Jiri Lukas

Jiri Lukas

Executive Director, Professor

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    ORCID: 0000-0001-9087-506X

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    1. Published

      Ectopic expression of RNF168 and 53BP1 increases mutagenic but not physiological non-homologous end joining

      Zong, D., Callén, E., Pegoraro, G., Lukas, Claudia, Lukas, Jiri & Nussenzweig, A., 26 May 2015, In: Nucleic Acids Research. 43, 10, p. 4950-61 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Published

      ATR-Chk1-APC/C-dependent stabilization of Cdc7-ASK (Dbf4) kinase is required for DNA lesion bypass under replication stress

      Yamada, M., Watanabe, K., Mistrik, M., Vesela, E., Protivankova, I., Mailand, Niels, Lee, M. H., Masai, H., Lukas, Jiri & Bartek, J., 15 Nov 2013, In: Genes & Development. 27, 22, p. 2459-2472 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Published

      JMJD1C demethylates MDC1 to regulate the RNF8 and BRCA1-mediated chromatin response to DNA breaks

      Watanabe, S., Watanabe, K., Akimov, V., Bartkova, J., Blagoev, B., Lukas, Jiri & Bartek, J., 17 Nov 2013, In: Nature Structural and Molecular Biology. 20, p. 1425-1433

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      ATR Prohibits Replication Catastrophe by Preventing Global Exhaustion of RPA

      Toledo Lazaro, L. I., Altmeyer, M., Rask, M., Lukas, Claudia, Larsen, D. H., Povlsen, L. K., Bekker-Jensen, Simon Holst, Mailand, Niels, Bartek, J. & Lukas, Jiri, 21 Nov 2013, In: Cell. 155, 5, p. 1088-1103 16 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      Replication Catastrophe: When a Checkpoint Fails because of Exhaustion

      Toledo, L., Neelsen, K. J. & Lukas, Jiri, 15 Jun 2017, In: Molecular Cell. 66, 6, p. 735-749 15 p.

      Research output: Contribution to journal › Review › Research › peer-review

    6. Published

      53BP1 nuclear bodies enforce replication timing at under-replicated DNA to limit heritable DNA damage

      Spies, J., Lukas, Claudia, Somyajit, K., Rask, M., Lukas, Jiri & Neelsen, K. J., 2019, In: Nature Cell Biology. 21, p. 487-497

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      Homologous recombination as a fundamental genome surveillance mechanism during dna replication

      Spies, J., Polasek-Sedlackova, H., Lukas, Jiri & Somyajit, K., 2021, In: Genes. 12, 12, 17 p., 1960.

      Research output: Contribution to journal › Review › Research › peer-review

    8. Published

      Mammalian RAD52 Functions in Break-Induced Replication Repair of Collapsed DNA Replication Forks

      Sotiriou, S. K., Kamileri, I., Lugli, N., Evangelou, K., Da-Ré, C., Huber, F., Padayachy, L., Tardy, S., Nicati, N. L., Barriot, S., Ochs, Fena, Lukas, Claudia, Lukas, Jiri, Gorgoulis, V. G., Scapozza, L. & Halazonetis, T. D., 15 Dec 2016, In: Molecular Cell. 64, 6, p. 1127-1134 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      Homology-directed repair protects the replicating genome from metabolic assaults

      Somyajit, K., Spies, J., Coscia, F., Kirik, U., Rask, M., Lee, J., Neelsen, K. J., Mund, Andreas, Jensen, Lars Juhl, Paull, T. T., Mann, Matthias & Lukas, Jiri, 2021, In: Developmental Cell. 56, 4, p. 461-477.e7

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      Redox-sensitive alteration of replisome architecture safeguards genome integrity

      Somyajit, K., Gupta, R., Sedlackova, H., Neelsen, K. J., Ochs, Fena, Rask, M., Choudhary, Chunaram & Lukas, Jiri, 10 Nov 2017, In: Science. 358, 6364, p. 797-802 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      Equilibrium between nascent and parental MCM proteins protects replicating genomes

      Sedlackova, H., Rask, M., Gupta, R., Choudhary, Chunaram, Somyajit, K. & Lukas, Jiri, 2020, In: Nature. 587, p. 297-302 34 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      E2F activity is essential for survival of Myc-overexpressing human cancer cells

      Santoni Rugiu, Eric, Duro, D., Farkas, T., Mathiasen, I. S., Jäättelä, M., Bartek, J. & Lukas, Jiri, 2002, In: Oncogene. 21, 42, p. 6498-6509 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Involvement of Myc activity in a G(1)/S-promoting mechanism parallel to the pRb/E2F pathway

