Histone Acetyltransferase MOF Blocks Acquisition of Quiescence in Ground-State ESCs through Activating Fatty Acid Oxidation

Research output: Contribution to journal › Journal article › Research › peer-review

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Histone Acetyltransferase MOF Blocks Acquisition of Quiescence in Ground-State ESCs through Activating Fatty Acid Oxidation. / Khoa, Le Tran Phuc; Tsan, Yao-Chang; Mao, Fengbiao; Kremer, Daniel M; Sajjakulnukit, Peter; Zhang, Li; Zhou, Bo; Tong, Xin; Bhanu, Natarajan V; Choudhary, Chunaram; Garcia, Benjamin A; Yin, Lei; Smith, Gary D; Saunders, Thomas L; Bielas, Stephanie L; Lyssiotis, Costas A; Dou, Yali.

In: Cell Stem Cell, Vol. 27, No. 3, 2020, p. 441-458.e10.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Khoa, LTP, Tsan, Y-C, Mao, F, Kremer, DM, Sajjakulnukit, P, Zhang, L, Zhou, B, Tong, X, Bhanu, NV, Choudhary, C, Garcia, BA, Yin, L, Smith, GD, Saunders, TL, Bielas, SL, Lyssiotis, CA & Dou, Y 2020, 'Histone Acetyltransferase MOF Blocks Acquisition of Quiescence in Ground-State ESCs through Activating Fatty Acid Oxidation', Cell Stem Cell, vol. 27, no. 3, pp. 441-458.e10. https://doi.org/10.1016/j.stem.2020.06.005

APA

Khoa, L. T. P., Tsan, Y-C., Mao, F., Kremer, D. M., Sajjakulnukit, P., Zhang, L., Zhou, B., Tong, X., Bhanu, N. V., Choudhary, C., Garcia, B. A., Yin, L., Smith, G. D., Saunders, T. L., Bielas, S. L., Lyssiotis, C. A., & Dou, Y. (2020). Histone Acetyltransferase MOF Blocks Acquisition of Quiescence in Ground-State ESCs through Activating Fatty Acid Oxidation. Cell Stem Cell, 27(3), 441-458.e10. https://doi.org/10.1016/j.stem.2020.06.005

Vancouver

Khoa LTP, Tsan Y-C, Mao F, Kremer DM, Sajjakulnukit P, Zhang L et al. Histone Acetyltransferase MOF Blocks Acquisition of Quiescence in Ground-State ESCs through Activating Fatty Acid Oxidation. Cell Stem Cell. 2020;27(3):441-458.e10. https://doi.org/10.1016/j.stem.2020.06.005

Author

Khoa, Le Tran Phuc ; Tsan, Yao-Chang ; Mao, Fengbiao ; Kremer, Daniel M ; Sajjakulnukit, Peter ; Zhang, Li ; Zhou, Bo ; Tong, Xin ; Bhanu, Natarajan V ; Choudhary, Chunaram ; Garcia, Benjamin A ; Yin, Lei ; Smith, Gary D ; Saunders, Thomas L ; Bielas, Stephanie L ; Lyssiotis, Costas A ; Dou, Yali. / Histone Acetyltransferase MOF Blocks Acquisition of Quiescence in Ground-State ESCs through Activating Fatty Acid Oxidation. In: Cell Stem Cell. 2020 ; Vol. 27, No. 3. pp. 441-458.e10.

