Heat shock response and autophagy - cooperation and control
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Heat shock response and autophagy - cooperation and control. / Dokladny, Karol; Myers, Orrin B; Moseley, Pope L.
In: Autophagy, Vol. 11, No. 2, 2015, p. 200-213.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Heat shock response and autophagy - cooperation and control
AU - Dokladny, Karol
AU - Myers, Orrin B
AU - Moseley, Pope L
PY - 2015
Y1 - 2015
N2 - Protein quality control (proteostasis) depends on constant protein degradation and resynthesis, and is essential for proper homeostasis in systems from single cells to whole organisms. Cells possess several mechanisms and processes to maintain proteostasis. At one end of the spectrum, the heat shock proteins modulate protein folding and repair. At the other end, the proteasome and autophagy as well as other lysosome-dependent systems, function in the degradation of dysfunctional proteins. In this review, we examine how these systems interact to maintain proteostasis. Both the direct cellular data on heat shock control over autophagy and the time course of exercise-associated changes in humans support the model that heat shock response and autophagy are tightly linked. Studying the links between exercise stress and molecular control of proteostasis provides evidence that the heat shock response and autophagy coordinate and undergo sequential activation and downregulation, and that this is essential for proper proteostasis in eukaryotic systems.
AB - Protein quality control (proteostasis) depends on constant protein degradation and resynthesis, and is essential for proper homeostasis in systems from single cells to whole organisms. Cells possess several mechanisms and processes to maintain proteostasis. At one end of the spectrum, the heat shock proteins modulate protein folding and repair. At the other end, the proteasome and autophagy as well as other lysosome-dependent systems, function in the degradation of dysfunctional proteins. In this review, we examine how these systems interact to maintain proteostasis. Both the direct cellular data on heat shock control over autophagy and the time course of exercise-associated changes in humans support the model that heat shock response and autophagy are tightly linked. Studying the links between exercise stress and molecular control of proteostasis provides evidence that the heat shock response and autophagy coordinate and undergo sequential activation and downregulation, and that this is essential for proper proteostasis in eukaryotic systems.
KW - Animals
KW - Autophagy/physiology
KW - Heat-Shock Proteins/metabolism
KW - Heat-Shock Response/physiology
KW - Humans
KW - Lysosomes/metabolism
KW - Metabolic Networks and Pathways/physiology
KW - Signal Transduction/physiology
U2 - 10.1080/15548627.2015.1009776
DO - 10.1080/15548627.2015.1009776
M3 - Review
C2 - 25714619
VL - 11
SP - 200
EP - 213
JO - Autophagy
JF - Autophagy
SN - 1554-8627
IS - 2
ER -
ID: 195973479