TOPping up ATR activity
Research output: Contribution to journal › Comment/debate › Research › peer-review
The nuclear protein kinase ATR is a key regulator of genome integrity that functions at checkpoints for damaged or incompletely replicated DNA. In this issue of Cell, Kumagai et al. (2006) shed light on the molecular mechanism that controls ATR. They report that a physical interaction between ATR and a distinct domain of TopBP1 greatly enhances ATR kinase activity.
- Animals, Ataxia Telangiectasia Mutated Proteins, Carrier Proteins, Cell Cycle Proteins, DNA Repair, DNA-Binding Proteins, Enzyme Activation, Gene Expression Regulation, Humans, Models, Genetic, Nuclear Proteins, Protein-Serine-Threonine Kinases, Xenopus Proteins