Detailed stratified GWAS analysis for severe COVID-19 in four European populations

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Detailed stratified GWAS analysis for severe COVID-19 in four European populations. / Degenhardt, Frauke; Ellinghaus, David; Juzenas, Simonas; Lerga-Jaso, Jon; Wendorff, Mareike; Maya-Miles, Douglas; Uellendahl-Werth, Florian; ElAbd, Hesham; Rühlemann, Malte C; Arora, Jatin; Özer, Onur; Lenning, Ole Bernt; Myhre, Ronny; Vadla, May Sissel; Wacker, Eike M; Wienbrandt, Lars; Ortiz, Aaron Blandino; Salazar, Adolfo; Chercoles, Adolfo Garrido; Palom, Adriana; Ruiz, Agustín; Garcia-Fernandez, Alba-Estela; Blanco-Grau, Albert; Mantovani, Alberto; Zanella, Alberto; Holten, Aleksander Rygh; Mayer, Alena; Bandera, Alessandra; Cherubini, Alessandro; Protti, Alessandro; Aghemo, Alessio; Gerussi, Alessio; Ramirez, Alfredo; Braun, Alice; Nebel, Almut; Barreira, Ana; Lleo, Ana; Teles, Ana; Kildal, Anders Benjamin; Biondi, Andrea; Caballero-Garralda, Andrea; Ganna, Andrea; Gori, Andrea; Glück, Andreas; Lind, Andreas; Hinney, Anke; Jensen, Björn; Banasik, Karina; Castro, Pedro; Brunak, Søren; COVICAT study group, Aachen Study (COVAS).

In: Human Molecular Genetics, Vol. 31, No. 23, 2022, p. 3945-3966.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Degenhardt, F, Ellinghaus, D, Juzenas, S, Lerga-Jaso, J, Wendorff, M, Maya-Miles, D, Uellendahl-Werth, F, ElAbd, H, Rühlemann, MC, Arora, J, Özer, O, Lenning, OB, Myhre, R, Vadla, MS, Wacker, EM, Wienbrandt, L, Ortiz, AB, Salazar, A, Chercoles, AG, Palom, A, Ruiz, A, Garcia-Fernandez, A-E, Blanco-Grau, A, Mantovani, A, Zanella, A, Holten, AR, Mayer, A, Bandera, A, Cherubini, A, Protti, A, Aghemo, A, Gerussi, A, Ramirez, A, Braun, A, Nebel, A, Barreira, A, Lleo, A, Teles, A, Kildal, AB, Biondi, A, Caballero-Garralda, A, Ganna, A, Gori, A, Glück, A, Lind, A, Hinney, A, Jensen, B, Banasik, K, Castro, P, Brunak, S & COVICAT study group, Aachen Study (COVAS) 2022, 'Detailed stratified GWAS analysis for severe COVID-19 in four European populations', Human Molecular Genetics, vol. 31, no. 23, pp. 3945-3966. https://doi.org/10.1093/hmg/ddac158

APA

Degenhardt, F., Ellinghaus, D., Juzenas, S., Lerga-Jaso, J., Wendorff, M., Maya-Miles, D., Uellendahl-Werth, F., ElAbd, H., Rühlemann, M. C., Arora, J., Özer, O., Lenning, O. B., Myhre, R., Vadla, M. S., Wacker, E. M., Wienbrandt, L., Ortiz, A. B., Salazar, A., Chercoles, A. G., ... COVICAT study group, Aachen Study (COVAS) (2022). Detailed stratified GWAS analysis for severe COVID-19 in four European populations. Human Molecular Genetics, 31(23), 3945-3966. https://doi.org/10.1093/hmg/ddac158

Vancouver

Degenhardt F, Ellinghaus D, Juzenas S, Lerga-Jaso J, Wendorff M, Maya-Miles D et al. Detailed stratified GWAS analysis for severe COVID-19 in four European populations. Human Molecular Genetics. 2022;31(23):3945-3966. https://doi.org/10.1093/hmg/ddac158

