Jiri Lukas
Executive Director, Professor
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Proteome-wide Identification of Poly(ADP-Ribosyl)ation Targets in Different Genotoxic Stress Responses
Jungmichel, S., Rosenthal, F., Altmeyer, M., Lukas, Jiri, Hottiger, M. O. & Nielsen, Michael Lund, 24 Oct 2013, In: Molecular Cell. 52, 2, p. 272-285 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase
Krämer, A., Mailand, Niels, Lukas, Claudia, Syljuåsen, R. G., Wilkinson, C. J., Nigg, E. A., Bartek, J. & Lukas, Jiri, Sep 2004, In: Nature Cell Biology. 6, 9, p. 884-91 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The NBS1-Treacle complex controls ribosomal RNA transcription in response to DNA damage
Larsen, D. H., Hari, F., Clapperton, J. A., Gwerder, M., Gutsche, K., Altmeyer, M., Jungmichel, S., Toledo Lazaro, L. I., Fink, D., Rask, M., Grøfte, M., Lukas, Claudia, Nielsen, Michael Lund, Smerdon, S. J., Lukas, Jiri & Stucki, M., Aug 2014, In: Nature Cell Biology. 16, 8, p. 792-803 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Claspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activation
Liu, S., Bekker-Jensen, Simon Holst, Mailand, Niels, Lukas, Claudia, Bartek, J. & Lukas, Jiri, 2006, In: Molecular and Cellular Biology. 26, 16, p. 6056-64 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
DNA damage-activated kinase Chk2 is independent of proliferation or differentiation yet correlates with tissue biology
Lukas, Claudia, Bartkova, J., Latella, L., Falck, J., Mailand, Niels, Schroeder, T., Sehested, M., Lukas, Jiri & Bartek, J., 1 Jul 2001, In: Cancer Research. 61, 13, p. 4990-3 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress
Lukas, Claudia, Savic, V., Bekker-Jensen, Simon Holst, Doil, C., Neumann, B., Pedersen, R. S., Grøfte, M., Chan, K. L., Hickson, Ian David, Bartek, J. & Lukas, Jiri, 1 Mar 2011, In: Nature Cell Biology. 13, 3, p. 243-53 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Shielding broken DNA for a quick fix
Lukas, Jiri & Lukas, Claudia, 8 Feb 2013, In: Science. 339, 6120, p. 652-653 2 p.Research output: Contribution to journal › Review › Research › peer-review
Immunoprecipitation of Proteins under Nondenaturing Conditions
Lukas, Jiri, Bartek, J. & Hansen, K., 1 Dec 2006, Cell Biology, Four-Volume Set. Elsevier Science Inc., Vol. 4. p. 253-258 6 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Jiri Lukas: Visualizing genome integrity maintenance. Interview by Caitlin Sedwick
Lukas, Jiri, 9 Jul 2012, In: Journal of Cell Biology. 198, 1, p. 4-5 2 p.Research output: Contribution to journal › Journal article › Communication
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A lncRNA to repair DNA
Lukas, Jiri & Altmeyer, M., 2015, In: E M B O Reports. 16, 11, p. 1413-1414 2 p.Research output: Contribution to journal › Comment/debate › Research
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DNA repair: New tales of an old tail
Lukas, Jiri & Bartek, J., 2009, In: Nature. 458, 7238, p. 581-3 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress
Mailand, Niels, Bekker-Jensen, Simon Holst, Bartek, J. & Lukas, Jiri, 2006, In: Molecular Cell. 23, 3, p. 307-18 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation
Mailand, Niels, Lukas, Claudia, Kaiser, B. K., Jackson, P. K., Bartek, J. & Lukas, Jiri, Apr 2002, In: Nature Cell Biology. 4, 4, p. 317-22 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins
Mailand, Niels, Bekker-Jensen, Simon Holst, Faustrup, H., Melander, F., Bartek, J., Lukas, Claudia & Lukas, Jiri, 2007, In: Cell. 131, 5, p. 887-900 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
Regulation of G(2)/M events by Cdc25A through phosphorylation-dependent modulation of its stability.
