Matthias Mann
Professor, head of research, Professor
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A knowledge graph to interpret clinical proteomics data
Santos, A., Colaço, A. R., Nielsen, A. B., Niu, Lili, Strauss, Maximilian, Geyer, P. E., Coscia, F., Albrechtsen, Nicolai Jacob Wewer, Mundt, F., Jensen, Lars Juhl & Mann, Matthias, 2022, In: Nature Biotechnology. 40, p. 692–702Research output: Contribution to journal › Journal article › Research › peer-review
A20 and ABIN-1 cooperate in balancing CBM complex-triggered NF-κB signaling in activated T cells
Yin, H., Karayel, O., Chao, Y., Seeholzer, T., Hamp, I., Plettenburg, O., Gehring, T., Zielinski, C., Mann, Matthias & Krappmann, D., 31 Jan 2022, In: Cellular and Molecular Life Sciences. 79, 2, p. 112Research output: Contribution to journal › Journal article › Research › peer-review
Adverse stem cell clones within a single patient's tumor predict clinical outcome in AML patients
Zeller, C., Richter, D., Jurinovic, V., Valtierra-Gutiérrez, I. A., Jayavelu, A. K., Mann, Matthias, Bagnoli, J. W., Hellmann, I., Herold, T., Enard, W., Vick, B. & Jeremias, I., 12 Mar 2022, In: Journal of Hematology & Oncology. 15, 1, p. 25Research output: Contribution to journal › Journal article › Research › peer-review
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AlphaMap: an open-source Python package for the visual annotation of proteomics data with sequence-specific knowledge
Voytik, E., Bludau, I., Willems, S., Hansen, F. M., Brunner, A., Strauss, Maximilian & Mann, Matthias, 2022, In: Bioinformatics. 38, 3, p. 849-852Research output: Contribution to journal › Journal article › Research › peer-review
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AlphaPeptDeep: a modular deep learning framework to predict peptide properties for proteomics
Zeng, W. F., Zhou, X. X., Willems, S., Ammar, C., Wahle, M., Bludau, I., Voytik, E., Strauss, Maximilian & Mann, Matthias, 2022, In: Nature Communications. 13, 14 p., 7238.Research output: Contribution to journal › Journal article › Research › peer-review
Amyloid-like aggregating proteins cause lysosomal defects in neurons via gain-of-function toxicity
Riera-Tur, I., Schäfer, T., Hornburg, D., Mishra, A., da Silva Padilha, M., Fernández-Mosquera, L., Feigenbutz, D., Auer, P., Mann, Matthias, Baumeister, W., Klein, R., Meissner, F., Raimundo, N., Fernández-Busnadiego, R. & Dudanova, I., Mar 2022, In: Life Science Alliance. 5, 3Research output: Contribution to journal › Journal article › Research › peer-review
Analysis of RANK-c interaction partners identifies TRAF3 as a critical regulator of breast cancer aggressiveness
Sirinian, C., Papanastasiou, A. D., Karayel, O., Degn, S. E., Peroukidis, S., Chaniotis, D., Nonni, A., Repanti, M., Kriegsmann, M., Makatsoris, T., Koutras, A., Mann, Matthias & Kalofonos, H. P., Nov 2022, In: Neoplasia (New York, N.Y.). 33, p. 100836Research output: Contribution to journal › Journal article › Research › peer-review
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Association of Complement and MAPK Activation With SARS-CoV-2-Associated Myocardial Inflammation
Weckbach, L. T., Schweizer, L., Kraechan, A., Bieber, S., Ishikawa-Ankerhold, H., Hausleiter, J., Massberg, S., Straub, T., Klingel, K., Grabmaier, U., Zwiebel, M., Mann, Matthias & Schulz, C., 2022, In: JAMA Cardiology. 7, 3, p. 286-297 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Cotranslational N-degron masking by acetylation promotes proteome stability in plants
Linster, E., Forero Ruiz, F. L., Miklankova, P., Ruppert, T., Mueller, J., Armbruster, L., Gong, X., Serino, G., Mann, Matthias, Hell, R. & Wirtz, M., 2022, In: Nature Communications. 13, 1, p. 810Research output: Contribution to journal › Journal article › Research › peer-review
Cryo-EM structures of Gid12-bound GID E3 reveal steric blockade as a mechanism inhibiting substrate ubiquitylation
