Domain Model Explains Propagation Dynamics and Stability of Histone H3K27 and H3K36 Methylation Landscapes

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Domain Model Explains Propagation Dynamics and Stability of Histone H3K27 and H3K36 Methylation Landscapes. / Alabert, Constance; Loos, Carolin; Voelker-Albert, Moritz; Graziano, Simona; Forné, Ignasi; Reveron-Gomez, Nazaret; Schuh, Lea; Hasenauer, Jan; Marr, Carsten; Imhof, Axel; Groth, Anja.

In: Cell Reports, Vol. 30, No. 4, 2020, p. 1223-1234.e8.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Alabert, C, Loos, C, Voelker-Albert, M, Graziano, S, Forné, I, Reveron-Gomez, N, Schuh, L, Hasenauer, J, Marr, C, Imhof, A & Groth, A 2020, 'Domain Model Explains Propagation Dynamics and Stability of Histone H3K27 and H3K36 Methylation Landscapes', Cell Reports, vol. 30, no. 4, pp. 1223-1234.e8. https://doi.org/10.1016/j.celrep.2019.12.060

APA

Alabert, C., Loos, C., Voelker-Albert, M., Graziano, S., Forné, I., Reveron-Gomez, N., Schuh, L., Hasenauer, J., Marr, C., Imhof, A., & Groth, A. (2020). Domain Model Explains Propagation Dynamics and Stability of Histone H3K27 and H3K36 Methylation Landscapes. Cell Reports, 30(4), 1223-1234.e8. https://doi.org/10.1016/j.celrep.2019.12.060

Vancouver

Alabert C, Loos C, Voelker-Albert M, Graziano S, Forné I, Reveron-Gomez N et al. Domain Model Explains Propagation Dynamics and Stability of Histone H3K27 and H3K36 Methylation Landscapes. Cell Reports. 2020;30(4):1223-1234.e8. https://doi.org/10.1016/j.celrep.2019.12.060

Author

Alabert, Constance ; Loos, Carolin ; Voelker-Albert, Moritz ; Graziano, Simona ; Forné, Ignasi ; Reveron-Gomez, Nazaret ; Schuh, Lea ; Hasenauer, Jan ; Marr, Carsten ; Imhof, Axel ; Groth, Anja. / Domain Model Explains Propagation Dynamics and Stability of Histone H3K27 and H3K36 Methylation Landscapes. In: Cell Reports. 2020 ; Vol. 30, No. 4. pp. 1223-1234.e8.

Bibtex

@article{819d44b74230469681c222897de189fa,
title = "Domain Model Explains Propagation Dynamics and Stability of Histone H3K27 and H3K36 Methylation Landscapes",
abstract = "Chromatin states must be maintained during cell proliferation to uphold cellular identity and genome integrity. Inheritance of histone modifications is central in this process. However, the histone modification landscape is challenged by incorporation of new unmodified histones during each cell cycle, and the principles governing heritability remain unclear. We take a quantitative computational modeling approach to describe propagation of histone H3K27 and H3K36 methylation states. We measure combinatorial H3K27 and H3K36 methylation patterns by quantitative mass spectrometry on subsequent generations of histones. Using model comparison, we reject active global demethylation and invoke the existence of domains defined by distinct methylation endpoints. We find that H3K27me3 on pre-existing histones stimulates the rate of de novo H3K27me3 establishment, supporting a read-write mechanism in timely chromatin restoration. Finally, we provide a detailed quantitative picture of the mutual antagonism between H3K27 and H3K36 methylation and propose that it stabilizes epigenetic states across cell division.",
author = "Constance Alabert and Carolin Loos and Moritz Voelker-Albert and Simona Graziano and Ignasi Forn{\'e} and Nazaret Reveron-Gomez and Lea Schuh and Jan Hasenauer and Carsten Marr and Axel Imhof and Anja Groth",
year = "2020",
doi = "10.1016/j.celrep.2019.12.060",
language = "English",
volume = "30",
pages = "1223--1234.e8",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "4",

}

RIS

TY - JOUR

T1 - Domain Model Explains Propagation Dynamics and Stability of Histone H3K27 and H3K36 Methylation Landscapes

AU - Alabert, Constance

AU - Loos, Carolin

AU - Voelker-Albert, Moritz

AU - Graziano, Simona

AU - Forné, Ignasi

AU - Reveron-Gomez, Nazaret

AU - Schuh, Lea

AU - Hasenauer, Jan

AU - Marr, Carsten

AU - Imhof, Axel

AU - Groth, Anja

PY - 2020

Y1 - 2020

N2 - Chromatin states must be maintained during cell proliferation to uphold cellular identity and genome integrity. Inheritance of histone modifications is central in this process. However, the histone modification landscape is challenged by incorporation of new unmodified histones during each cell cycle, and the principles governing heritability remain unclear. We take a quantitative computational modeling approach to describe propagation of histone H3K27 and H3K36 methylation states. We measure combinatorial H3K27 and H3K36 methylation patterns by quantitative mass spectrometry on subsequent generations of histones. Using model comparison, we reject active global demethylation and invoke the existence of domains defined by distinct methylation endpoints. We find that H3K27me3 on pre-existing histones stimulates the rate of de novo H3K27me3 establishment, supporting a read-write mechanism in timely chromatin restoration. Finally, we provide a detailed quantitative picture of the mutual antagonism between H3K27 and H3K36 methylation and propose that it stabilizes epigenetic states across cell division.

AB - Chromatin states must be maintained during cell proliferation to uphold cellular identity and genome integrity. Inheritance of histone modifications is central in this process. However, the histone modification landscape is challenged by incorporation of new unmodified histones during each cell cycle, and the principles governing heritability remain unclear. We take a quantitative computational modeling approach to describe propagation of histone H3K27 and H3K36 methylation states. We measure combinatorial H3K27 and H3K36 methylation patterns by quantitative mass spectrometry on subsequent generations of histones. Using model comparison, we reject active global demethylation and invoke the existence of domains defined by distinct methylation endpoints. We find that H3K27me3 on pre-existing histones stimulates the rate of de novo H3K27me3 establishment, supporting a read-write mechanism in timely chromatin restoration. Finally, we provide a detailed quantitative picture of the mutual antagonism between H3K27 and H3K36 methylation and propose that it stabilizes epigenetic states across cell division.

U2 - 10.1016/j.celrep.2019.12.060

DO - 10.1016/j.celrep.2019.12.060

M3 - Journal article

C2 - 31995760

VL - 30

SP - 1223-1234.e8

JO - Cell Reports

JF - Cell Reports

SN - 2211-1247

IS - 4

ER -

ID: 235529786