Matthias Mann
Professor, head of research, Professor
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Rapid proteomic analysis for solid tumors reveals LSD1 as a drug target in an end-stage cancer patient
Doll, S., Kriegmair, M. C., Santos, A., Wierer, M., Coscia, F., Neil, H. M., Porubsky, S., Geyer, P. E., Mund, Andreas, Nuhn, P. & Mann, Matthias, 2018, In: Molecular Oncology. 12, 8, p. 1296-1307 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Systems Analyses Reveal Shared and Diverse Attributes of Oct4 Regulation in Pluripotent Cells
Ding, L., Paszkowski-Rogacz, M., Winzi, M., Chakraborty, D., Theis, M., Singh, S., Ciotta, G., Poser, I., Roguev, A., Chu, W. K., Choudhary, Chunaram, Mann, Matthias, Stewart, A. F., Krogan, N. & Buchholz, F., 26 Aug 2015, In: Cell Systems. 1, 2, p. 141-151 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Gene-selective transcription promotes the inhibition of tissue reparative macrophages by TNF
Dichtl, S., Sanin, D. E., Koss, C. K., Willenborg, S., Petzold, A., Tanzer, M. C., Dahl, A., Kabat, A. M., Lindenthal, L., Zeitler, L., Satzinger, S., Strasser, A., Mann, Matthias, Roers, A., Eming, S. A., El Kasmi, K. C., Pearce, E. J. & Murray, P. J., Apr 2022, In: Life Science Alliance. 5, 4Research output: Contribution to journal › Journal article › Research › peer-review
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Organ-specific metabolic pathways distinguish prediabetes, type 2 diabetes, and normal tissues
Diamanti, K., Cavalli, M., Pereira, M. J., Pan, G., Castillejo-López, C., Kumar, C., Mundt Madsen, Filip Oskar, Komorowski, J., Deshmukh, Atul Shahaji, Mann, Matthias, Korsgren, O., Eriksson, J. W. & Wadelius, C., 2022, In: Cell Reports Medicine. 3, 10, 21 p., 100763.Research output: Contribution to journal › Journal article › Research › peer-review
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C/EBPα creates elite cells for iPSC reprogramming by upregulating Klf4 and increasing the levels of Lsd1 and Brd4
Di Stefano, B., Collombet, S., Jakobsen, J. S., Wierer, M., Sardina, J. L., Lackner, A., Stadhouders, R., Segura-Morales, C., Francesconi, M., Limone, F., Mann, Matthias, Porse, Bo Torben, Thieffry, D. & Graf, T., Apr 2016, In: Nature Cell Biology. 18, 4, p. 371-81 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
CRL2(Lrr1) promotes unloading of the vertebrate replisome from chromatin during replication termination
Dewar, J. M., Low, E., Mann, Matthias, Räschle, M. & Walter, J. C., 1 Feb 2017, In: Genes & Development. 31, 3, p. 275-290 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Deep muscle-proteomic analysis of freeze-dried human muscle biopsies reveals fiber type-specific adaptations to exercise training
Deshmukh, Atul Shahaji, Steenberg, D. E., Hostrup, Morten, Birk, Jesper Bratz, Larsen, Jeppe Kjærgaard, Santos, A., Kjøbsted, Rasmus, Hingst, J. R., Schéele, Camilla Charlotte Nielsen, Murgia, M., Kiens, Bente, Richter, Erik A., Mann, Matthias & Wojtaszewski, Jørgen F P, 2021, In: Nature Communications. 12, 15 p., 304.Research output: Contribution to journal › Journal article › Research › peer-review
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Proteomics-Based Comparative Mapping of the Secretomes of Human Brown and White Adipocytes Reveals EPDR1 as a Novel Batokine
Deshmukh, A. S., Peijs, L., Beaudry, J. L., Jespersen, N. Z., Nielsen, C. H., Ma, T., Brunner, A. D., Larsen, T. J., Bayarri-Olmos, R., Prabhakar, B. S., Helgstrand, C., Severinsen, M. C. K., Holst, B., Kjaer, A., Tang-Christensen, M., Sanfridson, A., Garred, P., Privé, G. G., Pedersen, B. K., Gerhart-Hines, Z. & 4 others, , 2019, In: Cell Metabolism. 30, 5, p. 963-975.e7 21 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Secretome Analysis of Lipid-Induced Insulin Resistance in Skeletal Muscle Cells by a Combined Experimental and Bioinformatics Workflow
Deshmukh, Atul Shahaji, Cox, J., Jensen, Lars Juhl, Meissner, F. & Mann, Matthias, 6 Nov 2015, In: Journal of Proteome Research. 14, 11, p. 4885-95 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Deep proteomics of mouse skeletal muscle enables quantitation of protein isoforms, metabolic pathways and transcription factors
