Matthias Mann

Matthias Mann

Professor, head of research, Professor


  1. Published

    Rapid proteomic analysis for solid tumors reveals LSD1 as a drug target in an end-stage cancer patient

    Doll, S., Kriegmair, M. C., Santos, A., Wierer, M., Coscia, F., Neil, H. M., Porubsky, S., Geyer, P. E., Mund, Andreas, Nuhn, P. & Mann, Matthias, 2018, In: Molecular Oncology. 12, 8, p. 1296-1307 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    Systems Analyses Reveal Shared and Diverse Attributes of Oct4 Regulation in Pluripotent Cells

    Ding, L., Paszkowski-Rogacz, M., Winzi, M., Chakraborty, D., Theis, M., Singh, S., Ciotta, G., Poser, I., Roguev, A., Chu, W. K., Choudhary, Chunaram, Mann, Matthias, Stewart, A. F., Krogan, N. & Buchholz, F., 26 Aug 2015, In: Cell Systems. 1, 2, p. 141-151 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Gene-selective transcription promotes the inhibition of tissue reparative macrophages by TNF

    Dichtl, S., Sanin, D. E., Koss, C. K., Willenborg, S., Petzold, A., Tanzer, M. C., Dahl, A., Kabat, A. M., Lindenthal, L., Zeitler, L., Satzinger, S., Strasser, A., Mann, Matthias, Roers, A., Eming, S. A., El Kasmi, K. C., Pearce, E. J. & Murray, P. J., Apr 2022, In: Life Science Alliance. 5, 4

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Organ-specific metabolic pathways distinguish prediabetes, type 2 diabetes, and normal tissues

    Diamanti, K., Cavalli, M., Pereira, M. J., Pan, G., Castillejo-López, C., Kumar, C., Mundt Madsen, Filip Oskar, Komorowski, J., Deshmukh, Atul Shahaji, Mann, Matthias, Korsgren, O., Eriksson, J. W. & Wadelius, C., 2022, In: Cell Reports Medicine. 3, 10, 21 p., 100763.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    C/EBPα creates elite cells for iPSC reprogramming by upregulating Klf4 and increasing the levels of Lsd1 and Brd4

    Di Stefano, B., Collombet, S., Jakobsen, J. S., Wierer, M., Sardina, J. L., Lackner, A., Stadhouders, R., Segura-Morales, C., Francesconi, M., Limone, F., Mann, Matthias, Porse, Bo Torben, Thieffry, D. & Graf, T., Apr 2016, In: Nature Cell Biology. 18, 4, p. 371-81 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. CRL2(Lrr1) promotes unloading of the vertebrate replisome from chromatin during replication termination

    Dewar, J. M., Low, E., Mann, Matthias, Räschle, M. & Walter, J. C., 1 Feb 2017, In: Genes & Development. 31, 3, p. 275-290 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published
  8. Published

    Proteomics-Based Comparative Mapping of the Secretomes of Human Brown and White Adipocytes Reveals EPDR1 as a Novel Batokine

    Deshmukh, A. S., Peijs, L., Beaudry, J. L., Jespersen, N. Z., Nielsen, C. H., Ma, T., Brunner, A. D., Larsen, T. J., Bayarri-Olmos, R., Prabhakar, B. S., Helgstrand, C., Severinsen, M. C. K., Holst, B., Kjaer, A., Tang-Christensen, M., Sanfridson, A., Garred, P., Privé, G. G., Pedersen, B. K., Gerhart-Hines, Z. & 4 others, Nielsen, S., Drucker, D. J., Mann, Matthias & Schéele, Camilla Charlotte Nielsen, 2019, In: Cell Metabolism. 30, 5, p. 963-975.e7 21 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Secretome Analysis of Lipid-Induced Insulin Resistance in Skeletal Muscle Cells by a Combined Experimental and Bioinformatics Workflow

    Deshmukh, Atul Shahaji, Cox, J., Jensen, Lars Juhl, Meissner, F. & Mann, Matthias, 6 Nov 2015, In: Journal of Proteome Research. 14, 11, p. 4885-95 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Deep proteomics of mouse skeletal muscle enables quantitation of protein isoforms, metabolic pathways and transcription factors

    Deshmukh, Atul Shahaji, Murgia, M., Nagaraja, N., Treebak, Jonas Thue, Cox, J. & Mann, Matthias, Apr 2015, In: Molecular and Cellular Proteomics. 14, 4, p. 841-853

