Overview of the Knowledge Management Center for Illuminating the Druggable Genome

Research output: Contribution to journal › Review › Research › peer-review

Standard

Overview of the Knowledge Management Center for Illuminating the Druggable Genome. / Oprea, Tudor I.; Bologa, Cristian; Holmes, Jayme; Mathias, Stephen; Metzger, Vincent T.; Waller, Anna; Yang, Jeremy J.; Leach, Andrew R.; Jensen, Lars Juhl; Kelleher, Keith J.; Sheils, Timothy K.; Mathé, Ewy; Avram, Sorin; Edwards, Jeremy S.

In: Drug Discovery Today, Vol. 29, No. 3, 103882, 2024.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Oprea, TI, Bologa, C, Holmes, J, Mathias, S, Metzger, VT, Waller, A, Yang, JJ, Leach, AR, Jensen, LJ, Kelleher, KJ, Sheils, TK, Mathé, E, Avram, S & Edwards, JS 2024, 'Overview of the Knowledge Management Center for Illuminating the Druggable Genome', Drug Discovery Today, vol. 29, no. 3, 103882. https://doi.org/10.1016/j.drudis.2024.103882

APA

Oprea, T. I., Bologa, C., Holmes, J., Mathias, S., Metzger, V. T., Waller, A., Yang, J. J., Leach, A. R., Jensen, L. J., Kelleher, K. J., Sheils, T. K., Mathé, E., Avram, S., & Edwards, J. S. (2024). Overview of the Knowledge Management Center for Illuminating the Druggable Genome. Drug Discovery Today, 29(3), [103882]. https://doi.org/10.1016/j.drudis.2024.103882

Vancouver

Oprea TI, Bologa C, Holmes J, Mathias S, Metzger VT, Waller A et al. Overview of the Knowledge Management Center for Illuminating the Druggable Genome. Drug Discovery Today. 2024;29(3). 103882. https://doi.org/10.1016/j.drudis.2024.103882

Author

Oprea, Tudor I. ; Bologa, Cristian ; Holmes, Jayme ; Mathias, Stephen ; Metzger, Vincent T. ; Waller, Anna ; Yang, Jeremy J. ; Leach, Andrew R. ; Jensen, Lars Juhl ; Kelleher, Keith J. ; Sheils, Timothy K. ; Mathé, Ewy ; Avram, Sorin ; Edwards, Jeremy S. / Overview of the Knowledge Management Center for Illuminating the Druggable Genome. In: Drug Discovery Today. 2024 ; Vol. 29, No. 3.

Bibtex

@article{eca22382aacb430cac1f8dd1f665602e,
title = "Overview of the Knowledge Management Center for Illuminating the Druggable Genome",
abstract = "The Knowledge Management Center (KMC) for the Illuminating the Druggable Genome (IDG) project aims to aggregate, update, and articulate protein-centric data knowledge for the entire human proteome, with emphasis on the understudied proteins from the three IDG protein families. KMC collates and analyzes data from over 70 resources to compile the Target Central Resource Database (TCRD), which is the web-based informatics platform (Pharos). These data include experimental, computational, and text-mined information on protein structures, compound interactions, and disease and phenotype associations. Based on this knowledge, proteins are classified into different Target Development Levels (TDLs) for identification of understudied targets. Additional work by the KMC focuses on enriching target knowledge and producing DrugCentral and other data visualization tools for expanding investigation of understudied targets.",
keywords = "database, druggable genome, knowledge management, pharos",
author = "Oprea, {Tudor I.} and Cristian Bologa and Jayme Holmes and Stephen Mathias and Metzger, {Vincent T.} and Anna Waller and Yang, {Jeremy J.} and Leach, {Andrew R.} and Jensen, {Lars Juhl} and Kelleher, {Keith J.} and Sheils, {Timothy K.} and Ewy Math{\'e} and Sorin Avram and Edwards, {Jeremy S.}",
note = "Publisher Copyright: {\textcopyright} 2024 The Author(s)",
year = "2024",
doi = "10.1016/j.drudis.2024.103882",
language = "English",
volume = "29",
journal = "Drug Discovery Today: BIOSILICO",
issn = "1359-6446",
publisher = "Elsevier Ltd. * Trends Journals",
number = "3",

}

RIS

TY - JOUR

T1 - Overview of the Knowledge Management Center for Illuminating the Druggable Genome

AU - Oprea, Tudor I.

AU - Bologa, Cristian

AU - Holmes, Jayme

AU - Mathias, Stephen

AU - Metzger, Vincent T.

AU - Waller, Anna

AU - Yang, Jeremy J.

AU - Leach, Andrew R.

AU - Jensen, Lars Juhl

AU - Kelleher, Keith J.

AU - Sheils, Timothy K.

AU - Mathé, Ewy

AU - Avram, Sorin

AU - Edwards, Jeremy S.

N1 - Publisher Copyright: © 2024 The Author(s)

PY - 2024

Y1 - 2024

N2 - The Knowledge Management Center (KMC) for the Illuminating the Druggable Genome (IDG) project aims to aggregate, update, and articulate protein-centric data knowledge for the entire human proteome, with emphasis on the understudied proteins from the three IDG protein families. KMC collates and analyzes data from over 70 resources to compile the Target Central Resource Database (TCRD), which is the web-based informatics platform (Pharos). These data include experimental, computational, and text-mined information on protein structures, compound interactions, and disease and phenotype associations. Based on this knowledge, proteins are classified into different Target Development Levels (TDLs) for identification of understudied targets. Additional work by the KMC focuses on enriching target knowledge and producing DrugCentral and other data visualization tools for expanding investigation of understudied targets.

AB - The Knowledge Management Center (KMC) for the Illuminating the Druggable Genome (IDG) project aims to aggregate, update, and articulate protein-centric data knowledge for the entire human proteome, with emphasis on the understudied proteins from the three IDG protein families. KMC collates and analyzes data from over 70 resources to compile the Target Central Resource Database (TCRD), which is the web-based informatics platform (Pharos). These data include experimental, computational, and text-mined information on protein structures, compound interactions, and disease and phenotype associations. Based on this knowledge, proteins are classified into different Target Development Levels (TDLs) for identification of understudied targets. Additional work by the KMC focuses on enriching target knowledge and producing DrugCentral and other data visualization tools for expanding investigation of understudied targets.

KW - database

KW - druggable genome

KW - knowledge management

KW - pharos

U2 - 10.1016/j.drudis.2024.103882

DO - 10.1016/j.drudis.2024.103882

M3 - Review

C2 - 38218214

AN - SCOPUS:85184021698

VL - 29

JO - Drug Discovery Today: BIOSILICO

JF - Drug Discovery Today: BIOSILICO

SN - 1359-6446

IS - 3

M1 - 103882

ER -

ID: 382499946