SuperTarget and Matador: resources for exploring drug-target relationships
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SuperTarget and Matador : resources for exploring drug-target relationships. / Günther, Stefan; Kuhn, Michael; Dunkel, Mathias; Campillos, Monica; Senger, Christian; Petsalaki, Evangelia; Ahmed, Jessica; Urdiales, Eduardo Garcia; Gewiess, Andreas; Jensen, Lars Juhl; Schneider, Reinhard; Skoblo, Roman; Russell, Robert B; Bourne, Philip E; Bork, Peer; Preissner, Robert.
In: Nucleic Acids Research, Vol. 36, No. Database issue, 2008, p. D919-22.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - SuperTarget and Matador
T2 - resources for exploring drug-target relationships
AU - Günther, Stefan
AU - Kuhn, Michael
AU - Dunkel, Mathias
AU - Campillos, Monica
AU - Senger, Christian
AU - Petsalaki, Evangelia
AU - Ahmed, Jessica
AU - Urdiales, Eduardo Garcia
AU - Gewiess, Andreas
AU - Jensen, Lars Juhl
AU - Schneider, Reinhard
AU - Skoblo, Roman
AU - Russell, Robert B
AU - Bourne, Philip E
AU - Bork, Peer
AU - Preissner, Robert
PY - 2008
Y1 - 2008
N2 - The molecular basis of drug action is often not well understood. This is partly because the very abundant and diverse information generated in the past decades on drugs is hidden in millions of medical articles or textbooks. Therefore, we developed a one-stop data warehouse, SuperTarget that integrates drug-related information about medical indication areas, adverse drug effects, drug metabolization, pathways and Gene Ontology terms of the target proteins. An easy-to-use query interface enables the user to pose complex queries, for example to find drugs that target a certain pathway, interacting drugs that are metabolized by the same cytochrome P450 or drugs that target the same protein but are metabolized by different enzymes. Furthermore, we provide tools for 2D drug screening and sequence comparison of the targets. The database contains more than 2500 target proteins, which are annotated with about 7300 relations to 1500 drugs; the vast majority of entries have pointers to the respective literature source. A subset of these drugs has been annotated with additional binding information and indirect interactions and is available as a separate resource called Matador. SuperTarget and Matador are available at http://insilico.charite.de/supertarget and http://matador.embl.de.
AB - The molecular basis of drug action is often not well understood. This is partly because the very abundant and diverse information generated in the past decades on drugs is hidden in millions of medical articles or textbooks. Therefore, we developed a one-stop data warehouse, SuperTarget that integrates drug-related information about medical indication areas, adverse drug effects, drug metabolization, pathways and Gene Ontology terms of the target proteins. An easy-to-use query interface enables the user to pose complex queries, for example to find drugs that target a certain pathway, interacting drugs that are metabolized by the same cytochrome P450 or drugs that target the same protein but are metabolized by different enzymes. Furthermore, we provide tools for 2D drug screening and sequence comparison of the targets. The database contains more than 2500 target proteins, which are annotated with about 7300 relations to 1500 drugs; the vast majority of entries have pointers to the respective literature source. A subset of these drugs has been annotated with additional binding information and indirect interactions and is available as a separate resource called Matador. SuperTarget and Matador are available at http://insilico.charite.de/supertarget and http://matador.embl.de.
U2 - 10.1093/nar/gkm862
DO - 10.1093/nar/gkm862
M3 - Journal article
C2 - 17942422
VL - 36
SP - D919-22
JO - Nucleic Acids Research
JF - Nucleic Acids Research
SN - 0305-1048
IS - Database issue
ER -
ID: 40740227