SAC during early cell divisions: Sacrificing fidelity over timely division, regulated differently across organisms Chromosome alignment and segregation are left unsupervised from the onset of development until checkpoint activity is acquired, varying from species to species

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

SAC during early cell divisions : Sacrificing fidelity over timely division, regulated differently across organisms Chromosome alignment and segregation are left unsupervised from the onset of development until checkpoint activity is acquired, varying from species to species. / Duro, Joana; Nilsson, Jakob.

In: BioEssays, Vol. 43, No. 3, 2000174, 2021.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Duro, J & Nilsson, J 2021, 'SAC during early cell divisions: Sacrificing fidelity over timely division, regulated differently across organisms Chromosome alignment and segregation are left unsupervised from the onset of development until checkpoint activity is acquired, varying from species to species', BioEssays, vol. 43, no. 3, 2000174. https://doi.org/10.1002/bies.202000174

APA

Duro, J., & Nilsson, J. (2021). SAC during early cell divisions: Sacrificing fidelity over timely division, regulated differently across organisms Chromosome alignment and segregation are left unsupervised from the onset of development until checkpoint activity is acquired, varying from species to species. BioEssays, 43(3), [2000174]. https://doi.org/10.1002/bies.202000174

Vancouver

Duro J, Nilsson J. SAC during early cell divisions: Sacrificing fidelity over timely division, regulated differently across organisms Chromosome alignment and segregation are left unsupervised from the onset of development until checkpoint activity is acquired, varying from species to species. BioEssays. 2021;43(3). 2000174. https://doi.org/10.1002/bies.202000174

Author

Duro, Joana ; Nilsson, Jakob. / SAC during early cell divisions : Sacrificing fidelity over timely division, regulated differently across organisms Chromosome alignment and segregation are left unsupervised from the onset of development until checkpoint activity is acquired, varying from species to species. In: BioEssays. 2021 ; Vol. 43, No. 3.

Bibtex

@article{1cadc48af84543a8934cd0f09fcdb630,
title = "SAC during early cell divisions: Sacrificing fidelity over timely division, regulated differently across organisms Chromosome alignment and segregation are left unsupervised from the onset of development until checkpoint activity is acquired, varying from species to species",
abstract = "Early embryogenesis is marked by a frail Spindle Assembly Checkpoint (SAC). The time of SAC acquisition varies depending on the species, cell size or a yet to be uncovered developmental timer. This means that for a specific number of divisions, biorientation of sister chromatids occurs unsupervised. When error-prone segregation is an issue, an aneuploidy-selective apoptosis system can come into play to eliminate chromosomally unbalanced cells resulting in healthy newborns. However, aneuploidy content can be too great to overcome, endangering viability.SAC generates a diffusible signal to lengthen time spent in mitosis if needed, ensuring correct chromosome segregation, a fundamental factor in the generation of euploid cells. Thus, it remains puzzling what benefit could come from delaying SAC acquisition till later in the development. In this review, we describe what is known on SAC acquisition in distinct species and highlight pending research as well as potential applications for such knowledge.",
keywords = "aneuploidy, chromosome segregation, early embryogenesis, SAC, SPINDLE ASSEMBLY CHECKPOINT, HUMAN PREIMPLANTATION EMBRYOS, CYCLE CONTROL, MIDBLASTULA TRANSITION, MICROTUBULE-BINDING, DNA-REPLICATION, XENOPUS, ATTACHMENT, PROTEIN, MPS1",
author = "Joana Duro and Jakob Nilsson",
year = "2021",
doi = "10.1002/bies.202000174",
language = "English",
volume = "43",
journal = "BioEssays",
issn = "0265-9247",
publisher = "Wiley",
number = "3",

}

RIS

TY - JOUR

T1 - SAC during early cell divisions

T2 - Sacrificing fidelity over timely division, regulated differently across organisms Chromosome alignment and segregation are left unsupervised from the onset of development until checkpoint activity is acquired, varying from species to species

AU - Duro, Joana

AU - Nilsson, Jakob

PY - 2021

Y1 - 2021

N2 - Early embryogenesis is marked by a frail Spindle Assembly Checkpoint (SAC). The time of SAC acquisition varies depending on the species, cell size or a yet to be uncovered developmental timer. This means that for a specific number of divisions, biorientation of sister chromatids occurs unsupervised. When error-prone segregation is an issue, an aneuploidy-selective apoptosis system can come into play to eliminate chromosomally unbalanced cells resulting in healthy newborns. However, aneuploidy content can be too great to overcome, endangering viability.SAC generates a diffusible signal to lengthen time spent in mitosis if needed, ensuring correct chromosome segregation, a fundamental factor in the generation of euploid cells. Thus, it remains puzzling what benefit could come from delaying SAC acquisition till later in the development. In this review, we describe what is known on SAC acquisition in distinct species and highlight pending research as well as potential applications for such knowledge.

AB - Early embryogenesis is marked by a frail Spindle Assembly Checkpoint (SAC). The time of SAC acquisition varies depending on the species, cell size or a yet to be uncovered developmental timer. This means that for a specific number of divisions, biorientation of sister chromatids occurs unsupervised. When error-prone segregation is an issue, an aneuploidy-selective apoptosis system can come into play to eliminate chromosomally unbalanced cells resulting in healthy newborns. However, aneuploidy content can be too great to overcome, endangering viability.SAC generates a diffusible signal to lengthen time spent in mitosis if needed, ensuring correct chromosome segregation, a fundamental factor in the generation of euploid cells. Thus, it remains puzzling what benefit could come from delaying SAC acquisition till later in the development. In this review, we describe what is known on SAC acquisition in distinct species and highlight pending research as well as potential applications for such knowledge.

KW - aneuploidy

KW - chromosome segregation

KW - early embryogenesis

KW - SAC

KW - SPINDLE ASSEMBLY CHECKPOINT

KW - HUMAN PREIMPLANTATION EMBRYOS

KW - CYCLE CONTROL

KW - MIDBLASTULA TRANSITION

KW - MICROTUBULE-BINDING

KW - DNA-REPLICATION

KW - XENOPUS

KW - ATTACHMENT

KW - PROTEIN

KW - MPS1

U2 - 10.1002/bies.202000174

DO - 10.1002/bies.202000174

M3 - Journal article

C2 - 33251610

VL - 43

JO - BioEssays

JF - BioEssays

SN - 0265-9247

IS - 3

M1 - 2000174

ER -

ID: 253078466