Jiri Lukas

Jiri Lukas

Executive Director, Professor

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    ORCID: 0000-0001-9087-506X

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    1. Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress

      Mailand, Niels, Bekker-Jensen, Simon Holst, Bartek, J. & Lukas, Jiri, 2006, In: Molecular Cell. 23, 3, p. 307-18 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation

      Mailand, Niels, Lukas, Claudia, Kaiser, B. K., Jackson, P. K., Bartek, J. & Lukas, Jiri, Apr 2002, In: Nature Cell Biology. 4, 4, p. 317-22 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins

      Mailand, Niels, Bekker-Jensen, Simon Holst, Faustrup, H., Melander, F., Bartek, J., Lukas, Claudia & Lukas, Jiri, 2007, In: Cell. 131, 5, p. 887-900 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Regulation of G(2)/M events by Cdc25A through phosphorylation-dependent modulation of its stability.

      Mailand, Niels, Podtelejnikov, A. V., Groth, Anja, Mann, M., Bartek, J. & Lukas, Jiri, 2002, In: EMBO Journal. 21, 21, p. 5911-20 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Rapid destruction of human Cdc25A in response to DNA damage

      Mailand, Niels, Falck, J., Lukas, Claudia, Syljuåsen, R. G., Welcker, M., Bartek, J. & Lukas, Jiri, 26 May 2000, In: Science (New York, N.Y.). 288, 5470, p. 1425-9 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Immunoprecipitation of Proteins under Nondenaturing Conditions

      Lukas, Jiri, Bartek, J. & Hansen, K., 1 Dec 2006, Cell Biology, Four-Volume Set. Elsevier Science Inc., Vol. 4. p. 253-258 6 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    7. Published

      Jiri Lukas: Visualizing genome integrity maintenance. Interview by Caitlin Sedwick

      Lukas, Jiri, 9 Jul 2012, In: Journal of Cell Biology. 198, 1, p. 4-5 2 p.

      Research output: Contribution to journal › Journal article › Communication

    8. Published

      A lncRNA to repair DNA

      Lukas, Jiri & Altmeyer, M., 2015, In: E M B O Reports. 16, 11, p. 1413-1414 2 p.

      Research output: Contribution to journal › Comment/debate › Research

    9. Published

      DNA repair: New tales of an old tail

      Lukas, Jiri & Bartek, J., 2009, In: Nature. 458, 7238, p. 581-3 2 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      Shielding broken DNA for a quick fix

      Lukas, Jiri & Lukas, Claudia, 8 Feb 2013, In: Science. 339, 6120, p. 652-653 2 p.

      Research output: Contribution to journal › Review › Research › peer-review

    11. Published

      53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress

      Lukas, Claudia, Savic, V., Bekker-Jensen, Simon Holst, Doil, C., Neumann, B., Pedersen, R. S., Grøfte, M., Chan, K. L., Hickson, Ian David, Bartek, J. & Lukas, Jiri, 1 Mar 2011, In: Nature Cell Biology. 13, 3, p. 243-53 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. DNA damage-activated kinase Chk2 is independent of proliferation or differentiation yet correlates with tissue biology

      Lukas, Claudia, Bartkova, J., Latella, L., Falck, J., Mailand, Niels, Schroeder, T., Sehested, M., Lukas, Jiri & Bartek, J., 1 Jul 2001, In: Cancer Research. 61, 13, p. 4990-3 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation

      Liu, S., Bekker-Jensen, Simon Holst, Mailand, Niels, Lukas, Claudia, Bartek, J. & Lukas, Jiri, 2006, In: Molecular and Cellular Biology. 26, 16, p. 6056-64 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      The NBS1-Treacle complex controls ribosomal RNA transcription in response to DNA damage

      Larsen, D. H., Hari, F., Clapperton, J. A., Gwerder, M., Gutsche, K., Altmeyer, M., Jungmichel, S., Toledo Lazaro, L. I., Fink, D., Rask, M., Grøfte, M., Lukas, Claudia, Nielsen, Michael Lund, Smerdon, S. J., Lukas, Jiri & Stucki, M., Aug 2014, In: Nature Cell Biology. 16, 8, p. 792-803 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase

