The impact of health-related quality of life and depressive symptoms on blood donor career - Results from the Danish blood donor study
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The impact of health-related quality of life and depressive symptoms on blood donor career - Results from the Danish blood donor study. / Didriksen, Maria; Thørner, Lise W.; Larsen, Margit A.H.; Sørensen, Erik; Burgdorf, Kristoffer; Mikkelsen, Susan; Rostgaard, Klaus; Banasik, Karina; Pedersen, Ole B.; Erikstrup, Christian; Nielsen, Kaspar R.; Bruun, Mie T.; Hjalgrim, Henrik; Ullum, Henrik.
In: Transfusion, Vol. 61, No. 5, 2021, p. 1479-1488.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The impact of health-related quality of life and depressive symptoms on blood donor career - Results from the Danish blood donor study
AU - Didriksen, Maria
AU - Thørner, Lise W.
AU - Larsen, Margit A.H.
AU - Sørensen, Erik
AU - Burgdorf, Kristoffer
AU - Mikkelsen, Susan
AU - Rostgaard, Klaus
AU - Banasik, Karina
AU - Pedersen, Ole B.
AU - Erikstrup, Christian
AU - Nielsen, Kaspar R.
AU - Bruun, Mie T.
AU - Hjalgrim, Henrik
AU - Ullum, Henrik
N1 - Funding information: Copenhagen University Hospital Research Fond; Danish Regions, Grant/Award Number: 02/2611; Det Frie Forskningsråd, Grant/Award Number: 09-069412; Novo Nordic Research Foundation, Grant/Award Number: NNF17OC0027594
PY - 2021
Y1 - 2021
N2 - Background: Blood donors report better health-related quality of life (HRQL) than non-donors. Likewise, donors reporting good health are less likely to stop donating and have a higher donation frequency. This is evidence of the healthy donor effect (HDE). This study is the first to investigate the impact of HRQL and depressive symptoms on subsequent donor career. Study Design and Methods: Prospective cohort study includes 102,065 participants from the Danish Blood Donor Study applying the 12-item short-form health survey (SF-12) measuring a mental (MCS) and a physical component score (PCS) and the Major Depression Inventory (MDI). Poisson and Cox regression models were used to assess the effect of SF-12 and MDI scores on donation frequency and donor cessation. Higher MCS/PCS scores indicate good HRQL, while higher MDI score indicates higher experience of depressive symptoms. Results: For both sexes, MCS was positively correlated with donation frequency for up to 5 years, and similarly for PCS among women. A negative correlation between MDI score and donation frequency in the year following assessment was observed only among men. No correlation was observed among women. An increase in both MCS and PCS was associated with a lower risk of donation cessation in both sexes, while an increase in MDI score was only associated with an increased risk of donation cessation in men. Conclusion: MCS, PCS, and MDI score affect donor career. Thus, adjusting for donation frequency may reduce HDE-bias in donor health research. However, because of the small effect sizes, other ways of quantifying HDE may be beneficial.
AB - Background: Blood donors report better health-related quality of life (HRQL) than non-donors. Likewise, donors reporting good health are less likely to stop donating and have a higher donation frequency. This is evidence of the healthy donor effect (HDE). This study is the first to investigate the impact of HRQL and depressive symptoms on subsequent donor career. Study Design and Methods: Prospective cohort study includes 102,065 participants from the Danish Blood Donor Study applying the 12-item short-form health survey (SF-12) measuring a mental (MCS) and a physical component score (PCS) and the Major Depression Inventory (MDI). Poisson and Cox regression models were used to assess the effect of SF-12 and MDI scores on donation frequency and donor cessation. Higher MCS/PCS scores indicate good HRQL, while higher MDI score indicates higher experience of depressive symptoms. Results: For both sexes, MCS was positively correlated with donation frequency for up to 5 years, and similarly for PCS among women. A negative correlation between MDI score and donation frequency in the year following assessment was observed only among men. No correlation was observed among women. An increase in both MCS and PCS was associated with a lower risk of donation cessation in both sexes, while an increase in MDI score was only associated with an increased risk of donation cessation in men. Conclusion: MCS, PCS, and MDI score affect donor career. Thus, adjusting for donation frequency may reduce HDE-bias in donor health research. However, because of the small effect sizes, other ways of quantifying HDE may be beneficial.
KW - donors
KW - health research methodology
KW - statistics
KW - study design
U2 - 10.1111/trf.16336
DO - 10.1111/trf.16336
M3 - Journal article
C2 - 33650703
AN - SCOPUS:85101882064
VL - 61
SP - 1479
EP - 1488
JO - Transfusion
JF - Transfusion
SN - 0041-1132
IS - 5
ER -
ID: 258778570