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Quantitative proteomic assessment of very early cellular signaling events

    Dengjel, J., Akimov, V., Olsen, Jesper Velgaard, Bunkenborg, J., Mann, Matthias, Blagoev, B. & Andersen, J. S., 2007, In: Nature Biotechnology. 25, 5, p. 566-8 2 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Identification of the transcription factor MAZ as a regulator of erythropoiesis

    Deen, D., Butter, F., Daniels, D. E., Ferrer-Vicens, I., Ferguson, D. C. J., Holland, M. L., Samara, V., Sloane-Stanley, J. A., Ayyub, H., Mann, Matthias, Frayne, J., Garrick, D. & Vernimmen, D., 10 Aug 2021, In: Blood advances. 5, 15, p. 3002-3015 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. N-linked glycosylation enrichment for in-depth cell surface proteomics of diffuse large B-cell lymphoma subtypes

    Deeb, S. J., Cox, J., Schmidt-Supprian, M. & Mann, Matthias, 4 Nov 2013, In: Molecular & Cellular Proteomics.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Hepatocyte-specific perturbation of NAD+ biosynthetic pathways in mice induces reversible nonalcoholic steatohepatitis-like phenotypes

    Dall, M., Hassing, Anna Skab, Niu, Lili, Nielsen, Thomas Svava, Ingerslev, L. R., Sulek, K., Trammell, Sam, Gillum, M. P., Barrès, Romain, Larsen, Steen, Poulsen, Steen Seier, Mann, Matthias, Ørskov, Cathrine & Treebak, Jonas Thue, 2021, In: Journal of Biological Chemistry. 297, 6, 26 p., 101388.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Andromeda - a peptide search engine integrated into the MaxQuant environment

    Cox, J., Neuhauser, N., Michalski, A., Scheltema, R. A., Olsen, Jesper Velgaard & Mann, Matthias, 1 Apr 2011, In: Journal of Proteome Research. 10, 4, p. 1794-805 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. 1D and 2D annotation enrichment: a statistical method integrating quantitative proteomics with complementary high-throughput data

    Cox, J. & Mann, Matthias, 2012, In: B M C Bioinformatics. 13 Suppl 16, p. S12

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Quantitative, high-resolution proteomics for data-driven systems biology

    Cox, J. & Mann, Matthias, 7 Jul 2011, In: Annual Review of Biochemistry. 80, p. 273-299 27 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Multi-level Proteomics Identifies CT45 as a Chemosensitivity Mediator and Immunotherapy Target in Ovarian Cancer

    Coscia, F., Lengyel, E., Duraiswamy, J., Ashcroft, B., Bassani-Sternberg, M., Wierer, M., Johnson, A., Wroblewski, K., Montag, A., Yamada, S. D., López-Méndez, B., Nilsson, Jakob, Mund, Andreas, Mann, Matthias & Curtis, M., 2018, In: Cell. 175, 1, p. 159-170.e16

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    A streamlined mass spectrometry-based proteomics workflow for large scale FFPE tissue analysis

    Coscia, F., Doll, S., Bech, J. M., Schweizer, L., Mund, Andreas, Lengyel, E., Lindebjerg, J., Madsen, G. I., Moreira, José & Mann, Matthias, 2020, In: Journal of Pathology. 251, p. 110-112

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Proteomics for blood biomarker exploration of severe mental illness: pitfalls of the past and potential for the future

    Comes, A. L., Papiol, S., Mueller, T., Geyer, P. E., Mann, Matthias & Schulze, T. G., 1 Dec 2018, In: Translational Psychiatry. 8, p. 1-15 15 p., 160.

