tanzer, M. C., Karayel, O., Schulman, B. A. & Mann, Matthias, 2022, In: PLOS Biology. 20, 5, 23 p., e3001636.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The social and structural architecture of the yeast protein interactome
Michaelis, A. C., Brunner, A., Zwiebel, M., Meier, F., Strauss, Maximilian, Bludau, I. & Mann, Matthias, 2023, In: Nature. 624, 7990, p. 192-200 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
The serine/threonine/tyrosine phosphoproteome of the model bacterium Bacillus subtilis
Macek, B., Mijakovic, I., Olsen, Jesper Velgaard, Gnad, F., Kumar, C., Jensen, P. R. & Mann, Matthias, Feb 2008, In: Molecular and Cellular Proteomics. 6, 4, p. 697-707 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
The proteome of the calcified layer organic matrix of turkey (Meleagris gallopavo) eggshell
Mann, K. & Mann, Matthias, 2013, In: Proteome Science. 11, 1, p. 40Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The proteome of prostate cancer bone metastasis reveals heterogeneity with prognostic implications
Iglesias Gato, Diego, Thysell, E., Tyanova, S., Crnalic, S., Santos, A., Lima, T. S., Geiger, T., Cox, J., Widmark, A., Bergh, A., Mann, Matthias, Flores-Morales, A. & Wikström, P., 1 Nov 2018, In: Clinical Cancer Research. 24, 21, p. 5433-5444 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The proteome landscape of the kingdoms of life
Müller, J. B., Geyer, P. E., Colaço, A. R., Treit, P. V., Strauss, M. T., Oroshi, M., Doll, S., Virreira Winter, S., Bader, J. M., Köhler, N., Theis, F., Santos, A. & Mann, Matthias, 2020, In: Nature. 582, p. 592-596Research output: Contribution to journal › Journal article › Research › peer-review
The non-classical nuclear import carrier Transportin 1 modulates circadian rhythms through its effect on PER1 nuclear localization
Korge, S., Maier, B., Brüning, F., Ehrhardt, L., Korte, T., Mann, Matthias, Herrmann, A., Robles, M. S. & Kramer, A., Jan 2018, In: P L o S Genetics. 14, 1, p. e1007189Research output: Contribution to journal › Journal article › Research › peer-review
The low molecular weight proteome of Halobacterium salinarum
Klein, C., Aivaliotis, M., Olsen, Jesper Velgaard, Falb, M., Besir, H., Scheffer, B., Bisle, B., Tebbe, A., Konstantinidis, K., Siedler, F., Pfeiffer, F., Mann, Matthias & Oesterhelt, D., 2007, In: Journal of Proteome Research. 6, 4, p. 1510-8 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
The human urinary proteome contains more than 1500 proteins, including a large proportion of membrane proteins
Adachi, J., Kumar, C., Zhang, Y., Olsen, Jesper Velgaard & Mann, Matthias, 2006, In: Genome Biology. 7, 9, p. R80Research output: Contribution to journal › Journal article › Research › peer-review
The hemicellulose-degrading enzyme system of the thermophilic bacterium Clostridium stercorarium: comparative characterisation and addition of new hemicellulolytic glycoside hydrolases
Broeker, J., Mechelke, M., Baudrexl, M., Mennerich, D., Hornburg, D., Mann, Matthias, Schwarz, W. H., Liebl, W. & Zverlov, V. V., 2018, In: Biotechnology for Biofuels. 11, p. 229Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The growing landscape of lysine acetylation links metabolism and cell signalling
Choudhary, Chunaram, Weinert, B. T., Nishida, Y., Verdin, E. & Mann, Matthias, 23 Jul 2014, In: Nature Reviews. Molecular Cell Biology. 15, 8, p. 536-50 15 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
The forebrain synaptic transcriptome is organized by clocks but its proteome is driven by sleep
Noya, S. B., Colameo, D., Brüning, F., Spinnler, A., Mircsof, D., Opitz, L., Mann, Matthias, Tyagarajan, S. K., Robles, M. S. & Brown, S. A., 2019, In: Science. 366, 6462, eaav2642 .Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The ever expanding scope of electrospray mass spectrometry-a 30 year journey
Mann, Matthias, 2019, In: Nature Communications. 10, 3744.Research output: Contribution to journal › Comment/debate › Research
- Published
The emerging role of mass spectrometry-based proteomics in drug discovery
Meissner, F., Geddes-McAlister, J., Mann, Matthias & Bantscheff, M., 2022, In: Nature Reviews Drug Discovery. 21, p. 637-654 18 p.Research output: Contribution to journal › Review › Research › peer-review
The chromodomain helicase Chd4 is required for Polycomb-mediated inhibition of astroglial differentiation
Sparmann, A., Xie, Y., Verhoeven, E., Vermeulen, M., Lancini, C., Gargiulo, G., Hulsman, D., Mann, Matthias, Knoblich, J. A. & van Lohuizen, M., 29 May 2013, In: E M B O Journal. 32, 11, p. 1598-612 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
The Transcription Factor ETV1 Induces Atrial Remodeling and Arrhythmia
