Differentially Expressed miRNAs in Ulcerative Colitis and Crohn's Disease

Research output: Contribution to journal › Review › Research › peer-review

Standard

Differentially Expressed miRNAs in Ulcerative Colitis and Crohn's Disease. / Yarani, Reza; Shojaeian, Ali; Palasca, Oana; Doncheva, Nadezhda T; Jensen, Lars Juhl; Gorodkin, Jan; Pociot, Flemming.

In: Frontiers in Immunology, Vol. 13, 865777, 2022.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Yarani, R, Shojaeian, A, Palasca, O, Doncheva, NT, Jensen, LJ, Gorodkin, J & Pociot, F 2022, 'Differentially Expressed miRNAs in Ulcerative Colitis and Crohn's Disease', Frontiers in Immunology, vol. 13, 865777. https://doi.org/10.3389/fimmu.2022.865777

APA

Yarani, R., Shojaeian, A., Palasca, O., Doncheva, N. T., Jensen, L. J., Gorodkin, J., & Pociot, F. (2022). Differentially Expressed miRNAs in Ulcerative Colitis and Crohn's Disease. Frontiers in Immunology, 13, [865777]. https://doi.org/10.3389/fimmu.2022.865777

Vancouver

Yarani R, Shojaeian A, Palasca O, Doncheva NT, Jensen LJ, Gorodkin J et al. Differentially Expressed miRNAs in Ulcerative Colitis and Crohn's Disease. Frontiers in Immunology. 2022;13. 865777. https://doi.org/10.3389/fimmu.2022.865777

Author

Yarani, Reza ; Shojaeian, Ali ; Palasca, Oana ; Doncheva, Nadezhda T ; Jensen, Lars Juhl ; Gorodkin, Jan ; Pociot, Flemming. / Differentially Expressed miRNAs in Ulcerative Colitis and Crohn's Disease. In: Frontiers in Immunology. 2022 ; Vol. 13.

Bibtex

@article{0dcb925284124ba7a1c6a8ca97ce15c1,
title = "Differentially Expressed miRNAs in Ulcerative Colitis and Crohn's Disease",
abstract = "Differential microRNA (miRNA or miR) regulation is linked to the development and progress of many diseases, including inflammatory bowel disease (IBD). It is well-established that miRNAs are involved in the differentiation, maturation, and functional control of immune cells. miRNAs modulate inflammatory cascades and affect the extracellular matrix, tight junctions, cellular hemostasis, and microbiota. This review summarizes current knowledge of differentially expressed miRNAs in mucosal tissues and peripheral blood of patients with ulcerative colitis and Crohn's disease. We combined comprehensive literature curation with computational meta-analysis of publicly available high-throughput datasets to obtain a consensus set of miRNAs consistently differentially expressed in mucosal tissues. We further describe the role of the most relevant differentially expressed miRNAs in IBD, extract their potential targets involved in IBD, and highlight their diagnostic and therapeutic potential for future investigations.",
keywords = "Colitis, Ulcerative/therapy, Crohn Disease/diagnosis, Humans, Inflammatory Bowel Diseases, MicroRNAs/genetics",
author = "Reza Yarani and Ali Shojaeian and Oana Palasca and Doncheva, {Nadezhda T} and Jensen, {Lars Juhl} and Jan Gorodkin and Flemming Pociot",
note = "Copyright {\textcopyright} 2022 Yarani, Shojaeian, Palasca, Doncheva, Jensen, Gorodkin and Pociot.",
year = "2022",
doi = "10.3389/fimmu.2022.865777",
language = "English",
volume = "13",
journal = "Frontiers in Immunology",
issn = "1664-3224",
publisher = "Frontiers Research Foundation",

}

RIS

TY - JOUR

T1 - Differentially Expressed miRNAs in Ulcerative Colitis and Crohn's Disease

AU - Yarani, Reza

AU - Shojaeian, Ali

AU - Palasca, Oana

AU - Doncheva, Nadezhda T

AU - Jensen, Lars Juhl

AU - Gorodkin, Jan

AU - Pociot, Flemming

N1 - Copyright © 2022 Yarani, Shojaeian, Palasca, Doncheva, Jensen, Gorodkin and Pociot.

PY - 2022

Y1 - 2022

N2 - Differential microRNA (miRNA or miR) regulation is linked to the development and progress of many diseases, including inflammatory bowel disease (IBD). It is well-established that miRNAs are involved in the differentiation, maturation, and functional control of immune cells. miRNAs modulate inflammatory cascades and affect the extracellular matrix, tight junctions, cellular hemostasis, and microbiota. This review summarizes current knowledge of differentially expressed miRNAs in mucosal tissues and peripheral blood of patients with ulcerative colitis and Crohn's disease. We combined comprehensive literature curation with computational meta-analysis of publicly available high-throughput datasets to obtain a consensus set of miRNAs consistently differentially expressed in mucosal tissues. We further describe the role of the most relevant differentially expressed miRNAs in IBD, extract their potential targets involved in IBD, and highlight their diagnostic and therapeutic potential for future investigations.

AB - Differential microRNA (miRNA or miR) regulation is linked to the development and progress of many diseases, including inflammatory bowel disease (IBD). It is well-established that miRNAs are involved in the differentiation, maturation, and functional control of immune cells. miRNAs modulate inflammatory cascades and affect the extracellular matrix, tight junctions, cellular hemostasis, and microbiota. This review summarizes current knowledge of differentially expressed miRNAs in mucosal tissues and peripheral blood of patients with ulcerative colitis and Crohn's disease. We combined comprehensive literature curation with computational meta-analysis of publicly available high-throughput datasets to obtain a consensus set of miRNAs consistently differentially expressed in mucosal tissues. We further describe the role of the most relevant differentially expressed miRNAs in IBD, extract their potential targets involved in IBD, and highlight their diagnostic and therapeutic potential for future investigations.

KW - Colitis, Ulcerative/therapy

KW - Crohn Disease/diagnosis

KW - Humans

KW - Inflammatory Bowel Diseases

KW - MicroRNAs/genetics

U2 - 10.3389/fimmu.2022.865777

DO - 10.3389/fimmu.2022.865777

M3 - Review

C2 - 35734163

VL - 13

JO - Frontiers in Immunology

JF - Frontiers in Immunology

SN - 1664-3224

M1 - 865777

ER -

ID: 312356565