    Research output: Contribution to journalReviewResearchpeer-review

  21. Published

    MiT/TFEfactors controlER-phagy via transcriptional regulation ofFAM134B

    Cinque, L., De Leonibus, C., Iavazzo, M., Krahmer, N., Intartaglia, D., Salierno, F. G., De Cegli, R., Di Malta, C., Svelto, M., Lanzara, C., Maddaluno, M., Wanderlingh, L. G., Huebner, A. K., Cesana, M., Bonn, F., Polishchuk, E., Huebner, C. A., Conte, I., Dikic, I., Mann, M. & 4 others, Ballabio, A., Sacco, F., Grumati, P. & Settembre, C., 2020, In: EMBO Journal. 39, 17, 22 p., 105696.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Sequencing of the First Draft of the Human Acetylome

    Choudhary, Chunaram & Mann, Matthias, 2020, In: Clinical Chemistry. 66, 6, p. 852-853 2 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Lysine acetylation targets protein complexes and co-regulates major cellular functions

    Choudhary, Chunaram, Kumar, C., Gnad, F., Nielsen, Michael Lund, Rehman, M., Walther, T. C., Olsen, Jesper Velgaard & Mann, Matthias, 2009, In: Science. 325, 5942, p. 834-40 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Decoding signalling networks by mass spectrometry-based proteomics

    Choudhary, Chunaram & Mann, Matthias, 1 Jun 2010, In: Nature Reviews. Molecular Cell Biology. 11, 6, p. 427-39 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Mislocalized activation of oncogenic RTKs switches downstream signaling outcomes

    Choudhary, Chunaram, Olsen, Jesper Velgaard, Brandts, C., Cox, J., Reddy, P. N. G., Böhmer, F. D., Gerke, V., Schmidt-Arras, D., Berdel, W. E., Müller-Tidow, C., Mann, Matthias & Serve, H., 2009, In: Molecular Cell. 36, 2, p. 326-39 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    The growing landscape of lysine acetylation links metabolism and cell signalling

    Choudhary, Chunaram, Weinert, B. T., Nishida, Y., Verdin, E. & Mann, Matthias, 23 Jul 2014, In: Nature Reviews. Molecular Cell Biology. 15, 8, p. 536-50 15 p.

    Research output: Contribution to journalReviewResearchpeer-review

  27. DEAD box protein DDX1 regulates cytoplasmic localization of KSRP

    Chou, C., Lin, W., Lin, C., Luber, C. A., Godbout, R., Mann, Matthias & Chen, C., 4 Sep 2013, In: P L o S One. 8, 9, e73752.

    Research output: Contribution to journalJournal articleResearch

  28. Published

    OpenCell: Endogenous tagging for the cartography of human cellular organization

    Cho, N. H., Cheveralls, K. C., Brunner, A. D., Kim, K., Michaelis, A. C., Raghavan, P., Kobayashi, H., Savy, L., Li, J. Y., Canaj, H., Kim, J. Y. S., Stewart, E. M., Gnann, C., McCarthy, F., Cabrera, J. P., Brunetti, R. M., Chhun, B. B., Dingle, G., Hein, M. Y., Huang, B. & 7 others, Mehta, S. B., Weissman, J. S., Gómez-Sjöberg, R., Itzhak, D. N., Royer, L. A., Mann, Matthias & Leonetti, M. D., 2022, In: Science. 375, 6585, eabi6983.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Novel and shared neoantigen derived from histone 3 variant H3.3K27M mutation for glioma T cell therapy

    Chheda, Z. S., Kohanbash, G., Okada, K., Jahan, N., Sidney, J., Pecoraro, M., Yang, X., Carrera, D. A., Downey, K. M., Shrivastav, S., Liu, S., Lin, Y., Lagisetti, C., Chuntova, P., Watchmaker, P. B., Mueller, S., Pollack, I. F., Rajalingam, R., Carcaboso, A. M., Mann, M. & 4 others, Sette, A., Garcia, K. C., Hou, Y. & Okada, H., Jan 2018, In: The Journal of Experimental Medicine. 215, 1, p. 141-157 17 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Pervasive functional translation of noncanonical human open reading frames

    Chen, J., Brunner, A., Cogan, J. Z., Nuñez, J. K., Fields, A. P., Adamson, B., Itzhak, D. N., Li, J. Y., Mann, Matthias, Leonetti, M. D. & Weissman, J. S., 2020, In: Science. 367, 6482, p. 1140-1146 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    A Multi-Omics Approach to Liver Diseases: Integration of Single Nuclei Transcriptomics with Proteomics and HiCap Bulk Data in Human Liver

    Cavalli, M., Diamanti, K., Pan, G., Spalinskas, R., Kumar, C., Deshmukh, Atul Shahaji, Mann, Matthias, Sahlén, P., Komorowski, J. & Wadelius, C., 2020, In: O M I C S: A Journal of Integrative Biology. 24, 4, 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Cortical circuit alterations precede motor impairments in Huntington's disease mice