Deshmukh, Atul Shahaji, Murgia, M., Nagaraja, N., Treebak, Jonas Thue, Cox, J. & Mann, Matthias, Apr 2015, In: Molecular and Cellular Proteomics. 14, 4, p. 841-853Research output: Contribution to journal › Journal article › Research › peer-review
Quantitative proteomic assessment of very early cellular signaling events
Dengjel, J., Akimov, V., Olsen, Jesper Velgaard, Bunkenborg, J., Mann, Matthias, Blagoev, B. & Andersen, J. S., 2007, In: Nature Biotechnology. 25, 5, p. 566-8 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
Identification of the transcription factor MAZ as a regulator of erythropoiesis
Deen, D., Butter, F., Daniels, D. E., Ferrer-Vicens, I., Ferguson, D. C. J., Holland, M. L., Samara, V., Sloane-Stanley, J. A., Ayyub, H., Mann, Matthias, Frayne, J., Garrick, D. & Vernimmen, D., 10 Aug 2021, In: Blood advances. 5, 15, p. 3002-3015 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
N-linked glycosylation enrichment for in-depth cell surface proteomics of diffuse large B-cell lymphoma subtypes
Deeb, S. J., Cox, J., Schmidt-Supprian, M. & Mann, Matthias, 4 Nov 2013, In: Molecular & Cellular Proteomics.Research output: Contribution to journal › Journal article › Research › peer-review
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Hepatocyte-specific perturbation of NAD+ biosynthetic pathways in mice induces reversible nonalcoholic steatohepatitis-like phenotypes
Dall, M., Hassing, Anna Skab, Niu, Lili, Nielsen, Thomas Svava, Ingerslev, L. R., Sulek, K., Trammell, Sam, Gillum, M. P., Barrès, Romain, Larsen, Steen, Poulsen, Steen Seier, Mann, Matthias, Ørskov, Cathrine & Treebak, Jonas Thue, 2021, In: Journal of Biological Chemistry. 297, 6, 26 p., 101388.Research output: Contribution to journal › Journal article › Research › peer-review
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Andromeda - a peptide search engine integrated into the MaxQuant environment
Cox, J., Neuhauser, N., Michalski, A., Scheltema, R. A., Olsen, Jesper Velgaard & Mann, Matthias, 1 Apr 2011, In: Journal of Proteome Research. 10, 4, p. 1794-805 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
1D and 2D annotation enrichment: a statistical method integrating quantitative proteomics with complementary high-throughput data
Cox, J. & Mann, Matthias, 2012, In: B M C Bioinformatics. 13 Suppl 16, p. S12Research output: Contribution to journal › Journal article › Research › peer-review
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Quantitative, high-resolution proteomics for data-driven systems biology
Cox, J. & Mann, Matthias, 7 Jul 2011, In: Annual Review of Biochemistry. 80, p. 273-299 27 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Multi-level Proteomics Identifies CT45 as a Chemosensitivity Mediator and Immunotherapy Target in Ovarian Cancer
Coscia, F., Lengyel, E., Duraiswamy, J., Ashcroft, B., Bassani-Sternberg, M., Wierer, M., Johnson, A., Wroblewski, K., Montag, A., Yamada, S. D., López-Méndez, B., Nilsson, Jakob, Mund, Andreas, Mann, Matthias & Curtis, M., 2018, In: Cell. 175, 1, p. 159-170.e16Research output: Contribution to journal › Journal article › Research › peer-review
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A streamlined mass spectrometry-based proteomics workflow for large scale FFPE tissue analysis
Coscia, F., Doll, S., Bech, J. M., Schweizer, L., Mund, Andreas, Lengyel, E., Lindebjerg, J., Madsen, G. I., Moreira, José & Mann, Matthias, 2020, In: Journal of Pathology. 251, p. 110-112Research output: Contribution to journal › Journal article › Research › peer-review
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Proteomics for blood biomarker exploration of severe mental illness: pitfalls of the past and potential for the future
Comes, A. L., Papiol, S., Mueller, T., Geyer, P. E., Mann, Matthias & Schulze, T. G., 1 Dec 2018, In: Translational Psychiatry. 8, p. 1-15 15 p., 160.Research output: Contribution to journal › Review › Research › peer-review
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MiT/TFEfactors controlER-phagy via transcriptional regulation ofFAM134B
