sAOP: linking chemical stressors to adverse outcomes pathway networks

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

sAOP : linking chemical stressors to adverse outcomes pathway networks. / Aguayo-Orozco, Alejandro; Audouze, Karine; Siggaard, Troels; Barouki, Robert; Brunak, Søren; Taboureau, Olivier.

In: Bioinformatics, 2019.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Aguayo-Orozco, A, Audouze, K, Siggaard, T, Barouki, R, Brunak, S & Taboureau, O 2019, 'sAOP: linking chemical stressors to adverse outcomes pathway networks', Bioinformatics. https://doi.org/10.1093/bioinformatics/btz570

APA

Aguayo-Orozco, A., Audouze, K., Siggaard, T., Barouki, R., Brunak, S., & Taboureau, O. (2019). sAOP: linking chemical stressors to adverse outcomes pathway networks. Bioinformatics. https://doi.org/10.1093/bioinformatics/btz570

Vancouver

Aguayo-Orozco A, Audouze K, Siggaard T, Barouki R, Brunak S, Taboureau O. sAOP: linking chemical stressors to adverse outcomes pathway networks. Bioinformatics. 2019. https://doi.org/10.1093/bioinformatics/btz570

Author

Aguayo-Orozco, Alejandro ; Audouze, Karine ; Siggaard, Troels ; Barouki, Robert ; Brunak, Søren ; Taboureau, Olivier. / sAOP : linking chemical stressors to adverse outcomes pathway networks. In: Bioinformatics. 2019.

Bibtex

@article{6ad4d4892e9f42a982d208fed77193f1,
title = "sAOP: linking chemical stressors to adverse outcomes pathway networks",
abstract = "MOTIVATION: Adverse outcome pathway (AOP) is a toxicological concept proposed to provide a mechanistic representation of biological perturbation over different layers of biological organization. Although AOPs are by definition chemical-agnostic, many chemical stressors can putatively interfere with one or several AOPs and such information would be relevant for regulatory decision-making.RESULTS: With the recent development of AOPs networks aiming to facilitate the identification of interactions among AOPs, we developed a stressor-AOP network (sAOP). Using the {"}cytotoxitiy burst{"} (CTB) approach, we mapped bioactive compounds from the ToxCast data to a list of AOPs reported in AOP-Wiki database. With this analysis, a variety of relevant connections between chemicals and AOP components can be identified suggesting multiple effects not observed in the simplified {"}one-biological perturbation to one-adverse outcome{"} model. The results may assist in the prioritization of chemicals to assess risk-based evaluations in the context of human health.AVAILABILITY: sAOP is available at http://saop.cpr.ku.dk.SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.",
author = "Alejandro Aguayo-Orozco and Karine Audouze and Troels Siggaard and Robert Barouki and S{\o}ren Brunak and Olivier Taboureau",
year = "2019",
doi = "10.1093/bioinformatics/btz570",
language = "English",
journal = "Computer Applications in the Biosciences",
issn = "1471-2105",
publisher = "Oxford University Press",

}

RIS

TY - JOUR

T1 - sAOP

T2 - linking chemical stressors to adverse outcomes pathway networks

AU - Aguayo-Orozco, Alejandro

AU - Audouze, Karine

AU - Siggaard, Troels

AU - Barouki, Robert

AU - Brunak, Søren

AU - Taboureau, Olivier

PY - 2019

Y1 - 2019

N2 - MOTIVATION: Adverse outcome pathway (AOP) is a toxicological concept proposed to provide a mechanistic representation of biological perturbation over different layers of biological organization. Although AOPs are by definition chemical-agnostic, many chemical stressors can putatively interfere with one or several AOPs and such information would be relevant for regulatory decision-making.RESULTS: With the recent development of AOPs networks aiming to facilitate the identification of interactions among AOPs, we developed a stressor-AOP network (sAOP). Using the "cytotoxitiy burst" (CTB) approach, we mapped bioactive compounds from the ToxCast data to a list of AOPs reported in AOP-Wiki database. With this analysis, a variety of relevant connections between chemicals and AOP components can be identified suggesting multiple effects not observed in the simplified "one-biological perturbation to one-adverse outcome" model. The results may assist in the prioritization of chemicals to assess risk-based evaluations in the context of human health.AVAILABILITY: sAOP is available at http://saop.cpr.ku.dk.SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.

AB - MOTIVATION: Adverse outcome pathway (AOP) is a toxicological concept proposed to provide a mechanistic representation of biological perturbation over different layers of biological organization. Although AOPs are by definition chemical-agnostic, many chemical stressors can putatively interfere with one or several AOPs and such information would be relevant for regulatory decision-making.RESULTS: With the recent development of AOPs networks aiming to facilitate the identification of interactions among AOPs, we developed a stressor-AOP network (sAOP). Using the "cytotoxitiy burst" (CTB) approach, we mapped bioactive compounds from the ToxCast data to a list of AOPs reported in AOP-Wiki database. With this analysis, a variety of relevant connections between chemicals and AOP components can be identified suggesting multiple effects not observed in the simplified "one-biological perturbation to one-adverse outcome" model. The results may assist in the prioritization of chemicals to assess risk-based evaluations in the context of human health.AVAILABILITY: sAOP is available at http://saop.cpr.ku.dk.SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.

U2 - 10.1093/bioinformatics/btz570

DO - 10.1093/bioinformatics/btz570

M3 - Journal article

C2 - 31329252

JO - Computer Applications in the Biosciences

JF - Computer Applications in the Biosciences

SN - 1471-2105

ER -

ID: 227083176