Jiri Lukas
Executive Director, Professor
- 2010
HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes
Bekker-Jensen, Simon Holst, Danielsen, J. M. R., Fugger, K., Gromova, I., Nerstedt, A., Bartek, J., Lukas, Jiri & Mailand, Niels, 2010, In: Nature Cell Biology. 12, 1, p. 80-6; sup pp 1-12Research output: Contribution to journal › Letter › Research › peer-review
- 2011
- Published
53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress
Lukas, Claudia, Savic, V., Bekker-Jensen, Simon Holst, Doil, C., Neumann, B., Pedersen, R. S., Grøfte, M., Chan, K. L., Hickson, Ian David, Bartek, J. & Lukas, Jiri, 1 Mar 2011, In: Nature Cell Biology. 13, 3, p. 243-53 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2012
- Published
DVC1 (C1orf124) is a DNA damage-targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks
Mosbech, A., Gibbs-Seymour, I., Kagias, K., Thorslund, T., Beli, P., Povlsen, L., Nielsen, S. V., Smedegaard, S., Sedgwick, G., Lukas, Claudia, Hartmann-Petersen, Rasmus, Lukas, Jiri, Choudhary, Chunaram, Pocock, R. D. J., Bekker-Jensen, Simon Holst & Mailand, Niels, 2012, In: Nature Structural and Molecular Biology. 19, 11, p. 1084-92 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Autocrine VEGF-VEGFR2-Neuropilin-1 signaling promotes glioma stem-like cell viability and tumor growth
Hamerlik, P., Lathia, J. D., Rasmussen, R., Wu, Q., Bartkova, J., Lee, M., Moudry, P., Bartek, J., Fischer, W., Lukas, Jiri, Rich, J. N. & Bartek, J., 12 Mar 2012, In: The Journal of Experimental Medicine. 209, 3, p. 507-20 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
Ubiquitin-activating enzyme UBA1 is required for cellular response to DNA damage
Moudry, P., Lukas, Claudia, Macurek, L., Hanzlikova, H., Hodny, Z., Lukas, Jiri & Bartek, J., 15 Apr 2012, In: Cell Cycle. 11, 8, p. 1573-82 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
CDK targeting of NBS1 promotes DNA-end resection, replication restart and homologous recombination
Falck, J., Forment, J. V., Coates, J., Mistrik, M., Lukas, Jiri, Bartek, J. & Jackson, S. P., Jun 2012, In: E M B O Reports. 13, 6, p. 561-8 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Jiri Lukas: Visualizing genome integrity maintenance. Interview by Caitlin Sedwick
Lukas, Jiri, 9 Jul 2012, In: Journal of Cell Biology. 198, 1, p. 4-5 2 p.Research output: Contribution to journal › Journal article › Communication
- Published
LEDGF (p75) promotes DNA-end resection and homologous recombination
Daugaard, M., Baude, A., Fugger, K., Povlsen, L. K., Beck, H., Sørensen, Claus Storgaard, Petersen, N. H. T., Sorensen, P. H. B., Lukas, Claudia, Bartek, J., Lukas, Jiri, Rohde, M. & Jaattela, Marja, Aug 2012, In: Nature Structural & Molecular Biology. 19, 8, p. 803-810 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
TRIP12 and UBR5 Suppress Spreading of Chromatin Ubiquitylation at Damaged Chromosomes
Gudjónsson, Thorkell, Altmeyer, M. F., Savic, V., Toledo Lazaro, L. I., Dinant, C., Grøfte, M., Bartkova, J., Poulsen, M., Oka, Y., Bekker-Jensen, Simon Holst, Mailand, Niels, Neumann, B., Heriche, J., Shearer, R., Saunders, D., Bartek, J., Lukas, Jiri & Lukas, Claudia, 17 Aug 2012, In: Cell. 150, 4, p. 697-709 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Evaluation of candidate biomarkers to predict cancer cell sensitivity or resistance to PARP-1 inhibitor treatment
Oplustilova, L., Wolanin, K., Bartkova, J., Lukas, Jiri, Bartek, J., Lau, A., O'Connor, M. J., Mistrik, M., Korinkova, G., Simkova, D., Bouchal, J. & Lenobel, R., 15 Oct 2012, In: Cell Cycle. 11, 20, p. 3837-3850 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2013
- Published
To spread or not to spread - chromatin modifications in response to DNA damage
Altmeyer, M. & Lukas, Jiri, 9 Jan 2013, In: Current Opinion in Genetics & Development. 23, 2, p. 156-165 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Shielding broken DNA for a quick fix
Lukas, Jiri & Lukas, Claudia, 8 Feb 2013, In: Science. 339, 6120, p. 652-653 2 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Acetylation dynamics of human nuclear proteins during the ionizing radiation-induced DNA damage response
Bennetzen, M., Andersen, J. S., Lasen, D. H., Dinant, C., Watanabe, S., Bartek, J. & Lukas, Jiri, 1 Jun 2013, In: Cell Cycle. 12, 11, p. 1688-1695 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Guarding against Collateral Damage during Chromatin Transactions
Altmeyer, M. & Lukas, Jiri, 20 Jun 2013, In: Cell. 153, 7, p. 1431-4 4 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Proteome-wide Identification of Poly(ADP-Ribosyl)ation Targets in Different Genotoxic Stress Responses
