Regulation of PCNA-protein interactions for genome stability

Research output: Contribution to journalJournal articleResearchpeer-review

Proliferating cell nuclear antigen (PCNA) has a central role in promoting faithful DNA replication, providing a molecular platform that facilitates the myriad protein-protein and protein-DNA interactions that occur at the replication fork. Numerous PCNA-associated proteins compete for binding to a common surface on PCNA; hence these interactions need to be tightly regulated and coordinated to ensure proper chromosome replication and integrity. Control of PCNA-protein interactions is multilayered and involves post-translational modifications, in particular ubiquitylation, accessory factors and regulated degradation of PCNA-associated proteins. This regulatory framework allows cells to maintain a fine-tuned balance between replication fidelity and processivity in response to DNA damage.
Original languageEnglish
JournalNature Reviews. Molecular Cell Biology
Issue number5
Pages (from-to)269-82
Number of pages14
Publication statusPublished - May 2013

ID: 45698166