Qiao, S., Lee, C., Sherpa, D., Chrustowicz, J., Cheng, J., Duennebacke, M., Steigenberger, B., Karayel, O., Vu, D. T., von Gronau, S., Mann, Matthias, Wilfling, F. & Schulman, B. A., 2022, In: Nature Communications. 13, 3041.Research output: Contribution to journal › Journal article › Research › peer-review
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D13 Saliva biomarker discovery in Huntington’s disease
Qvist, Filippa Liliendahl, Hellem, M. N., Nielsen, Jørgen Erik, Mann, Matthias & Skotte, Niels Henning, 2022, In: Journal of Neurology, Neurosurgery and Psychiatry. 93, Suppl. 1, p. A24-A25Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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Deep Visual Proteomics defines single-cell identity and heterogeneity
Mund, A., Coscia, F., Kriston, A., Hollandi, R., Kovács, F., Brunner, A-D., Migh, E., Schweizer, L., Santos, A., Bzorek, M., Naimy, S., Rahbek-Gjerdrum, L. M., Dyring-Andersen, B., Bulkescher, J., Lukas, C., Eckert, M. A., Lengyel, E., Gnann, C., Lundberg, E., Horvath, P. & 1 others, , 2022, In: Nature Biotechnology. 40, p. 1231-1240Research output: Contribution to journal › Journal article › Research › peer-review
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Dynamic human liver proteome atlas reveals functional insights into disease pathways
Niu, Lili, Geyer, P. E., Gupta, R., Santos, A., Meier, F., Doll, S., Albrechtsen, Nicolai Jacob Wewer, Klein, S., Ortiz, C., Uschner, F. E., Schierwagen, R., Trebicka, J. & Mann, Matthias, 2022, In: Molecular Systems Biology. 18, 5, 24 p., e10947.Research output: Contribution to journal › Journal article › Research › peer-review
Gel-like inclusions of C-terminal fragments of TDP-43 sequester stalled proteasomes in neurons
Riemenschneider, H., Guo, Q., Bader, J., Frottin, F., Farny, D., Kleinberger, G., Haass, C., Mann, Matthias, Hartl, F. U., Baumeister, W., Hipp, M. S., Meissner, F., Fernández-Busnadiego, R. & Edbauer, D., 2022, In: EMBO Reports. 23, 6, e53890.Research output: Contribution to journal › Journal article › Research › peer-review
Gene-selective transcription promotes the inhibition of tissue reparative macrophages by TNF
Dichtl, S., Sanin, D. E., Koss, C. K., Willenborg, S., Petzold, A., Tanzer, M. C., Dahl, A., Kabat, A. M., Lindenthal, L., Zeitler, L., Satzinger, S., Strasser, A., Mann, Matthias, Roers, A., Eming, S. A., El Kasmi, K. C., Pearce, E. J. & Murray, P. J., Apr 2022, In: Life Science Alliance. 5, 4Research output: Contribution to journal › Journal article › Research › peer-review
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HYPK promotes the activity of the Nα-acetyltransferase A complex to determine proteostasis of nonAc-X2/N-degron-containing proteins
Miklánková, P., Linster, E., Boyer, J., Weidenhausen, J., Mueller, J., Armbruster, L., Lapouge, K., De La Torre, C., Bienvenut, W., Sticht, C., Mann, Matthias, Meinnel, T., Sinning, I., Giglione, C., Hell, R. & Wirtz, M., 2022, In: Science Advances. 8, 24, 14 p., eabn6153.Research output: Contribution to journal › Journal article › Research › peer-review
IKKβ primes inflammasome formation by recruiting NLRP3 to the trans-Golgi network
Schmacke, N. A., O'Duill, F., Gaidt, M. M., Szymanska, I., Kamper, J. M., Schmid-Burgk, J. L., Mädler, S. C., Mackens-Kiani, T., Kozaki, T., Chauhan, D., Nagl, D., Stafford, C. A., Harz, H., Fröhlich, A. L., Pinci, F., Ginhoux, F., Beckmann, R., Mann, Matthias, Leonhardt, H. & Hornung, V., 2022, In: Immunity. 55, 12, p. 2271-2284.e7Research output: Contribution to journal › Journal article › Research › peer-review
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Identification of early neurodegenerative pathways in progressive multiple sclerosis
Kaufmann, M., Schaupp, A. L., Sun, R., Coscia, F., Dendrou, C. A., Cortes, A., Kaur, G., Evans, H. G., Mollbrink, A., Navarro, J. F., Sonner, J. K., Mayer, C., DeLuca, G. C., Lundeberg, J., Matthews, P. M., Attfield, K. E., Friese, M. A., Mann, Matthias & Fugger, Lars, 2022, In: Nature Neuroscience. 25, p. 944-955Research output: Contribution to journal › Journal article › Research › peer-review
