The Hippo pathway controls myofibril assembly and muscle fiber growth by regulating sarcomeric gene expression

Research output: Contribution to journal › Journal article › Research › peer-review

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The Hippo pathway controls myofibril assembly and muscle fiber growth by regulating sarcomeric gene expression. / Kaya-Çopur, Aynur; Marchiano, Fabio; Hein, Marco Y; Alpern, Daniel; Russeil, Julie; Luis, Nuno Miguel; Mann, Matthias; Deplancke, Bart; Habermann, Bianca H; Schnorrer, Frank.

In: eLife, Vol. 10, 06.01.2021.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Kaya-Çopur, A, Marchiano, F, Hein, MY, Alpern, D, Russeil, J, Luis, NM, Mann, M, Deplancke, B, Habermann, BH & Schnorrer, F 2021, 'The Hippo pathway controls myofibril assembly and muscle fiber growth by regulating sarcomeric gene expression', eLife, vol. 10. https://doi.org/10.7554/eLife.63726

APA

Kaya-Çopur, A., Marchiano, F., Hein, M. Y., Alpern, D., Russeil, J., Luis, N. M., Mann, M., Deplancke, B., Habermann, B. H., & Schnorrer, F. (2021). The Hippo pathway controls myofibril assembly and muscle fiber growth by regulating sarcomeric gene expression. eLife, 10. https://doi.org/10.7554/eLife.63726

Vancouver

Kaya-Çopur A, Marchiano F, Hein MY, Alpern D, Russeil J, Luis NM et al. The Hippo pathway controls myofibril assembly and muscle fiber growth by regulating sarcomeric gene expression. eLife. 2021 Jan 6;10. https://doi.org/10.7554/eLife.63726

Author

Kaya-Çopur, Aynur ; Marchiano, Fabio ; Hein, Marco Y ; Alpern, Daniel ; Russeil, Julie ; Luis, Nuno Miguel ; Mann, Matthias ; Deplancke, Bart ; Habermann, Bianca H ; Schnorrer, Frank. / The Hippo pathway controls myofibril assembly and muscle fiber growth by regulating sarcomeric gene expression. In: eLife. 2021 ; Vol. 10.

Bibtex

@article{d872b77c9f144154be795a52fd6b180d,
title = "The Hippo pathway controls myofibril assembly and muscle fiber growth by regulating sarcomeric gene expression",
abstract = "Skeletal muscles are composed of gigantic cells called muscle fibers, packed with force-producing myofibrils. During development, the size of individual muscle fibers must dramatically enlarge to match with skeletal growth. How muscle growth is coordinated with growth of the contractile apparatus is not understood. Here, we use the large Drosophila flight muscles to mechanistically decipher how muscle fiber growth is controlled. We find that regulated activity of core members of the Hippo pathway is required to support flight muscle growth. Interestingly, we identify Dlg5 and Slmap as regulators of the STRIPAK phosphatase, which negatively regulates Hippo to enable post-mitotic muscle growth. Mechanistically, we show that the Hippo pathway controls timing and levels of sarcomeric gene expression during development and thus regulates the key components that physically mediate muscle growth. Since Dlg5, STRIPAK and the Hippo pathway are conserved a similar mechanism may contribute to muscle or cardiomyocyte growth in humans.",
author = "Aynur Kaya-{\c C}opur and Fabio Marchiano and Hein, {Marco Y} and Daniel Alpern and Julie Russeil and Luis, {Nuno Miguel} and Matthias Mann and Bart Deplancke and Habermann, {Bianca H} and Frank Schnorrer",
note = "{\textcopyright} 2021, Kaya-{\c C}opur et al.",
year = "2021",
month = jan,
day = "6",
doi = "10.7554/eLife.63726",
language = "English",
volume = "10",
journal = "eLife",
issn = "2050-084X",
publisher = "eLife Sciences Publications Ltd.",

}

RIS

TY - JOUR

T1 - The Hippo pathway controls myofibril assembly and muscle fiber growth by regulating sarcomeric gene expression

AU - Kaya-Çopur, Aynur

AU - Marchiano, Fabio

AU - Hein, Marco Y

AU - Alpern, Daniel

AU - Russeil, Julie

AU - Luis, Nuno Miguel

AU - Mann, Matthias

AU - Deplancke, Bart

AU - Habermann, Bianca H

AU - Schnorrer, Frank

N1 - © 2021, Kaya-Çopur et al.

PY - 2021/1/6

Y1 - 2021/1/6

N2 - Skeletal muscles are composed of gigantic cells called muscle fibers, packed with force-producing myofibrils. During development, the size of individual muscle fibers must dramatically enlarge to match with skeletal growth. How muscle growth is coordinated with growth of the contractile apparatus is not understood. Here, we use the large Drosophila flight muscles to mechanistically decipher how muscle fiber growth is controlled. We find that regulated activity of core members of the Hippo pathway is required to support flight muscle growth. Interestingly, we identify Dlg5 and Slmap as regulators of the STRIPAK phosphatase, which negatively regulates Hippo to enable post-mitotic muscle growth. Mechanistically, we show that the Hippo pathway controls timing and levels of sarcomeric gene expression during development and thus regulates the key components that physically mediate muscle growth. Since Dlg5, STRIPAK and the Hippo pathway are conserved a similar mechanism may contribute to muscle or cardiomyocyte growth in humans.

AB - Skeletal muscles are composed of gigantic cells called muscle fibers, packed with force-producing myofibrils. During development, the size of individual muscle fibers must dramatically enlarge to match with skeletal growth. How muscle growth is coordinated with growth of the contractile apparatus is not understood. Here, we use the large Drosophila flight muscles to mechanistically decipher how muscle fiber growth is controlled. We find that regulated activity of core members of the Hippo pathway is required to support flight muscle growth. Interestingly, we identify Dlg5 and Slmap as regulators of the STRIPAK phosphatase, which negatively regulates Hippo to enable post-mitotic muscle growth. Mechanistically, we show that the Hippo pathway controls timing and levels of sarcomeric gene expression during development and thus regulates the key components that physically mediate muscle growth. Since Dlg5, STRIPAK and the Hippo pathway are conserved a similar mechanism may contribute to muscle or cardiomyocyte growth in humans.

U2 - 10.7554/eLife.63726

DO - 10.7554/eLife.63726

M3 - Journal article

C2 - 33404503

VL - 10

JO - eLife

JF - eLife

SN - 2050-084X

ER -

ID: 259830471