The Drosophila Microtubule-Associated Protein Mars Stabilizes Mitotic Spindles by Crosslinking Microtubules through Its N-Terminal Region

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The Drosophila Microtubule-Associated Protein Mars Stabilizes Mitotic Spindles by Crosslinking Microtubules through Its N-Terminal Region. / Zhang, Gang; Beati, Hamze; Nilsson, Jakob; Wodarz, Andreas.

In: P L o S One, Vol. 8, No. 4, 04.04.2013, p. e60596.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Zhang, G, Beati, H, Nilsson, J & Wodarz, A 2013, 'The Drosophila Microtubule-Associated Protein Mars Stabilizes Mitotic Spindles by Crosslinking Microtubules through Its N-Terminal Region', P L o S One, vol. 8, no. 4, pp. e60596. https://doi.org/10.1371/journal.pone.0060596

APA

Zhang, G., Beati, H., Nilsson, J., & Wodarz, A. (2013). The Drosophila Microtubule-Associated Protein Mars Stabilizes Mitotic Spindles by Crosslinking Microtubules through Its N-Terminal Region. P L o S One, 8(4), e60596. https://doi.org/10.1371/journal.pone.0060596

Vancouver

Zhang G, Beati H, Nilsson J, Wodarz A. The Drosophila Microtubule-Associated Protein Mars Stabilizes Mitotic Spindles by Crosslinking Microtubules through Its N-Terminal Region. P L o S One. 2013 Apr 4;8(4):e60596. https://doi.org/10.1371/journal.pone.0060596

Author

Zhang, Gang ; Beati, Hamze ; Nilsson, Jakob ; Wodarz, Andreas. / The Drosophila Microtubule-Associated Protein Mars Stabilizes Mitotic Spindles by Crosslinking Microtubules through Its N-Terminal Region. In: P L o S One. 2013 ; Vol. 8, No. 4. pp. e60596.

Bibtex

@article{e1e99f893f8349c7ac5d6a93cd605fcc,
title = "The Drosophila Microtubule-Associated Protein Mars Stabilizes Mitotic Spindles by Crosslinking Microtubules through Its N-Terminal Region",
abstract = "Correct segregation of genetic material relies on proper assembly and maintenance of the mitotic spindle. How the highly dynamic microtubules (MTs) are maintained in stable mitotic spindles is a key question to be answered. Motor and non-motor microtubule associated proteins (MAPs) have been reported to stabilize the dynamic spindle through crosslinking adjacent MTs. Mars, a novel MAP, is essential for the early development of Drosophila embryos. Previous studies showed that Mars is required for maintaining an intact mitotic spindle but did not provide a molecular mechanism for this function. Here we show that Mars is able to stabilize the mitotic spindle in vivo. Both in vivo and in vitro data reveal that the N-terminal region of Mars functions in the stabilization of the mitotic spindle by crosslinking adjacent MTs.",
author = "Gang Zhang and Hamze Beati and Jakob Nilsson and Andreas Wodarz",
year = "2013",
month = apr,
day = "4",
doi = "10.1371/journal.pone.0060596",
language = "English",
volume = "8",
pages = "e60596",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "4",

}

RIS

TY - JOUR

T1 - The Drosophila Microtubule-Associated Protein Mars Stabilizes Mitotic Spindles by Crosslinking Microtubules through Its N-Terminal Region

AU - Zhang, Gang

AU - Beati, Hamze

AU - Nilsson, Jakob

AU - Wodarz, Andreas

PY - 2013/4/4

Y1 - 2013/4/4

N2 - Correct segregation of genetic material relies on proper assembly and maintenance of the mitotic spindle. How the highly dynamic microtubules (MTs) are maintained in stable mitotic spindles is a key question to be answered. Motor and non-motor microtubule associated proteins (MAPs) have been reported to stabilize the dynamic spindle through crosslinking adjacent MTs. Mars, a novel MAP, is essential for the early development of Drosophila embryos. Previous studies showed that Mars is required for maintaining an intact mitotic spindle but did not provide a molecular mechanism for this function. Here we show that Mars is able to stabilize the mitotic spindle in vivo. Both in vivo and in vitro data reveal that the N-terminal region of Mars functions in the stabilization of the mitotic spindle by crosslinking adjacent MTs.

AB - Correct segregation of genetic material relies on proper assembly and maintenance of the mitotic spindle. How the highly dynamic microtubules (MTs) are maintained in stable mitotic spindles is a key question to be answered. Motor and non-motor microtubule associated proteins (MAPs) have been reported to stabilize the dynamic spindle through crosslinking adjacent MTs. Mars, a novel MAP, is essential for the early development of Drosophila embryos. Previous studies showed that Mars is required for maintaining an intact mitotic spindle but did not provide a molecular mechanism for this function. Here we show that Mars is able to stabilize the mitotic spindle in vivo. Both in vivo and in vitro data reveal that the N-terminal region of Mars functions in the stabilization of the mitotic spindle by crosslinking adjacent MTs.

U2 - 10.1371/journal.pone.0060596

DO - 10.1371/journal.pone.0060596

M3 - Journal article

C2 - 23593258

VL - 8

SP - e60596

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 4

ER -

ID: 45617417