Jiri Lukas
Executive Director, Professor
- 2023
- Published
- 2022
- Published
Solving the MCM paradox by visualizing the scaffold of CMG helicase at active replisomes
Polasek-Sedlackova, H., Miller, Thomas, Krejci, J., Rask, M. B. & Lukas, Jiri, 2022, In: Nature Communications. 13, 11 p., 6090.Research output: Contribution to journal › Journal article › Research › peer-review
- 2021
- Published
Homology-directed repair protects the replicating genome from metabolic assaults
Somyajit, K., Spies, J., Coscia, F., Kirik, U., Rask, M., Lee, J., Neelsen, K. J., Mund, Andreas, Jensen, Lars Juhl, Paull, T. T., Mann, Matthias & Lukas, Jiri, 2021, In: Developmental Cell. 56, 4, p. 461-477.e7Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Homologous recombination as a fundamental genome surveillance mechanism during dna replication
Spies, J., Polasek-Sedlackova, H., Lukas, Jiri & Somyajit, K., 2021, In: Genes. 12, 12, 17 p., 1960.Research output: Contribution to journal › Review › Research › peer-review
- 2020
- Published
Physiological Tolerance to ssDNA Enables Strand Uncoupling during DNA Replication
Ercilla, A., Benada, Jan, Gadi, Sampath Amitash, Zonderland, Gijs, Baldi, G., Somyajit, K., Ochs, Fena, Costanzo, V., Lukas, Jiri & Toledo, L., 2020, In: Cell Reports. 30, 7, p. 2416-2429.e7 22 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Equilibrium between nascent and parental MCM proteins protects replicating genomes
Sedlackova, H., Rask, M., Gupta, R., Choudhary, Chunaram, Somyajit, K. & Lukas, Jiri, 2020, In: Nature. 587, p. 297-302 34 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2019
- Published
Stabilization of chromatin topology safeguards genome integrity
Ochs, Fena, Karemore, G., Miron, E., Brown, J., Sedlackova, H., Rask, M., Lampe, M., Buckle, V., Schermelleh, L., Lukas, Jiri & Lukas, Claudia, 2019, In: Nature. 574, 7779, p. 571-574 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
53BP1 nuclear bodies enforce replication timing at under-replicated DNA to limit heritable DNA damage
Spies, J., Lukas, Claudia, Somyajit, K., Rask, M., Lukas, Jiri & Neelsen, K. J., 2019, In: Nature Cell Biology. 21, p. 487-497Research output: Contribution to journal › Journal article › Research › peer-review
- 2018
- Published
DNA damage-induced dynamic changes in abundance and cytosol-nuclear translocation of proteins involved in translational processes, metabolism, and autophagy
Bennetzen, M. V., Kosar, M., Bunkenborg, J., Payne, M. R., Bartkova, J., Lindström, M. S., Lukas, Jiri, Andersen, J. S., Bartek, J. & Larsen, D. H., 2018, In: Cell Cycle. 17, 17, p. 2146-2163Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability
Galanos, P., Pappas, G., Polyzos, A., Kotsinas, A., Svolaki, I., Giakoumakis, N. N., Glytsou, C., Pateras, I. S., Swain, U., Souliotis, V. L., Georgakilas, A. G., Geacintov, N., Scorrano, L., Lukas, C., Lukas, J., Livneh, Z., Lygerou, Z., Chowdhury, D., Sørensen, C. S., Bartek, J. & 1 others, , 2018, In: Genome Biology (Online Edition). 19, p. 1-18 37.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity
Gupta, R., Somyajit, K., Narita, Takeo, Maskey, E., Stanlie, A., Kremer, M., Typas, D., Lammers, M., Mailand, Niels, Nussenzweig, A., Lukas, Jiri & Choudhary, Chunaram, 2018, In: Cell. 173, 4, p. 972-988Research output: Contribution to journal › Journal article › Research › peer-review
- 2017
- Published
Redox-sensitive alteration of replisome architecture safeguards genome integrity
Somyajit, K., Gupta, R., Sedlackova, H., Neelsen, K. J., Ochs, Fena, Rask, M., Choudhary, Chunaram & Lukas, Jiri, 10 Nov 2017, In: Science. 358, 6364, p. 797-802 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Replication Catastrophe: When a Checkpoint Fails because of Exhaustion
Toledo, L., Neelsen, K. J. & Lukas, Jiri, 15 Jun 2017, In: Molecular Cell. 66, 6, p. 735-749 15 p.Research output: Contribution to journal › Review › Research › peer-review
- 2016
- Published
TOPBP1 regulates RAD51 phosphorylation and chromatin loading and determines PARP inhibitor sensitivity