Cinque, L., De Leonibus, C., Iavazzo, M., Krahmer, N., Intartaglia, D., Salierno, F. G., De Cegli, R., Di Malta, C., Svelto, M., Lanzara, C., Maddaluno, M., Wanderlingh, L. G., Huebner, A. K., Cesana, M., Bonn, F., Polishchuk, E., Huebner, C. A., Conte, I., Dikic, I., Mann, M. & 4 others, , 2020, In: EMBO Journal. 39, 17, 22 p., 105696.Research output: Contribution to journal › Journal article › Research › peer-review
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Sequencing of the First Draft of the Human Acetylome
Choudhary, Chunaram & Mann, Matthias, 2020, In: Clinical Chemistry. 66, 6, p. 852-853 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Lysine acetylation targets protein complexes and co-regulates major cellular functions
Choudhary, Chunaram, Kumar, C., Gnad, F., Nielsen, Michael Lund, Rehman, M., Walther, T. C., Olsen, Jesper Velgaard & Mann, Matthias, 2009, In: Science. 325, 5942, p. 834-40 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Decoding signalling networks by mass spectrometry-based proteomics
Choudhary, Chunaram & Mann, Matthias, 1 Jun 2010, In: Nature Reviews. Molecular Cell Biology. 11, 6, p. 427-39 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Mislocalized activation of oncogenic RTKs switches downstream signaling outcomes
Choudhary, Chunaram, Olsen, Jesper Velgaard, Brandts, C., Cox, J., Reddy, P. N. G., Böhmer, F. D., Gerke, V., Schmidt-Arras, D., Berdel, W. E., Müller-Tidow, C., Mann, Matthias & Serve, H., 2009, In: Molecular Cell. 36, 2, p. 326-39 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The growing landscape of lysine acetylation links metabolism and cell signalling
Choudhary, Chunaram, Weinert, B. T., Nishida, Y., Verdin, E. & Mann, Matthias, 23 Jul 2014, In: Nature Reviews. Molecular Cell Biology. 15, 8, p. 536-50 15 p.Research output: Contribution to journal › Review › Research › peer-review
DEAD box protein DDX1 regulates cytoplasmic localization of KSRP
Chou, C., Lin, W., Lin, C., Luber, C. A., Godbout, R., Mann, Matthias & Chen, C., 4 Sep 2013, In: P L o S One. 8, 9, e73752.Research output: Contribution to journal › Journal article › Research
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OpenCell: Endogenous tagging for the cartography of human cellular organization
Cho, N. H., Cheveralls, K. C., Brunner, A. D., Kim, K., Michaelis, A. C., Raghavan, P., Kobayashi, H., Savy, L., Li, J. Y., Canaj, H., Kim, J. Y. S., Stewart, E. M., Gnann, C., McCarthy, F., Cabrera, J. P., Brunetti, R. M., Chhun, B. B., Dingle, G., Hein, M. Y., Huang, B. & 7 others, , 2022, In: Science. 375, 6585, eabi6983.Research output: Contribution to journal › Journal article › Research › peer-review
Novel and shared neoantigen derived from histone 3 variant H3.3K27M mutation for glioma T cell therapy
Chheda, Z. S., Kohanbash, G., Okada, K., Jahan, N., Sidney, J., Pecoraro, M., Yang, X., Carrera, D. A., Downey, K. M., Shrivastav, S., Liu, S., Lin, Y., Lagisetti, C., Chuntova, P., Watchmaker, P. B., Mueller, S., Pollack, I. F., Rajalingam, R., Carcaboso, A. M., Mann, M. & 4 others, , Jan 2018, In: The Journal of Experimental Medicine. 215, 1, p. 141-157 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
Pervasive functional translation of noncanonical human open reading frames
Chen, J., Brunner, A., Cogan, J. Z., Nuñez, J. K., Fields, A. P., Adamson, B., Itzhak, D. N., Li, J. Y., Mann, Matthias, Leonetti, M. D. & Weissman, J. S., 2020, In: Science. 367, 6482, p. 1140-1146 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A Multi-Omics Approach to Liver Diseases: Integration of Single Nuclei Transcriptomics with Proteomics and HiCap Bulk Data in Human Liver
Cavalli, M., Diamanti, K., Pan, G., Spalinskas, R., Kumar, C., Deshmukh, Atul Shahaji, Mann, Matthias, Sahlén, P., Komorowski, J. & Wadelius, C., 2020, In: O M I C S: A Journal of Integrative Biology. 24, 4, 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
Cortical circuit alterations precede motor impairments in Huntington's disease mice
Burgold, J., Schulz-Trieglaff, E. K., Voelkl, K., Gutiérrez-Ángel, S., Bader, J. M., Hosp, F., Mann, Matthias, Arzberger, T., Klein, R., Liebscher, S. & Dudanova, I., 29 Apr 2019, In: Scientific Reports. 9, 1, p. 6634Research output: Contribution to journal › Journal article › Research › peer-review
