Integration of clinical chemistry, expression, and metabolite data leads to better toxicological class separation
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Integration of clinical chemistry, expression, and metabolite data leads to better toxicological class separation. / Spicker, Jeppe; Brunak, Søren; Frederiksen, Klaus; Toft, Henrik.
In: Toxicological sciences : an official journal of the Society of Toxicology, Vol. 102, No. 2, 2008, p. 444-54.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Integration of clinical chemistry, expression, and metabolite data leads to better toxicological class separation
AU - Spicker, Jeppe
AU - Brunak, Søren
AU - Frederiksen, Klaus
AU - Toft, Henrik
PY - 2008
Y1 - 2008
N2 - A large number of databases are currently being implemented within toxicology aiming to integrate diverse biological data, such as clinical chemistry, expression, and other types of data. However, for these endeavors to be successful, tools for integration, visualization, and interpretation are needed. This paper presents a method for data integration using a hierarchical model based on either principal component analysis or partial least squares discriminant analysis of clinical chemistry, expression, and nuclear magnetic resonance data using a toxicological study as case. The study includes the three toxicants alpha-naphthyl-isothiocyanate, dimethylnitrosamine, and N-methylformamide administered to rats. Improved predictive ability of the different classes is seen, suggesting that this approach is a suitable method for data integration and visualization of biological data. Furthermore, the method allows for correlation of biological parameters between the different data types, which could lead to an improvement in biological interpretation.
AB - A large number of databases are currently being implemented within toxicology aiming to integrate diverse biological data, such as clinical chemistry, expression, and other types of data. However, for these endeavors to be successful, tools for integration, visualization, and interpretation are needed. This paper presents a method for data integration using a hierarchical model based on either principal component analysis or partial least squares discriminant analysis of clinical chemistry, expression, and nuclear magnetic resonance data using a toxicological study as case. The study includes the three toxicants alpha-naphthyl-isothiocyanate, dimethylnitrosamine, and N-methylformamide administered to rats. Improved predictive ability of the different classes is seen, suggesting that this approach is a suitable method for data integration and visualization of biological data. Furthermore, the method allows for correlation of biological parameters between the different data types, which could lead to an improvement in biological interpretation.
U2 - 10.1093/toxsci/kfn001
DO - 10.1093/toxsci/kfn001
M3 - Journal article
C2 - 18178960
VL - 102
SP - 444
EP - 454
JO - Toxicological Sciences
JF - Toxicological Sciences
SN - 1096-6080
IS - 2
ER -
ID: 40804600