DNA damage-activated kinase Chk2 is independent of proliferation or differentiation yet correlates with tissue biology

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DNA damage-activated kinase Chk2 is independent of proliferation or differentiation yet correlates with tissue biology. / Lukas, C; Bartkova, J; Latella, L; Falck, J; Mailand, Niels; Schroeder, T; Sehested, M; Lukas, J; Bartek, J.

In: Cancer Research, Vol. 61, No. 13, 01.07.2001, p. 4990-3.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Lukas, C, Bartkova, J, Latella, L, Falck, J, Mailand, N, Schroeder, T, Sehested, M, Lukas, J & Bartek, J 2001, 'DNA damage-activated kinase Chk2 is independent of proliferation or differentiation yet correlates with tissue biology', Cancer Research, vol. 61, no. 13, pp. 4990-3. <http://cancerres.aacrjournals.org/content/61/13/4990.full>

APA

Lukas, C., Bartkova, J., Latella, L., Falck, J., Mailand, N., Schroeder, T., Sehested, M., Lukas, J., & Bartek, J. (2001). DNA damage-activated kinase Chk2 is independent of proliferation or differentiation yet correlates with tissue biology. Cancer Research, 61(13), 4990-3. http://cancerres.aacrjournals.org/content/61/13/4990.full

Vancouver

Lukas C, Bartkova J, Latella L, Falck J, Mailand N, Schroeder T et al. DNA damage-activated kinase Chk2 is independent of proliferation or differentiation yet correlates with tissue biology. Cancer Research. 2001 Jul 1;61(13):4990-3.

Author

Lukas, C ; Bartkova, J ; Latella, L ; Falck, J ; Mailand, Niels ; Schroeder, T ; Sehested, M ; Lukas, J ; Bartek, J. / DNA damage-activated kinase Chk2 is independent of proliferation or differentiation yet correlates with tissue biology. In: Cancer Research. 2001 ; Vol. 61, No. 13. pp. 4990-3.

Bibtex

@article{4c542f0fd11a494bb244bf7f5e3b29ad,
title = "DNA damage-activated kinase Chk2 is independent of proliferation or differentiation yet correlates with tissue biology",
abstract = "The Chk2 kinase is a tumor suppressor and key transducer of DNA-damage checkpoints. We show that the human Chk2 protein is relatively stable, nuclear, and responding to gamma-radiation throughout the cell cycle. Contrary to the retinoblastoma protein-regulated, labile Chk1 kinase restricted to S-G(2) phases, Chk2 remains activatable even in quiescent and differentiating cells. In human tissues, Chk2 is homogeneously expressed in renewing cell populations such as epidermis or intestine, heterogeneous in conditionally renewing tissues, and absent or cytoplasmic in static tissues such as muscle or brain. These data highlight striking differences between Chk2 and Chk1 and show unexpected correlation of Chk2 expression with tissue biology.",
keywords = "Antibodies, Monoclonal, Cell Cycle, Cell Differentiation, Cell Division, Cell Line, Checkpoint Kinase 2, DNA Damage, Enzyme Activation, Fibroblasts, G1 Phase, Humans, Osteosarcoma, Protein Kinases, Protein-Serine-Threonine Kinases, S Phase, Tumor Cells, Cultured",
author = "C Lukas and J Bartkova and L Latella and J Falck and Niels Mailand and T Schroeder and M Sehested and J Lukas and J Bartek",
year = "2001",
month = jul,
day = "1",
language = "English",
volume = "61",
pages = "4990--3",
journal = "Cancer Research",
issn = "0008-5472",
publisher = "American Association for Cancer Research",
number = "13",

}

RIS

TY - JOUR

T1 - DNA damage-activated kinase Chk2 is independent of proliferation or differentiation yet correlates with tissue biology

AU - Lukas, C

AU - Bartkova, J

AU - Latella, L

AU - Falck, J

AU - Mailand, Niels

AU - Schroeder, T

AU - Sehested, M

AU - Lukas, J

AU - Bartek, J

PY - 2001/7/1

Y1 - 2001/7/1

N2 - The Chk2 kinase is a tumor suppressor and key transducer of DNA-damage checkpoints. We show that the human Chk2 protein is relatively stable, nuclear, and responding to gamma-radiation throughout the cell cycle. Contrary to the retinoblastoma protein-regulated, labile Chk1 kinase restricted to S-G(2) phases, Chk2 remains activatable even in quiescent and differentiating cells. In human tissues, Chk2 is homogeneously expressed in renewing cell populations such as epidermis or intestine, heterogeneous in conditionally renewing tissues, and absent or cytoplasmic in static tissues such as muscle or brain. These data highlight striking differences between Chk2 and Chk1 and show unexpected correlation of Chk2 expression with tissue biology.

AB - The Chk2 kinase is a tumor suppressor and key transducer of DNA-damage checkpoints. We show that the human Chk2 protein is relatively stable, nuclear, and responding to gamma-radiation throughout the cell cycle. Contrary to the retinoblastoma protein-regulated, labile Chk1 kinase restricted to S-G(2) phases, Chk2 remains activatable even in quiescent and differentiating cells. In human tissues, Chk2 is homogeneously expressed in renewing cell populations such as epidermis or intestine, heterogeneous in conditionally renewing tissues, and absent or cytoplasmic in static tissues such as muscle or brain. These data highlight striking differences between Chk2 and Chk1 and show unexpected correlation of Chk2 expression with tissue biology.

KW - Antibodies, Monoclonal

KW - Cell Cycle

KW - Cell Differentiation

KW - Cell Division

KW - Cell Line

KW - Checkpoint Kinase 2

KW - DNA Damage

KW - Enzyme Activation

KW - Fibroblasts

KW - G1 Phase

KW - Humans

KW - Osteosarcoma

KW - Protein Kinases

KW - Protein-Serine-Threonine Kinases

KW - S Phase

KW - Tumor Cells, Cultured

M3 - Journal article

C2 - 11431331

VL - 61

SP - 4990

EP - 4993

JO - Cancer Research

JF - Cancer Research

SN - 0008-5472

IS - 13

ER -

ID: 124904871