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Sleep-wake cycles drive daily dynamics of synaptic phosphorylation
Brüning, F., Noya, S. B., Bange, T., Koutsouli, S., Rudolph, J. D., Tyagarajan, S. K., Cox, J., Mann, Matthias, Brown, S. A. & Robles, M. S., 2019, In: Science (New York, N.Y.). 366, 6462, eaav3617 .Research output: Contribution to journal › Journal article › Research › peer-review
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Ultra-high sensitivity mass spectrometry quantifies single-cell proteome changes upon perturbation
Brunner, A., Thielert, Marvin Christoffer, Vasilopoulou, C., Ammar, C., Coscia, F., Mund, Andreas, Hoerning, O. B., Bache, N., Apalategui, A., Lubeck, M., Richter, S., Fischer, D. S., Raether, O., Park, M. A., Meier, F., Theis, F. J. & Mann, Matthias, 2022, In: Molecular Systems Biology. 18, 3, 15 p., e10798.Research output: Contribution to journal › Journal article › Research › peer-review
The hemicellulose-degrading enzyme system of the thermophilic bacterium Clostridium stercorarium: comparative characterisation and addition of new hemicellulolytic glycoside hydrolases
Broeker, J., Mechelke, M., Baudrexl, M., Mennerich, D., Hornburg, D., Mann, Matthias, Schwarz, W. H., Liebl, W. & Zverlov, V. V., 2018, In: Biotechnology for Biofuels. 11, p. 229Research output: Contribution to journal › Journal article › Research › peer-review
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Quantification of the N-glycosylated secretome by super-SILAC during breast cancer progression and in human blood Samples
Boersema, P. J., Geiger, T., Wiśniewski, J. R. & Mann, Matthias, 1 Jan 2013, In: Molecular & Cellular Proteomics. 12, 1, p. 158-171 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The structural context of posttranslational modifications at a proteome-wide scale
Bludau, I., Willems, S., Zeng, W. F., Strauss, Maximilian, Hansen, F. M., Tanzer, M. C., Karayel, O., Schulman, B. A. & Mann, Matthias, 2022, In: PLOS Biology. 20, 5, 23 p., e3001636.Research output: Contribution to journal › Journal article › Research › peer-review
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Spatial proteomics in three-dimensional intact specimens
Bhatia, H. S., Brunner, A-D., Öztürk, F., Kapoor, S., Rong, Z., Mai, H., Thielert, M., Ali, M., Al-Maskari, R., Paetzold, J. C., Kofler, F., Todorov, M. I., Molbay, M., Kolabas, Z. I., Negwer, M., Hoeher, L., Steinke, H., Dima, A., Gupta, B., Kaltenecker, D. & 11 others, , 2022, In: Cell. 185, 26, p. 5040-5058.e19Research output: Contribution to journal › Journal article › Research › peer-review
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A unified classification approach rating clinical utility of protein biomarkers across neurologic diseases
Bernhardt, A. M., Tiedt, S., Teupser, D., Dichgans, M., Meyer, B., Gempt, J., Kuhn, P. H., Simons, M., Palleis, C., Weidinger, E., Nübling, G., Holdt, L., Hönikl, L., Gasperi, C., Giesbertz, P., Müller, S. A., Breimann, S., Lichtenthaler, S. F., Kuster, B., Mann, M. & 8 others, , 2023, In: EBioMedicine. 89, 13 p., 104456.Research output: Contribution to journal › Review › Research › peer-review
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Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response
Beli, P., Lukashchuk, N., Wagner, S. A., Weinert, B. T., Olsen, Jesper Velgaard, Baskcomb, L., Mann, Matthias, Jackson, S. P. & Choudhary, Chunaram, 2012, In: Molecular Cell. 46, 2, p. 212-25 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
Identification of a novel membrane protein that interacts specifically with the upar-prourokinase complex
Behrendt, Niels, Engelholm, Lars Henning, Jensen, O. N., Mörtz, E., Ranne, E., Mann, Matthias & Dan, K., 1997, In: Fibrinolysis and Proteolysis. 11, Supl. 3, p. 10 1 p.Research output: Contribution to journal › Conference abstract in journal › Research
A urokinase receptor-associated protein with specific collagen binding properties