    Burgold, J., Schulz-Trieglaff, E. K., Voelkl, K., Gutiérrez-Ángel, S., Bader, J. M., Hosp, F., Mann, Matthias, Arzberger, T., Klein, R., Liebscher, S. & Dudanova, I., 29 Apr 2019, In: Scientific Reports. 9, 1, p. 6634

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Sleep-wake cycles drive daily dynamics of synaptic phosphorylation

    Brüning, F., Noya, S. B., Bange, T., Koutsouli, S., Rudolph, J. D., Tyagarajan, S. K., Cox, J., Mann, Matthias, Brown, S. A. & Robles, M. S., 2019, In: Science (New York, N.Y.). 366, 6462, eaav3617 .

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Ultra-high sensitivity mass spectrometry quantifies single-cell proteome changes upon perturbation

    Brunner, A., Thielert, Marvin Christoffer, Vasilopoulou, C., Ammar, C., Coscia, F., Mund, Andreas, Hoerning, O. B., Bache, N., Apalategui, A., Lubeck, M., Richter, S., Fischer, D. S., Raether, O., Park, M. A., Meier, F., Theis, F. J. & Mann, Matthias, 2022, In: Molecular Systems Biology. 18, 3, 15 p., e10798.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. The hemicellulose-degrading enzyme system of the thermophilic bacterium Clostridium stercorarium: comparative characterisation and addition of new hemicellulolytic glycoside hydrolases

    Broeker, J., Mechelke, M., Baudrexl, M., Mennerich, D., Hornburg, D., Mann, Matthias, Schwarz, W. H., Liebl, W. & Zverlov, V. V., 2018, In: Biotechnology for Biofuels. 11, p. 229

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Quantification of the N-glycosylated secretome by super-SILAC during breast cancer progression and in human blood Samples

    Boersema, P. J., Geiger, T., Wiśniewski, J. R. & Mann, Matthias, 1 Jan 2013, In: Molecular & Cellular Proteomics. 12, 1, p. 158-171 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    The structural context of posttranslational modifications at a proteome-wide scale

    Bludau, I., Willems, S., Zeng, W. F., Strauss, Maximilian, Hansen, F. M., Tanzer, M. C., Karayel, O., Schulman, B. A. & Mann, Matthias, 2022, In: PLOS Biology. 20, 5, 23 p., e3001636.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Spatial proteomics in three-dimensional intact specimens

    Bhatia, H. S., Brunner, A-D., Öztürk, F., Kapoor, S., Rong, Z., Mai, H., Thielert, M., Ali, M., Al-Maskari, R., Paetzold, J. C., Kofler, F., Todorov, M. I., Molbay, M., Kolabas, Z. I., Negwer, M., Hoeher, L., Steinke, H., Dima, A., Gupta, B., Kaltenecker, D. & 11 others, Caliskan, Ö. S., Brandt, D., Krahmer, N., Müller, S., Lichtenthaler, S. F., Hellal, F., Bechmann, I., Menze, B., Theis, F., Mann, Matthias & Ertürk, A., 2022, In: Cell. 185, 26, p. 5040-5058.e19

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    A unified classification approach rating clinical utility of protein biomarkers across neurologic diseases

    Bernhardt, A. M., Tiedt, S., Teupser, D., Dichgans, M., Meyer, B., Gempt, J., Kuhn, P. H., Simons, M., Palleis, C., Weidinger, E., Nübling, G., Holdt, L., Hönikl, L., Gasperi, C., Giesbertz, P., Müller, S. A., Breimann, S., Lichtenthaler, S. F., Kuster, B., Mann, M. & 8 others, Imhof, A., Barth, T., Hauck, S. M., Zetterberg, H., Otto, M., Weichert, W., Hemmer, B. & Levin, J., 2023, In: EBioMedicine. 89, 13 p., 104456.

    Research output: Contribution to journalReviewResearchpeer-review

  40. Published

    Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response

    Beli, P., Lukashchuk, N., Wagner, S. A., Weinert, B. T., Olsen, Jesper Velgaard, Baskcomb, L., Mann, Matthias, Jackson, S. P. & Choudhary, Chunaram, 2012, In: Molecular Cell. 46, 2, p. 212-25 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Identification of a novel membrane protein that interacts specifically with the upar-prourokinase complex

    Behrendt, Niels, Engelholm, Lars Henning, Jensen, O. N., Mörtz, E., Ranne, E., Mann, Matthias & Dan, K., 1997, In: Fibrinolysis and Proteolysis. 11, Supl. 3, p. 10 1 p.

