The genetic structure of Norway

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

The genetic structure of Norway. / Mattingsdal, Morten; Ebenesersdóttir, S. Sunna; Moore, Kristjan H.S.; Andreassen, Ole A.; Hansen, Thomas F.; Werge, Thomas; Kockum, Ingrid; Olsson, Tomas; Alfredsson, Lars; Helgason, Agnar; Stefánsson, Kári; Hovig, Eivind.

In: European Journal of Human Genetics, Vol. 29, 2021, p. 1710–1718.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Mattingsdal, M, Ebenesersdóttir, SS, Moore, KHS, Andreassen, OA, Hansen, TF, Werge, T, Kockum, I, Olsson, T, Alfredsson, L, Helgason, A, Stefánsson, K & Hovig, E 2021, 'The genetic structure of Norway', European Journal of Human Genetics, vol. 29, pp. 1710–1718. https://doi.org/10.1038/s41431-021-00899-6

APA

Mattingsdal, M., Ebenesersdóttir, S. S., Moore, K. H. S., Andreassen, O. A., Hansen, T. F., Werge, T., Kockum, I., Olsson, T., Alfredsson, L., Helgason, A., Stefánsson, K., & Hovig, E. (2021). The genetic structure of Norway. European Journal of Human Genetics, 29, 1710–1718. https://doi.org/10.1038/s41431-021-00899-6

Vancouver

Mattingsdal M, Ebenesersdóttir SS, Moore KHS, Andreassen OA, Hansen TF, Werge T et al. The genetic structure of Norway. European Journal of Human Genetics. 2021;29:1710–1718. https://doi.org/10.1038/s41431-021-00899-6

Author

Mattingsdal, Morten ; Ebenesersdóttir, S. Sunna ; Moore, Kristjan H.S. ; Andreassen, Ole A. ; Hansen, Thomas F. ; Werge, Thomas ; Kockum, Ingrid ; Olsson, Tomas ; Alfredsson, Lars ; Helgason, Agnar ; Stefánsson, Kári ; Hovig, Eivind. / The genetic structure of Norway. In: European Journal of Human Genetics. 2021 ; Vol. 29. pp. 1710–1718.

Bibtex

@article{f0aa635824eb4153a8cfd5d86fb13cc2,
title = "The genetic structure of Norway",
abstract = "The aim of the present study was to describe the genetic structure of the Norwegian population using genotypes from 6369 unrelated individuals with detailed information about places of residence. Using standard single marker- and haplotype-based approaches, we report evidence of two regions with distinctive patterns of genetic variation, one in the far northeast, and another in the south of Norway, as indicated by fixation indices, haplotype sharing, homozygosity, and effective population size. We detect and quantify a component of Uralic Sami ancestry that is enriched in the North. On a finer scale, we find that rates of migration have been affected by topography like mountain ridges. In the broader Scandinavian context, we detect elevated relatedness between the mid- and northern border areas towards Sweden. The main finding of this study is that despite Norway{\textquoteright}s long maritime history and as a former Danish territory, the region closest to mainland Europe in the south appears to have been an isolated region in Norway, highlighting the open sea as a barrier to gene flow into Norway.",
author = "Morten Mattingsdal and Ebenesersd{\'o}ttir, {S. Sunna} and Moore, {Kristjan H.S.} and Andreassen, {Ole A.} and Hansen, {Thomas F.} and Thomas Werge and Ingrid Kockum and Tomas Olsson and Lars Alfredsson and Agnar Helgason and K{\'a}ri Stef{\'a}nsson and Eivind Hovig",
note = "Publisher Copyright: {\textcopyright} 2021, The Author(s).",
year = "2021",
doi = "10.1038/s41431-021-00899-6",
language = "English",
volume = "29",
pages = "1710–1718",
journal = "European Journal of Human Genetics",
issn = "1018-4813",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - The genetic structure of Norway

AU - Mattingsdal, Morten

AU - Ebenesersdóttir, S. Sunna

AU - Moore, Kristjan H.S.

AU - Andreassen, Ole A.

AU - Hansen, Thomas F.

AU - Werge, Thomas

AU - Kockum, Ingrid

AU - Olsson, Tomas

AU - Alfredsson, Lars

AU - Helgason, Agnar

AU - Stefánsson, Kári

AU - Hovig, Eivind

N1 - Publisher Copyright: © 2021, The Author(s).

PY - 2021

Y1 - 2021

N2 - The aim of the present study was to describe the genetic structure of the Norwegian population using genotypes from 6369 unrelated individuals with detailed information about places of residence. Using standard single marker- and haplotype-based approaches, we report evidence of two regions with distinctive patterns of genetic variation, one in the far northeast, and another in the south of Norway, as indicated by fixation indices, haplotype sharing, homozygosity, and effective population size. We detect and quantify a component of Uralic Sami ancestry that is enriched in the North. On a finer scale, we find that rates of migration have been affected by topography like mountain ridges. In the broader Scandinavian context, we detect elevated relatedness between the mid- and northern border areas towards Sweden. The main finding of this study is that despite Norway’s long maritime history and as a former Danish territory, the region closest to mainland Europe in the south appears to have been an isolated region in Norway, highlighting the open sea as a barrier to gene flow into Norway.

AB - The aim of the present study was to describe the genetic structure of the Norwegian population using genotypes from 6369 unrelated individuals with detailed information about places of residence. Using standard single marker- and haplotype-based approaches, we report evidence of two regions with distinctive patterns of genetic variation, one in the far northeast, and another in the south of Norway, as indicated by fixation indices, haplotype sharing, homozygosity, and effective population size. We detect and quantify a component of Uralic Sami ancestry that is enriched in the North. On a finer scale, we find that rates of migration have been affected by topography like mountain ridges. In the broader Scandinavian context, we detect elevated relatedness between the mid- and northern border areas towards Sweden. The main finding of this study is that despite Norway’s long maritime history and as a former Danish territory, the region closest to mainland Europe in the south appears to have been an isolated region in Norway, highlighting the open sea as a barrier to gene flow into Norway.

U2 - 10.1038/s41431-021-00899-6

DO - 10.1038/s41431-021-00899-6

M3 - Journal article

C2 - 34002043

AN - SCOPUS:85108784676

VL - 29

SP - 1710

EP - 1718

JO - European Journal of Human Genetics

JF - European Journal of Human Genetics

SN - 1018-4813

ER -

ID: 273647979