Insights into the Genetic Susceptibility to Type 2 Diabetes from Genome-Wide Association Studies of Obesity-Related Traits
Research output: Contribution to journal › Review › Research › peer-review
Obesity and type 2 diabetes (T2D) are common and complex metabolic diseases, which are caused by an interchange between environmental and genetic factors. Recently, a number of large-scale genome-wide association studies (GWAS) have improved our knowledge of the genetic architecture and biological mechanisms of these diseases. Currently, more than ~250 genetic loci have been found for monogenic, syndromic, or common forms of T2D and/or obesity-related traits. In this review, we discuss the implications of these GWAS for obesity and T2D, and investigate the overlap of loci for obesity-related traits and T2D, highlighting potential mechanisms that affect T2D susceptibility.
| Original language | English |
|---|---|
| Article number | 83 |
| Journal | Current Diabetes Reports |
| Volume | 15 |
| Issue number | 10 |
| ISSN | 1534-4827 |
| DOIs | |
| Publication status | Published - 22 Oct 2015 |
| Externally published | Yes |
- Adiponectin, Beta-cell function, Body mass index, Fat distribution, Fat percent, Genome-wide association study, Insulin resistance, Leptin, Non-alcoholic fatty liver disease, Obesity, Pericardial fat, Sexual dimorphism, Subcutaneous fat, Type 2 diabetes, Visceral fat, Waist-to-hip ratio
Research areas
ID: 226395607