Behrendt, Niels, Jensen, O. N., Engelholm, Lars Henning, Mørtz, E., Mann, Matthias & Danø, K., 2000, In: The Journal of Biological Chemistry. 275, 3, p. 1993-2002 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Proteomic Profiling of Colorectal Adenomas Identifies a Predictive Risk Signature for Development of Metachronous Advanced Colorectal Neoplasia
Bech, J. M., Terkelsen, Thilde Bagger, Bartels, Annette Snejbjerg, Coscia, F., Doll, S., Zhao, S., Zhang, Z., Brünner, N., Lindebjerg, J., Madsen, G. I., Fang, X., Mann, Matthias & Moreira, José, 2023, In: Gastroenterology. 165, 1, p. 121-132.e5Research output: Contribution to journal › Journal article › Research › peer-review
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A Cell-Autonomous Signature of Dysregulated Protein Phosphorylation Underlies Muscle Insulin Resistance in Type 2 Diabetes
Batista, T. M., Jayavelu, A. K., Albrechtsen, Nicolai Jacob Wewer, Iovino, S., Lebastchi, J., Pan, H., Dreyfuss, J. M., Krook, A., Zierath, Juleen R, Mann, Matthias & Kahn, C. R., 2020, In: Cell Metabolism. 32, 5, p. 844-859.e5Research output: Contribution to journal › Journal article › Research › peer-review
A systematic mammalian genetic interaction map reveals pathways underlying ricin susceptibility
Bassik, M. C., Kampmann, M., Lebbink, R. J., Wang, S., Hein, M. Y., Poser, I., Weibezahn, J., Horlbeck, M. A., Chen, S., Mann, Matthias, Hyman, A. A., Leproust, E. M., McManus, M. T. & Weissman, J. S., 14 Feb 2013, In: Cell. 152, 4, p. 909-22 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Mass Spectrometry of Human Leukocyte Antigen Class I Peptidomes Reveals Strong Effects of Protein Abundance and Turnover on Antigen Presentation
Bassani-Sternberg, M., Pletscher-Frankild, S., Jensen, Lars Juhl & Mann, Matthias, Mar 2015, In: Molecular and Cellular Proteomics. 14, 3, p. 658-73 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
Direct identification of clinically relevant neoepitopes presented on native human melanoma tissue by mass spectrometry
Bassani-Sternberg, M., Bräunlein, E., Klar, R., Engleitner, T., Sinitcyn, P., Audehm, S., Straub, M., Weber, J., Slotta-Huspenina, J., Specht, K., Martignoni, M. E., Werner, A., Hein, R., H Busch, D., Peschel, C., Rad, R., Cox, J., Mann, Matthias & Krackhardt, A. M., 21 Nov 2016, In: Nature Communications. 7, p. 13404Research output: Contribution to journal › Journal article › Research › peer-review
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Proteomics separates adult-type diffuse high-grade gliomas in metabolic subgroups independent of 1p/19q codeletion and across IDH mutational status
Bader, J. M., Deigendesch, N., Misch, M., Mann, Matthias, Koch, A. & Meissner, F., 2023, In: Cell Reports Medicine. 4, 1, 100877.Research output: Contribution to journal › Journal article › Research › peer-review
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MS-Based Proteomics of Body Fluids: The End of the Beginning
Bader, J. M., Albrecht, V. & Mann, Matthias, 2023, In: Molecular and Cellular Proteomics. 22, 7, 18 p., 100577.Research output: Contribution to journal › Review › Research › peer-review
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Proteome profiling in cerebrospinal fluid reveals novel biomarkers of Alzheimer's disease
Bader, J. M., Geyer, P. E., Müller, J. B., Strauss, M. T., Koch, M., Leypoldt, F., Koertvelyessy, P., Bittner, D., Schipke, C. G., Incesoy, E. I., Peters, O., Deigendesch, N., Simons, M., Jensen, Majken Karoline, Zetterberg, H. & Mann, Matthias, 2020, In: Molecular Systems Biology. 16, 6, 17 p., e9356.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 5650809
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2009
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Activation of the ATR kinase by the RPA-binding protein ETAA1
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515
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Region and cell-type resolved quantitative proteomic map of the human heart
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498
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Revisiting biomarker discovery by plasma proteomics
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