Jungmichel, S., Rosenthal, F., Altmeyer, M., Lukas, Jiri, Hottiger, M. O. & Nielsen, Michael Lund, 24 Oct 2013, In: Molecular Cell. 52, 2, p. 272-285 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Chromatin Scaffold Protein SAFB1 Renders Chromatin Permissive for DNA Damage Signaling
Altmeyer, M., Toledo Lazaro, L. I., Gudjónsson, Thorkell, Grøfte, M., Rask, M., Lukas, Claudia, Akimov, V., Blagoev, B., Bartek, J. & Lukas, Jiri, 24 Oct 2013, In: Molecular Cell. 52, 2, p. 206-220Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The DNA damage checkpoint precedes activation of ARF in response to escalating oncogenic stress during tumorigenesis
Evangelou, K., Bartkova, J., Kotsinas, A., Pateras, I. S., Liontos, M., Velimezi, G., Kosar, M., Liloglou, T., Trougakos, I. P., Dyrskjot, L., Andersen, C. L., Papaioannou, M., Drosos, Y., Papafotiou, G., Hodny, Z., Sosa-Pineda, B., Wu, X-R., Klinakis, A., Ørntoft, T. F., Lukas, J. & 2 others, , 1 Nov 2013, In: Cell Death and Differentiation. 20, 11, p. 1485-1497 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
ATR-Chk1-APC/C-dependent stabilization of Cdc7-ASK (Dbf4) kinase is required for DNA lesion bypass under replication stress
Yamada, M., Watanabe, K., Mistrik, M., Vesela, E., Protivankova, I., Mailand, Niels, Lee, M. H., Masai, H., Lukas, Jiri & Bartek, J., 15 Nov 2013, In: Genes & Development. 27, 22, p. 2459-2472 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
JMJD1C demethylates MDC1 to regulate the RNF8 and BRCA1-mediated chromatin response to DNA breaks
Watanabe, S., Watanabe, K., Akimov, V., Bartkova, J., Blagoev, B., Lukas, Jiri & Bartek, J., 17 Nov 2013, In: Nature Structural and Molecular Biology. 20, p. 1425-1433Research output: Contribution to journal › Journal article › Research › peer-review
- Published
ATR Prohibits Replication Catastrophe by Preventing Global Exhaustion of RPA
Toledo Lazaro, L. I., Altmeyer, M., Rask, M., Lukas, Claudia, Larsen, D. H., Povlsen, L. K., Bekker-Jensen, Simon Holst, Mailand, Niels, Bartek, J. & Lukas, Jiri, 21 Nov 2013, In: Cell. 155, 5, p. 1088-1103 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2014
- Published
The NBS1-Treacle complex controls ribosomal RNA transcription in response to DNA damage
Larsen, D. H., Hari, F., Clapperton, J. A., Gwerder, M., Gutsche, K., Altmeyer, M., Jungmichel, S., Toledo Lazaro, L. I., Fink, D., Rask, M., Grøfte, M., Lukas, Claudia, Nielsen, Michael Lund, Smerdon, S. J., Lukas, Jiri & Stucki, M., Aug 2014, In: Nature Cell Biology. 16, 8, p. 792-803 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2015
- Published
A lncRNA to repair DNA
Lukas, Jiri & Altmeyer, M., 2015, In: E M B O Reports. 16, 11, p. 1413-1414 2 p.Research output: Contribution to journal › Comment/debate › Research
- Published
Ectopic expression of RNF168 and 53BP1 increases mutagenic but not physiological non-homologous end joining
Zong, D., Callén, E., Pegoraro, G., Lukas, Claudia, Lukas, Jiri & Nussenzweig, A., 26 May 2015, In: Nucleic Acids Research. 43, 10, p. 4950-61 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Liquid demixing of intrinsically disordered proteins is seeded by poly(ADP-ribose)
Altmeyer, M., Neelsen, K. J., Teloni, F., Pozdnyakova, I., Pellegrino, S., Grøfte, M., Rask, M. D., Streicher, W., Jungmichel, S., Nielsen, Michael Lund & Lukas, Jiri, 19 Aug 2015, In: Nature Communications. 6, p. 1-12 8088.Research output: Contribution to journal › Journal article › Research › peer-review
- 2016
- Published
TOPBP1 regulates RAD51 phosphorylation and chromatin loading and determines PARP inhibitor sensitivity
Moudry, P., Watanabe, K., Wolanin, K. M., Bartkova, J., Wassing, I. E., Watanabe, S., Strauss, R., Pedersen, R. T., Østergaard, Vibe Hallundbæk, Lisby, Michael, Andújar-Sánchez, M., Maya-Mendoza, A., Esashi, F., Lukas, Jiri & Bartek, J., 2016, In: The Journal of Cell Biology. 212, 3, p. 281-288 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 37762642
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TOPBP1 regulates RAD51 phosphorylation and chromatin loading and determines PARP inhibitor sensitivity
Research output: Contribution to journal › Journal article › Research › peer-review
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Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability
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Physiological Tolerance to ssDNA Enables Strand Uncoupling during DNA Replication
Research output: Contribution to journal › Journal article › Research › peer-review
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