Mailand, Niels, Podtelejnikov, A. V., Groth, Anja, Mann, M., Bartek, J. & Lukas, Jiri, 2002, In: EMBO Journal. 21, 21, p. 5911-20 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Rapid destruction of human Cdc25A in response to DNA damage
Mailand, Niels, Falck, J., Lukas, Claudia, Syljuåsen, R. G., Welcker, M., Bartek, J. & Lukas, Jiri, 26 May 2000, In: Science (New York, N.Y.). 288, 5470, p. 1425-9 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
Nucleotide excision repair-induced H2A ubiquitination is dependent on MDC1 and RNF8 and reveals a universal DNA damage response
Marteijn, J. A., Bekker-Jensen, Simon Holst, Mailand, Niels, Lans, H., Schwertman, P., Gourdin, A. M., Dantuma, N. P., Lukas, Jiri & Vermeulen, W., 2009, In: Journal of Cell Biology. 186, 6, p. 835-47 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Phosphorylation of SDT repeats in the MDC1 N terminus triggers retention of NBS1 at the DNA damage-modified chromatin
Melander, F., Bekker-Jensen, Simon Holst, Falck, J., Bartek, J., Mailand, Niels & Lukas, Jiri, 21 Apr 2008, In: Journal of Cell Biology. 181, 2, p. 213-26 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Low-dose DNA damage and replication stress responses quantified by optimized automated single-cell image analysis
Mistrik, M., Oplustilova, L., Lukas, Jiri & Bartek, J., 2009, In: Cell Cycle. 8, 16, p. 2592-9 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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DVC1 (C1orf124) is a DNA damage-targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks
Mosbech, A., Gibbs-Seymour, I., Kagias, K., Thorslund, T., Beli, P., Povlsen, L., Nielsen, S. V., Smedegaard, S., Sedgwick, G., Lukas, Claudia, Hartmann-Petersen, Rasmus, Lukas, Jiri, Choudhary, Chunaram, Pocock, R. D. J., Bekker-Jensen, Simon Holst & Mailand, Niels, 2012, In: Nature Structural and Molecular Biology. 19, 11, p. 1084-92 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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TOPBP1 regulates RAD51 phosphorylation and chromatin loading and determines PARP inhibitor sensitivity
Moudry, P., Watanabe, K., Wolanin, K. M., Bartkova, J., Wassing, I. E., Watanabe, S., Strauss, R., Pedersen, R. T., Østergaard, Vibe Hallundbæk, Lisby, Michael, Andújar-Sánchez, M., Maya-Mendoza, A., Esashi, F., Lukas, Jiri & Bartek, J., 2016, In: The Journal of Cell Biology. 212, 3, p. 281-288 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
Ubiquitin-activating enzyme UBA1 is required for cellular response to DNA damage
Moudry, P., Lukas, Claudia, Macurek, L., Hanzlikova, H., Hodny, Z., Lukas, Jiri & Bartek, J., 15 Apr 2012, In: Cell Cycle. 11, 8, p. 1573-82 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Stabilization of chromatin topology safeguards genome integrity
Ochs, Fena, Karemore, G., Miron, E., Brown, J., Sedlackova, H., Rask, M., Lampe, M., Buckle, V., Schermelleh, L., Lukas, Jiri & Lukas, Claudia, 2019, In: Nature. 574, 7779, p. 571-574 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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53BP1 fosters fidelity of homology-directed DNA repair
Ochs, Fena, Somyajit, K., Altmeyer, M., Rask, M. D., Lukas, Jiri & Lukas, Claudia, Aug 2016, In: Nature Structural and Molecular Biology. 23, 8, p. 714-21 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Evaluation of candidate biomarkers to predict cancer cell sensitivity or resistance to PARP-1 inhibitor treatment
Oplustilova, L., Wolanin, K., Bartkova, J., Lukas, Jiri, Bartek, J., Lau, A., O'Connor, M. J., Mistrik, M., Korinkova, G., Simkova, D., Bouchal, J. & Lenobel, R., 15 Oct 2012, In: Cell Cycle. 11, 20, p. 3837-3850 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 37762642
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TOPBP1 regulates RAD51 phosphorylation and chromatin loading and determines PARP inhibitor sensitivity
Research output: Contribution to journal › Journal article › Research › peer-review
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175
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Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability
Research output: Contribution to journal › Journal article › Research › peer-review
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156
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Physiological Tolerance to ssDNA Enables Strand Uncoupling during DNA Replication
Research output: Contribution to journal › Journal article › Research › peer-review
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