Standard
The implications of alternative splicing in the ENCODE protein complement. / Tress, Michael L; Martelli, Pier Luigi; Frankish, Adam; Reeves, Gabrielle A; Wesselink, Jan Jaap; Yeats, Corin; Olason, Páll Isólfur; Albrecht, Mario; Hegyi, Hedi; Giorgetti, Alejandro; Raimondo, Domenico; Lagarde, Julien; Laskowski, Roman A; López, Gonzalo; Sadowski, Michael I; Watson, James D; Fariselli, Piero; Rossi, Ivan; Nagy, Alinda; Kai, Wang; Størling, Zenia; Orsini, Massimiliano; Assenov, Yassen; Blankenburg, Hagen; Huthmacher, Carola; Ramírez, Fidel; Schlicker, Andreas; Denoeud, France; Jones, Phil; Kerrien, Samuel; Orchard, Sandra; Antonarakis, Stylianos E; Reymond, Alexandre; Birney, Ewan; Brunak, Søren; Casadio, Rita; Guigo, Roderic; Harrow, Jennifer; Hermjakob, Henning; Jones, David T; Lengauer, Thomas; Orengo, Christine A; Patthy, László; Thornton, Janet M; Tramontano, Anna; Valencia, Alfonso.
In:
Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, No. 13, 2007, p. 5495-500.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Tress, ML, Martelli, PL, Frankish, A, Reeves, GA, Wesselink, JJ, Yeats, C, Olason, PI, Albrecht, M, Hegyi, H, Giorgetti, A, Raimondo, D, Lagarde, J, Laskowski, RA, López, G, Sadowski, MI, Watson, JD, Fariselli, P, Rossi, I, Nagy, A, Kai, W, Størling, Z, Orsini, M, Assenov, Y, Blankenburg, H, Huthmacher, C, Ramírez, F, Schlicker, A, Denoeud, F, Jones, P, Kerrien, S, Orchard, S, Antonarakis, SE, Reymond, A, Birney, E
, Brunak, S, Casadio, R, Guigo, R, Harrow, J, Hermjakob, H, Jones, DT, Lengauer, T, Orengo, CA, Patthy, L, Thornton, JM, Tramontano, A & Valencia, A 2007, '
The implications of alternative splicing in the ENCODE protein complement',
Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 13, pp. 5495-500.
https://doi.org/10.1073/pnas.0700800104APA
Tress, M. L., Martelli, P. L., Frankish, A., Reeves, G. A., Wesselink, J. J., Yeats, C., Olason, P. I., Albrecht, M., Hegyi, H., Giorgetti, A., Raimondo, D., Lagarde, J., Laskowski, R. A., López, G., Sadowski, M. I., Watson, J. D., Fariselli, P., Rossi, I., Nagy, A., ... Valencia, A. (2007).
The implications of alternative splicing in the ENCODE protein complement.
Proceedings of the National Academy of Sciences of the United States of America,
104(13), 5495-500.
https://doi.org/10.1073/pnas.0700800104Vancouver
Tress ML, Martelli PL, Frankish A, Reeves GA, Wesselink JJ, Yeats C et al.
The implications of alternative splicing in the ENCODE protein complement.
Proceedings of the National Academy of Sciences of the United States of America. 2007;104(13):5495-500.
https://doi.org/10.1073/pnas.0700800104Author
Tress, Michael L ; Martelli, Pier Luigi ; Frankish, Adam ; Reeves, Gabrielle A ; Wesselink, Jan Jaap ; Yeats, Corin ; Olason, Páll Isólfur ; Albrecht, Mario ; Hegyi, Hedi ; Giorgetti, Alejandro ; Raimondo, Domenico ; Lagarde, Julien ; Laskowski, Roman A ; López, Gonzalo ; Sadowski, Michael I ; Watson, James D ; Fariselli, Piero ; Rossi, Ivan ; Nagy, Alinda ; Kai, Wang ; Størling, Zenia ; Orsini, Massimiliano ; Assenov, Yassen ; Blankenburg, Hagen ; Huthmacher, Carola ; Ramírez, Fidel ; Schlicker, Andreas ; Denoeud, France ; Jones, Phil ; Kerrien, Samuel ; Orchard, Sandra ; Antonarakis, Stylianos E ; Reymond, Alexandre ; Birney, Ewan ; Brunak, Søren ; Casadio, Rita ; Guigo, Roderic ; Harrow, Jennifer ; Hermjakob, Henning ; Jones, David T ; Lengauer, Thomas ; Orengo, Christine A ; Patthy, László ; Thornton, Janet M ; Tramontano, Anna ; Valencia, Alfonso. / The implications of alternative splicing in the ENCODE protein complement. In: Proceedings of the National Academy of Sciences of the United States of America. 2007 ; Vol. 104, No. 13. pp. 5495-500.