      Krämer, A., Mailand, Niels, Lukas, Claudia, Syljuåsen, R. G., Wilkinson, C. J., Nigg, E. A., Bartek, J. & Lukas, Jiri, Sep 2004, In: Nature Cell Biology. 6, 9, p. 884-91 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      Proteome-wide Identification of Poly(ADP-Ribosyl)ation Targets in Different Genotoxic Stress Responses

      Jungmichel, S., Rosenthal, F., Altmeyer, M., Lukas, Jiri, Hottiger, M. O. & Nielsen, Michael Lund, 24 Oct 2013, In: Molecular Cell. 52, 2, p. 272-285 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Published

      Autocrine VEGF-VEGFR2-Neuropilin-1 signaling promotes glioma stem-like cell viability and tumor growth

      Hamerlik, P., Lathia, J. D., Rasmussen, R., Wu, Q., Bartkova, J., Lee, M., Moudry, P., Bartek, J., Fischer, W., Lukas, Jiri, Rich, J. N. & Bartek, J., 12 Mar 2012, In: The Journal of Experimental Medicine. 209, 3, p. 507-20 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Published

      DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity

      Gupta, R., Somyajit, K., Narita, Takeo, Maskey, E., Stanlie, A., Kremer, M., Typas, D., Lammers, M., Mailand, Niels, Nussenzweig, A., Lukas, Jiri & Choudhary, Chunaram, 2018, In: Cell. 173, 4, p. 972-988

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      TRIP12 and UBR5 Suppress Spreading of Chromatin Ubiquitylation at Damaged Chromosomes

      Gudjónsson, Thorkell, Altmeyer, M. F., Savic, V., Toledo Lazaro, L. I., Dinant, C., Grøfte, M., Bartkova, J., Poulsen, M., Oka, Y., Bekker-Jensen, Simon Holst, Mailand, Niels, Neumann, B., Heriche, J., Shearer, R., Saunders, D., Bartek, J., Lukas, Jiri & Lukas, Claudia, 17 Aug 2012, In: Cell. 150, 4, p. 697-709 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint.

      Groth, Anja, Lukas, Jiri, Nigg, E., Silljé, H., Wernstedt, C., Bartek, J. & Hansen, K., Apr 2003, In: The EMBO Journal. 22, 7, p. 1676-1687

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability

      Galanos, P., Pappas, G., Polyzos, A., Kotsinas, A., Svolaki, I., Giakoumakis, N. N., Glytsou, C., Pateras, I. S., Swain, U., Souliotis, V. L., Georgakilas, A. G., Geacintov, N., Scorrano, L., Lukas, C., Lukas, J., Livneh, Z., Lygerou, Z., Chowdhury, D., Sørensen, C. S., Bartek, J. & 1 others, Gorgoulis, V. G., 2018, In: Genome Biology (Online Edition). 19, p. 1-18 37.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Human Fbh1 helicase contributes to genome maintenance via pro- and anti-recombinase activities

      Fugger, K., Mistrik, M., Danielsen, J. R., Dinant, C., Falck, J., Bartek, J., Lukas, Jiri & Mailand, Niels, 2009, In: Journal of Cell Biology. 186, 5, p. 655-63 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. USP7 counteracts SCFbetaTrCP- but not APCCdh1-mediated proteolysis of Claspin

      Faustrup, H., Bekker-Jensen, Simon Holst, Bartek, J., Lukas, Jiri & Mailand, Niels, 2009, In: Journal of Cell Biology. 184, 1, p. 13-9 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. CDK targeting of NBS1 promotes DNA-end resection, replication restart and homologous recombination

      Falck, J., Forment, J. V., Coates, J., Mistrik, M., Lukas, Jiri, Bartek, J. & Jackson, S. P., Jun 2012, In: E M B O Reports. 13, 6, p. 561-8 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis

      Falck, J., Mailand, Niels, Syljuåsen, R. G., Bartek, J. & Lukas, Jiri, 12 Apr 2001, In: Nature. 410, 6830, p. 842-7 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

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