Moudry, P., Watanabe, K., Wolanin, K. M., Bartkova, J., Wassing, I. E., Watanabe, S., Strauss, R., Pedersen, R. T., Østergaard, Vibe Hallundbæk, Lisby, Michael, Andújar-Sánchez, M., Maya-Mendoza, A., Esashi, F., Lukas, Jiri & Bartek, J., 2016, In: The Journal of Cell Biology. 212, 3, p. 281-288 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
53BP1 fosters fidelity of homology-directed DNA repair
Ochs, Fena, Somyajit, K., Altmeyer, M., Rask, M. D., Lukas, Jiri & Lukas, Claudia, Aug 2016, In: Nature Structural and Molecular Biology. 23, 8, p. 714-21 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Profiling DNA damage response following mitotic perturbations
Pedersen, R. S., Karemore, G., Gudjónsson, Thorkell, Rask, M., Neumann, B., Hériché, J., Pepperkok, R., Ellenberg, J., Gerlich, D. W., Lukas, Jiri & Lukas, Claudia, 15 Dec 2016, In: Nature Communications. 7, 12 p., 13887.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mammalian RAD52 Functions in Break-Induced Replication Repair of Collapsed DNA Replication Forks
Sotiriou, S. K., Kamileri, I., Lugli, N., Evangelou, K., Da-Ré, C., Huber, F., Padayachy, L., Tardy, S., Nicati, N. L., Barriot, S., Ochs, Fena, Lukas, Claudia, Lukas, Jiri, Gorgoulis, V. G., Scapozza, L. & Halazonetis, T. D., 15 Dec 2016, In: Molecular Cell. 64, 6, p. 1127-1134 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2015
- Published
Liquid demixing of intrinsically disordered proteins is seeded by poly(ADP-ribose)
Altmeyer, M., Neelsen, K. J., Teloni, F., Pozdnyakova, I., Pellegrino, S., Grøfte, M., Rask, M. D., Streicher, W., Jungmichel, S., Nielsen, Michael Lund & Lukas, Jiri, 19 Aug 2015, In: Nature Communications. 6, p. 1-12 8088.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A lncRNA to repair DNA
Lukas, Jiri & Altmeyer, M., 2015, In: E M B O Reports. 16, 11, p. 1413-1414 2 p.Research output: Contribution to journal › Comment/debate › Research
- Published
Ectopic expression of RNF168 and 53BP1 increases mutagenic but not physiological non-homologous end joining
Zong, D., Callén, E., Pegoraro, G., Lukas, Claudia, Lukas, Jiri & Nussenzweig, A., 26 May 2015, In: Nucleic Acids Research. 43, 10, p. 4950-61 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2014
- Published
The NBS1-Treacle complex controls ribosomal RNA transcription in response to DNA damage
Larsen, D. H., Hari, F., Clapperton, J. A., Gwerder, M., Gutsche, K., Altmeyer, M., Jungmichel, S., Toledo Lazaro, L. I., Fink, D., Rask, M., Grøfte, M., Lukas, Claudia, Nielsen, Michael Lund, Smerdon, S. J., Lukas, Jiri & Stucki, M., Aug 2014, In: Nature Cell Biology. 16, 8, p. 792-803 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2013
- Published
To spread or not to spread - chromatin modifications in response to DNA damage
Altmeyer, M. & Lukas, Jiri, 9 Jan 2013, In: Current Opinion in Genetics & Development. 23, 2, p. 156-165 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Guarding against Collateral Damage during Chromatin Transactions
Altmeyer, M. & Lukas, Jiri, 20 Jun 2013, In: Cell. 153, 7, p. 1431-4 4 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
The Chromatin Scaffold Protein SAFB1 Renders Chromatin Permissive for DNA Damage Signaling
Altmeyer, M., Toledo Lazaro, L. I., Gudjónsson, Thorkell, Grøfte, M., Rask, M., Lukas, Claudia, Akimov, V., Blagoev, B., Bartek, J. & Lukas, Jiri, 24 Oct 2013, In: Molecular Cell. 52, 2, p. 206-220Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Acetylation dynamics of human nuclear proteins during the ionizing radiation-induced DNA damage response
Bennetzen, M., Andersen, J. S., Lasen, D. H., Dinant, C., Watanabe, S., Bartek, J. & Lukas, Jiri, 1 Jun 2013, In: Cell Cycle. 12, 11, p. 1688-1695 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 37762642
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326
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TOPBP1 regulates RAD51 phosphorylation and chromatin loading and determines PARP inhibitor sensitivity
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
175
downloads
Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
156
downloads
Physiological Tolerance to ssDNA Enables Strand Uncoupling during DNA Replication
Research output: Contribution to journal › Journal article › Research › peer-review
Published