The Interplay of Non-coding RNAs and X Chromosome Inactivation in Human Disease

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

Standard

The Interplay of Non-coding RNAs and X Chromosome Inactivation in Human Disease. / Russo, Francesco; De Masi, Federico; Brunak, Søren; Belling, Kirstine G.

Systems Biology. ed. / Nikolaus Rajewsky; Stefan Jurga; Jan Barciszewski. Springer, 2018. p. 229-238 (RNA Technologies).

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

Harvard

Russo, F, De Masi, F, Brunak, S & Belling, KG 2018, The Interplay of Non-coding RNAs and X Chromosome Inactivation in Human Disease. in N Rajewsky, S Jurga & J Barciszewski (eds), Systems Biology. Springer, RNA Technologies, pp. 229-238. https://doi.org/10.1007/978-3-319-92967-5_11

APA

Russo, F., De Masi, F., Brunak, S., & Belling, K. G. (2018). The Interplay of Non-coding RNAs and X Chromosome Inactivation in Human Disease. In N. Rajewsky, S. Jurga, & J. Barciszewski (Eds.), Systems Biology (pp. 229-238). Springer. RNA Technologies https://doi.org/10.1007/978-3-319-92967-5_11

Vancouver

Russo F, De Masi F, Brunak S, Belling KG. The Interplay of Non-coding RNAs and X Chromosome Inactivation in Human Disease. In Rajewsky N, Jurga S, Barciszewski J, editors, Systems Biology. Springer. 2018. p. 229-238. (RNA Technologies). https://doi.org/10.1007/978-3-319-92967-5_11

Author

Russo, Francesco ; De Masi, Federico ; Brunak, Søren ; Belling, Kirstine G. / The Interplay of Non-coding RNAs and X Chromosome Inactivation in Human Disease. Systems Biology. editor / Nikolaus Rajewsky ; Stefan Jurga ; Jan Barciszewski. Springer, 2018. pp. 229-238 (RNA Technologies).

Bibtex

@inbook{607adfa9351849beb8f9fd2288dd07a1,
title = "The Interplay of Non-coding RNAs and X Chromosome Inactivation in Human Disease",
abstract = "Non-coding RNAs (ncRNAs) represent key molecular players in biological processes and human disease. Several ncRNA types have been discovered including microRNAs (miRNAs) of around 23 nucleotides and long non-coding RNAs (lncRNAs) that are above 200 nucleotides in length. One of the first functional ncRNAs discovered was the lncRNA named X inactive specific transcript (XIST). XIST is the main actor in a fundamental process called X chromosome inactivation (XCI) where, in females, one of the two X chromosomes is silenced to balance the extra gene expression dosage. In this book chapter, we present the emerging evidence for the importance of XCI in diseases such as gastric and bladder cancer and genetic pathologies such as Klinefelter (47,XXY) and Turner (45,X0) syndromes. Furthermore, a new role for the crosstalk between XIST and miRNAs is discussed. Finally, new evidence for sex bias of XCI in human tissues and development of cancer is presented.",
author = "Francesco Russo and {De Masi}, Federico and S{\o}ren Brunak and Belling, {Kirstine G}",
year = "2018",
doi = "10.1007/978-3-319-92967-5_11",
language = "English",
isbn = "978-3-319-92966-8",
series = "RNA Technologies",
publisher = "Springer",
pages = "229--238",
editor = "Nikolaus Rajewsky and Stefan Jurga and Jan Barciszewski",
booktitle = "Systems Biology",
address = "Switzerland",

}

RIS

TY - CHAP

T1 - The Interplay of Non-coding RNAs and X Chromosome Inactivation in Human Disease

AU - Russo, Francesco

AU - De Masi, Federico

AU - Brunak, Søren

AU - Belling, Kirstine G

PY - 2018

Y1 - 2018

N2 - Non-coding RNAs (ncRNAs) represent key molecular players in biological processes and human disease. Several ncRNA types have been discovered including microRNAs (miRNAs) of around 23 nucleotides and long non-coding RNAs (lncRNAs) that are above 200 nucleotides in length. One of the first functional ncRNAs discovered was the lncRNA named X inactive specific transcript (XIST). XIST is the main actor in a fundamental process called X chromosome inactivation (XCI) where, in females, one of the two X chromosomes is silenced to balance the extra gene expression dosage. In this book chapter, we present the emerging evidence for the importance of XCI in diseases such as gastric and bladder cancer and genetic pathologies such as Klinefelter (47,XXY) and Turner (45,X0) syndromes. Furthermore, a new role for the crosstalk between XIST and miRNAs is discussed. Finally, new evidence for sex bias of XCI in human tissues and development of cancer is presented.

AB - Non-coding RNAs (ncRNAs) represent key molecular players in biological processes and human disease. Several ncRNA types have been discovered including microRNAs (miRNAs) of around 23 nucleotides and long non-coding RNAs (lncRNAs) that are above 200 nucleotides in length. One of the first functional ncRNAs discovered was the lncRNA named X inactive specific transcript (XIST). XIST is the main actor in a fundamental process called X chromosome inactivation (XCI) where, in females, one of the two X chromosomes is silenced to balance the extra gene expression dosage. In this book chapter, we present the emerging evidence for the importance of XCI in diseases such as gastric and bladder cancer and genetic pathologies such as Klinefelter (47,XXY) and Turner (45,X0) syndromes. Furthermore, a new role for the crosstalk between XIST and miRNAs is discussed. Finally, new evidence for sex bias of XCI in human tissues and development of cancer is presented.

U2 - 10.1007/978-3-319-92967-5_11

DO - 10.1007/978-3-319-92967-5_11

M3 - Book chapter

SN - 978-3-319-92966-8

T3 - RNA Technologies

SP - 229

EP - 238

BT - Systems Biology

A2 - Rajewsky, Nikolaus

A2 - Jurga, Stefan

A2 - Barciszewski, Jan

PB - Springer

ER -

ID: 209325620