In vivo PDX CRISPR/Cas9 screens reveal mutual therapeutic targets to overcome heterogeneous acquired chemo-resistance
Wirth, A-K., Wange, L., Vosberg, S., Henrich, K-O., Rausch, C., Özdemir, E., Zeller, C. M., Richter, D., Feuchtinger, T., Kaller, M., Hermeking, H., Greif, P. A., Senft, D., Jurinovic, V., Bahrami, E., Jayavelu, A. K., Westermann, F., Mann, M., Enard, W., Herold, T. & 1 others, , 2022, In: Leukemia. 36, p. 2863-2874 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Mast cells in lung damage of COVID-19 autopsies: A descriptive study
Schaller, T., Märkl, B., Claus, R., Sholl, L., Hornick, J. L., Giannetti, M. P., Schweizer, L., Mann, Matthias & Castells, M., 2022, In: Allergy. 77, 7, p. 2237-2239 3 p.Research output: Contribution to journal › Comment/debate › Research
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Noninvasive proteomic biomarkers for alcohol-related liver disease
Niu, Lili, Thiele, M., Geyer, P. E., Rasmussen, D. N., Webel, Henry, Santos, A., Gupta, R., Meier, F., Strauss, Maximilian, Kjaergaard, M., Lindvig, K., Jacobsen, S., Rasmussen, Simon, Hansen, Torben, Krag, A. & Mann, Matthias, 2022, In: Nature Medicine. 28, 6, p. 1277-1287 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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OpenCell: Endogenous tagging for the cartography of human cellular organization
Cho, N. H., Cheveralls, K. C., Brunner, A. D., Kim, K., Michaelis, A. C., Raghavan, P., Kobayashi, H., Savy, L., Li, J. Y., Canaj, H., Kim, J. Y. S., Stewart, E. M., Gnann, C., McCarthy, F., Cabrera, J. P., Brunetti, R. M., Chhun, B. B., Dingle, G., Hein, M. Y., Huang, B. & 7 others, , 2022, In: Science. 375, 6585, eabi6983.Research output: Contribution to journal › Journal article › Research › peer-review
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Organ-specific metabolic pathways distinguish prediabetes, type 2 diabetes, and normal tissues
Diamanti, K., Cavalli, M., Pereira, M. J., Pan, G., Castillejo-López, C., Kumar, C., Mundt Madsen, Filip Oskar, Komorowski, J., Deshmukh, Atul Shahaji, Mann, Matthias, Korsgren, O., Eriksson, J. W. & Wadelius, C., 2022, In: Cell Reports Medicine. 3, 10, 21 p., 100763.Research output: Contribution to journal › Journal article › Research › peer-review
PLCG1 is required for AML1-ETO leukemia stem cell self-renewal
Schnoeder, T. M., Schwarzer, A., Jayavelu, A. K., Hsu, C-J., Kirkpatrick, J., Döhner, K., Perner, F., Eifert, T., Huber, N., Arreba-Tutusaus, P., Dolnik, A., Assi, S. A., Nafria, M., Jiang, L., Dai, Y-T., Chen, Z., Chen, S-J., Kellaway, S. G., Ptasinska, A., Ng, E. S. & 17 others, , 2022, In: Blood. 139, 7, p. 1080-1097 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Phosphorylation of muramyl peptides by NAGK is required for NOD2 activation
Stafford, C. A., Gassauer, A. M., de Oliveira Mann, C. C., Tanzer, M. C., Fessler, E., Wefers, B., Nagl, D., Kuut, G., Sulek, K., Vasilopoulou, C., Schwojer, S. J., Wiest, A., Pfautsch, M. K., Wurst, W., Yabal, M., Fröhlich, T., Mann, Matthias, Gisch, N., Jae, L. T. & Hornung, V., 2022, In: Nature. 609, p. 590-596 28 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 5650809
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2010
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Activation of the ATR kinase by the RPA-binding protein ETAA1
Research output: Contribution to journal › Journal article › Research › peer-review
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516
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Region and cell-type resolved quantitative proteomic map of the human heart
Research output: Contribution to journal › Journal article › Research › peer-review
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498
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Revisiting biomarker discovery by plasma proteomics
Research output: Contribution to journal › Review › Research › peer-review
Published