Post-load glucose subgroups and associated metabolic traits in individuals with type 2 diabetes: An IMI-DIRECT study
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Post-load glucose subgroups and associated metabolic traits in individuals with type 2 diabetes : An IMI-DIRECT study. / Obura, Morgan; Beulens, Joline W.J.; Slieker, Roderick; Koopman, Anitra D.M.; Hoekstra, Trynke; Nijpels, Giel; Elders, Petra; Koivula, Robert W.; Kurbasic, Azra; Laakso, Markku; Hansen, Tue H.; Ridderstråle, Martin; Hansen, Torben; Pavo, Imre; Forgie, Ian; Jablonka, Bernd; Ruetten, Hartmut; Mari, Andrea; McCarthy, Mark I.; Walker, Mark; Heggie, Alison; McDonald, Timothy J.; Perry, Mandy H.; De Masi, Federico; Brunak, Søren; Mahajan, Anubha; Giordano, Giuseppe N.; Kokkola, Tarja; Dermitzakis, Emmanouil; Viñuela, Ana; Pedersen, Oluf; Schwenk, Jochen M.; Adamski, Jurek; Teare, Harriet J.A.; Pearson, Ewan R.; Franks, Paul W.; Hart, Leen M.t.; Rutters, Femke; for the IMI-DIRECT Consortium.
In: PLoS ONE, Vol. 15, No. 11, e0242360, 2020.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Post-load glucose subgroups and associated metabolic traits in individuals with type 2 diabetes
T2 - An IMI-DIRECT study
AU - Obura, Morgan
AU - Beulens, Joline W.J.
AU - Slieker, Roderick
AU - Koopman, Anitra D.M.
AU - Hoekstra, Trynke
AU - Nijpels, Giel
AU - Elders, Petra
AU - Koivula, Robert W.
AU - Kurbasic, Azra
AU - Laakso, Markku
AU - Hansen, Tue H.
AU - Ridderstråle, Martin
AU - Hansen, Torben
AU - Pavo, Imre
AU - Forgie, Ian
AU - Jablonka, Bernd
AU - Ruetten, Hartmut
AU - Mari, Andrea
AU - McCarthy, Mark I.
AU - Walker, Mark
AU - Heggie, Alison
AU - McDonald, Timothy J.
AU - Perry, Mandy H.
AU - De Masi, Federico
AU - Brunak, Søren
AU - Mahajan, Anubha
AU - Giordano, Giuseppe N.
AU - Kokkola, Tarja
AU - Dermitzakis, Emmanouil
AU - Viñuela, Ana
AU - Pedersen, Oluf
AU - Schwenk, Jochen M.
AU - Adamski, Jurek
AU - Teare, Harriet J.A.
AU - Pearson, Ewan R.
AU - Franks, Paul W.
AU - Hart, Leen M.t.
AU - Rutters, Femke
AU - for the IMI-DIRECT Consortium
PY - 2020
Y1 - 2020
N2 - Aim Subclasses of different glycaemic disturbances could explain the variation in characteristics of individuals with type 2 diabetes (T2D). We aimed to examine the association between subgroups based on their glucose curves during a five-point mixed-meal tolerance test (MMT) and metabolic traits at baseline and glycaemic deterioration in individuals with T2D. Methods The study included 787 individuals with newly diagnosed T2D from the Diabetes Research on Patient Stratification (IMI-DIRECT) Study. Latent class trajectory analysis (LCTA) was used to identify distinct glucose curve subgroups during a five-point MMT. Using general linear models, these subgroups were associated with metabolic traits at baseline and after 18 months of follow up, adjusted for potential confounders. Results At baseline, we identified three glucose curve subgroups, labelled in order of increasing glucose peak levels as subgroup 1–3. Individuals in subgroup 2 and 3 were more likely to have higher levels of HbA1c, triglycerides and BMI at baseline, compared to those in subgroup 1. At 18 months (n = 651), the beta coefficients (95% CI) for change in HbA1c (mmol/mol) increased across subgroups with 0.37 (-0.18–1.92) for subgroup 2 and 1.88 (-0.08–3.85) for subgroup 3, relative to subgroup 1. The same trend was observed for change in levels of triglycerides and fasting glucose. Conclusions Different glycaemic profiles with different metabolic traits and different degrees of subsequent glycaemic deterioration can be identified using data from a frequently sampled mixed-meal tolerance test in individuals with T2D. Subgroups with the highest peaks had greater metabolic risk.
AB - Aim Subclasses of different glycaemic disturbances could explain the variation in characteristics of individuals with type 2 diabetes (T2D). We aimed to examine the association between subgroups based on their glucose curves during a five-point mixed-meal tolerance test (MMT) and metabolic traits at baseline and glycaemic deterioration in individuals with T2D. Methods The study included 787 individuals with newly diagnosed T2D from the Diabetes Research on Patient Stratification (IMI-DIRECT) Study. Latent class trajectory analysis (LCTA) was used to identify distinct glucose curve subgroups during a five-point MMT. Using general linear models, these subgroups were associated with metabolic traits at baseline and after 18 months of follow up, adjusted for potential confounders. Results At baseline, we identified three glucose curve subgroups, labelled in order of increasing glucose peak levels as subgroup 1–3. Individuals in subgroup 2 and 3 were more likely to have higher levels of HbA1c, triglycerides and BMI at baseline, compared to those in subgroup 1. At 18 months (n = 651), the beta coefficients (95% CI) for change in HbA1c (mmol/mol) increased across subgroups with 0.37 (-0.18–1.92) for subgroup 2 and 1.88 (-0.08–3.85) for subgroup 3, relative to subgroup 1. The same trend was observed for change in levels of triglycerides and fasting glucose. Conclusions Different glycaemic profiles with different metabolic traits and different degrees of subsequent glycaemic deterioration can be identified using data from a frequently sampled mixed-meal tolerance test in individuals with T2D. Subgroups with the highest peaks had greater metabolic risk.
U2 - 10.1371/journal.pone.0242360
DO - 10.1371/journal.pone.0242360
M3 - Journal article
C2 - 33253307
AN - SCOPUS:85097034291
VL - 15
JO - PLoS ONE
JF - PLoS ONE
SN - 1932-6203
IS - 11
M1 - e0242360
ER -
ID: 256881906