Jiri Lukas

Jiri Lukas

Executive Director

  • Lukas Group

    Blegdamsvej 3, 2200 København N, Bygning 6, Building: 06-1-20

    Phone: +45 35 32 50 04Mobile: +45 23 26 82 70

Primary fields of research

Jiri Lukas studies protein pathways that orchestrate spatial and temporal dynamics of chromosomes during the mammalian cell cycle and after DNA damage, with an emphasis on how are these mechanisms subverted in cancer and other diseases associated with unstable genomes. His long-term interests include high-content microscopy screens for genome caretakers and real-time imaging of signaling and repair proteins.

Current research

Recent discoveries from Jiri’s lab include:
• Ubiquitin-driven signalling pathways that barcode chromatin near the DNA lesions to assemble repair and signaling proteins
• Heritability of chromosomal lesions generated on unreplicated DNA during mitosis
• The concept of rate imitation of nodal signaling components as a mechanism to confine repair reactions and posttranslational chromatin modifications to damaged loci in the genome

Selected publications

  1. Published

    Stabilization of chromatin topology safeguards genome integrity

    Ochs, F., Karemore, Gopal, Miron, E., Brown, J., Sedlackova, Hana, Rask, M., Lampe, M., Buckle, V., Schermelleh, L., Lukas, Jiri & Lukas, Claudia, 2019, In : Nature. 574, 7779, p. 571-574 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    Replication Catastrophe: When a Checkpoint Fails because of Exhaustion

    Toledo Lazaro, Luis Ignacio, Neelsen, K. J. & Lukas, Jiri, 15 Jun 2017, In : Molecular Cell. 66, 6, p. 735-749 15 p.

    Research output: Contribution to journalReviewResearchpeer-review

  3. Published

    Redox-sensitive alteration of replisome architecture safeguards genome integrity

    Somyajit, Kumar, Gupta, R., Sedlackova, Hana, Neelsen, K. J., Ochs, F., Rask, M., Choudhary, Chuna Ram & Lukas, Jiri, 10 Nov 2017, In : Science. 358, 6364, p. 797-802 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    ATR Prohibits Replication Catastrophe by Preventing Global Exhaustion of RPA

    Toledo Lazaro, Luis Ignacio, Altmeyer, M., Rask, M., Lukas, Claudia, Larsen, D. H., Povlsen, L. K., Bekker-Jensen, Simon Holst, Mailand, Niels, Bartek, J. & Lukas, Jiri, 21 Nov 2013, In : Cell. 155, 5, p. 1088-1103 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    TRIP12 and UBR5 Suppress Spreading of Chromatin Ubiquitylation at Damaged Chromosomes

    Gudjónsson, Thorkell, Altmeyer, M. F., Savic, V., Toledo Lazaro, Luis Ignacio, Dinant, C., Grøfte, M., Bartkova, J., Poulsen, M., Oka, Y., Bekker-Jensen, Simon Holst, Mailand, Niels, Neumann, B., Heriche, J., Shearer, R., Saunders, D., Bartek, J., Lukas, Jiri & Lukas, Claudia, 17 Aug 2012, In : Cell. 150, 4, p. 697-709 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress

    Lukas, Claudia, Savic, V., Bekker-Jensen, Simon Holst, Doil, C., Neumann, B., Pedersen, R. S., Grøfte, M., Chan, K. L., Hickson, Ian David, Bartek, J. & Lukas, Jiri, 1 Mar 2011, In : Nature Cell Biology. 13, 3, p. 243-53 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins

    Doil, C., Mailand, Niels, Bekker-Jensen, Simon Holst, Ménard, Patrice, Larsen, D. H., Pepperkok, R., Ellenberg, J., Panier, S., Durocher, D., Bartek, J., Lukas, Jiri & Lukas, Claudia, 2009, In : Cell. 136, 3, p. 435-46 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 37762642