T-cell acute lymphoblastic leukemia in association with Börjeson-Forssman-Lehmann syndrome due to a mutation in PHF6

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T-cell acute lymphoblastic leukemia in association with Börjeson-Forssman-Lehmann syndrome due to a mutation in PHF6. / Chao, Mwe Mwe; Todd, Matthew A.; Kontny, Udo; Neas, Katherine; Sullivan, Michael J.; Hunter, Alasdair G.; Picketts, David J.; Kratz, Christian P.

In: Pediatric Blood and Cancer, Vol. 55, No. 4, 10.2010, p. 722-724.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Chao, MM, Todd, MA, Kontny, U, Neas, K, Sullivan, MJ, Hunter, AG, Picketts, DJ & Kratz, CP 2010, 'T-cell acute lymphoblastic leukemia in association with Börjeson-Forssman-Lehmann syndrome due to a mutation in PHF6', Pediatric Blood and Cancer, vol. 55, no. 4, pp. 722-724. https://doi.org/10.1002/pbc.22574

APA

Chao, M. M., Todd, M. A., Kontny, U., Neas, K., Sullivan, M. J., Hunter, A. G., Picketts, D. J., & Kratz, C. P. (2010). T-cell acute lymphoblastic leukemia in association with Börjeson-Forssman-Lehmann syndrome due to a mutation in PHF6. Pediatric Blood and Cancer, 55(4), 722-724. https://doi.org/10.1002/pbc.22574

Vancouver

Chao MM, Todd MA, Kontny U, Neas K, Sullivan MJ, Hunter AG et al. T-cell acute lymphoblastic leukemia in association with Börjeson-Forssman-Lehmann syndrome due to a mutation in PHF6. Pediatric Blood and Cancer. 2010 Oct;55(4):722-724. https://doi.org/10.1002/pbc.22574

Author

Chao, Mwe Mwe ; Todd, Matthew A. ; Kontny, Udo ; Neas, Katherine ; Sullivan, Michael J. ; Hunter, Alasdair G. ; Picketts, David J. ; Kratz, Christian P. / T-cell acute lymphoblastic leukemia in association with Börjeson-Forssman-Lehmann syndrome due to a mutation in PHF6. In: Pediatric Blood and Cancer. 2010 ; Vol. 55, No. 4. pp. 722-724.

Bibtex

@article{6d538771496a421b843d7c8a8c670482,
title = "T-cell acute lymphoblastic leukemia in association with B{\"o}rjeson-Forssman-Lehmann syndrome due to a mutation in PHF6",
abstract = "B{\"o}rjeson-Forssman-Lehmann syndrome (BFLS) is a rare X-linked mental retardation syndrome that is caused by germline mutations in PHF6. We describe a 9-year-old male with BFLS, who developed T-cell acute lymphoblastic leukemia (T-ALL). The PHF6 gene is located on the X chromosome and encodes a protein with two PHD-type zinc finger domains and four nuclear localization sequences. Previously, overexpression of Phf6 was observed in murine T-cell lymphomas. Our observation indicates that BFLS may represent a cancer predisposition syndrome and that mutations of PHF6 contribute to T-ALL. Pediatr Blood Cancer.",
keywords = "B{\"o}rjeson-Forssman-Lehmann syndrome, PHF6, T-cell ALL/lymphoma",
author = "Chao, {Mwe Mwe} and Todd, {Matthew A.} and Udo Kontny and Katherine Neas and Sullivan, {Michael J.} and Hunter, {Alasdair G.} and Picketts, {David J.} and Kratz, {Christian P.}",
year = "2010",
month = oct,
doi = "10.1002/pbc.22574",
language = "English",
volume = "55",
pages = "722--724",
journal = "Medical and Pediatric Oncology. Supplement",
issn = "0740-8226",
publisher = "JohnWiley & Sons, Inc.",
number = "4",

}

RIS

TY - JOUR

T1 - T-cell acute lymphoblastic leukemia in association with Börjeson-Forssman-Lehmann syndrome due to a mutation in PHF6

AU - Chao, Mwe Mwe

AU - Todd, Matthew A.

AU - Kontny, Udo

AU - Neas, Katherine

AU - Sullivan, Michael J.

AU - Hunter, Alasdair G.

AU - Picketts, David J.

AU - Kratz, Christian P.

PY - 2010/10

Y1 - 2010/10

N2 - Börjeson-Forssman-Lehmann syndrome (BFLS) is a rare X-linked mental retardation syndrome that is caused by germline mutations in PHF6. We describe a 9-year-old male with BFLS, who developed T-cell acute lymphoblastic leukemia (T-ALL). The PHF6 gene is located on the X chromosome and encodes a protein with two PHD-type zinc finger domains and four nuclear localization sequences. Previously, overexpression of Phf6 was observed in murine T-cell lymphomas. Our observation indicates that BFLS may represent a cancer predisposition syndrome and that mutations of PHF6 contribute to T-ALL. Pediatr Blood Cancer.

AB - Börjeson-Forssman-Lehmann syndrome (BFLS) is a rare X-linked mental retardation syndrome that is caused by germline mutations in PHF6. We describe a 9-year-old male with BFLS, who developed T-cell acute lymphoblastic leukemia (T-ALL). The PHF6 gene is located on the X chromosome and encodes a protein with two PHD-type zinc finger domains and four nuclear localization sequences. Previously, overexpression of Phf6 was observed in murine T-cell lymphomas. Our observation indicates that BFLS may represent a cancer predisposition syndrome and that mutations of PHF6 contribute to T-ALL. Pediatr Blood Cancer.

KW - Börjeson-Forssman-Lehmann syndrome

KW - PHF6

KW - T-cell ALL/lymphoma

UR - http://www.scopus.com/inward/record.url?scp=77957078794&partnerID=8YFLogxK

U2 - 10.1002/pbc.22574

DO - 10.1002/pbc.22574

M3 - Journal article

C2 - 20806366

AN - SCOPUS:77957078794

VL - 55

SP - 722

EP - 724

JO - Medical and Pediatric Oncology. Supplement

JF - Medical and Pediatric Oncology. Supplement

SN - 0740-8226

IS - 4

ER -

ID: 319873959