Symmetric inheritance of parental histones governs epigenome maintenance and embryonic stem cell identity

Research output: Contribution to journal › Journal article › Research › peer-review

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Symmetric inheritance of parental histones governs epigenome maintenance and embryonic stem cell identity. / Wenger, Alice; Biran, Alva; Alcaraz, Nicolas; Redó-Riveiro, Alba; Sell, Annika Charlotte; Krautz, Robert; Flury, Valentin; Reverón-Gómez, Nazaret; Solis-Mezarino, Victor; Völker-Albert, Moritz; Imhof, Axel; Andersson, Robin; Brickman, Joshua M.; Groth, Anja.

In: Nature Genetics, Vol. 55, No. 9, 2023, p. 1567-1578.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Wenger, A, Biran, A, Alcaraz, N, Redó-Riveiro, A, Sell, AC, Krautz, R, Flury, V, Reverón-Gómez, N, Solis-Mezarino, V, Völker-Albert, M, Imhof, A, Andersson, R, Brickman, JM & Groth, A 2023, 'Symmetric inheritance of parental histones governs epigenome maintenance and embryonic stem cell identity', Nature Genetics, vol. 55, no. 9, pp. 1567-1578. https://doi.org/10.1038/s41588-023-01476-x

APA

Wenger, A., Biran, A., Alcaraz, N., Redó-Riveiro, A., Sell, A. C., Krautz, R., Flury, V., Reverón-Gómez, N., Solis-Mezarino, V., Völker-Albert, M., Imhof, A., Andersson, R., Brickman, J. M., & Groth, A. (2023). Symmetric inheritance of parental histones governs epigenome maintenance and embryonic stem cell identity. Nature Genetics, 55(9), 1567-1578. https://doi.org/10.1038/s41588-023-01476-x

Vancouver

Wenger A, Biran A, Alcaraz N, Redó-Riveiro A, Sell AC, Krautz R et al. Symmetric inheritance of parental histones governs epigenome maintenance and embryonic stem cell identity. Nature Genetics. 2023;55(9):1567-1578. https://doi.org/10.1038/s41588-023-01476-x

Author

Wenger, Alice ; Biran, Alva ; Alcaraz, Nicolas ; Redó-Riveiro, Alba ; Sell, Annika Charlotte ; Krautz, Robert ; Flury, Valentin ; Reverón-Gómez, Nazaret ; Solis-Mezarino, Victor ; Völker-Albert, Moritz ; Imhof, Axel ; Andersson, Robin ; Brickman, Joshua M. ; Groth, Anja. / Symmetric inheritance of parental histones governs epigenome maintenance and embryonic stem cell identity. In: Nature Genetics. 2023 ; Vol. 55, No. 9. pp. 1567-1578.

Bibtex

@article{d0631e16e0864194a0fcf557da0d6d45,
title = "Symmetric inheritance of parental histones governs epigenome maintenance and embryonic stem cell identity",
abstract = "Modified parental histones are segregated symmetrically to daughter DNA strands during replication and can be inherited through mitosis. How this may sustain the epigenome and cell identity remains unknown. Here we show that transmission of histone-based information during DNA replication maintains epigenome fidelity and embryonic stem cell plasticity. Asymmetric segregation of parental histones H3–H4 in MCM2-2A mutants compromised mitotic inheritance of histone modifications and globally altered the epigenome. This included widespread spurious deposition of repressive modifications, suggesting elevated epigenetic noise. Moreover, H3K9me3 loss at repeats caused derepression and H3K27me3 redistribution across bivalent promoters correlated with misexpression of developmental genes. MCM2-2A mutation challenged dynamic transitions in cellular states across the cell cycle, enhancing na{\"i}ve pluripotency and reducing lineage priming in G1. Furthermore, developmental competence was diminished, correlating with impaired exit from pluripotency. Collectively, this argues that epigenetic inheritance of histone modifications maintains a correctly balanced and dynamic chromatin landscape able to support mammalian cell differentiation.",
author = "Alice Wenger and Alva Biran and Nicolas Alcaraz and Alba Red{\'o}-Riveiro and Sell, {Annika Charlotte} and Robert Krautz and Valentin Flury and Nazaret Rever{\'o}n-G{\'o}mez and Victor Solis-Mezarino and Moritz V{\"o}lker-Albert and Axel Imhof and Robin Andersson and Brickman, {Joshua M.} and Anja Groth",
note = "Publisher Copyright: {\textcopyright} 2023, The Author(s).",
year = "2023",
doi = "10.1038/s41588-023-01476-x",
language = "English",
volume = "55",
pages = "1567--1578",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "nature publishing group",
number = "9",