Author

Degenhardt, Frauke ; Ellinghaus, David ; Juzenas, Simonas ; Lerga-Jaso, Jon ; Wendorff, Mareike ; Maya-Miles, Douglas ; Uellendahl-Werth, Florian ; ElAbd, Hesham ; Rühlemann, Malte C ; Arora, Jatin ; Özer, Onur ; Lenning, Ole Bernt ; Myhre, Ronny ; Vadla, May Sissel ; Wacker, Eike M ; Wienbrandt, Lars ; Ortiz, Aaron Blandino ; Salazar, Adolfo ; Chercoles, Adolfo Garrido ; Palom, Adriana ; Ruiz, Agustín ; Garcia-Fernandez, Alba-Estela ; Blanco-Grau, Albert ; Mantovani, Alberto ; Zanella, Alberto ; Holten, Aleksander Rygh ; Mayer, Alena ; Bandera, Alessandra ; Cherubini, Alessandro ; Protti, Alessandro ; Aghemo, Alessio ; Gerussi, Alessio ; Ramirez, Alfredo ; Braun, Alice ; Nebel, Almut ; Barreira, Ana ; Lleo, Ana ; Teles, Ana ; Kildal, Anders Benjamin ; Biondi, Andrea ; Caballero-Garralda, Andrea ; Ganna, Andrea ; Gori, Andrea ; Glück, Andreas ; Lind, Andreas ; Hinney, Anke ; Jensen, Björn ; Banasik, Karina ; Castro, Pedro ; Brunak, Søren ; COVICAT study group, Aachen Study (COVAS). / Detailed stratified GWAS analysis for severe COVID-19 in four European populations. In: Human Molecular Genetics. 2022 ; Vol. 31, No. 23. pp. 3945-3966.

Bibtex

@article{28d224ede8464731a527508a45411ef5,
title = "Detailed stratified GWAS analysis for severe COVID-19 in four European populations",
abstract = "Given the highly variable clinical phenotype of Coronavirus disease 2019 (COVID-19), a deeper analysis of the host genetic contribution to severe COVID-19 is important to improve our understanding of underlying disease mechanisms. Here, we describe an extended GWAS meta-analysis of a well-characterized cohort of 3255 COVID-19 patients with respiratory failure and 12 488 population controls from Italy, Spain, Norway and Germany/Austria, including stratified analyses based on age, sex and disease severity, as well as targeted analyses of chromosome Y haplotypes, the human leukocyte antigen (HLA) region and the SARS-CoV-2 peptidome. By inversion imputation, we traced a reported association at 17q21.31 to a ~ 0.9-Mb inversion polymorphism that creates two highly differentiated haplotypes and characterized the potential effects of the inversion in detail. Our data, together with the 5th release of summary statistics from the COVID-19 Host Genetics Initiative including non-Caucasian individuals, also identified a new locus at 19q13.33, including NAPSA, a gene which is expressed primarily in alveolar cells responsible for gas exchange in the lung.",
author = "Frauke Degenhardt and David Ellinghaus and Simonas Juzenas and Jon Lerga-Jaso and Mareike Wendorff and Douglas Maya-Miles and Florian Uellendahl-Werth and Hesham ElAbd and R{\"u}hlemann, {Malte C} and Jatin Arora and Onur {\"O}zer and Lenning, {Ole Bernt} and Ronny Myhre and Vadla, {May Sissel} and Wacker, {Eike M} and Lars Wienbrandt and Ortiz, {Aaron Blandino} and Adolfo Salazar and Chercoles, {Adolfo Garrido} and Adriana Palom and Agust{\'i}n Ruiz and Alba-Estela Garcia-Fernandez and Albert Blanco-Grau and Alberto Mantovani and Alberto Zanella and Holten, {Aleksander Rygh} and Alena Mayer and Alessandra Bandera and Alessandro Cherubini and Alessandro Protti and Alessio Aghemo and Alessio Gerussi and Alfredo Ramirez and Alice Braun and Almut Nebel and Ana Barreira and Ana Lleo and Ana Teles and Kildal, {Anders Benjamin} and Andrea Biondi and Andrea Caballero-Garralda and Andrea Ganna and Andrea Gori and Andreas Gl{\"u}ck and Andreas Lind and Anke Hinney and Bj{\"o}rn Jensen and Karina Banasik and Pedro Castro and S{\o}ren Brunak and {COVICAT study group, Aachen Study (COVAS)}",
note = "{\textcopyright} The Author(s) 2022. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.",
year = "2022",
doi = "10.1093/hmg/ddac158",
language = "English",
volume = "31",
pages = "3945--3966",
journal = "Human Molecular Genetics",
issn = "0964-6906",
publisher = "Oxford University Press",
number = "23",

