The Interplay of Non-coding RNAs and X Chromosome Inactivation in Human Disease
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The Interplay of Non-coding RNAs and X Chromosome Inactivation in Human Disease. / Russo, Francesco; De Masi, Federico; Brunak, Søren; Belling, Kirstine G.
Systems Biology. ed. / Nikolaus Rajewsky; Stefan Jurga; Jan Barciszewski. Springer, 2018. p. 229-238 (RNA Technologies).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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TY - CHAP
T1 - The Interplay of Non-coding RNAs and X Chromosome Inactivation in Human Disease
AU - Russo, Francesco
AU - De Masi, Federico
AU - Brunak, Søren
AU - Belling, Kirstine G
PY - 2018
Y1 - 2018
N2 - Non-coding RNAs (ncRNAs) represent key molecular players in biological processes and human disease. Several ncRNA types have been discovered including microRNAs (miRNAs) of around 23 nucleotides and long non-coding RNAs (lncRNAs) that are above 200 nucleotides in length. One of the first functional ncRNAs discovered was the lncRNA named X inactive specific transcript (XIST). XIST is the main actor in a fundamental process called X chromosome inactivation (XCI) where, in females, one of the two X chromosomes is silenced to balance the extra gene expression dosage. In this book chapter, we present the emerging evidence for the importance of XCI in diseases such as gastric and bladder cancer and genetic pathologies such as Klinefelter (47,XXY) and Turner (45,X0) syndromes. Furthermore, a new role for the crosstalk between XIST and miRNAs is discussed. Finally, new evidence for sex bias of XCI in human tissues and development of cancer is presented.
AB - Non-coding RNAs (ncRNAs) represent key molecular players in biological processes and human disease. Several ncRNA types have been discovered including microRNAs (miRNAs) of around 23 nucleotides and long non-coding RNAs (lncRNAs) that are above 200 nucleotides in length. One of the first functional ncRNAs discovered was the lncRNA named X inactive specific transcript (XIST). XIST is the main actor in a fundamental process called X chromosome inactivation (XCI) where, in females, one of the two X chromosomes is silenced to balance the extra gene expression dosage. In this book chapter, we present the emerging evidence for the importance of XCI in diseases such as gastric and bladder cancer and genetic pathologies such as Klinefelter (47,XXY) and Turner (45,X0) syndromes. Furthermore, a new role for the crosstalk between XIST and miRNAs is discussed. Finally, new evidence for sex bias of XCI in human tissues and development of cancer is presented.
U2 - 10.1007/978-3-319-92967-5_11
DO - 10.1007/978-3-319-92967-5_11
M3 - Book chapter
SN - 978-3-319-92966-8
T3 - RNA Technologies
SP - 229
EP - 238
BT - Systems Biology
A2 - Rajewsky, Nikolaus
A2 - Jurga, Stefan
A2 - Barciszewski, Jan
PB - Springer
ER -
ID: 209325620