Structural insights into the role of GTPBP10 in the RNA maturation of the mitoribosome

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Structural insights into the role of GTPBP10 in the RNA maturation of the mitoribosome. / Nguyen, Thu Giang; Ritter, Christina; Kummer, Eva.

In: Nature Communications, Vol. 14, 7991, 2023.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Nguyen, TG, Ritter, C & Kummer, E 2023, 'Structural insights into the role of GTPBP10 in the RNA maturation of the mitoribosome', Nature Communications, vol. 14, 7991. https://doi.org/10.1038/s41467-023-43599-z

APA

Nguyen, T. G., Ritter, C., & Kummer, E. (2023). Structural insights into the role of GTPBP10 in the RNA maturation of the mitoribosome. Nature Communications, 14, [7991]. https://doi.org/10.1038/s41467-023-43599-z

Vancouver

Nguyen TG, Ritter C, Kummer E. Structural insights into the role of GTPBP10 in the RNA maturation of the mitoribosome. Nature Communications. 2023;14. 7991. https://doi.org/10.1038/s41467-023-43599-z

Author

Nguyen, Thu Giang ; Ritter, Christina ; Kummer, Eva. / Structural insights into the role of GTPBP10 in the RNA maturation of the mitoribosome. In: Nature Communications. 2023 ; Vol. 14.

Bibtex

@article{84b77fa30c1041808f720d3258a7c347,
title = "Structural insights into the role of GTPBP10 in the RNA maturation of the mitoribosome",
abstract = "Mitochondria contain their own genetic information and a dedicated translation system to express it. The mitochondrial ribosome is assembled from mitochondrial-encoded RNA and nuclear-encoded ribosomal proteins. Assembly is coordinated in the mitochondrial matrix by biogenesis factors that transiently associate with the maturing particle. Here, we present a structural snapshot of a large mitoribosomal subunit assembly intermediate containing 7 biogenesis factors including the GTPases GTPBP7 and GTPBP10. Our structure illustrates how GTPBP10 aids the folding of the ribosomal RNA during the biogenesis process, how this process is related to bacterial ribosome biogenesis, and why mitochondria require two biogenesis factors in contrast to only one in bacteria.",
keywords = "Mitochondrial Ribosomes/metabolism, RNA/metabolism, Mitochondrial Proteins/genetics, Mitochondria/genetics, Ribosomal Proteins/genetics, RNA, Ribosomal/genetics",
author = "Nguyen, {Thu Giang} and Christina Ritter and Eva Kummer",
note = "{\textcopyright} 2023. The Author(s).",
year = "2023",
doi = "10.1038/s41467-023-43599-z",
language = "English",
volume = "14",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Structural insights into the role of GTPBP10 in the RNA maturation of the mitoribosome

AU - Nguyen, Thu Giang

AU - Ritter, Christina

AU - Kummer, Eva

N1 - © 2023. The Author(s).

PY - 2023

Y1 - 2023

N2 - Mitochondria contain their own genetic information and a dedicated translation system to express it. The mitochondrial ribosome is assembled from mitochondrial-encoded RNA and nuclear-encoded ribosomal proteins. Assembly is coordinated in the mitochondrial matrix by biogenesis factors that transiently associate with the maturing particle. Here, we present a structural snapshot of a large mitoribosomal subunit assembly intermediate containing 7 biogenesis factors including the GTPases GTPBP7 and GTPBP10. Our structure illustrates how GTPBP10 aids the folding of the ribosomal RNA during the biogenesis process, how this process is related to bacterial ribosome biogenesis, and why mitochondria require two biogenesis factors in contrast to only one in bacteria.

AB - Mitochondria contain their own genetic information and a dedicated translation system to express it. The mitochondrial ribosome is assembled from mitochondrial-encoded RNA and nuclear-encoded ribosomal proteins. Assembly is coordinated in the mitochondrial matrix by biogenesis factors that transiently associate with the maturing particle. Here, we present a structural snapshot of a large mitoribosomal subunit assembly intermediate containing 7 biogenesis factors including the GTPases GTPBP7 and GTPBP10. Our structure illustrates how GTPBP10 aids the folding of the ribosomal RNA during the biogenesis process, how this process is related to bacterial ribosome biogenesis, and why mitochondria require two biogenesis factors in contrast to only one in bacteria.

KW - Mitochondrial Ribosomes/metabolism

KW - RNA/metabolism

KW - Mitochondrial Proteins/genetics

KW - Mitochondria/genetics

KW - Ribosomal Proteins/genetics

KW - RNA, Ribosomal/genetics

U2 - 10.1038/s41467-023-43599-z

DO - 10.1038/s41467-023-43599-z

M3 - Journal article

C2 - 38042949

VL - 14

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 7991

ER -

ID: 378868236