Sex differences in oncogenic mutational processes

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Sex differences in oncogenic mutational processes. / Li, Constance H; Prokopec, Stephenie D; Sun, Ren X; Yousif, Fouad; Schmitz, Nathaniel; Boutros, Paul C; PCAWG Tumour Subtypes and Clinical Translation ; Brunak, Søren.

In: Nature Communications, Vol. 11, No. 1, 4330, 2020.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Li, CH, Prokopec, SD, Sun, RX, Yousif, F, Schmitz, N, Boutros, PC, PCAWG Tumour Subtypes and Clinical Translation & Brunak, S 2020, 'Sex differences in oncogenic mutational processes', Nature Communications, vol. 11, no. 1, 4330. https://doi.org/10.1038/s41467-020-17359-2

APA

Li, C. H., Prokopec, S. D., Sun, R. X., Yousif, F., Schmitz, N., Boutros, P. C., PCAWG Tumour Subtypes and Clinical Translation, & Brunak, S. (2020). Sex differences in oncogenic mutational processes. Nature Communications, 11(1), [4330]. https://doi.org/10.1038/s41467-020-17359-2

Vancouver

Li CH, Prokopec SD, Sun RX, Yousif F, Schmitz N, Boutros PC et al. Sex differences in oncogenic mutational processes. Nature Communications. 2020;11(1). 4330. https://doi.org/10.1038/s41467-020-17359-2

Author

Li, Constance H ; Prokopec, Stephenie D ; Sun, Ren X ; Yousif, Fouad ; Schmitz, Nathaniel ; Boutros, Paul C ; PCAWG Tumour Subtypes and Clinical Translation ; Brunak, Søren. / Sex differences in oncogenic mutational processes. In: Nature Communications. 2020 ; Vol. 11, No. 1.

Bibtex

@article{4d1c033c600e4cd6b1a2ba81af0c4c6a,
title = "Sex differences in oncogenic mutational processes",
abstract = "Sex differences have been observed in multiple facets of cancer epidemiology, treatment and biology, and in most cancers outside the sex organs. Efforts to link these clinical differences to specific molecular features have focused on somatic mutations within the coding regions of the genome. Here we report a pan-cancer analysis of sex differences in whole genomes of 1983 tumours of 28 subtypes as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. We both confirm the results of exome studies, and also uncover previously undescribed sex differences. These include sex-biases in coding and non-coding cancer drivers, mutation prevalence and strikingly, in mutational signatures related to underlying mutational processes. These results underline the pervasiveness of molecular sex differences and strengthen the call for increased consideration of sex in molecular cancer research.",
keywords = "Chromosomal Instability, Exome, Female, Genome, Human, Genomic Instability, Humans, Logistic Models, Male, Mutation, Neoplasms/genetics, Oncogenes/genetics, Open Reading Frames, Sex Characteristics, beta Catenin/genetics",
author = "Li, {Constance H} and Prokopec, {Stephenie D} and Sun, {Ren X} and Fouad Yousif and Nathaniel Schmitz and Boutros, {Paul C} and {PCAWG Tumour Subtypes and Clinical Translation} and S{\o}ren Brunak",
year = "2020",
doi = "10.1038/s41467-020-17359-2",
language = "English",
volume = "11",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",
number = "1",

}

RIS

TY - JOUR

T1 - Sex differences in oncogenic mutational processes

AU - Li, Constance H

AU - Prokopec, Stephenie D

AU - Sun, Ren X

AU - Yousif, Fouad

AU - Schmitz, Nathaniel

AU - Boutros, Paul C

AU - PCAWG Tumour Subtypes and Clinical Translation

AU - Brunak, Søren

PY - 2020

Y1 - 2020

N2 - Sex differences have been observed in multiple facets of cancer epidemiology, treatment and biology, and in most cancers outside the sex organs. Efforts to link these clinical differences to specific molecular features have focused on somatic mutations within the coding regions of the genome. Here we report a pan-cancer analysis of sex differences in whole genomes of 1983 tumours of 28 subtypes as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. We both confirm the results of exome studies, and also uncover previously undescribed sex differences. These include sex-biases in coding and non-coding cancer drivers, mutation prevalence and strikingly, in mutational signatures related to underlying mutational processes. These results underline the pervasiveness of molecular sex differences and strengthen the call for increased consideration of sex in molecular cancer research.

AB - Sex differences have been observed in multiple facets of cancer epidemiology, treatment and biology, and in most cancers outside the sex organs. Efforts to link these clinical differences to specific molecular features have focused on somatic mutations within the coding regions of the genome. Here we report a pan-cancer analysis of sex differences in whole genomes of 1983 tumours of 28 subtypes as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. We both confirm the results of exome studies, and also uncover previously undescribed sex differences. These include sex-biases in coding and non-coding cancer drivers, mutation prevalence and strikingly, in mutational signatures related to underlying mutational processes. These results underline the pervasiveness of molecular sex differences and strengthen the call for increased consideration of sex in molecular cancer research.

KW - Chromosomal Instability

KW - Exome

KW - Female

KW - Genome, Human

KW - Genomic Instability

KW - Humans

KW - Logistic Models

KW - Male

KW - Mutation

KW - Neoplasms/genetics

KW - Oncogenes/genetics

KW - Open Reading Frames

KW - Sex Characteristics

KW - beta Catenin/genetics

U2 - 10.1038/s41467-020-17359-2

DO - 10.1038/s41467-020-17359-2

M3 - Journal article

C2 - 32859912

VL - 11

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

IS - 1

M1 - 4330

ER -

ID: 248764165