SCO-ping out the mechanisms underlying the etiology of hydrocephalus
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SCO-ping out the mechanisms underlying the etiology of hydrocephalus. / Huh, Michael S.; Todd, Matthew A.M.; Picketts, David J.
In: Physiology, Vol. 24, No. 2, 04.2009, p. 117-126.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - SCO-ping out the mechanisms underlying the etiology of hydrocephalus
AU - Huh, Michael S.
AU - Todd, Matthew A.M.
AU - Picketts, David J.
PY - 2009/4
Y1 - 2009/4
N2 - The heterogeneous nature of congenital hydrocephalus has hampered our understanding of the molecular basis of this common clinical problem. However, disease gene identification and characterization of multiple transgenic mouse models has highlighted the importance of the subcommissural organ (SCO) and the ventricular ependymal (vel) cells. Here, we review how altered development and function of the SCO and vel cells contributes to hydrocephalus.
AB - The heterogeneous nature of congenital hydrocephalus has hampered our understanding of the molecular basis of this common clinical problem. However, disease gene identification and characterization of multiple transgenic mouse models has highlighted the importance of the subcommissural organ (SCO) and the ventricular ependymal (vel) cells. Here, we review how altered development and function of the SCO and vel cells contributes to hydrocephalus.
UR - http://www.scopus.com/inward/record.url?scp=66149108004&partnerID=8YFLogxK
U2 - 10.1152/physiol.00039.2008
DO - 10.1152/physiol.00039.2008
M3 - Review
C2 - 19364914
AN - SCOPUS:66149108004
VL - 24
SP - 117
EP - 126
JO - Physiology
JF - Physiology
SN - 1548-9213
IS - 2
ER -
ID: 319874068