}

RIS

TY - JOUR

T1 - Symmetric inheritance of parental histones governs epigenome maintenance and embryonic stem cell identity

AU - Wenger, Alice

AU - Biran, Alva

AU - Alcaraz, Nicolas

AU - Redó-Riveiro, Alba

AU - Sell, Annika Charlotte

AU - Krautz, Robert

AU - Flury, Valentin

AU - Reverón-Gómez, Nazaret

AU - Solis-Mezarino, Victor

AU - Völker-Albert, Moritz

AU - Imhof, Axel

AU - Andersson, Robin

AU - Brickman, Joshua M.

AU - Groth, Anja

N1 - Publisher Copyright: © 2023, The Author(s).

PY - 2023

Y1 - 2023

N2 - Modified parental histones are segregated symmetrically to daughter DNA strands during replication and can be inherited through mitosis. How this may sustain the epigenome and cell identity remains unknown. Here we show that transmission of histone-based information during DNA replication maintains epigenome fidelity and embryonic stem cell plasticity. Asymmetric segregation of parental histones H3–H4 in MCM2-2A mutants compromised mitotic inheritance of histone modifications and globally altered the epigenome. This included widespread spurious deposition of repressive modifications, suggesting elevated epigenetic noise. Moreover, H3K9me3 loss at repeats caused derepression and H3K27me3 redistribution across bivalent promoters correlated with misexpression of developmental genes. MCM2-2A mutation challenged dynamic transitions in cellular states across the cell cycle, enhancing naïve pluripotency and reducing lineage priming in G1. Furthermore, developmental competence was diminished, correlating with impaired exit from pluripotency. Collectively, this argues that epigenetic inheritance of histone modifications maintains a correctly balanced and dynamic chromatin landscape able to support mammalian cell differentiation.

AB - Modified parental histones are segregated symmetrically to daughter DNA strands during replication and can be inherited through mitosis. How this may sustain the epigenome and cell identity remains unknown. Here we show that transmission of histone-based information during DNA replication maintains epigenome fidelity and embryonic stem cell plasticity. Asymmetric segregation of parental histones H3–H4 in MCM2-2A mutants compromised mitotic inheritance of histone modifications and globally altered the epigenome. This included widespread spurious deposition of repressive modifications, suggesting elevated epigenetic noise. Moreover, H3K9me3 loss at repeats caused derepression and H3K27me3 redistribution across bivalent promoters correlated with misexpression of developmental genes. MCM2-2A mutation challenged dynamic transitions in cellular states across the cell cycle, enhancing naïve pluripotency and reducing lineage priming in G1. Furthermore, developmental competence was diminished, correlating with impaired exit from pluripotency. Collectively, this argues that epigenetic inheritance of histone modifications maintains a correctly balanced and dynamic chromatin landscape able to support mammalian cell differentiation.

U2 - 10.1038/s41588-023-01476-x

DO - 10.1038/s41588-023-01476-x

M3 - Journal article

C2 - 37666988

AN - SCOPUS:85169834888

VL - 55

SP - 1567

EP - 1578

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 9

ER -

ID: 366646965