Bibtex
@article{50e1ec0819a24f9f821ecf51daf59a7f,
title = "The implications of alternative splicing in the ENCODE protein complement",
abstract = "Alternative premessenger RNA splicing enables genes to generate more than one gene product. Splicing events that occur within protein coding regions have the potential to alter the biological function of the expressed protein and even to create new protein functions. Alternative splicing has been suggested as one explanation for the discrepancy between the number of human genes and functional complexity. Here, we carry out a detailed study of the alternatively spliced gene products annotated in the ENCODE pilot project. We find that alternative splicing in human genes is more frequent than has commonly been suggested, and we demonstrate that many of the potential alternative gene products will have markedly different structure and function from their constitutively spliced counterparts. For the vast majority of these alternative isoforms, little evidence exists to suggest they have a role as functional proteins, and it seems unlikely that the spectrum of conventional enzymatic or structural functions can be substantially extended through alternative splicing.",
author = "Tress, {Michael L} and Martelli, {Pier Luigi} and Adam Frankish and Reeves, {Gabrielle A} and Wesselink, {Jan Jaap} and Corin Yeats and Olason, {P{\'a}ll Is{\'o}lfur} and Mario Albrecht and Hedi Hegyi and Alejandro Giorgetti and Domenico Raimondo and Julien Lagarde and Laskowski, {Roman A} and Gonzalo L{\'o}pez and Sadowski, {Michael I} and Watson, {James D} and Piero Fariselli and Ivan Rossi and Alinda Nagy and Wang Kai and Zenia St{\o}rling and Massimiliano Orsini and Yassen Assenov and Hagen Blankenburg and Carola Huthmacher and Fidel Ram{\'i}rez and Andreas Schlicker and France Denoeud and Phil Jones and Samuel Kerrien and Sandra Orchard and Antonarakis, {Stylianos E} and Alexandre Reymond and Ewan Birney and S{\o}ren Brunak and Rita Casadio and Roderic Guigo and Jennifer Harrow and Henning Hermjakob and Jones, {David T} and Thomas Lengauer and Orengo, {Christine A} and L{\'a}szl{\'o} Patthy and Thornton, {Janet M} and Anna Tramontano and Alfonso Valencia",
year = "2007",
doi = "10.1073/pnas.0700800104",
language = "English",
volume = "104",
pages = "5495--500",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
publisher = "The National Academy of Sciences of the United States of America",
number = "13",
}
RIS
TY - JOUR
T1 - The implications of alternative splicing in the ENCODE protein complement
AU - Tress, Michael L
AU - Martelli, Pier Luigi
AU - Frankish, Adam
AU - Reeves, Gabrielle A
AU - Wesselink, Jan Jaap
AU - Yeats, Corin
AU - Olason, Páll Isólfur
AU - Albrecht, Mario
AU - Hegyi, Hedi
AU - Giorgetti, Alejandro
AU - Raimondo, Domenico
AU - Lagarde, Julien
AU - Laskowski, Roman A
AU - López, Gonzalo
AU - Sadowski, Michael I
AU - Watson, James D
AU - Fariselli, Piero
AU - Rossi, Ivan
AU - Nagy, Alinda
AU - Kai, Wang
AU - Størling, Zenia
AU - Orsini, Massimiliano
AU - Assenov, Yassen
AU - Blankenburg, Hagen
AU - Huthmacher, Carola
AU - Ramírez, Fidel
AU - Schlicker, Andreas
AU - Denoeud, France
AU - Jones, Phil
AU - Kerrien, Samuel
AU - Orchard, Sandra
AU - Antonarakis, Stylianos E
AU - Reymond, Alexandre
AU - Birney, Ewan
AU - Brunak, Søren
AU - Casadio, Rita
AU - Guigo, Roderic
AU - Harrow, Jennifer
AU - Hermjakob, Henning
AU - Jones, David T
AU - Lengauer, Thomas
AU - Orengo, Christine A
AU - Patthy, László
AU - Thornton, Janet M
AU - Tramontano, Anna
AU - Valencia, Alfonso
PY - 2007
Y1 - 2007
N2 - Alternative premessenger RNA splicing enables genes to generate more than one gene product. Splicing events that occur within protein coding regions have the potential to alter the biological function of the expressed protein and even to create new protein functions. Alternative splicing has been suggested as one explanation for the discrepancy between the number of human genes and functional complexity. Here, we carry out a detailed study of the alternatively spliced gene products annotated in the ENCODE pilot project. We find that alternative splicing in human genes is more frequent than has commonly been suggested, and we demonstrate that many of the potential alternative gene products will have markedly different structure and function from their constitutively spliced counterparts. For the vast majority of these alternative isoforms, little evidence exists to suggest they have a role as functional proteins, and it seems unlikely that the spectrum of conventional enzymatic or structural functions can be substantially extended through alternative splicing.
AB - Alternative premessenger RNA splicing enables genes to generate more than one gene product. Splicing events that occur within protein coding regions have the potential to alter the biological function of the expressed protein and even to create new protein functions. Alternative splicing has been suggested as one explanation for the discrepancy between the number of human genes and functional complexity. Here, we carry out a detailed study of the alternatively spliced gene products annotated in the ENCODE pilot project. We find that alternative splicing in human genes is more frequent than has commonly been suggested, and we demonstrate that many of the potential alternative gene products will have markedly different structure and function from their constitutively spliced counterparts. For the vast majority of these alternative isoforms, little evidence exists to suggest they have a role as functional proteins, and it seems unlikely that the spectrum of conventional enzymatic or structural functions can be substantially extended through alternative splicing.
U2 - 10.1073/pnas.0700800104
DO - 10.1073/pnas.0700800104
M3 - Journal article
C2 - 17372197
VL - 104
SP - 5495
EP - 5500
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
SN - 0027-8424
IS - 13
ER -