    Research output: Contribution to journalConference abstract in journalResearch

  42. A urokinase receptor-associated protein with specific collagen binding properties

    Behrendt, Niels, Jensen, O. N., Engelholm, Lars Henning, Mørtz, E., Mann, Matthias & Danø, K., 2000, In: The Journal of Biological Chemistry. 275, 3, p. 1993-2002 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Proteomic Profiling of Colorectal Adenomas Identifies a Predictive Risk Signature for Development of Metachronous Advanced Colorectal Neoplasia

    Bech, J. M., Terkelsen, Thilde Bagger, Bartels, Annette Snejbjerg, Coscia, F., Doll, S., Zhao, S., Zhang, Z., Brünner, N., Lindebjerg, J., Madsen, G. I., Fang, X., Mann, Matthias & Moreira, José, 2023, In: Gastroenterology. 165, 1, p. 121-132.e5

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    A Cell-Autonomous Signature of Dysregulated Protein Phosphorylation Underlies Muscle Insulin Resistance in Type 2 Diabetes

    Batista, T. M., Jayavelu, A. K., Albrechtsen, Nicolai Jacob Wewer, Iovino, S., Lebastchi, J., Pan, H., Dreyfuss, J. M., Krook, A., Zierath, Juleen R, Mann, Matthias & Kahn, C. R., 2020, In: Cell Metabolism. 32, 5, p. 844-859.e5

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. A systematic mammalian genetic interaction map reveals pathways underlying ricin susceptibility

    Bassik, M. C., Kampmann, M., Lebbink, R. J., Wang, S., Hein, M. Y., Poser, I., Weibezahn, J., Horlbeck, M. A., Chen, S., Mann, Matthias, Hyman, A. A., Leproust, E. M., McManus, M. T. & Weissman, J. S., 14 Feb 2013, In: Cell. 152, 4, p. 909-22 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Mass Spectrometry of Human Leukocyte Antigen Class I Peptidomes Reveals Strong Effects of Protein Abundance and Turnover on Antigen Presentation

    Bassani-Sternberg, M., Pletscher-Frankild, S., Jensen, Lars Juhl & Mann, Matthias, Mar 2015, In: Molecular and Cellular Proteomics. 14, 3, p. 658-73 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Direct identification of clinically relevant neoepitopes presented on native human melanoma tissue by mass spectrometry

    Bassani-Sternberg, M., Bräunlein, E., Klar, R., Engleitner, T., Sinitcyn, P., Audehm, S., Straub, M., Weber, J., Slotta-Huspenina, J., Specht, K., Martignoni, M. E., Werner, A., Hein, R., H Busch, D., Peschel, C., Rad, R., Cox, J., Mann, Matthias & Krackhardt, A. M., 21 Nov 2016, In: Nature Communications. 7, p. 13404

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Proteomics separates adult-type diffuse high-grade gliomas in metabolic subgroups independent of 1p/19q codeletion and across IDH mutational status

    Bader, J. M., Deigendesch, N., Misch, M., Mann, Matthias, Koch, A. & Meissner, F., 2023, In: Cell Reports Medicine. 4, 1, 100877.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    MS-Based Proteomics of Body Fluids: The End of the Beginning

    Bader, J. M., Albrecht, V. & Mann, Matthias, 2023, In: Molecular and Cellular Proteomics. 22, 7, 18 p., 100577.

    Research output: Contribution to journalReviewResearchpeer-review

  50. Published

    Proteome profiling in cerebrospinal fluid reveals novel biomarkers of Alzheimer's disease

    Bader, J. M., Geyer, P. E., Müller, J. B., Strauss, M. T., Koch, M., Leypoldt, F., Koertvelyessy, P., Bittner, D., Schipke, C. G., Incesoy, E. I., Peters, O., Deigendesch, N., Simons, M., Jensen, Majken Karoline, Zetterberg, H. & Mann, Matthias, 2020, In: Molecular Systems Biology. 16, 6, 17 p., e9356.

    Research output: Contribution to journalJournal articleResearchpeer-review

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ID: 5650809