Structural basis of CRISPR-Cas Type III prokaryotic defence systems

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Structural basis of CRISPR-Cas Type III prokaryotic defence systems. / Molina, Rafael; Sofos, Nicholas; Montoya, Guillermo.

In: Current Opinion in Structural Biology, Vol. 65, 2020, p. 119-129.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Molina, R, Sofos, N & Montoya, G 2020, 'Structural basis of CRISPR-Cas Type III prokaryotic defence systems', Current Opinion in Structural Biology, vol. 65, pp. 119-129. https://doi.org/10.1016/j.sbi.2020.06.010

APA

Molina, R., Sofos, N., & Montoya, G. (2020). Structural basis of CRISPR-Cas Type III prokaryotic defence systems. Current Opinion in Structural Biology, 65, 119-129. https://doi.org/10.1016/j.sbi.2020.06.010

Vancouver

Molina R, Sofos N, Montoya G. Structural basis of CRISPR-Cas Type III prokaryotic defence systems. Current Opinion in Structural Biology. 2020;65:119-129. https://doi.org/10.1016/j.sbi.2020.06.010

Author

Molina, Rafael ; Sofos, Nicholas ; Montoya, Guillermo. / Structural basis of CRISPR-Cas Type III prokaryotic defence systems. In: Current Opinion in Structural Biology. 2020 ; Vol. 65. pp. 119-129.

Bibtex

@article{cb0c2c0c969c4ee28eef0d75c23c6e24,
title = "Structural basis of CRISPR-Cas Type III prokaryotic defence systems",
abstract = "CRISPR loci and CRISPR-associated (Cas) genes encode an adaptive immune system that protects many bacterial and almost all archaea against invasive genetic elements from bacteriophages and plasmids. Several classes of CRISPR systems have been characterized, of which the type III CRISPR systems exhibit the most unique functions. Members of type III cleave both RNA and DNA not only through their corresponding effector complexes but also by CRISPR-Cas associated proteins activated by second messengers produced by those effector complexes. Furthermore, the recent discovery of second messenger degrading proteins called ring nucleases adds an extra regulatory layer to fine-tune these immunity systems. Here, we review the defense mechanisms that govern type III CRISPR interference immunity systems focusing on the structural information available.",
author = "Rafael Molina and Nicholas Sofos and Guillermo Montoya",
year = "2020",
doi = "10.1016/j.sbi.2020.06.010",
language = "English",
volume = "65",
pages = "119--129",
journal = "Current Opinion in Structural Biology",
issn = "0959-440X",
publisher = "Elsevier Ltd. * Current Opinion Journals",

}

RIS

TY - JOUR

T1 - Structural basis of CRISPR-Cas Type III prokaryotic defence systems

AU - Molina, Rafael

AU - Sofos, Nicholas

AU - Montoya, Guillermo

PY - 2020

Y1 - 2020

N2 - CRISPR loci and CRISPR-associated (Cas) genes encode an adaptive immune system that protects many bacterial and almost all archaea against invasive genetic elements from bacteriophages and plasmids. Several classes of CRISPR systems have been characterized, of which the type III CRISPR systems exhibit the most unique functions. Members of type III cleave both RNA and DNA not only through their corresponding effector complexes but also by CRISPR-Cas associated proteins activated by second messengers produced by those effector complexes. Furthermore, the recent discovery of second messenger degrading proteins called ring nucleases adds an extra regulatory layer to fine-tune these immunity systems. Here, we review the defense mechanisms that govern type III CRISPR interference immunity systems focusing on the structural information available.

AB - CRISPR loci and CRISPR-associated (Cas) genes encode an adaptive immune system that protects many bacterial and almost all archaea against invasive genetic elements from bacteriophages and plasmids. Several classes of CRISPR systems have been characterized, of which the type III CRISPR systems exhibit the most unique functions. Members of type III cleave both RNA and DNA not only through their corresponding effector complexes but also by CRISPR-Cas associated proteins activated by second messengers produced by those effector complexes. Furthermore, the recent discovery of second messenger degrading proteins called ring nucleases adds an extra regulatory layer to fine-tune these immunity systems. Here, we review the defense mechanisms that govern type III CRISPR interference immunity systems focusing on the structural information available.

U2 - 10.1016/j.sbi.2020.06.010

DO - 10.1016/j.sbi.2020.06.010

M3 - Review

C2 - 32712502

AN - SCOPUS:85088222059

VL - 65

SP - 119

EP - 129

JO - Current Opinion in Structural Biology

JF - Current Opinion in Structural Biology

SN - 0959-440X

ER -

ID: 248563869