Rommel, C., Rösner, S., Lother, A., Barg, M., Schwaderer, M., Gilsbach, R., Bömicke, T., Schnick, T., Mayer, S., Doll, S., Hesse, M., Kretz, O., Stiller, B., Neumann, F., Mann, Matthias, Krane, M., Fleischmann, B. K., Ravens, U. & Hein, L., 2018, In: Circulation Research. 123, 5, p. 550-563 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The SH2 domain interaction landscape
Tinti, M., Kiemer, L., Costa, S., Miller, M. L., Sacco, F., Olsen, Jesper Velgaard, Carducci, M., Paoluzi, S., Langone, F., Workman, C., Blom, N., Machida, K., Thompson, C. M., Schutkowski, M., Brunak, Søren, Mann, Matthias, Mayer, B. J., Castagnoli, L. & Cesareni, G., 2013, In: Cell Reports. 3, 4, p. 1293-1305 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Proteome of Primary Prostate Cancer
Iglesias Gato, Diego, Wikström, P., Tyanova, S., Lavallee, C., Thysell, E., Carlsson, J., Hägglöf, C., Cox, J., Andrén, O., Stattin, P., Egevad, L., Widmark, A., Bjartell, A., Collins, C. C., Bergh, A., Geiger, T., Mann, Matthias & Flores-Morales, A., May 2016, In: European Urology. 69, 5, p. 942-952 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Proteome of Hand Eczema Assessed by Tape Stripping
Sølberg, J. B. K., Quaade, A. S., Drici, L., Sulek, K., Ulrich, N. H., Løvendorf, Marianne Bengtson, Thyssen, Jacob Pontoppidan, Mann, Matthias, Dyring-Andersen, Beatrice & Johansen, Jeanne Duus, 2023, In: Journal of Investigative Dermatology. 143, p. 1559-1568Research output: Contribution to journal › Journal article › Research › peer-review
The Perseus computational platform for comprehensive analysis of (prote)omics data
Tyanova, S., Temu, T., Sinitcyn, P., Carlson, A., Hein, M. Y., Geiger, T., Mann, Matthias & Cox, J., Sep 2016, In: Nature Methods. 13, 9, p. 731-40 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Origins of Organellar Mapping by Protein Correlation Profiling
Mann, Matthias, 2020, In: Proteomics. 20, 23, 4 p., e1900330.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The NSP3 protein of SARS-CoV-2 binds fragile X mental retardation proteins to disrupt UBAP2L interactions
Garvanska, D. H., Alvarado, R. E., Mundt, F. O., Lindqvist, R., Duel, J. K., Coscia, F., Nilsson, E., Lokugamage, K., Johnson, B. A., Plante, J. A., Morris, D. R., Vu, M. N., Estes, L. K., McLeland, A. M., Walker, J., Crocquet-Valdes, P. A., Mendez, B. L., Plante, K. S., Walker, D. H., Weisser, M. B. & 4 others, , 2024, In: EMBO Reports.Research output: Contribution to journal › Journal article › Research › peer-review
The Hippo pathway controls myofibril assembly and muscle fiber growth by regulating sarcomeric gene expression
Kaya-Çopur, A., Marchiano, F., Hein, M. Y., Alpern, D., Russeil, J., Luis, N. M., Mann, Matthias, Deplancke, B., Habermann, B. H. & Schnorrer, F., 6 Jan 2021, In: eLife. 10Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Coming Age of Complete, Accurate, and Ubiquitous Proteomes
Mann, Matthias, Kulak, N. A., Nagaraj, N. & Cox, J., 21 Feb 2013, In: Molecular Cell. 49, 4, p. 583-590 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Case for Proteomics and Phospho-Proteomics in Personalized Cancer Medicine
Doll, S., Gnad, F. & Mann, Matthias, 2019, In: Proteomics - Clinical Applications. 13, 2, 10 p., e1800113.Research output: Contribution to journal › Review › Research › peer-review
- Published
The CMG Helicase Bypasses DNA-Protein Cross-Links to Facilitate Their Repair
Sparks, J. L., Chistol, G., Gao, A. O., Räschle, M., Larsen, N. B., Mann, Matthias, Duxin, Julien & Walter, J. C., 2019, In: Cell. 176, 1-2, p. 167-181.e21Research output: Contribution to journal › Journal article › Research › peer-review
The Atherosclerosis Risk Variant rs2107595 Mediates Allele-Specific Transcriptional Regulation of HDAC9 via E2F3 and Rb1
Prestel, M., Prell-Schicker, C., Webb, T., Malik, R., Lindner, B., Ziesch, N., Rex-Haffner, M., Röh, S., Viturawong, T., Lehm, M., Mokry, M., den Ruijter, H., Haitjema, S., Asare, Y., Söllner, F., Najafabadi, M. G., Aherrahrou, R., Civelek, M., Samani, N. J., Mann, M. & 2 others, , Oct 2019, In: Stroke. 50, 10, p. 2651-2660 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 5650809
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Activation of the ATR kinase by the RPA-binding protein ETAA1
Research output: Contribution to journal › Journal article › Research › peer-review
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Region and cell-type resolved quantitative proteomic map of the human heart
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Revisiting biomarker discovery by plasma proteomics
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