Bibtex

@article{7ad1235e9306494fa685f72c3755fa29,
title = "Histone Acetyltransferase MOF Blocks Acquisition of Quiescence in Ground-State ESCs through Activating Fatty Acid Oxidation",
abstract = "Self-renewing embryonic stem cells (ESCs) respond to environmental cues by exiting pluripotency or entering a quiescent state. The molecular basis underlying this fate choice remains unclear. Here, we show that histone acetyltransferase MOF plays a critical role in this process through directly activating fatty acid oxidation (FAO) in the ground-state ESCs. We further show that the ground-state ESCs particularly rely on elevated FAO for oxidative phosphorylation (OXPHOS) and energy production. Mof deletion or FAO inhibition induces bona fide quiescent ground-state ESCs with an intact core pluripotency network and transcriptome signatures akin to the diapaused epiblasts in vivo. Mechanistically, MOF/FAO inhibition acts through reducing mitochondrial respiration (i.e., OXPHOS), which in turn triggers reversible pluripotent quiescence specifically in the ground-state ESCs. The inhibition of FAO/OXPHOS also induces quiescence in naive human ESCs. Our study suggests a general function of the MOF/FAO/OXPHOS axis in regulating cell fate determination in stem cells.",
author = "Khoa, {Le Tran Phuc} and Yao-Chang Tsan and Fengbiao Mao and Kremer, {Daniel M} and Peter Sajjakulnukit and Li Zhang and Bo Zhou and Xin Tong and Bhanu, {Natarajan V} and Chunaram Choudhary and Garcia, {Benjamin A} and Lei Yin and Smith, {Gary D} and Saunders, {Thomas L} and Bielas, {Stephanie L} and Lyssiotis, {Costas A} and Yali Dou",
year = "2020",
doi = "10.1016/j.stem.2020.06.005",
language = "English",
volume = "27",
pages = "441--458.e10",
journal = "Cell Stem Cell",
issn = "1934-5909",
publisher = "Cell Press",
number = "3",

}

RIS

TY - JOUR

T1 - Histone Acetyltransferase MOF Blocks Acquisition of Quiescence in Ground-State ESCs through Activating Fatty Acid Oxidation

AU - Khoa, Le Tran Phuc

AU - Tsan, Yao-Chang

AU - Mao, Fengbiao

AU - Kremer, Daniel M

AU - Sajjakulnukit, Peter

AU - Zhang, Li

AU - Zhou, Bo

AU - Tong, Xin

AU - Bhanu, Natarajan V

AU - Choudhary, Chunaram

AU - Garcia, Benjamin A

AU - Yin, Lei

AU - Smith, Gary D

AU - Saunders, Thomas L

AU - Bielas, Stephanie L

AU - Lyssiotis, Costas A

AU - Dou, Yali

PY - 2020

Y1 - 2020

N2 - Self-renewing embryonic stem cells (ESCs) respond to environmental cues by exiting pluripotency or entering a quiescent state. The molecular basis underlying this fate choice remains unclear. Here, we show that histone acetyltransferase MOF plays a critical role in this process through directly activating fatty acid oxidation (FAO) in the ground-state ESCs. We further show that the ground-state ESCs particularly rely on elevated FAO for oxidative phosphorylation (OXPHOS) and energy production. Mof deletion or FAO inhibition induces bona fide quiescent ground-state ESCs with an intact core pluripotency network and transcriptome signatures akin to the diapaused epiblasts in vivo. Mechanistically, MOF/FAO inhibition acts through reducing mitochondrial respiration (i.e., OXPHOS), which in turn triggers reversible pluripotent quiescence specifically in the ground-state ESCs. The inhibition of FAO/OXPHOS also induces quiescence in naive human ESCs. Our study suggests a general function of the MOF/FAO/OXPHOS axis in regulating cell fate determination in stem cells.

AB - Self-renewing embryonic stem cells (ESCs) respond to environmental cues by exiting pluripotency or entering a quiescent state. The molecular basis underlying this fate choice remains unclear. Here, we show that histone acetyltransferase MOF plays a critical role in this process through directly activating fatty acid oxidation (FAO) in the ground-state ESCs. We further show that the ground-state ESCs particularly rely on elevated FAO for oxidative phosphorylation (OXPHOS) and energy production. Mof deletion or FAO inhibition induces bona fide quiescent ground-state ESCs with an intact core pluripotency network and transcriptome signatures akin to the diapaused epiblasts in vivo. Mechanistically, MOF/FAO inhibition acts through reducing mitochondrial respiration (i.e., OXPHOS), which in turn triggers reversible pluripotent quiescence specifically in the ground-state ESCs. The inhibition of FAO/OXPHOS also induces quiescence in naive human ESCs. Our study suggests a general function of the MOF/FAO/OXPHOS axis in regulating cell fate determination in stem cells.

U2 - 10.1016/j.stem.2020.06.005

DO - 10.1016/j.stem.2020.06.005

M3 - Journal article

C2 - 32610040

VL - 27

SP - 441-458.e10

JO - Cell Stem Cell

JF - Cell Stem Cell

SN - 1934-5909

IS - 3

ER -

ID: 244995365