}

RIS

TY - JOUR

T1 - Detailed stratified GWAS analysis for severe COVID-19 in four European populations

AU - Degenhardt, Frauke

AU - Ellinghaus, David

AU - Juzenas, Simonas

AU - Lerga-Jaso, Jon

AU - Wendorff, Mareike

AU - Maya-Miles, Douglas

AU - Uellendahl-Werth, Florian

AU - ElAbd, Hesham

AU - Rühlemann, Malte C

AU - Arora, Jatin

AU - Özer, Onur

AU - Lenning, Ole Bernt

AU - Myhre, Ronny

AU - Vadla, May Sissel

AU - Wacker, Eike M

AU - Wienbrandt, Lars

AU - Ortiz, Aaron Blandino

AU - Salazar, Adolfo

AU - Chercoles, Adolfo Garrido

AU - Palom, Adriana

AU - Ruiz, Agustín

AU - Garcia-Fernandez, Alba-Estela

AU - Blanco-Grau, Albert

AU - Mantovani, Alberto

AU - Zanella, Alberto

AU - Holten, Aleksander Rygh

AU - Mayer, Alena

AU - Bandera, Alessandra

AU - Cherubini, Alessandro

AU - Protti, Alessandro

AU - Aghemo, Alessio

AU - Gerussi, Alessio

AU - Ramirez, Alfredo

AU - Braun, Alice

AU - Nebel, Almut

AU - Barreira, Ana

AU - Lleo, Ana

AU - Teles, Ana

AU - Kildal, Anders Benjamin

AU - Biondi, Andrea

AU - Caballero-Garralda, Andrea

AU - Ganna, Andrea

AU - Gori, Andrea

AU - Glück, Andreas

AU - Lind, Andreas

AU - Hinney, Anke

AU - Jensen, Björn

AU - Banasik, Karina

AU - Castro, Pedro

AU - Brunak, Søren

AU - COVICAT study group, Aachen Study (COVAS)

N1 - © The Author(s) 2022. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

PY - 2022

Y1 - 2022

N2 - Given the highly variable clinical phenotype of Coronavirus disease 2019 (COVID-19), a deeper analysis of the host genetic contribution to severe COVID-19 is important to improve our understanding of underlying disease mechanisms. Here, we describe an extended GWAS meta-analysis of a well-characterized cohort of 3255 COVID-19 patients with respiratory failure and 12 488 population controls from Italy, Spain, Norway and Germany/Austria, including stratified analyses based on age, sex and disease severity, as well as targeted analyses of chromosome Y haplotypes, the human leukocyte antigen (HLA) region and the SARS-CoV-2 peptidome. By inversion imputation, we traced a reported association at 17q21.31 to a ~ 0.9-Mb inversion polymorphism that creates two highly differentiated haplotypes and characterized the potential effects of the inversion in detail. Our data, together with the 5th release of summary statistics from the COVID-19 Host Genetics Initiative including non-Caucasian individuals, also identified a new locus at 19q13.33, including NAPSA, a gene which is expressed primarily in alveolar cells responsible for gas exchange in the lung.

AB - Given the highly variable clinical phenotype of Coronavirus disease 2019 (COVID-19), a deeper analysis of the host genetic contribution to severe COVID-19 is important to improve our understanding of underlying disease mechanisms. Here, we describe an extended GWAS meta-analysis of a well-characterized cohort of 3255 COVID-19 patients with respiratory failure and 12 488 population controls from Italy, Spain, Norway and Germany/Austria, including stratified analyses based on age, sex and disease severity, as well as targeted analyses of chromosome Y haplotypes, the human leukocyte antigen (HLA) region and the SARS-CoV-2 peptidome. By inversion imputation, we traced a reported association at 17q21.31 to a ~ 0.9-Mb inversion polymorphism that creates two highly differentiated haplotypes and characterized the potential effects of the inversion in detail. Our data, together with the 5th release of summary statistics from the COVID-19 Host Genetics Initiative including non-Caucasian individuals, also identified a new locus at 19q13.33, including NAPSA, a gene which is expressed primarily in alveolar cells responsible for gas exchange in the lung.

U2 - 10.1093/hmg/ddac158

DO - 10.1093/hmg/ddac158

M3 - Journal article

C2 - 35848942

VL - 31

SP - 3945

EP - 3966

JO - Human Molecular Genetics

JF - Human Molecular Genetics

SN - 0964-6906

IS - 23

ER -

ID: 315773233