      Santoni Rugiu, Eric, Falck, J., Mailand, Niels, Bartek, J. & Lukas, Jiri, May 2000, In: Molecular and Cellular Biology. 20, 10, p. 3497-509 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      HCLK2 is required for activity of the DNA damage response kinase ATR

      Rendtlew Danielsen, J. M., Larsen, D. H., Schou, K. B., Freire, R., Falck, J., Bartek, J. & Lukas, Jiri, 2008, In: Journal of Biological Chemistry. 284, 7, p. 4140-7 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Published

      Solving the MCM paradox by visualizing the scaffold of CMG helicase at active replisomes

      Polasek-Sedlackova, H., Miller, Thomas, Krejci, J., Rask, M. B. & Lukas, Jiri, 2022, In: Nature Communications. 13, 11 p., 6090.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      Profiling DNA damage response following mitotic perturbations

      Pedersen, R. S., Karemore, G., Gudjónsson, Thorkell, Rask, M., Neumann, B., Hériché, J., Pepperkok, R., Ellenberg, J., Gerlich, D. W., Lukas, Jiri & Lukas, Claudia, 15 Dec 2016, In: Nature Communications. 7, 12 p., 13887.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Published

      Evaluation of candidate biomarkers to predict cancer cell sensitivity or resistance to PARP-1 inhibitor treatment

      Oplustilova, L., Wolanin, K., Bartkova, J., Lukas, Jiri, Bartek, J., Lau, A., O'Connor, M. J., Mistrik, M., Korinkova, G., Simkova, D., Bouchal, J. & Lenobel, R., 15 Oct 2012, In: Cell Cycle. 11, 20, p. 3837-3850 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Published

      Stabilization of chromatin topology safeguards genome integrity

      Ochs, Fena, Karemore, G., Miron, E., Brown, J., Sedlackova, H., Rask, M., Lampe, M., Buckle, V., Schermelleh, L., Lukas, Jiri & Lukas, Claudia, 2019, In: Nature. 574, 7779, p. 571-574 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      53BP1 fosters fidelity of homology-directed DNA repair

      Ochs, Fena, Somyajit, K., Altmeyer, M., Rask, M. D., Lukas, Jiri & Lukas, Claudia, Aug 2016, In: Nature Structural and Molecular Biology. 23, 8, p. 714-21 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      TOPBP1 regulates RAD51 phosphorylation and chromatin loading and determines PARP inhibitor sensitivity

      Moudry, P., Watanabe, K., Wolanin, K. M., Bartkova, J., Wassing, I. E., Watanabe, S., Strauss, R., Pedersen, R. T., Østergaard, Vibe Hallundbæk, Lisby, Michael, Andújar-Sánchez, M., Maya-Mendoza, A., Esashi, F., Lukas, Jiri & Bartek, J., 2016, In: The Journal of Cell Biology. 212, 3, p. 281-288 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Ubiquitin-activating enzyme UBA1 is required for cellular response to DNA damage

      Moudry, P., Lukas, Claudia, Macurek, L., Hanzlikova, H., Hodny, Z., Lukas, Jiri & Bartek, J., 15 Apr 2012, In: Cell Cycle. 11, 8, p. 1573-82 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Published

      DVC1 (C1orf124) is a DNA damage-targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks

      Mosbech, A., Gibbs-Seymour, I., Kagias, K., Thorslund, T., Beli, P., Povlsen, L., Nielsen, S. V., Smedegaard, S., Sedgwick, G., Lukas, Claudia, Hartmann-Petersen, Rasmus, Lukas, Jiri, Choudhary, Chunaram, Pocock, R. D. J., Bekker-Jensen, Simon Holst & Mailand, Niels, 2012, In: Nature Structural and Molecular Biology. 19, 11, p. 1084-92 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      Low-dose DNA damage and replication stress responses quantified by optimized automated single-cell image analysis

      Mistrik, M., Oplustilova, L., Lukas, Jiri & Bartek, J., 2009, In: Cell Cycle. 8, 16, p. 2592-9 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Phosphorylation of SDT repeats in the MDC1 N terminus triggers retention of NBS1 at the DNA damage-modified chromatin

      Melander, F., Bekker-Jensen, Simon Holst, Falck, J., Bartek, J., Mailand, Niels & Lukas, Jiri, 21 Apr 2008, In: Journal of Cell Biology. 181, 2, p. 213-26 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Nucleotide excision repair-induced H2A ubiquitination is dependent on MDC1 and RNF8 and reveals a universal DNA damage response

      Marteijn, J. A., Bekker-Jensen, Simon Holst, Mailand, Niels, Lans, H., Schwertman, P., Gourdin, A. M., Dantuma, N. P., Lukas, Jiri & Vermeulen, W., 2009, In: Journal of Cell Biology. 186, 6, p. 835-47 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

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