MicroRNAs, Regulatory Networks, and Comorbidities: Decoding Complex Systems

Research output: Contribution to journal › Journal article › Research › peer-review

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MicroRNAs, Regulatory Networks, and Comorbidities : Decoding Complex Systems. / Russo, Francesco; Belling, Kirstine; Jensen, Anders Boeck; Scoyni, Flavia; Brunak, Søren; Pellegrini, Marco.

In: Methods in molecular biology (Clifton, N.J.), Vol. 1580, 2017, p. 281-295.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Russo, F, Belling, K, Jensen, AB, Scoyni, F, Brunak, S & Pellegrini, M 2017, 'MicroRNAs, Regulatory Networks, and Comorbidities: Decoding Complex Systems', Methods in molecular biology (Clifton, N.J.), vol. 1580, pp. 281-295. https://doi.org/10.1007/978-1-4939-6866-4_19

APA

Russo, F., Belling, K., Jensen, A. B., Scoyni, F., Brunak, S., & Pellegrini, M. (2017). MicroRNAs, Regulatory Networks, and Comorbidities: Decoding Complex Systems. Methods in molecular biology (Clifton, N.J.), 1580, 281-295. https://doi.org/10.1007/978-1-4939-6866-4_19

Vancouver

Russo F, Belling K, Jensen AB, Scoyni F, Brunak S, Pellegrini M. MicroRNAs, Regulatory Networks, and Comorbidities: Decoding Complex Systems. Methods in molecular biology (Clifton, N.J.). 2017;1580:281-295. https://doi.org/10.1007/978-1-4939-6866-4_19

Author

Russo, Francesco ; Belling, Kirstine ; Jensen, Anders Boeck ; Scoyni, Flavia ; Brunak, Søren ; Pellegrini, Marco. / MicroRNAs, Regulatory Networks, and Comorbidities : Decoding Complex Systems. In: Methods in molecular biology (Clifton, N.J.). 2017 ; Vol. 1580. pp. 281-295.

Bibtex

@article{cbf23fe640b14816bfbf840ba6d6bf3e,
title = "MicroRNAs, Regulatory Networks, and Comorbidities: Decoding Complex Systems",
abstract = "MicroRNAs (miRNAs) are small noncoding RNAs involved in the posttranscriptional regulation of messenger RNAs (mRNAs). Each miRNA targets a specific set of mRNAs. Upon binding the miRNA inhibits mRNA translation or facilitate mRNA degradation. miRNAs are frequently deregulated in several pathologies including cancer and cardiovascular diseases. Since miRNAs have a crucial role in fine-tuning the expression of their targets, they have been proposed as biomarkers of disease progression and prognostication.In this chapter we discuss different approaches for computational predictions of miRNA targets based on sequence complementarity and integration of expression data. In the last section of the chapter we discuss new opportunities in the study of miRNA regulatory networks in the context of temporal disease progression and comorbidities.",
keywords = "Journal Article",
author = "Francesco Russo and Kirstine Belling and Jensen, {Anders Boeck} and Flavia Scoyni and S{\o}ren Brunak and Marco Pellegrini",
year = "2017",
doi = "10.1007/978-1-4939-6866-4_19",
language = "English",
volume = "1580",
pages = "281--295",
journal = "Methods in Molecular Biology",
issn = "1064-3745",
publisher = "Humana Press",

}

RIS

TY - JOUR

T1 - MicroRNAs, Regulatory Networks, and Comorbidities

T2 - Decoding Complex Systems

AU - Russo, Francesco

AU - Belling, Kirstine

AU - Jensen, Anders Boeck

AU - Scoyni, Flavia

AU - Brunak, Søren

AU - Pellegrini, Marco

PY - 2017

Y1 - 2017

N2 - MicroRNAs (miRNAs) are small noncoding RNAs involved in the posttranscriptional regulation of messenger RNAs (mRNAs). Each miRNA targets a specific set of mRNAs. Upon binding the miRNA inhibits mRNA translation or facilitate mRNA degradation. miRNAs are frequently deregulated in several pathologies including cancer and cardiovascular diseases. Since miRNAs have a crucial role in fine-tuning the expression of their targets, they have been proposed as biomarkers of disease progression and prognostication.In this chapter we discuss different approaches for computational predictions of miRNA targets based on sequence complementarity and integration of expression data. In the last section of the chapter we discuss new opportunities in the study of miRNA regulatory networks in the context of temporal disease progression and comorbidities.

AB - MicroRNAs (miRNAs) are small noncoding RNAs involved in the posttranscriptional regulation of messenger RNAs (mRNAs). Each miRNA targets a specific set of mRNAs. Upon binding the miRNA inhibits mRNA translation or facilitate mRNA degradation. miRNAs are frequently deregulated in several pathologies including cancer and cardiovascular diseases. Since miRNAs have a crucial role in fine-tuning the expression of their targets, they have been proposed as biomarkers of disease progression and prognostication.In this chapter we discuss different approaches for computational predictions of miRNA targets based on sequence complementarity and integration of expression data. In the last section of the chapter we discuss new opportunities in the study of miRNA regulatory networks in the context of temporal disease progression and comorbidities.

KW - Journal Article

U2 - 10.1007/978-1-4939-6866-4_19

DO - 10.1007/978-1-4939-6866-4_19

M3 - Journal article

C2 - 28439840

VL - 1580

SP - 281

EP - 295

JO - Methods in Molecular Biology

JF - Methods in Molecular Biology

SN - 1064-3745

ER -

ID: 177047578